Digital Commons Network^™

Drug Milk To Serum Ratio Prediction And Ontogeny Of Cyp3a Clearance Pathway As A Model Of Drug Exposure In The Developing Rat, Maggie Magdi Abbassi

University of Kentucky Doctoral Dissertations

Transfer of drugs into milk and the clearance of drugs in neonates are critical determinants of the exposure of infants to drugs in breast milk. Models predicting both parameters have been proposed. The objective of this dissertation is to test two models predicting milk to serum ratio and an ontogeny clearance model predicting clearance in the neonate. Predicted milk to serum ratio (M/S) values were generated according to the Atkinson and Begg model. The model did not adequately predict M/S when comparing the predicted values to observed values in the literature. The Fleishaker model was also tested. The model was …

Identification And Characterization Of Components Of The Yeast Spliceosome, Shatakshi Shreekant Pandit

University of Kentucky Doctoral Dissertations

The spliceosome is a complex, dynamic ribonucleoprotein (RNP) complex that undergoes numerous conformational changes during its assembly, activation, catalysis and disassembly. Defects in spliceosome assembly are thought to trigger active dissociation of faulty splicing complexes. A yeast genetic screen was performed to identify components of the putative discard pathway. This study found that weak mutant alleles of SPP382 suppress defects in several proteins required for spliceosome activation (Prp38p, Prp8p and Prp19p) as well as substrate mutations (weak branch point mutants). This evolutionary conserved protein had been found in both yeast and mammalian splicing complexes. However, its role in splicing had …

Molecular Transport Properties Through Carbon Nanotube Membranes, Mainak Majumder

University of Kentucky Doctoral Dissertations

Molecular transport through hollow cores of crystalline carbon nanotubes (CNTs) are of considerable interest from the fundamental and application point of view. This dissertation focuses on understanding molecular transport through a membrane platform consisting of open ended CNTs with ~ 7 nm core diameter and ~ 1010 CNTs/cm2 encapsulated in an inert polymer matrix. While ionic diffusion through the membrane is close to bulk diffusion expectations, gases and liquids were respectively observed to be transported ~ 10 times faster than Knudsen diffusion and ~ 10000-100000 times faster than hydrodynamic flow predictions. This phenomenon has been attributed to the non-interactive and …

Characterization Of Colloidal Nanoparticle Aggregates Using Light Scattering Techniques, Mehmet Kozan

University of Kentucky Doctoral Dissertations

Light scattering is a powerful characterization tool for determining shape, size, and size distribution of fine particles, as well as complex, irregular structures of their aggregates. Small angle static light scattering and elliptically polarized light scattering techniques produce accurate results and provide real time, non-intrusive, and in-situ observations on prevailing process conditions in three-dimensional systems. As such, they complement conventional characterization tools such as SEM and TEM which have their known disadvantages and limitations. In this study, we provide a thorough light scattering analysis of colloidal tungsten trioxide (WO3) nanoparticles in the shape of irregular nanospheres and cylindrical nanowires, and …

Cigarette Smoking As A Public Health Hazard: Crafting Common Law And Legislative Strategies For Abatemen, George P. Smith Ii

Scholarly Articles

The debate over when, and to what extent, the government may regulate public smoking, is a contentious one of great moment. The point at which the line will be drawn with regard to an individual's right to smoke in public is narrowing. This right may stop at public restaurants and the workplace; or it may reach as far as public stadia, outdoor gathering spots and public streets. In 2006, one report showed 461 municipalities in thirty-three states and the District of Columbia, had adopted one-hundred percent smoke-free coverage in restaurants, bars or workplaces; and 135 municipalities had one-hundred percent coverage …

Gis-Based Integration Of Swat And Remm For Estimating Water Quality Benefits Of Riparian Buffers In Agricultural Watersheds, Y. Liu, Wanhong Yang, Xixi Wang

Civil & Environmental Engineering Faculty Publications

The Soil and Water Assessment Tool (SWAT) is a process-based, watershed-scale model with a hydrologic response unit (HRU) as the basic computation element, which makes it difficult to accurately represent riparian buffers using their physical parameters (e.g., vegetation structure). On the other hand, the field-scale Riparian Ecosystem Management Model (REMM) provides the opportunity to consider details of hydrologic processes within a riparian buffer zone. However, the runoff and its associated constituents from the upland area that is hydraulically connected to the riparian buffer zone must be provided as inputs into REMM. The rationale proposed here is that the integration of …

The Tower Clock 2007, Tower Clock

Tower Clock Yearbooks

No abstract provided.

Effects Of Long-Term Exposure To Low Salinity On The Brackish-Water Amphiurid Brittlestar Ophiophragmus Filograneus (Lyman, 1875) From The Indian River Lagoon System, Florida, Richard L. Turner

Ocean Engineering and Marine Sciences Faculty Publications

Previous studies on salinity tolerance of Ophiophragmus filograneus have documented its ability to acclimate to a wide range of salinities in the laboratory and to acclimatize to short-term natural reductions in salinity. In all cases, salinities below 10% were lethal within a few weeks of exposure. Recent long-term changes in hydrology have exposed a dense population of O. filograneus in the Banana River lagoon to 3 yr of salinities between 10% and 20%. The burrowing response of animals subjected to acute exposure was tested in the present study at salinities of 8, 10, 12, 14 (ambient), 19, and 24%. After …

The Ethics Of Torture, Rebecca Evans

Human Rights & Human Welfare

A review of:

Torture: Does It Make Us Safer? Is It Ever OK? A Human Rights Perspective. Edited by Kenneth Roth and Mindy Worden. New York: The New Press, 2005. 201 pp.

Disability Rights, Annika Johnson

Human Rights & Human Welfare

Disability rights are often ignored in discussions of human rights. Recently, however, scholars and activists have begun producing a body of literature on disability rights in Russia and the former Soviet bloc states. Much of the literature focuses on children’s rights with an emphasis on the right to inclusive education. The literature addressing adult issues includes articles considering civil society, civil rights, and community integration. Finally, several articles address the intersection of disability rights with gender rights and ethnic minority rights.

Biogeography And The Cambrian Radiation Of Arachnomorph Arthropods, Jonathan R. Hendricks, Bruce S. Lieberman

Faculty Publications

Biogeographic patterns in primarily Cambrian arachnomorph taxa are investigated using a recently constructed phylogenetic hypothesis in order to explore the biogeographic context of the Cambrian radiation. A modified version of Brooks Parsimony Analysis is employed to elucidate patterns of vicariance and geodispersal in taxa from six regions (Laurentia, Baltica, Siberia, Australia, Africa and China). Well resolved vicariance and geodispersal trees are very similar and reconstruct Laurentia and China as sister areas. This close area relationship between Laurentia and China provides extensive evidence for congruent vicariance and range expansion in Cambrian arachnomorphs, while data from trilobites do not show this pattern. …

Learning 2.0 At Sjsu And Sjpl, Susan L. Kendall

Faculty and Staff Publications

No abstract provided.

Strategies For Odor Coding In The Piriform Cortex, Jessica H. Brann, Shari R. Saideman, Matthew T. Valley, Denise Wiedl

Biology: Faculty Publications and Other Works

No abstract provided.

Interdisciplinary Research At The University Of Illinois At Chicago: A Campus-Wide Survey Of Climate, Obstacles And Opportunities, Dennis Rosenbaum, Amie Schuck, Mark Mattaini, Ericka Adams

Faculty Publications

In recent years, the administration, faculty and research professionals at the University of Illinois at Chicago have shown considerable interest in facilitating interdisciplinary research on campus. Beginning in 2006, the Office of the Provost and the Office of the Vice Chancellor for Research provided seed funding for the creation of several interdisciplinary research (IDR) centers on campus to encourage interdisciplinary and transdisciplinary scholarship and education. This study is a product of one of those centers – the UIC Interdisciplinary Center for Research on Violence. The study was undertaken with three primary objectives: (1) to assess the IDR climate and level …

The Quest For Tenure-Track Faculty Positions By Community College Adjunct Faculty, Leandra Powell Martin

Doctoral Dissertations

unavailable

Arginine-To-Lysine Substitutions Influence Recombinant Horseradish Peroxidase Stability And Immobilisation Effectiveness., Barry Ryan, CiaráN Fagan

Articles

Background: Horseradish Peroxidase (HRP) plays important roles in many biotechnological fields, including diagnostics, biosensors and biocatalysis. Often, it is used in immobilised form. With conventional immobilisation techniques, the enzyme adheres in random orientation: the active site may face the solid phase rather than bulk medium, impeding substrate access and leading to sub-optimal catalytic performance. The ability to immobilise HRP in a directional manner, such that the active site would always face outwards from the insoluble matrix, would maximise the immobilised enzyme’s catalytic potential and could increase HRP’s range of actual and potential applications. Results: We have replaced arginine residues on …

A Conversation With Michael Joaquin Grey, Thomas Asmuth

SWITCH

In this interview, Michael Joaquin Grey discusses his work at the intersection of art, science, and pedagogy, including the art/science movement of the 1970’s and its counterpart around the year 2000. With a background in both genetics and sculpture, he’s interested in how complex systems like biology, computers, or culture grow and connect. Grey also talks about inventing ZOOB, a building toy that helps kids understand how living systems work. Throughout the conversation, he reflects on why artists don’t always need big institutions to do meaningful research and how early learning and play can shape how we think about the …

Efficacy Of Steamer Jet-Injection As Alternative To Chlorine In Fresh-Cut Lettuce, Ana Belen Martin-Diana, Daniel Rico, Catherine Barry-Ryan, Jesus Maria Frias, Gary Henehan, J. Barat

Articles

Short-time steam processing was used as an alternative to chlorine (100 mg L⁻¹) in sanitising fresh-cut lettuce. Quality (pH, water content, colour, potential browning, browning-related enzymes and texture), safety (mesophilic counts) and antioxidant markers (ascorbic and carotenoids) were monitored in lettuce stored for 10 days at 4 °C. The steam treatment produced a shocking effect on lettuce metabolism, showing a significant (p < 0.05) reduction in respiration (from day 3 to 7) and a partial inactivation of browning-related enzymes. Both effects were reflected in a significant reduction of browning. From a safety point of view, steam treatment kept the mesophilic load as low as chlorine treatment, and significantly lowers than the water control. However, antioxidant content, especially ascorbic acid but also carotenoids in a lower degree, showed a reduction compared with chlorine-treated samples. Despite the lower visual browning in steam-treated samples, the sensory panel scored similar values of acceptability and fresh appearance for both samples similarity.

Ef Fi Cacy Of Steamer Jet-Injection As Alternative To Chlorine In Fresh-Cut Lettuce, Daniel Rico, Ana Belen Martin-Diana, Jesus Maria Frias, J. Barat, Gary Henehan, Catherine Barry-Ryan

Articles

The use of calcium lactate solutions has been shown to be a healthy alternative to chlorine washing in order to maintain the shelf-life of fresh-cut products. The aim of this research was to analyse the effects of calcium lactate (15 g L⁻¹) treatment at 25 °C and 50 °C (heat-shock) on the textural properties of sliced carrots and to compare those with the chlorine treatment (120 mg L⁻¹) widely used in industry. Several direct and indirect markers of textural changes in carrots during storage were used: Instron textural analysis, Cryo-SEM and optical microscopic, sensory analysis, pectin …

Comparing Citizens' And Managers' Concerns About Sagebrush Management And Restoration In The Great Basin, Mark W. Brunson, Jennifer Peterson

Reports

The Great Basin sagebrush steppe ecosystem is among the most imperiled in the U.S. Cheatgrass invasion, conifer encroachment, and catastrophic wildfires are considered to be primary catalysts of decline. Efforts are underway to restore and increase the resiliency of this damaged ecosystem through broad-scale applications of fuel reduction and restoration treatments involving mechanical removal, prescribed fire, and herbicide application. While research points to the potential benefits of these treatments, controversy and challenge often surface when treatments are proposed on public lands. Therefore it is critical for land managers to understand the views held by key stakeholder groups concerning management and …

Ballast Water And Invasive Species In The Northeast: The Current Situation And Policy Recommendations, Jennifer Mehaffey J.D.

Sea Grant Law Fellow Publications

No abstract provided.

Requirements For Evaluating The Performance Of Individual Fishing Quota (Ifq): A Legal Analysis, Tory Randall

Sea Grant Law Fellow Publications

No abstract provided.

First Circuit Interprets Rapanos To Determine Which Test To Apply, Jonathan Lew

Sea Grant Law Fellow Publications

No abstract provided.

The Law Of Liability For Maritime Accidents In India, R. Bhanu Krishna Kiran

Journal of Maritime Law and Commerce

No abstract provided.

The Common Body Of Knowledge: A Framework To Promote Relevant Information Security Research, Kenneth J. Knapp, F. N. Ford, Thomas E. Marshall, R. K. Rainer

Journal of Digital Forensics, Security and Law

This study proposes using an established common body of knowledge (CBK) as one means of organizing information security literature. Consistent with calls for more relevant information systems (IS) research, this industrydeveloped framework can motivate future research towards topics that are important to the security practitioner. In this review, forty-eight articles from ten IS journals from 1995 to 2004 are selected and cross-referenced to the ten domains of the information security CBK. Further, we distinguish articles as empirical research, frameworks, or tutorials. Generally, this study identified a need for additional empirical research in every CBK domain including topics related to legal …

The Evolution And Palaeobiogeography Of Mesozoic Planktonic Foraminifera, Wendy Hudson

School of Geography, Earth and Environmental Sciences Theses

In the 1960s Oberhauser and Fuchs (palaeontologists working at the Geologische Bundesanstalt in Vienna) described a range of new taxa from the Triassic of Austria that were thought to be the earliest planktonic foraminifera. The first reactions of the palaeontological community were negative but in the subsequent forty years our knowledge of Jurassic planktonic foraminifera has expanded considerably. A thorough re-evaluation of the Oberhauser and Fuchs collections in Vienna has shown that these species are probably not planktonic and that the first planktonic taxa appeared in the Toarcian. This origination in the centre of Western Tethys was followed by a …

Avoiding Collapse: Resilience And Sustainable Development In Vulnerable Small Islands, Matthew Paul Bunce

School of Geography, Earth and Environmental Sciences Theses

Small islands dependent on reef fisheries, farming and tourism are vulnerable to rising human and natural pressures and may target "sustainable" development. Marine Protected Areas (MPA) have a proven ability to meet ecological goals, such as restoring fisheries and preserving ecosystem function across scales. However, there is a comparative lack of scientific baseline data and social research which may help local MPA to overcome failures in achieving mixed conservation and development goals in populated coastal areas facing intense pressure. This fieldwork-based case study researched in French and Creole languages in the sub-tropical, mid-Oceanic island of Rodrigues (Mauritius, Indian Ocean) addresses …

Productivity Management Of The Cacao Agro-Food System In Tabasco (Mexico): A Fitness Approach, Cesar Jesus Vazquez Navarrete

School of Geography, Earth and Environmental Sciences Theses

The farming industry and the agro-food system as a whole are now required to adapt to a challenging and more competitive environment. How the food industry can fit itself into such environment is the main question that is addressed in this study. The fitness approach, an exploratory framework, is applied in order to study the Cacao Agro-food System (CAPS) in Tabasco. Mexico. The final sample consisted of 356 farmers, 37 curing plants, 6 wholesaling firms, and 7 chocolate firms. An anatomical model using correspondence analysis was adopted to understand the main features of every industry in the CAPS. The Pitness …

The Photodegradation Of Diazepam And Its Human Metabolites In Water, Charles Edward West

School of Geography, Earth and Environmental Sciences Theses

In recent years, the environmental occurrence, fate and effects of pharmaceuticals or pharmaceutically active compounds (PhACs) and their metabolites have received increased attention. PhACs have been detected in wastewater, river water, marine waters and even sewage sludge and soil. Since PhACs are developed with the intention of stimulating or inhibiting physiological responses, these findings have prompted concern over their environmental fate and potential adverse effects on nontarget ecological species. The major source of discharge of PhACs to the environment is through sewage treatment works (STWs) effluents and sludges. Although used in quantities similar to many agrochemicals and other organic micropollutants, …

The Impacts Of Atmospherically Derived Metals On Coastal Marine Systems, Mohammed Orif

School of Geography, Earth and Environmental Sciences Theses

The total concentrations of trace metals (Al, Fe, Mn, Co, Na, Cu, Zn, Mo, Ni, V, Cd, Pb) have been determined in the marine aerosol at two contrasting coastal sites, Plymouth UK, (December 2001 to April 2003) and Jeddah, Saudi Arabia (August 2002-January 2004). Trace metal concentrations in the Plymouth urban aerosol were lower (2-13 times) than those observed at other comparative UK. urban locations and generally comparable with those observed at European coastal non-urban locations. Statistically significant differences were found in aerosol metal concentrations associated with populations of contrasting air mass sources (i.e. Atlantic and UK/European), being greatest in …