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Articles 9871 - 9900 of 14124
Full-Text Articles in Entire DC Network
Full Issue, Number 25, Spring 2007, The Congregational And Synodical Mission Unit, The Evangelical Lutheran Church In America
Full Issue, Number 25, Spring 2007, The Congregational And Synodical Mission Unit, The Evangelical Lutheran Church In America
Intersections
No abstract provided.
Lutheran Identity, Academic Integrity, And Religious Diversity, Storm Bailey
Lutheran Identity, Academic Integrity, And Religious Diversity, Storm Bailey
Intersections
No abstract provided.
Sojourners In A Pluralistic Land: The Promise And Peril Of Christian Higher Education, Randall Balmer
Sojourners In A Pluralistic Land: The Promise And Peril Of Christian Higher Education, Randall Balmer
Intersections
No abstract provided.
Why Diversity And Civic Engagement Don’T Talk To Each Other On College Campuses: The Need For Public Work, José Marichal
Why Diversity And Civic Engagement Don’T Talk To Each Other On College Campuses: The Need For Public Work, José Marichal
Intersections
No abstract provided.
Ap-Ls Teaching Techniques: Deliberating The Benefits Of Learning Through Focus Groups, Garrett Berman, Judith Platania
Ap-Ls Teaching Techniques: Deliberating The Benefits Of Learning Through Focus Groups, Garrett Berman, Judith Platania
Arts & Sciences Faculty Publications
This article describes how students in an undergraduate legal psychology class utilized focus group research (i.e., a jury simulation exercise) to assist in planning strategies for trial. In addition to conducting the focus group, students were responsible for providing an analysis of the results, and preparing their team for trial. Ultimately, students reported the focus group exercise helped them develop trial strategies, understand the role of trial consultants, and gain a better understanding of scientific jury selection. Rationale, course objectives, and a description of the activity are outlined, as well as suggestions for including this exercise in an upper-level legal …
Use Of Nmr Metabolomics To Analyze The Targets Of D-Cycloserine In Mycobacteria: Role Of D-Alanine Racemase, Steven M. Halouska, Ofelia Chacon, Robert J. Fenton, Denise K. Zinniel, Raul G. Barletta, Robert Powers
Use Of Nmr Metabolomics To Analyze The Targets Of D-Cycloserine In Mycobacteria: Role Of D-Alanine Racemase, Steven M. Halouska, Ofelia Chacon, Robert J. Fenton, Denise K. Zinniel, Raul G. Barletta, Robert Powers
Robert Powers Publications
D-cycloserine (DCS) is only used with multi-drug resistant strains of tuberculosis because of serious side-effects. DCS is known to inhibit cell wall biosynthesis, but the in vivo lethal target is still unknown. We have applied NMR-based metabolomics combined with principal component analysis to monitor the in vivo affect of DCS on M. smegmatis. Our analysis suggests DCS functions by inhibiting multiple protein targets.
Combating Terrorism, San Antonio Public Library
Combating Terrorism, San Antonio Public Library
Crime/Violence
Bibliography and photograph of a display of government documents from the San Antonio Public Library, Texas.
Dec-205 Receptor On Dendritic Cells Mediates Presentation Of Hiv Gag Protein To Cd8+ T Cells In A Spectrum Of Human Mhc I Haplotypes, Leonia Bozzacco, Christine Trumpfheller, Frederick P. Siegal
Dec-205 Receptor On Dendritic Cells Mediates Presentation Of Hiv Gag Protein To Cd8+ T Cells In A Spectrum Of Human Mhc I Haplotypes, Leonia Bozzacco, Christine Trumpfheller, Frederick P. Siegal
Publications
Optimal HIV vaccines should elicit CD8+ T cells specific for HIV proteins presented on MHC class I products, because these T cells contribute to host resistance to viruses. We had previously found that the targeting of antigen to dendritic cells (DCs) in mice efficiently induces CD8+ T cell responses. To extend this finding to humans, we introduced the HIV p24 gag protein into a mAb that targets DEC-205/CD205, an endocytic receptor of DCs. We then assessed cross-presentation, which is the processing of nonreplicating internalized antigen onto MHC class I for recognition by CD8+ T cells. Low doses …
Selective Blockade Of The Inhibitory Fcγ Receptor (Fcγriib) In Human Dendritic Cells And Monocytes Induces A Type I Interferon Response Program, Madhav V. Dhodapkar, Devi K. Banerjee, John E. Connolly
Selective Blockade Of The Inhibitory Fcγ Receptor (Fcγriib) In Human Dendritic Cells And Monocytes Induces A Type I Interferon Response Program, Madhav V. Dhodapkar, Devi K. Banerjee, John E. Connolly
Publications
The ability of dendritic cells (DCs) to activate immunity is linked to their maturation status. In prior studies, we have shown that selective antibody-mediated blockade of inhibitory FcγRIIB receptor on human DCs in the presence of activating immunoglobulin (Ig) ligands leads to DC maturation and enhanced immunity to antibody-coated tumor cells. We show that Fcγ receptor (FcγR)-mediated activation of human monocytes and monocyte-derived DCs is associated with a distinct gene expression pattern, including several inflammationassociated chemokines, as well as type 1 interferon (IFN) response genes, including the activation of signal transducer and activator of transcription 1 (STAT1). FcγR-mediated STAT1 activation …
Genetic And Molecular Characterization Of Programmed Cell Death In The C.Elegans Tail-Spike Cell, Carine Waase-Maurer
Genetic And Molecular Characterization Of Programmed Cell Death In The C.Elegans Tail-Spike Cell, Carine Waase-Maurer
Student Theses and Dissertations
Work in Caenorhabditis elegans has been instrumental in deciphering the molecular basis of programmed cell death. However, despite extensive characterization of broadacting cell death genes, the molecular events triggering cell-specific activation of the cell death machinery remain, for the most part, unknown. In some C. elegans somatic cells, transcription of the egl-1/BH3-only gene is believed to promoted cell-specific death. EGL-1 protein inhibits the CED-9/Bcl-2 protein, resulting in release of the caspase activator CED-4/Apaf-1. Subsequent activation of CED-3 caspase by CED-4 leads to cell death. But despite the important role of egl-1 transcription in promoting CED-3 activity in cells destined to …
A Search For The Counter-Immune Mechanisms Of Mycobacterium Tuberculosis, Meghan Alida Kirksey
A Search For The Counter-Immune Mechanisms Of Mycobacterium Tuberculosis, Meghan Alida Kirksey
Student Theses and Dissertations
Tuberculosis is characterized by dynamic interactions between M. tuberculosis (Mtb) and the human immune response. The cytokine IFN-γ triggers macrophage production of bactericidal nitric oxide by inducible nitric oxide synthase (NOS2) and is essential for mammalian control of Mtb infection. Mice lacking NOS2 are unable to control replication of Mtb and rapidly succumb to infection. The persistent nature of TB infection suggests that Mtb has evolved counter-immune mechanisms to survive in the face of NOS2 and other pathways downstream of IFN-γ. A differential signature-tagged transposon mutagenesis screen was conducted to identify mutants attenuated in NOS2-/- mice, but retaining virulence in …
Cross-Presentation Of Glycolipid From Tumor Cells Loaded With Α-Galactosylceramide Leads To Potent And Long-Lived T Cell-Mediated Immunity Via Dendritic Cells, Kanako Shimizu, Yuri Kurosawa, Masaru Taniguchi
Cross-Presentation Of Glycolipid From Tumor Cells Loaded With Α-Galactosylceramide Leads To Potent And Long-Lived T Cell-Mediated Immunity Via Dendritic Cells, Kanako Shimizu, Yuri Kurosawa, Masaru Taniguchi
Publications
We report a mechanism to induce combined and long-lived CD4+ and CD8+ T cell immunity to several mouse tumors. Surprisingly, the initial source of antigen is a single low dose of tumor cells loaded with α-galactosylceramide (α-GalCer) glycolipid (tumor/Gal) but lacking co-stimulatory molecules. After tumor/Gal injection intravenously (i.v.), innate NKT and NK cells reject the tumor cells, some of which are taken up by dendritic cells (DCs). The DCs in turn cross-present glycolipid on CD1d molecules to NKT cells and undergo maturation. For B16 melanoma cells loaded with α-GalCer (B16/Gal), interferon γ-producing CD8+ T cells develop toward …
Role Of Laminins In The Development Of The Peripheral Nervous System, Wei-Ming Yu
Role Of Laminins In The Development Of The Peripheral Nervous System, Wei-Ming Yu
Student Theses and Dissertations
To investigate the function of laminins in peripheral nerve development, the laminin γ1 gene was specifically disrupted in Schwann cells. Disruption of laminin γ1 gene expression resulted in depletion of all other laminin chains known to be expressed in Schwann cells. Schwann cells lacking laminins fail to differentiate to myelinating and non-myelinating Schwann cells and do not extend processes required for initiating axonal sorting and mediating axon-Schwann cell interactions. These cells also fail to down-regulate Oct-6 and they arrest at the premyelinating stage. Impaired axon-Schwann cell interactions prevent phosphorylation of β-neuregulin-1 receptors, which results in decreased cell proliferation. Postnatally, laminin-null …
Haplotype-Based Association Studies: Approaches To Current Challenges, Mark A. Levenstien
Haplotype-Based Association Studies: Approaches To Current Challenges, Mark A. Levenstien
Student Theses and Dissertations
Haplotype-based association studies have greatly aided researchers in their attempts to map genes. However, current designs of haplotype-based association studies lead to several challenges from a statistical perspective. To reduce the number of variants, some researchers have employed hierarchical clustering. This thesis starts by addressing the multiple testing problem that results from applying a hierarchical clustering procedure to haplotypes and then performing a statistical test for association at each of the steps in the resulting hierarchy. Applying our method to a haplotype case-control dataset, we find a global p-value. Relative to the minimum p-value over all steps in the hierarchy, …
A Structural Basis For Host Cytoskeletal Disruption And Virulence By Yersinia Protein Kinase A, Gerd Prehna
A Structural Basis For Host Cytoskeletal Disruption And Virulence By Yersinia Protein Kinase A, Gerd Prehna
Student Theses and Dissertations
Yersinia spp. cause gastroenteritis and the plague, representing historically devastating pathogens that are currently an important biodefense and antibiotic resistance concern. Although several antibiotic therapies exist, the emergence of strains that have garnered multiple drug resistances in combination with the weaponization of Yersinia, make understanding the biology of this pathogen a high priority. Yersinia, along with other pathogenic bacteria such as Salmonella, utilize a macromolecular complex, called a type III secretion apparatus, to deliver virulence proteins directly into cells. These factors commandeer several signaling pathways, often targeting the Rho family of small GTPases which regulate actin cytoskeletal dynamics. A critical …
Regulation Of Histone Covalent Modifications During Yeast Apoptosis, Sung Hee Ahn-Upton
Regulation Of Histone Covalent Modifications During Yeast Apoptosis, Sung Hee Ahn-Upton
Student Theses and Dissertations
Chromatin compaction is a hallmark property of apoptosis, a highly coordinated suicide mechanism generally believed to be confined to vertebrates. However, invertebrates such as the budding yeast, Saccharomyces cerevisiae, display an apoptotic-like phenotypes including chromatin condensation, although its functions and mechanism are unclear. One mechanism that alters chromatin structure is the covalent modification of histones, which associates with DNA to form the nucleosome, the fundamental unit of chromatin. Phosphorylation of histone H2B at serine 14 (H2BS14ph), catalyzed by Mst1 kinase, has been linked to chromatin compaction during mammalian apoptosis. I extended these results to yeast by demonstrating that Ste20 kinase, …
Comparative Studies Of Processivity Clamp Loader Atp Site Function, Aaron M. Johnson
Comparative Studies Of Processivity Clamp Loader Atp Site Function, Aaron M. Johnson
Student Theses and Dissertations
DNA replicases utilize ring-shaped sliding clamps to ensure polymerase processivity. An ATP-dependent clamp loader topologically links the clamp around DNA in a multi-step mechanism. Clamp loaders are ring-shaped pentamers of AAA+ subunits. The pentamer complex contains 3-4 ATP sites, each located at the interface of two subunits. In each ATP site, an arginine residue from one subunit is located near the γ-phosphate of ATP bound to the adjacent subunit. These arginines act as "arginine fingers" that can potentially perform two functions: sensing that ATP is bound and catalyzing ATP hydrolysis. This thesis utilizes mutations in the arginine fingers of the …
Insect Host Seeking: Investigations Into The Molecular Mechanisms Of Chemosensation, Walton D. Jones
Insect Host Seeking: Investigations Into The Molecular Mechanisms Of Chemosensation, Walton D. Jones
Student Theses and Dissertations
Among other functions, chemosensory systems play a crucial role in the host-seeking behaviors of insects that allow them to find their preferred food sources. Quite often, however, these host-seeking behaviors have a negative impact on either human health or livelihood. The following details investigations into the evolution and molecular mechanisms of two distinct pathways involved in insect chemosensation. The atypical odorant receptor gene, Or83b, is co-expressed with other ORs in most olfactory sensory neurons (OSNs) of the Drosophila antenna. OR83b acts as a generic heterodimeric partner for other ORs coupling them to the ciliary trafficking machinery, which is responsible for …
From Naturally Occurring Tumor Immunity To Supernatural T Cells: Isolation And Characterization Of A Murine T Cell Receptor Specific For Human Breast And Ovarian Tumor Antigen Cdr2, Bianca D. Santomasso
From Naturally Occurring Tumor Immunity To Supernatural T Cells: Isolation And Characterization Of A Murine T Cell Receptor Specific For Human Breast And Ovarian Tumor Antigen Cdr2, Bianca D. Santomasso
Student Theses and Dissertations
Patients with paraneoplastic cerebellar degeneration (PCD), a form of neuronal autoimmunity, have a co-occurring natural immune response against a protein called cdr2 in their breast and ovarian carcinomas, and thus provide an innovative starting point for understanding how to harness the immune system to fight cancer. We previously demonstrated cdr2-specific cytotoxic T lymphocytes (CTL) in the peripheral blood of HLA-A2.1+ PCD patients, suggesting that CTLs mediate tumor immunity in these patients. Cdr2 is expressed by a large proportion of breast and ovarian tumors from individuals who do not develop neurological disease, suggesting that immune responses to this antigen may develop …
Characterization And Functional Analysis Of Astrotactin 2 Reveals A Role For Endocytosis In Glial-Guided Neuronal Migration, Perrin Megan Wilson
Characterization And Functional Analysis Of Astrotactin 2 Reveals A Role For Endocytosis In Glial-Guided Neuronal Migration, Perrin Megan Wilson
Student Theses and Dissertations
The cerebellum is essential for learning coordinated movements, balance, eye movements, and aspects of sensory cognition. The remarkably uniform array of the principal neurons of the cerebellar circuitry, granule cells and Purkinje cells, develops by glial-guided migrations that position these cell types in specific neuronal layers. Classical EM studies and real time imaging of the migration of granule neurons along glial fibers established the mode of movement of migrating neurons, including the formation of an interstitial junction beneath the cell soma. Biochemical and molecular biological experiments demonstrated that neuronal protein astrotactin (ASTN1) functions as a neuron-glial ligand during migration. This …
The Role Of Pot1 In Telomere Protection And Maintenance, Dirk Hockemeyer
The Role Of Pot1 In Telomere Protection And Maintenance, Dirk Hockemeyer
Student Theses and Dissertations
POT1 is a single stranded telomeric DNA binding protein implicated in telomere length regulation in human cells. To address the role of POT1 in telomere protection we used RNAi in human cells. We confirmed that POT1 acts as a negative regulator of telomerase and showed that POT1 is required to protect telomeres. Reduced levels of POT1 elicited a strong telomere DNA damage response and a growth arrest in primary cells; the 3' telomeric overhang shortened and the sequence of the 5' terminus changed from its precise sequence (ATC-5') to a randomized ending. In order to determine the phenotype of complete …
A New Type Of Programmed Cell Death In C. Elegans, Mary C. Abraham
A New Type Of Programmed Cell Death In C. Elegans, Mary C. Abraham
Student Theses and Dissertations
The most intensively studied form of programmed cell death (PCD) is apoptosis, which is characterized by stereotypical morphological features including chromatin compaction and by a requirement for the activity of caspase proteases, which are controlled by conserved gene pathways. Although non-apoptotic, caspase-independent programmed cell death pathways have been postulated, there is little evidence to convincingly prove their existence, and few insights regarding their molecular basis or possible in vivo functions. To investigate this question, we have studied the developmentally regulated PCD of the Caenorhabditis elegans linker cell. We have carried out transmission electron microscopy studies of dying linker cells, which …
A Genetic-Proteomic Approach To Identify Cellular Components That Interact With Hiv-1, Yang Luo
A Genetic-Proteomic Approach To Identify Cellular Components That Interact With Hiv-1, Yang Luo
Student Theses and Dissertations
Given the limited genetic coding capacity of HIV-1, it is reasonable to expect that the virus must interact with an extensive set of cellular factors and their complexes to complete its passage through the cell. Indeed, it is remarkable that the viral genome, comprising only about 0.0003% of the entire genetic capacity of the cell, commandeers the cellular environment to its own advantage. However, to date, only a small group of cellular proteins have been shown to be required for viral propagation. In an effort to recover and identify those host proteins that interact in complex with the viral machinery, …
Parker Mountain Adaptive Resources Management Group, David K. Dahlgren, M. Guttery, M. Monsen, Terry A. Messmer
Parker Mountain Adaptive Resources Management Group, David K. Dahlgren, M. Guttery, M. Monsen, Terry A. Messmer
Wildland Resources Faculty Publications
No abstract provided.
Winning By A Neck: Tall Giraffes Avoid Competing With Smaller Browsers, E. Z. Cameron, Johan T. Du Toit
Winning By A Neck: Tall Giraffes Avoid Competing With Smaller Browsers, E. Z. Cameron, Johan T. Du Toit
Wildland Resources Faculty Publications
With their vertically elongated body form, giraffes generally feed above the level of other browsers within the savanna browsing guild, despite having access to foliage at lower levels. They ingest more leaf mass per bite when foraging high in the tree, perhaps because smaller, more selective browsers deplete shoots at lower levels or because trees differentially allocate resources to promote shoot growth in the upper canopy. We erected exclosures around individual Acacia nigrescens trees in the greater Kruger ecosystem, South Africa. After a complete growing season, we found no differences in leaf biomass per shoot across height zones in excluded …
Arkansas Softball Media Guide, 2007, University Of Arkansas, Fayetteville. Athletics Media Relations, University Of Arkansas, Fayetteville. Women's Athletics Department. Women's Communications Office, University Of Arkansas, Fayetteville. Women's Athletics Department. Women's Sports Information Office
Arkansas Softball Media Guide, 2007, University Of Arkansas, Fayetteville. Athletics Media Relations, University Of Arkansas, Fayetteville. Women's Athletics Department. Women's Communications Office, University Of Arkansas, Fayetteville. Women's Athletics Department. Women's Sports Information Office
Arkansas Softball
No abstract provided.
Interview With A Second Generation Male Chinese Immigrant, Lisa Roy-Davis
Interview With A Second Generation Male Chinese Immigrant, Lisa Roy-Davis
Telling to Live: The Immigrant Experience in a Global Suburb
Male immigrant from China discusses his experience living and coping with having an immigrant mother. He tells stories explaining his struggle to find his place in both America and Chinese culture. Also relates difficulties he and his sister have with their Chinese mother's cultural practices and beliefs. Describes his and his families coming to terms with his sexuality.
Nietzsche Reception As "Philosopher Of Fuehrermenschen" In The Main Nazi Paper, David B. Dennis
Nietzsche Reception As "Philosopher Of Fuehrermenschen" In The Main Nazi Paper, David B. Dennis
History: Faculty Publications and Other Works
No abstract provided.
Medicine@Yale September/October 2007 Volume 3, Issue 5, Yale School Of Medicine Office Of Communications
Medicine@Yale September/October 2007 Volume 3, Issue 5, Yale School Of Medicine Office Of Communications
Medicine@Yale - development newsletter
Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.
How Can Adr Alleviate Long-Standing Social Problems?, Kenneth R. Feinberg
How Can Adr Alleviate Long-Standing Social Problems?, Kenneth R. Feinberg
Fordham Urban Law Journal
Keynote Address at Inaugual Fordham Dispute Resolution Society Symposium: "ADR as a Tool for Achieving Social Justice."