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Investigation Of Inosine And Hypoxanthine As Biomarkers Of Cardiac Ischemia In Plasma Of Non-Traumatic Chest Pain Patients And A Rapid Analytical System For Assessment, Don E. Farthing

Theses and Dissertations

Each year in the U.S., approximately 7-8 million patients with non-traumatic chest pain visit hospital emergency departments (ED) for medical evaluation. It is estimated that approximately 2-5% of these patients are experiencing acute cardiac ischemia, but due to the shortcomings of current test methods, they are incorrectly diagnosed and discharged without appropriate treatment provided, thus leading to poor patient outcome and potential medical malpractice litigation.The goals of this research were to evaluate plasma samples for potential biomarker(s) of acute cardiac ischemia prior to heart tissue necrosis, and to ultimately develop a rapid method for detection of the potential biomarker(s) in …

Task Force Report On The Ethical Responsibilities Of Presidential Rhetoric, Steven R. Goldzwig, Karrin Vasby Anderson, Frederick J. Antczak, Thomas W. Benson, Rita Kirk Whillock

College of Communication Faculty Research and Publications

No abstract provided.

The Response Of Vascular Dermal Enodethial Cells To House Dust Mite Extracts, Aaron Mathew Newman

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House dust mites are microscopic arthropods that can trigger moderate allergic symptoms such as sneezing, watery eyes, itching, and wheezing in sensitized individuals. People with more serious allergies to house dust mites can develop allergic diseases like atopic dermatitis and asthma. The effects of house dust mites on allergy sufferers make house dust mites and the study of their effects on the human body of great medical and economic importance. A majority of the research that has been done on house dust mite's effects on humans has dealt with the lungs and relevant disease like asthma. Little work has been …

Using Geographic Information Systems To Select Sites For Wetland Restoration In West Central Ohio's Agricultural Areas, Janice M. Hartkorn

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The Mississippi River Basin, includes a major part of Ohio has encountered increasing phosphorus and nitrogen loads from agricultural fields since the 1800's when intensive agriculture moved into the Midwest. Agriculture has drained ninety percent of Ohio's native wetlands. A portion of those drained wetlands can be restored to functional wetlands to intercept excess nutrients from non-productive or low yield agricultural fields to improve overall water quality. Little is known about finding potential restoration sites, partly because of the difficulty in locating sites capable of supporting successful restoration.

This study investigated the utility of Geographic Information Systems (GIS) as a …

Improved Structural Health Monitoring Using Random Decrement Signatures, Oleg V. Shiryayev

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Detection of structural damage phenomena such as cracks, delaminations, or loose fasteners is important because it increases safety and may allow significant reduction in operational costs. Many structural health monitoring techniques are based on detecting changes in vibration features obtained from the measured response. The technique presented in this work is based on the random decrement signatures calculated from the random response. No knowledge of input signal is required. Random decrement signatures have been used for damage detection purposes in the past. The significance of this work is that it explores the possibility of identifying the type of damage and …

Immunomodulation Of Human Skin Cells By Extracts Of The Scabies Mite, Sarcoptes Scabiei, Jeremi Stevan Mullins

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Sarcoptes scabiei infests its host through burrowing into the stratum corneum layer of skin. Keratinocytes and fibroblasts responding to the burrowing mite(s) and/or mite products produce inflammatory and immune activating cytokines and chemokines. The purpose of this study was to determine if an extract of S. scabiei can modulate cytokine and chemokine expression from keratinocytes and fibroblasts in vitro. Normal human keratinocytes and fibroblasts were exposed to an extract of S. scabiei var. canis with or without various pro-inflammatory stimuli. Cytokine and chemokine expression were measured by enzyme-linked immunosorbent assay (ELISA). Scabies extract increased expression of interleukin-6 (IL-6), growth-related oncogene-α …

A Descriptive Study Of Parenting Styles, Parental Feeding Behaviors And Bmi Percentiles In School-Age Children And Adolescents, Stephanie Jane Smith

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The rising rate of obesity in the pediatric population has demanded further investigation from members of the health care community. Numerous exercise and nutrition programs have been developed to help combat the growing rate of obesity within the pediatric population but many lack the family-centered approach needed to achieve increased compliance with the prescribed plan of care. Both parenting styles and parental feeding behaviors have been shown to play a contributing role in the weight of children. According to previous research, the authoritarian parenting style often leads to an increased BMI in children. Research examining parental feeding behaviors indicates that …

Effects Of Sepsis On Nerve Evoked Responses, Kevin Richard Novak

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Sepsis and SIRS (systemic inflammatory response syndrome) have become two expensive and complicated problems seen in the intensive care unit (ICU). These two illnesses have been known to cause dysfunction with excitable tissues in the body. Encephalopathy, neuropathy, and myopathy are the three biggest. In this paper we discuss the development of an animal model of sepsis and the neurological complications sepsis brought about. Nerve conduction studies showed increased durations on compound muscle action potential, and decreased amplitude as well as increased duration and latency on sensory nerve action potentials. These results were not consistent with the two most common …

An Assessment Of The Allelopathic Potential Of Alliaria Petiolata, Eulondia Kathryn Barto

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Garlic mustard (GM), Alliaria petiolata, a European biennial herb invasive in North America, produces secondary metabolites that may contribute to its invasive success by allelopathically inhibiting growth of native plants. I tested this hypothesis by determining the levels, and stability, of these compounds in field soils. I also explored differences in the phytochemical profiles of GM and closely related North American species, and biogeographic differences in allelopathic effects on North American and European arbuscular mycorrhizal fungi (AMF). Furthermore, I exposed a North American annual herb, pale jewelweed (Impatiens pallida), and its AMF, to GM extracts in order …

A Study Of Students' Perception Of The Freshman Seminar Course Influence On Academic Persistence And Career Planning, Maura J. Dunn

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Freshman seminars have become standard in higher education programming. Although there is evidence that these programs are effective in helping the freshman-to-sophomore year persistence rate, there is little research into the specific components of such programs and how they affect academic persistence and career planning. There is also little research on how different students perceive the effectiveness of such programs. This research examined the perceived influence of a freshman seminar on academic persistence and career planning between two student cohorts, a business-major and an undecided-major, via a post-course questionnaire. The student responses between the two cohorts resulted in a significant …

A Framework To Support Spatial, Temporal And Thematic Analytics Over Semantic Web Data, Matthew Steven Perry

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Spatial and temporal data are critical components in many applications. This is especially true in analytical applications ranging from scientific discovery to national security and criminal investigation. The analytical process often requires uncovering and analyzing complex thematic relationships between disparate people, places and events. Fundamentally new query operators based on the graph structure of Semantic Web data models, such as semantic associations, are proving useful for this purpose. However, these analysis mechanisms are primarily intended for thematic relationships. This dissertation proposes a framework built around the RDF data model for analysis of thematic, spatial and temporal relationships between named entities. …

Influences Of Eating Disorders And Behaviors On College Cross Country And Track Runners, Kimberly L. Ricker

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Outside sources can be a large influence on athlete's perceptions of themselves, including their body image. Men and women face the same issues and influences from outside sources. The SCOFF questionnaire was used to determine if an athlete has the possibility of developing or already has an eating disorder. An eight question survey was also used to see what outside sources influence the eating behaviors of college cross country and track runners.

Modeling Training Effects On Task Performance Using A Human Performance Taxonomy, Douglas P. Meador

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There is little argument that modern military systems are very complex, both in terms of the resources in time and money to develop them and the infrastructure that is required to produce trained operators. To properly execute human systems integration during the acquisition process, systems built to train operators must be developed that optimize training. Consequently, the training system community would benefit from simulation models that provide the ability to make accurate predictions of training processes, and allow the decision maker to specify an optimum combination of operator performance after training and the cost of that training. The goal of …

Implementation Of Simulation For Network Service Delivery Point Capacity Analysis, Tiffany Jill Harper

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As businesses consolidate and modernize their operations, the impact on their network and computing infrastructure is a major consideration. In this thesis, discrete event simulation is used to show how implementation of an Enterprise Resource Planning (ERP) system can impact network performance and ultimately affect end-users. More specifically, the model simulates the flow of data packets across a network, through a Service Delivery Point (SDP), which is comprised of routers, switches, and firewalls that connect a Local Area Network to a Wide Area Network.

The model was used to run to determine the affect of more network traffic and additional …

A System For Collecting Data To Characterize A Pre-Fall Change In Sway: Development And Proof-Of-Concept Analyses, Amy Renae Sipp

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Falls account for almost two million emergency department visits per year in the U.S. and are the leading cause of injury deaths among adults 65 years of age and older. Despite efforts to reduce fall risk factors, about one-third of community-dwelling older adults fall each year in the U.S. New methods and devices are needed to prevent falls and to reduce morbidity and mortality related to falls. Presently, it is unknown if there is a measurable change in sway before a person falls. In order to find out, a wireless data acquisition system was developed as no existing tools were …

Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils In Hiv/Aids Patients, Jude N. Atem

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Eosinophils express membrane CD4 protein and can bind HIV-1 glycoprotein (gp) 120. Therefore, eosinophils could serve as host cells for HIV-1 infection in vivo, especially in the late phase of the infection. In culture, HIV-1 infects eosinophil precursors and primary eosinophils. Additionally HIV-1 proviral DNA sequences have been detected in the eosinophils of some HIV-1 positive patients. Since elevated levels of eosinophils occur during HIV-1 infection and parasitic infections, it implies that co-infection of parasites and HIV-1 could cause a much greater increase in the level of potential HIV-1 susceptible eosinophils. Therefore HIV-1 infection of eosinophils could partly explain the …

Oxidative Stress And Cell Death In Osmotically Swollen Glial Cells, Crystal Elaine Stuckey

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Regulation of normal volume is an important aspect of cell homeostasis. Possible mechanisms which signal volume regulation are increasing the rate of reactive oxygen species (ROS) production and release of ATP for interaction with purinergic receptors. We examined whether an increase in ROS production during cell swelling also led to cell injury of C6 glioma cells. Cells were loaded with 5,6-carboxy-2,7-dihydrofluorscein diacetate (DCFDA) to fluoroscopically measure the rate of cellular ROS production and were perfused with phosphate-buffered saline solutions (PBS) containing 100 μM carbenoxolone to inhibit dye efflux. Cell death was determined cytometrically and by measuring the release of lactate …

Non-Linear Shunting Of Piezo-Actuators For Vibration Suppression, Anisetti Anusha

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Vibrations at a resonant frequency lead to catastrophic failure or at the very least, shorten the life span of the structure due to fatigue. These problems force engineers to implement damping techniques. Smart materials have been used over two decades to reduced vibration amplitudes. Recently, there has been much research and development on smart materials and structures.

This work introduces an innovative approach for vibration suppression using passively shunted piezolectric materials. Initially linear circuit elements such as resistors, capacitors, and inductances, or building a non-linear circuit with different impedance designs were used. Instead of such elements, a switched electromechanical shunt …

Effects Of Subcutaneous Postnatal Choline Supplementation On Hippocampus-Mediated Learning And Memory In Rat Pups, Jeremy Alan Moore

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The effects of postnatal injections of choline on the acquisition of two variants of eyeblink conditioning were examined in developing Long-Evans rat pups. Choline administration on postnatal days (PND) 15-27 was followed by evaluation of trace eyeblink conditioning (Experiment 1) and delay eyeblink conditioning (Experiment 2) on PND 28-29. The results of these experiments show that choline produced greater improvements in learning and memory during the trace condition than in the delay condition, presumably due to its effect on the hippocampus. Trace eyeblink conditioning relies heavily on an intact hippocampus but delay eyeblink conditioning does not, and it is understood …

Stress Reducing Effects Of Oxytocin In A Maternal Separation Paradigm, Keely Jane O'Connell

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This study compared the effects of centrally and peripherally administered oxytocin (OT) on HPA axis activity and the presence of both stress-induced active and passive behaviors in female guinea pig pups (Cavia porcellus) after 180-min of isolation . In Experiment 1, one dose of oxytocin (10μg/.2ml) was injected subcutaneously into the periphery. Plasma cortisol levels were reduced after 180-min of isolation and two passive behaviors, eye-closure and crouch, were reduced as well with the administration of oxytocin. In Experiment 2, two different doses (10μg/.2ml and 20μg/.2ml) were injected into the periphery with no significant results. In Experiment 3 one dose …

The Effects Of Nutritional Supplement, Mass Fx™, On Muscular Strength, Body Composition, And Blood Chemistries In Resistance Trained Adult Males, Patrick S. Dib

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The purpose of this study was to determine the effects of a nutritional supplement, Mass FX, on muscular strength, body composition, and blood chemistries in resistance-trained adult males. Eight subjects, mean age 25 +/- 3.02 years, were randomly assigned to two groups (n=4). Each group was given either Mass FX or a Placebo in a double-blind manner to be taken orally for six weeks (4caps/day regardless of bodyweight). For the duration of the study, both groups were following the same training program and a diet customized to each subject's bodyweight in conjunction to the supplementation. Data were analyzed using Analysis …

Shore Wives: The Lives Of British Naval Officers' Wives And Widows, 1750-1815, Amy Lynn Smallwood

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This thesis provides an analysis of the lives of mid- to late-eighteenth century Royal Navy officers'wives and widows, including how they coped with the challenges of being separated from their husbands for extended periods of time. This separation forced them to accept additional financial and management responsibilities. By successfully managing these tasks, they proved that women were capable of managing money, purchasing property, rearing and educating children, working the patronage system, being political activists, dealing with bureaucracy, and networking. Shore wives performed these duties with the very real fear that their husbands might never come home alive. By taking up …

Creating A New Guatemala: The 1952 Agrarian Reform Law, Tiffany Kwader Harbour

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In 1952, Guatemala enacted the Agrarian Reform Law Decree 900. The Decree became an instrument for national development through land redistribution and the development of agrarian rights. Although the law was only upheld for eighteen months, the Decree influenced land and labor legislation through today. Struggles for agrarian rights continued throughout the military dictatorship and civil war which plagued Guatemala until the signing of the 1996 Peace Accords. Ideals for land reform originating in the 1952 law continue to have a pervasive influence on the Guatemalan land reform movement. This study is further contextualized and framed with quotes and analysis …

The Moderating Influence Of Stress Appraisals And Affect On Performance Under Fatigue, Regina M. Schmidt

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This study demonstrated that in a group of seventeen active duty soldiers, performance on an attack combat simulation significantly degraded after approximately 30 h of sleep deprivation. In addition, individual differences were identified, as approximately half of the participants maintained performance throughout the sleep deprivation period, while other participants degraded in performance. The main objective of this study was to test the efficacy of micro-level cognitive performance and subject state factors to account for this dichotomy in performance that was particular to the last testing session. Results showed that performance on a decision making test with rapid reaction time constraints …

Model And Solution Approaches For The Equipment Scheduling Under Disruption Problems In Usps Mail Processing And Distribution Centers, Arvindkumar Ravi Chakravarthy

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This research addresses the equipment scheduling problem under disruptions in United States Postal Service mail processing and distribution centers. These facilities contain a large variety of equipment and employ a non-homogeneous workforce that work on shifts of various lengths and start times. The scheduling of equipment (the determination of the configuration and usage of equipment to match mail arrivals) and the scheduling of workforce (the determination of the optimal size and composition of the workforce, their days off / lunch assignments, and overtime usage) to meet processing service commitment with a constantly changing demand are some of the most challenging …

Availability And Toxicity Of Nickel To Lotic Periphyton And Macroinvertebrates, Stephanie Marie Bessom

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There is a lack of information regarding the bioaccumulation and toxicity of nickel (Ni) to lotic ecosystems. The objective of this study was to investigate the source, uptake, and toxicity of Ni by periphyton and macroinvertebrates (Hyalella azteca and Daphnia magna) in simulated stream ecosystems that included sediment and water. Periphyton were exposed to two types of sediment, a low-organic sandy mixture and a high organic silt, treated with varying levels of Ni. After 96 h, Ni levels in overlying water and periphyton were related to those in sediments, although differences existed between sediment types. Tests with 64Ni added to …

Exploring Team Dynamics: The Evolution Of Coordination In A Complex Command And Control Environment, Daniel H. Schwartz

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The present study explores the dynamic and emergent behavior of two teams, separately working through a synthetic task environment representing a battle management command and control domain under two levels of organizational centralization. While the manipulation of centralization had minimal effects on overall performance, evidence suggested that the need to seek authorization for actions from a central authority was a source of frustration. Both teams adapted over time, changing patterns of coordination to better meet the task demands. The results are discussed in the context of the concepts of normal accidents, high reliability organizations, and self-organization in complex organizations. Specific …

Two Dimensional Localization Of Passive Uhf Rfid Tags, Bhavik Contractor

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The advent of GPS has redefined the need of a positioning system in today*#8217;s ubiquitous computing world. While GPS works satisfactorily and is quite a norm in an outdoor environment, it fails to work indoors due to the inherent complexity of an indoor environment. There is an ever increasing need to develop an indoor positioning system and a lot of research has been done to solve the problem of indoor localization. These solutions differ on the basis of cost, dependency on environment, line of sight requirements and so on.

Passive RFID (Radio Frequency Identification) tags pose an interesting solution to …

An Algorithm For The Detection Of Handguns In Terahertz Images, Andrew J. Lingg

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This paper presents an algorithm for detecting handguns in terahertz images. Terahertz radiation is capable of penetrating certain materials which are opaque atoptical wavelengths, such as clothing, without the harmful effects of ionizing radiation. The approach taken is to segment objects of interest and classify them based on shape. We use a modified version of an active contour algorithm found in the open literature. Modifications include: a pre-processing step that includes clutter filtering and seeding of an initial contour; and a post-processing step that removes clutter pixels from the segmentation. The features used for classification are moment-based and Fourier shape …

Automated Analysis Of Metacarpal Cortical Thickness In Serial Hand Radiographs, Aarti Raheja

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To understand the roles of various genes that influence skeletal bone accumulation and loss, accurate measurement of bone mineralization is needed. However, it is a challenging task to accurately assess bone growth over a person's lifetime. Traditionally, manual analysis of hand radiographs has been used to quantify bone growth, but these measurements are tedious and may be impractical for a large-scale growth study. The aim of this project was to develop a tool to automate the measurement of metacarpal cortical bone thickness in standard hand-wrist radiographs of humans aged 3 months to 70+ years that would be more accurate, precise …