Digital Commons Network^™

Silencing Of The Pink1 Gene Expression By Conditional Rnai Does Not Induce Dopaminergic Neuron Death In Mice., Hongxia Zhou, Björn H Falkenburger, Jörg B Schulz, Kim Tieu, Zuoshang Xu, Xu Gang Xia

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Transgenic RNAi, an alternative to the gene knockout approach, can induce hypomorphic phenotypes that resemble those of the gene knockout in mice. Conditional transgenic RNAi is an attractive choice of method for reverse genetics in vivo because it can achieve temporal and spatial silencing of targeted genes. Pol III promoters such as U6 are widely used to drive the expression of RNAi transgenes in animals. Tested in transgenic mice, a Cre-loxP inducible U6 promoter drove the broad expression of an shRNA against the Pink1 gene whose loss-of-functional mutations cause one form of familial Parkinson's disease. The expression of the shRNA …

A Study Of Linear Error Correcting Codes, Cen Jung Tjhai

School of Engineering, Computing and Mathematics Theses

Since Shannon's ground-breaking work in 1948, there have been two main development streams of channel coding in approaching the limit of communication channels, namely classical coding theory which aims at designing codes with large minimum Hamming distance and probabilistic coding which places the emphasis on low complexity probabilistic decoding using long codes built from simple constituent codes. This work presents some further investigations in these two channel coding development streams. Low-density parity-check (LDPC) codes form a class of capacity-approaching codes with sparse parity-check matrix and low-complexity decoder Two novel methods of constructing algebraic binary LDPC codes are presented. These methods …

Improving The Prediction Of The Behaviour Of Masonry Wall Panels Using Model Updating And Artificial Intelligence Techniques, Chengfei Sui

School of Engineering, Computing and Mathematics Theses

Out-of-plane laterally loaded masonry wall panels are still much used in modem structures. However due to their anisotropic and highly composite nature, it is extremely difficult to understand their behaviour and to date there is no analytical method that is capable of accurately predicting the response of masonry panels to the applied loadings. This is one of the major obstacles in analysing and designing masonry structures. This research studied a new method that accurately predicts the response of laterally loaded masonry wall panels. In this dissertation, the method of using corrector factors developed by previous researchers was further studied using …

An Intelligent Navigation System For An Unmanned Surface Vehicle, Tao Xu

School of Engineering, Computing and Mathematics Theses

A multi-disciplinary research project has been carried out at the University of Plymouth to design and develop an Unmanned Surface Vehicle (USV) named ýpringer. The work presented herein relates to formulation of a robust, reliable, accurate and adaptable navigation system to enable opringei to undertake various environmental monitoring tasks. Synergistically, sensor mathematical modelling, fuzzy logic, Multi-Sensor Data Fusion (MSDF), Multi-Model Adaptive Estimation (MMAE), fault adaptive data acquisition and an user interface system are combined to enhance the robustness and fault tolerance of the onboard navigation system. This thesis not only provides a holistic framework but also a concourse of computational …

Effective Information Assurance With Risk Management, Vassileios Andreas Dimopoulos

School of Engineering, Computing and Mathematics Theses

Today's businesses base their operation on their IT infrastructure, which consequently demands that it should be protected accordingly. Nevertheless, surveys tend to indicate that the number of IT security incidents is increasing, resulting in significant losses for the organisations concerned. Leading in poor security practices, and therefore frequent victims of related security incidents, are Small and Medium Enterprises (SMEs). Even though there are a number of solutions, ranging from baseline guidelines to a detailed Risk Assessment (which can be followed to guide organisations through systematically selecting appropriate controls and practices to properly secure their networked assets), evidence suggests that these …

Fact Sheet, Yale University Office Of Institutional Research

Fact Sheets

No abstract provided.

Part 5: Affordable Housing In Hampton Roads: Facts And Issues, Regional Studies Institute, Old Dominion University

State of the Region Reports: Hampton Roads

The rapid increase in regional housing prices in recent years (97 percent between 1997 and 2006) has made it much more difficult for some people to own their own home. Between these years, the annual interest and principal payments required for a typical home purchase rose from only 21.5 percent of the median income of our region’s households to 32 percent. Economically viable solutions to affordable housing challenges nearly always include increased housing density in order to make more moderately priced housing profitable to builders.

Part 7: Is Hampton Roads Receiving It's "Fair" Share From The Commonwealth?, Regional Studies Institute, Old Dominion University

State of the Region Reports: Hampton Roads

All things considered, the region has a case to make when it argues that it receives less than its “fair” share of state government spending. The geographic distribution of expenditures is particularly disadvantageous to Hampton Roads in the areas of K-12 education and car tax reimbursements, but less so in transportation and higher education.

Response Of Eelgrass Zostera Marina To Co2 Enrichment: Possible Impacts Of Climate Change And Potential For Remediation Of Coastal Habitats, Sherry L. Palacios, Richard C. Zimmerman

OES Faculty Publications

Projected increases in dissolved aqueous concentrations of carbon dioxide [CO_2(aq)] may have significant impacts on photosynthesis Of CO₂-limited organisms such as seagrasses. Short-term CO_2(aq) enrichment increases photosynthetic rates and reduces light requirements for growth and survival of individual eelgrass Zostera marina L. shoots growing in the laboratory under artificial light regimes for at least 45 d. This study examined the effects of long-term CO_2(aq) enrichment on the performance of eelgrass growing under natural light-replete (33% surface irradiance) and light-limited (5% surface irradiance) conditions for a period of 1 yr. Eelgrass shoots were grown at …

Self-Consistent Analyses For Potential Conduction Block In Nerves By An Ultrashort High-Intensity Electric Pulse, R. P. Joshi, A. Mishra, Q. Hu, K. H. Schoenbach, A. Pakhomov

Bioelectrics Publications

Simulation studies are presented that probe the possibility of using high-field (>100kV ∕ cm), short-duration (∼50ns) electrical pulses for nonthermal and reversible cessation of biological electrical signaling pathways. This would have obvious applications in neurophysiology, clinical research, neuromuscular stimulation therapies, and even nonlethal bioweapons development. The concept is based on the creation of a sufficiently high density of pores on the nerve membrane by an electric pulse. This modulates membrane conductance and presents an effective "electrical short" to an incident voltage wave traveling across a nerve. Net blocking of action potential propagation can then result. A continuum approach based …

Developing A Method For Identifying And Reducing Functional Discrepancies Of Information Systems, Jung-Wei Chen

Dissertations and Theses (Open Access)

Currently more than half of Electronic Health Record (EHR) projects fail. Most of these failures are not due to flawed technology, but rather due to the lack of systematic considerations of human issues. Among the barriers for EHR adoption, function mismatching among users, activities, and systems is a major area that has not been systematically addressed from a human-centered perspective. A theoretical framework called Functional Framework was developed for identifying and reducing functional discrepancies among users, activities, and systems. The Functional Framework is composed of three models – the User Model, the Designer Model, and the Activity Model. The User …

The Journey Towards Technological Literacy For All In The United States — Are We There Yet?, Philip A. Reed

STEMPS Faculty Publications

The article discusses technological literacy in the U.S. The author focuses on the history of studying technology within general education and notes the scarcity of technology education requirements in American schools. He examines the impact of various studies conducted by the Standards for Technological Literacy (STL) and the National Research Council (NRC), among others, on technological literacy. The author compares the seventeen processes of researcher Harold Halfin's technological research to the theories outlined in various STL material, including observation, analysis, and visualization.

Review Of The Technology Education Research Conference (Terc), Surfer’S Paradise, Australia, Philip A. Reed

STEMPS Faculty Publications

The following report addresses questions established by the Technical Foundation of America prior to attending the Technology Education Research Conference (TERC) December 7-9, 2006 in Surfer's Paradise, Australia. Responses appear below each of the four questions.

Increasing Effectiveness Of Public Private Partnerships In The Irish Construction Industry, Louis Gunnigan

Doctoral

By 2003 the first Irish Public Private Partnership (PPP) projects had reached the operational stage. Media reports were emerging of significant differences in the effectiveness of these projects.

This research set out to find a means by which effectiveness of PPPs could be increased and to develop a model that would assist PPP practitioners with this task in the future. Through a literature review, the Irish PPP process was mapped, the changes encountered in the introduction of PPP were investigated and a conceptual model – based on a traditional process model - was proposed. The model was tested by examining …

The Regional Greenhouse Gas Initiative And California Assembly Bill 1493: Filling The American Greenhouse Gas Regulation Void, Michael H. Wall

University of Richmond Law Review

No abstract provided.

Architecture Vs. Art: The Aesthetics Of Art Museum Design[1], Larry Shiner

Contemporary Aesthetics (Journal Archive)

Many art critics have complained that the most dramatic art museum designs of the last decade have upstaged or interfered with the art within. This essay examines eight contemporary cases before drawing some lessons for art museum design, and ends by setting the architecture vs. art problem in the context of the philosophy of architecture, focusing on the issues of function and symbolism.

In Pursuit Of Frcp 1: Creative Approaches To Cutting And Shifting The Costs Of Discovery, Mia Mazza, Emmalena K. Quesada, Ashley L. Sternberg

Richmond Journal of Law & Technology

The most important rule of all is the last sentence of [FRCP] 1, which provides that the Federal Rules of Civil Procedure ‘shall be construed to secure the just, speedy, and inexpensive determination of every action.’ It is this command that gives all the other rules life and meaning and timbre in the realist world of the trial court.

Thermal Effectiveness Characteristics Of Low Approach Indirect Evaporative Cooling Systems In Buildings, Ben Costelloe, Donal Finn

Articles

Meteorological enthalpy analysis of temperate and maritime climates above latitude 45°N suggests that the water-side evaporative cooling technique has considerable unrealised potential with contemporary “high temperature” building cooling systems—such as chilled ceilings and displacement ventilation. As low approach conditions are the key to exploiting the cooling potential of the ambient air, thermal performance at such conditions needs to be investigated. To address the research issues, an industrial scale test rig, based on a low approach open cooling tower and plate heat exchanger and designed to maximise evaporative cooling potential, has been constructed. The thermal effectiveness of such systems (as a …

The Embodied Transport Energy Analysis Of Imported Wood Pellets, Aidan Duffy, Michael Conroy

Conference Papers

The Irish Government has recently introduced a series of capital grants to boost the uptake of domestic wood-pellet technologies in order to reduce greenhouse gas emissions. These have proved popular and have encouraged a significant number of people to switch from gas- and oil-fired boilers to the cleaner fuel. The demand for wood-pellets has, however, greatly exceeded the national capacity for production. The market for wood pellets elsewhere in Europe is also tight and, consequently, a large proportion of Irish pellets are sourced in Canada. This presents possible problems: the carbon emissions associated with long-distance transport may significantly offset the …

Ray-Trace Modelling Of Reflectors For Quantum Dot Solar Concentrators, Manus Kennedy, Sarah Mccormack, John Doran, Brian Norton

Conference Papers

Quantum Dot Solar Concentrators (QDSCs) are static, non-imaging concentrators which do not require expensive solar tracking and concentrate both direct and diffuse light. Optical efficiencies (ηopt) and concentration ratios (C) of a single plate QDSC were calculated by Monte-Carlo ray-trace modelling. Consideration of reflection, refraction, quantum dot (QD) photon emission and absorption and light attenuation in the device matrix were included in the analysis. In this paper, the effect of placing plane and diffuse reflectors at the rear surface was analyzed. Mirrors with a structured surface (saw-tooth shaped) were also modelled and the effect of each reflector type on C …

Graduate Digital Forensics Education At The Air Force Institute Of Technology, Gilbert L. Peterson, Richard A. Raines, Rusty O. Baldwin

Faculty Publications

The Department of Electrical and Computer Engineering (AFIT/ENG) at the Air Force Institute of Technology (AFIT), currently offers a graduate-level introductory course in digital forensics. Students are introduced and exposed to several challenges and topics in the digital forensics course. The course addresses the ethical and legal procedures as well as basic forensic science principles in only the most general manner. A larger percentage of lecture and lab time is spent discussing the technical details of incident response and media analysis. The detail into the network forensics and digital device analysis topics start to breach technical details but not to …

The Perspectives Of Students And Theological Educators On Good Teaching: A Look At Theological Education In Indonesia, Daniel Ronda

ATS Dissertations

No abstract provided.

Barium Strontium Titanate Films For Tunable Microwave And Acoustic Wave Applications, Venkataramanan Gurumurthy

USF Tampa Graduate Theses and Dissertations

The composition-dependent Curie temperature and bias-dependant dielectric permittivity of Barium Strontium Titanate (BST) makes it very attractive for tunable application in the RF/Microwave regime. In this research work, the performance of BST varactors fabricated on the conventional Pt/Ti/SiO2/Si bottom electrode stack were compared with those fabricated using chemical vapor deposited Nanocrystalline Diamond (NCD) as the diffusion barrier layer instead of SiO2. The varactors fabricated on NCD films displayed much better symmetry in capacitance-voltage behavior and better overall quality factors than varactors fabricated on SiO2. The improvement in performance can be attributed to existence of stable interfaces in the devices fabricated …

Voice Recognition System Based On Intra-Modal Fusion And Accent Classification, Srikanth Mangayyagari

USF Tampa Graduate Theses and Dissertations

Speaker or voice recognition is the task of automatically recognizing people from their speech signals. This technique makes it possible to use uttered speech to verify the speaker's identity and control access to secured services. Surveillance, counter-terrorism and homeland security department can collect voice data from telephone conversation without having to access to any other biometric dataset. In this type of scenario it would be beneficial if the confidence level of authentication is high. Other applicable areas include online transactions,database access services, information services, security control for confidential information areas, and remote access to computers. Speaker recognition systems, even though …

System Approach To Embedded System Design, Vikram Prabhakar Mehendale

USF Tampa Graduate Theses and Dissertations

During this research, the concepts of Systems Engineering were applied to embedded system design. The objective was to apply the Systems Engineering methodology to the design of a particular embedded system. A Video Surveillancesystem was chosen as the particular embedded system. Systems Engineering concepts provide the foundation for an optimized design process and for the coordination between system modules. The functionality of the Video Surveillance system was achieved through the partitioning of the overall system functionality into three separate modules. The three modules were Image Capture, Image Processing and Image Transmission. The methodology employed resulted in a system that was …

Warm: Wearable Assistant With Remote Monitoring, Lisa Michelle Provenzano Heugel

USF Tampa Graduate Theses and Dissertations

Wearable computing has been in existence as part of our attire for many years, a few examples being the watches, cell phones and MP3 players. Recently, many researchers have been devising ways to incorporate wearable devices seamlessly into our lives with the goal of making them an indispensable part of our daily routines. In this thesis, a new wearable computing device called WARM (Wearable Assistant for Remote Monitoring) for use by the elderly and the handicapped is proposed and its software architecture is defined and described. The physically challenged or the elderly, living on their own, but who require assistance …

Open Source Biology: A Means To Address The Access & Research Gaps, Katherine M. Nolan-Stevaux

Santa Clara High Technology Law Journal

No abstract provided.

Will Shrinkwrap Suffocate Fair Use?, Elizabeth M.N. Morris

Santa Clara High Technology Law Journal

No abstract provided.

Protecting Academic And Non-Profit Research: Creating A Compulsory Licensing Provision In The Absence Of An Experimental Use Exception, Kimberly M. Thomas

Santa Clara High Technology Law Journal

No abstract provided.

Is The Patent Paradox A Result A Large Firm Perspective? Differential Value Of Small Firm Patents Over Time Explains The Patent Paradox, Sean M. Coughlin

Santa Clara High Technology Law Journal

No abstract provided.