Digital Commons Network^™

Rational Design And Investigation Of Polypeptide Multilayer Films And Capsules, Ling Zhang

Doctoral Dissertations

Three major concerns in the science of materials today are control over structure and function at the molecular level, biodegradability, and scalability of production. Polymeric materials, notably polyelectrolyte multilayer films, have shown considerable promise in all these areas, and for rational development of multifunctionality. Polypeptides constitute an especially interesting class of polyelectrolyte, given their inherent biodegradability, means of control over structure, methods of large-scale synthesis, and ability to encode biological information. Relatively little is known, however, about polypeptide multilayer films, despite recent advances in the general area.

In this dissertation, ten heteropolypeptides were designed and synthesized by Fmoc chemistry. These …

Keeping Insects At Bay: Beyond Deet, Thomas P. Rooney

Biological Sciences Faculty Publications

No abstract provided.

Comparison Of C. Elegans And C. Briggsae Genome Sequences Reveals Extensive Conservation Of Chromosome Organization And Synteny, Ladeana W. Hiller, Raymond D. Miller, Scott Everet Baird, Asif Chinwalla, Lucinda A. Fulton, Daniel C. Koboldt, Robert H. Waterston

Biological Sciences Faculty Publications

To determine whether the distinctive features of Caenorhabditis elegans chromosomal organization are shared with the C. briggsae genome, we constructed a single nucleotide polymorphism-based genetic map to order and orient the whole genome shotgun assembly along the six C. briggsae chromosomes. Although these species are of the same genus, their most recent common ancestor existed 80-110 million years ago, and thus they are more evolutionarily distant than, for example, human and mouse. We found that, like C. elegans chromosomes, C. briggsae chromosomes exhibit high levels of recombination on the arms along with higher repeat density, a higher fraction of intronic …

From "Navigable Waters" To "Constitutional Waters": The Future Of Federal Wetlands Regulation, Mark Squillace

University of Michigan Journal of Law Reform

Wetlands regulation in the United States has a tumultuous history. The early European settlers viewed wetlands as obstacles to development, and they drained and filled wetlands and swamps at an astounding rate, often with government support, straight through the middle of the twentieth century. As evidence of the ecological significance of wetlands emerged over the last several decades, programs to protect and restore wetlands became prominent. Most notable among these is the permitting program under section 404 of the Clean Water Act. That provision prohibits dredging or filling of "navigable waters, " defined by law to mean "waters of the …

The Great Lakes As An Environmental Heritage Of Humankind: An International Law Perspective, A. Dan Tarlock

University of Michigan Journal of Law Reform

Since 1985, the eight Great Lakes states and the Canadian provinces of Ontario and Quebec have cooperated to prevent almost all diversions of water from the Great Lakes basin. In 2005, the eight states signed an Agreement to create a tiered system of reviews for diversions and a draft interstate Compact, which creates a binding process to regulate diversions. This cooperation is primarily a state initiative, supported by the federal governments in both countries, which has paid little attention to the international character of the lakes. This Essay argues that there are three major benefits to the region from the …

Volume 2006-2007 - Issue 3 - Summer, 2006-07, Echoes Staff

Rose Echoes

No abstract provided.

The Role Of Qui Tam Actions Under The False Claims Act In Preventing And Deterring Fraud Against Government, Dr. Carl Pacini, Michael Bret Hood

University of Miami Business Law Review

No abstract provided.

Theoretical Analysis Of Dynamic Chemical Imaging With Lasers Using High-Order Harmonic Generation, Van-Hoang Le, Anh-Thu Le, Rui-Hua Xie, C. D. Lin

Physics Faculty Research & Creative Works

We report theoretical investigations of the tomographic procedure suggested by Itatani et al. [Nature (London) 432, 867 (2004)] for reconstructing highest occupied molecular orbitals (HOMOs) using high-order harmonic generation (HHG). Due to the limited range of harmonics from the plateau region, we found that even under the most favorable assumptions, it is still very difficult to obtain accurate HOMO wave functions using the tomographic procedure, but the symmetry of the HOMOs and the internuclear separation between the atoms can be accurately extracted, especially when lasers of longer wavelengths are used to generate the HHG. Since the tomographic procedure relies on …

Lawrence Today, Volume 87, Number 4, Summer 2007, Lawrence University

Alumni Magazines

No abstract provided.

A Model Of Student Success: Coaching Students To Develop Critical Thinking Skills In Introductory Biology Courses, Susan Chaplin

International Journal for the Scholarship of Teaching & Learning

Science students who perform poorly in introductory science classes often don’t know how to do better because they “don’t know that they don’t know”, and they have poor critical thinking and problem solving skills. The current study describes how modeling and coaching students in “active study” improves higher order thinking skills. The data show that students who received such coaching performed significantly better on exams by the end of the semester compared to control groups. Modeling and coaching “active study” behavior is essential to ensure that students build confidence in their ability to study science and remain in the science …

Ua64/2 The Challenge: Magazine Of The Center For Gifted Studies (No. 19, Summer 2007), Center For Gifted Studies, Tracy Inman Editor

Gifted Studies Publications

No abstract provided.

Focus, Bob Evancho (Editor)

FOCUS on Boise State

Over the past 75 years, tens of thousands of Boise State students have realized their dreams and made a difference in the world, thanks in part to the far-reaching vision of Boise State’s founder and first president, Bishop Middleton Barnwell. This issue of FOCUS looks at some of those who benefited from that vision, as well as those who are shaping Boise State’s future. The photo above is part of a historical mural created by art professor Alma Gomez-Frith to commemorate Boise State’s diamond jubilee (page 24). Cover collage by Andrew Roberts.

Voices From The Caroliniana - Summer 2007, University Libraries--University Of South Carolina

Caroliniana Library – Oral History Newsletter

Contents:

Greetings..... p.1
Oral History Program Outreach Extends to Spartanburg..... p.1
Letters From Africa: The Loretta Dunbar Peace Corps Archive..... p.2
Remembering William H. Johnson and His “Girl In A Green Dress”..... p.2
Honoring Inspiration: The Thomas Crosby Oral History Collection..... p.3
Oral History Program Collaborates On Two New Books..... p.3
Digitization Project Exhibit Welcomes Colonial Dames..... p.4

Grand Valley Magazine, Vol. 6, No. 3 Summer 2007, Grand Valley State University

Grand Valley Magazine

Grand Valley Magazine is a quarterly publication about Grand Valley State University produced by University Communications since 2001.

Nsu Fischler School Of Education And Human Services (Fsehs) Catalog And Student Handbook 2007–2008, Nova Southeastern University

Abraham S. Fischler College of Education and School of Criminal Justice College Archive

No abstract provided.

Filming Eugenics: Teaching The History Of Eugenics Through Film, Melissa Ooten, Sarah Trembanis

Women, Gender and Sexuality Studies Faculty Publications

In teaching eugenics to undergraduate students and general public audiences, film should be considered as a provocative and fruitful medium that can generate important discussions about the intersections among eugenics, gender, class, race, and sexuality. This paper considers the use of two films, A Bill of Divorcement and The Lynchburg Story, as pedagogical tools for the history of eugenics. The authors provide background information on the films and suggestions for using the films to foster an active engagement with the historical eugenics movement.

Unidirectional Na+ And Ca2+ Fluxes In Two Euryhaline Teleost Fishes, Fundulus Heteroclitus And Oncorhynchus Mykiss, Acutely Submitted To A Progressive Salinity Increase, Viviane Prodocimo, Fernando Galvez, Carolina A. Freire, Chris M. Wood

Faculty Publications

Na+ and Ca2+ regulation were compared in two euryhaline species, killifish (normally estuarine-resident) and rainbow trout (normally freshwater-resident) during an incremental salinity increase. Whole-body unidirectional fluxes of Na+ and Ca2+, whole body Na+ and Ca2+, and plasma concentrations (trout only), were measured over 1-h periods throughout a total 6-h protocol of increasing salinity meant to simulate a natural tidal flow. Killifish exhibited significant increases in both Na+ influx and efflux rates, with efflux slightly lagging behind efflux up to 60% SW, but net Na+ balance was restored by the time killifish reached 100% SW. Whole body Na+ did not change, …

Energizing An Invertebrate Embryo: Bafilomycin-Dependent Respiration And The Metabolic Cost Of Proton Pumping By The V-Atpase, Joseph A. Covi, Steven C. Hand

Faculty Publications

We examine herein the contribution of V-ATPase activity to the energy budget of aerobically developing embryos of Artemia franciscana and discuss the results in the context of quiescence under anoxia. 31P-NMR analysis indicates that intracellular pH and NTP levels are unaffected by acute incubation of dechorionated embryos with the V-ATPase inhibitor, bafilomycin A1. Bafilomycin A1 also has no significant effect on oxygen consumption by isolated mitochondria. Taken together, these data indicate that bafilomycin does not affect energy-producing pathways in the developing embryo. However, the V-ATPase inhibitor exhibits a concentration-dependent inhibition of oxygen consumption in aerobic embryos. A conservative analysis of …

In Search Of Polymorphic Alu Insertions With Restricted Geographic Distributions, Richard Cordaux, Deepa Srikanta, Jungnam Lee, Mark Stoneking, Mark A. Batzer

Faculty Publications

Alu elements are transposable elements that have reached over one million copies in the human genome. Some Alu elements inserted in the genome so recently that they are still polymorphic for insertion presence or absence in human populations. Recently, there has been an increasing interest in using Alu variation for studies of human population genetic structure and inference of individual geographic origin. Currently, this requires a high number of Alu loci. Here, we used a linker-mediated polymerase chain reaction method to preferentially identify low-frequency Alu elements in various human DNA samples with different geographic origins. The candidate Alu loci were …

Sines, Evolution And Genome Structure In The Opossum, Wanjun Gu, David A. Ray, Jerilyn A. Walker, Erin W. Barnes, Andrew J. Gentles, Paul B. Samollow, Jerzy Jurka, Mark A. Batzer, David D. Pollock

Faculty Publications

Short INterspersed Elements (SINEs) are non-autonomous retrotransposons, usually between 100 and 500 base pairs (bp) in length, which are ubiquitous components of eukaryotic genomes. Their activity, distribution, and evolution can be highly informative on genomic structure and evolutionary processes. To determine recent activity, we amplified more than one hundred SINE1 loci in a panel of 43 M. domestica individuals derived from five diverse geographic locations. The SINE1 family has expanded recently enough that many loci were polymorphic, and the SINE1 insertion-based genetic distances among populations reflected geographic distance. Genome-wide comparisons of SINE1 densities and GC content revealed that high SINE1 …

Los Arcos - Spring / Summer 2007, University Of Texas-Pan American

UTPA Archives - Los Arcos Magazine

No abstract provided.

Orange & White - Summer 2007, University Of Texas At Brownsville, Texas Southmost College

UTB/TSC Archives - Orange & White Magazine

No abstract provided.

Physical Therapy Students' Perspectives On Disability, Renee M. Williams

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this qualitative study was to examine physical therapy students’ learning about disability through an Exploring Perspectives on Disability (EPOD) learning event that was developed by School of Rehabilitative Science, McMaster University. EPOD consists of two scheduled classes discussing disability, a shadowing experience with an individual with a disability living in the community, and writing a reflective summary assignment about their learning. The EPOD was developed to broaden students’ perspectives regarding disability, promote a positive attitude about disability, and facilitate best practice approaches in community-based care. Method: Fifty-seven students in the first semester of a Master’s entry …

Louisiana Agriculture Summer, 2007, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

Genomic Organization And Imprinting Of The Peg3 Domain In Bovine, Joomyeong Kim, Anne Bergmann, Jung Ha Choo, Lisa Stubbs

Faculty Publications

Using multiple mammalian genomic sequences, we have analyzed the evolution and imprinting of several genes located in the Peg3 domain, including Mim1 (approved name, Mimt1), Usp29, Zim3, and Zfp264. A series of comparative analyses shows that the overall genomic structure of this 500-kb imprinted domain has been well maintained throughout mammalian evolution but that several lineage-specific changes have also occurred in each species. In the bovine domain, Usp29 has lost its protein-coding capability, Zim3 has been duplicated, and the expression of Zfp264 has become biallelic in brain and testis, which differs from paternal expression of mouse Zfp264 in brain. In …

Population Spread Of The Introduced Red Imported Fire Ant Parasitoid, Pseudacteon Tricuspis Borgmeier (Diptera: Phoridae), In Louisiana, D. C. Henne, S. J. Johnson, J. T. Cronin

Faculty Publications

Predicting the spread of introduced species, such as natural enemies used in classical biological control programs, requires quantitative data on the rates of spread. Here, the pattern of spread of Pseudacteon tricuspis Borgmeier (Diptera: Phoridae), a parasitoid of the red imported fire ant (Solenopsis invicta Buren; Hymenoptera: Formicidae), was monitored at two widely separated release sites in Louisiana, USA. At both sites, P. tricuspis range expansion (measured as the mean radius of the range from four cardinal directions) was accelerating during the first four years post-release. This pattern contrasts with a linear pattern expected with simple diffusion. This suggests that …

Localization Of Ligand Binding Site In Proteins Identified In Silico, M. Michal Brylinski, Marek Kochanczyk, Elzbieta Broniatowska, Irena Roterman

Faculty Publications

Knowledge-based models for protein folding assume that the early-stage structural form of a polypeptide is determined by the backbone conformation, followed by hydrophobic collapse. Side chain-side chain interactions, mostly of hydrophobic character, lead to the formation of the hydrophobic core, which seems to stabilize the structure of the protein in its natural environment. The fuzzy-oil-drop model is employed to represent the idealized hydrophobicity distribution in the protein molecule. Comparing it with the one empirically observed in the protein molecule reveals that they are not in agreement. It is shown in this study that the irregularity of hydrophobic distributions is aim-oriented. …

Genome-Wide Association Scan Shows Genetic Variants In The Fto Gene Are Associated With Obesity-Related Traits, Angelo Scuteri, Serena Sanna, Wei Min Chen, Manuela Uda, Giuseppe Albai, James Strait, Samer Najjar, Ramaiah Nagaraja, Marco Orrú, Gianluca Usala, Mariano Dei, Sandra Lai, Andrea Maschio, Fabio Busonero, Antonella Mulas, Georg B. Ehret, Ashley A. Fink, Alan B. Weder, Richard S. Cooper, Pilar Galan, Aravinda Chakravarti, David Schlessinger, Antonio Cao, Edward Lakatta, Gonçalo R. Abecasis

Faculty Publications

The obesity epidemic is responsible for a substantial economic burden in developed countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is the result not only of several environmental risk factors, but also of genetic predisposition. To take advantage of recent advances in gene-mapping technology, we executed a genome-wide association scan to identify genetic variants associated with obesity-related quantitative traits in the genetically isolated population of Sardinia. Initial analysis suggested that several SNPs in the FTO and PFKP genes were associated with increased BMI, hip circumference, and weight. Within the FTO gene, rs9930506 …

Suppression Of Growth Of A Brown Rot Fungus, Gloeophyllum Trabeum, By Formosan Subterranean Termites (Isoptera: Rhinotermitidae), Poornima Jayasimha, Gregg Henderson

Faculty Publications

Although a brown rot fungus, Gloeophyllum trabeum (Pers.) Murrill, has been shown to be attractive and beneficial to subterranean termites, including Coptotermes formosanus Shiraki (Isoptera: Rhinotermitidae), no research has been conducted to determine whether the association is mutualistic. We first investigated whether the fungus could be spread by C. formosanus, because this would represent an obvious benefit to the fungus. We found that Formosan subterranean termites did not spread G. trabeum, rather they suppressed its growth. To further investigate this phenomenon, wood chips were inoculated with G. trabeum, and fungal growth was measured in treatments with termites or without termites …

Evolutionary Dynamics Of Transposable Elements In The Short-Tailed Opossum Monodelphis Domestica, Andrew J. Gentles, Matthew J. Wakefield, Oleksiy Kohany, Wanjun Gu, Mark A. Batzer, David D. Pollock, Jerzy Jurka

Faculty Publications

The genome of the gray short-tailed opossum Monodelphis domestica is notable for its large size (∼3.6 Gb). We characterized nearly 500 families of interspersed repeats from the Monodelphis. They cover ∼52% of the genome, higher than in any other amniotic lineage studied to date, and may account for the unusually large genome size. In comparison to other mammals, Monodelphis is significantly rich in non-LTR retrotransposons from the LINE-1, CR1, and RTE families, with <29% of the genome sequence comprised of copies of these elements. Monodelphis has at least four families of RTE, and we report support for horizontal transfer of this non-LTR retrotransposon. In addition to short interspersed elements (SINEs) mobilized by L1, we found several families of SINEs that appear to use RTE elements for mobilization. In contrast to L1-mobilized SINEs, the RTE-mobilized SINEs in Monodelphis appear to shift from G+C-rich to G+C-low regions with time. Endogenous retroviruses have colonized ∼10% of the opossum genome. We found that their density is enhanced in centromeric and/or telomeric regions of most Monodelphis chromosomes. We identified 83 new families of ancient repeats that are highly conserved across amniotic lineages, including 14 LINE-derived repeats; and a novel SINE element, MER131, that may have been exapted as a highly conserved functional noncoding RNA, and whose emergence dates back to ∼300 million years ago. Many of these conserved repeats are also present in human, and are highly over-represented in predicted cis-regulatory modules. Seventy-six of the 83 families are present in chicken in addition to mammals. ©2007 by Cold Spring Harbor Laboratory Press.