Digital Commons Network^™

An Examination Of The Bystander Effect In Multiple Models: From Cell Line To In-Vivo Exposure, Alice Vines

Doctoral

In recent years there has been a paradigm shift in radiobiology, to one which induces non-targeted effects, such as the bystander effect and genomic instability. The bystander effect has been defined as effects seen in cells that although never exposed to radiation, display similar effects to those that have, due to some form of communication with directly hit cells. This investigation aims to further the current understanding of this effect using three different models, cell lines, primary explant cultures and whole animals. Multiple cell lines were used to determine the relative importance of bystander signal production versus the response in …

Revolutionary Peacemaking: Using A Critical Pedagogy Approach For Peacemaking With "Terrorists", Steven Best, Peter Mclaren, Anthony J. Nocella Ii

Education Faculty Articles and Research

"The current global political atmosphere is steeped in fear of, and intense rhetoric about, political violence and "terrorism." Amidst this turbulent environment, it is clear that scholars and practitioners need to get beyond the manufactured fear and the hysterical rhetoric, peddled by what we call the corporate-state-military-media complex (or simply, the "power complex"), and instead seek a deeper understanding of political groups that defend or deploy the tactics of economic sabotage (property destruction) or armed struggle in order to change repressive and violent social structures (Best and Nocella 2004; Best and Nocella 2006). Such understanding is important to slow down …

Oncolog, Volume 52, Number 11, November 2007, Diane Witter, Karen Stuyck, Garth Powis Dphil

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Outsmarting Brain Cancer
• Protecting the Heart
• House Call: Recognize the Signs of Ovarian Cancer
• DiaLog: Advancing Drug Design in Academia, by Garth Powis, DPhil, Director, Center for Targeted Therapy, Chair, Department of Experimental Therapeutics

Macroscopic Consequences Of Calcium Signaling In Microdomains: A First-Passage-Time Approach, Robert Rovetti

Mathematics, Statistics and Data Science Faculty Works

Calcium (Ca) plays an important role in regulating various cellular processes. In a variety of cell types, Ca signaling occurs within microdomains where channels deliver localized pulses of Ca activating a nearby collection of Ca-sensitive receptors. The small number of channels involved ensures that the signaling process is stochastic. The aggregate response of several thousand of these microdomains yields a whole-cell response which dictates the cell behavior. Here, we study the statistical properties of a population of these microdomains in response to a trigger signal. We use a first-passage-time approach to show analytically how Ca release in the whole cell …

Refuge Update – November/December 2007, Volume 4, Number 6

RefugeUpdate (USFWS-NWRS)

Table of Contents:

Celebrating 20 Years of Science on the M/ V Tiglax, page 5 Kevin Bell is honored as Captain of the largest ship operated by the National Wildlife Refuge System.

Focus on…A River Runs Through It, pages 8-15 Rivers on refuges are managed for recreation, habitat restoration, water rights and sheer beauty.

The Fight Against Giant Salvinia, page 18 Caddo Lake National Wildlife Refuge in Texas is fighting a weed that can travel three-quarters of a mile in 24 hours.

Awards, page 21 From protecting the land to going “green,” awards recognize excellence.

The Routine Use Of Preoperative Non-Contrast Chest Computerized Tomography And Carotid Arteries Doppler Prior To Cardiac Surgery, Qing Fan, Kyung-Won Park, Zhiqiang Du, Kevin A Morano, Liming Li

Faculty, Staff and Student Publications

Yeast prions are a group of non-Mendelian genetic elements transmitted as altered and self-propagating conformations. Extensive studies in the last decade have provided valuable information on the mechanisms responsible for yeast prion propagation. How yeast prions are formed de novo and what cellular factors are required for determining prion "strains" or variants--a single polypeptide capable of existing in multiple conformations to result in distinct heritable phenotypes--continue to defy our understanding. We report here that Sse1, the yeast ortholog of the mammalian heat-shock protein 110 (Hsp110) and a nucleotide exchange factor for Hsp70 proteins, plays an important role in regulating [PSI+] …

Relative Contributions Of Enterococcus Faecalis Og1rf Sortase-Encoding Genes, Srta And Bps (Srtc), To Biofilm Formation And A Murine Model Of Urinary Tract Infection, Kelvin D Kemp, Kavindra V Singh, Sreedhar R Nallapareddy, Barbara E Murray

Faculty, Staff and Student Publications

Deletion mutants of the two sortase genes of Enterococcus faecalis OG1RF were constructed. srtC (renamed here bps for biofilm and pilus-associated sortase) was previously shown to be necessary for the production of Ebp pili and important for biofilm formation and endocarditis. Here, we report that a srtA deletion mutant showed a small (5%) yet significant (P = 0.037) reduction in biofilm relative to OG1RF, while a DeltasrtA Deltabps double mutant showed a much greater reduction (74% versus OG1RF and 44% versus the Deltabps mutant). In a murine urinary tract infection (UTI), the 50% infective doses of both the DeltasrtA Deltabps …

The Zebrafish Fleer Gene Encodes An Essential Regulator Of Cilia Tubulin Polyglutamylation, Narendra Pathak, Tomoko Obara, Steve Mangos, Yan Liu, Iain A. Drummond

Neuroscience: Faculty Publications

Cilia and basal bodies are essential organelles for a broad spectrum of functions, including the development of left-right asymmetry, kidney function, cerebrospinal fluid transport, generation of photoreceptor outer segments, and hedgehog signaling. Zebrafish fleer (flr) mutants exhibit kidney cysts, randomized left-right asymmetry, hydrocephalus, and rod outer segment defects, suggesting a pleiotropic defect in ciliogenesis. Positional cloning flr identified a tetratricopeptide repeat protein homologous to the Caenorhabditis elegans protein DYF1 that was highly expressed in ciliated cells, flr pronephric cilia were shortened and showed a reduced beat amplitude, and olfactory cilia were absent in mutants, flr cilia exhibited ultrastructural defects in …

Washington University Record, November 1, 2007

Washington University Record

No abstract provided.

The Daily Gamecock, Thursday, November 1, 2007, University Of South Carolina, Office Of Student Media

November

No abstract provided.

Comparison Of Probabilistic Boolean Network And Dynamic Bayesian Network Approaches For Inferring Gene Regulatory Networks, Peng Li, Chaoyang Zhang, Edward J. Perkins, Ping Gong, Youping Deng

Faculty Publications

Background: The regulation of gene expression is achieved through gene regulatory networks (GRNs) in which collections of genes interact with one another and other substances in a cell. In order to understand the underlying function of organisms, it is necessary to study the behavior of genes in a gene regulatory network context. Several computational approaches are available for modeling gene regulatory networks with different datasets. In order to optimize modeling of GRN, these approaches must be compared and evaluated in terms of accuracy and efficiency.

Results: In this paper, two important computational approaches for modeling gene regulatory networks, …

The Absence Of Justice In The United States Criminal Justice System, Yevgeny Roymisher

Honors College Theses

No abstract provided.

Characterization Of Polymorphic Microsatellite Loci For The Invasive Monk Parakeet (Myiopsitta Monachus), M. A. Russello, V. Saranathan, S. Buhrman-Deever, J. Eberhard, A. Caccone

Faculty Publications

Microsatellite loci were characterized for the monk parakeet (Myiopsitta monachus) from a GTn-enriched genomic library. Twelve of 14 microsatellite loci were polymorphic, averaging 6.7 alleles per locus across the 20 individuals genotyped. Mean expected heterozygosity was 0.72, with locus-specific values ranging from 0.53 to 0.90. An equally high multilocus probability of identity (2.48 × 10-12) was revealed for this set of loci. In addition, all 12 loci were demonstrated to cross-amplify to varying extents within three additional parrot genera suggesting their potential utility for population-level studies in a broad range of Neotropical psittacines. © 2007 The Authors.

Justice For Children, Adults With Disabilities And The Elderly: Reflections From 15 Years As An Attorney With The Office Of The Public Guardian Of Cook County, Illinois, Charles P. Golbert

DePaul Journal for Social Justice

No abstract provided.

Influence Of Genetic Polymorphisms Of Glutathione S-Transferases T1 And M1 On Serum Lipid Parameters, Mostafa Saadat

Saudi Medical Journal

OBJECTIVE: To determine the effect of genetic polymorphisms of glutathione S-transferase theta 1 (GSTT1) and GSTM1 on serum levels of lipid parameters. METHODS: We conducted this cross-sectional study on 152 adult healthy subjects (54 females and 98 males) from June 2004 to September 2004. The participants in our study were recruited from the Research Clinic in Abarku (Yazd province, central part of Iran). There were unrelated Iranian Muslims. The genotypes of GSTT1 and GSTM1 were determined using a polymerase chain reaction based method. After an overnight fasting, serum lipid indices including triglyceride (TG), total cholesterol (TC) and high density lipoprotein …

Comparison Of Real-Time, And Qualitative Polymerase Chain Reaction Assays In Detection Of Cytomegalovirus Dna In Clinical Specimens, Selma Gokahmetoglu, Esma Deniz

Saudi Medical Journal

OBJECTIVE: To compare the real-time (RT), and qualitative (Q) polymerase chain reaction (PCR) assays for detection of Cytomegalovirus (CMV) DNA. METHODS: The study took place in the Department of Microbiology, Erciyes University, Kayseri, and in Iontek Laboratory, Istanbul, Turkey, from August to December 2006. One hundred and seven clinical specimens from 67 patients were included in the study. Cytomegalovirus DNA was investigated using RT-PCR kit (Fluorion Iontek, Turkey) and Q-PCR kit (Fluorion Iontek, Turkey). Deoxyribonucleic acid sequencing was applied to the samples that yielded discrepant results in both assays. MacNemar9s Chi Square test was used for statistical analysis. RESULTS: Of …

Melanoma Differentiation-Associated Gene-7/Interleukin 24 Inhibits Invasion And Migration Of Human Cervical Cancer Cells In Vitro, Hua Shi, Li-Li Wei, Cheng-Fu Yuan, Jun-Xia Yang, Fa-Ping Yi, Yong-Ping Ma, Fang-Zhou Song

Saudi Medical Journal

OBJECTIVE: In this study, we used an adenoviral vector -melanoma differentiation-associated gene-7 (Ad-mda7) to examine the effect of the ectopic production of MDA-7/IL-24 on cell migration and invasion by human cervical cancer cells. METHODS: The study took place in the Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China, between April 2006 and November 2006. The change of metastasis of cervical cancer cells (CaSki) cells were detected by Cell Migration Assay and Cell Invasion Assay after treated with Ad-mda7. The production of proteins associated with cell migration and invasion were detected by western blot. RESULTS: Cervical cancer cells …

Disarming Rogues: Deterring First-Use Of Weapons Of Mass Destruction, David Szabo

The US Army War College Quarterly: Parameters

No abstract provided.

Are There Rearrangement Hotspots In The Human Genome?, Max A. Alekseyev, Pavel A. Pevzner

Faculty Publications

In a landmark paper, Nadeau and Taylor [18] formulated the random breakage model (RBM) of chromosome evolution that postulates that there are no rearrangement hotspots in the human genome. In the next two decades, numerous studies with progressively increasing levels of resolution made RBM the de facto theory of chromosome evolution. Despite the fact that RBM had prophetic prediction power, it was recently refuted by Pevzner and Tesler [4], who introduced the fragile breakage model (FBM), postulating that the human genome is a mosaic of solid regions (with low propensity for rearrangements) and fragile regions (rearrangement hotspots). However, the rebuttal …

Faculty Senate Chronicle For November 1, 2007, Richard Stratton

The University of Akron Faculty Senate Chronicle

Minutes of the regular meeting of The University of Akron Faculty Senate on November 7, 2007.

Family And Juvenile Law, Lynne Marie Kohn

University of Richmond Law Review

No abstract provided.

Initial Sequence And Comparative Analysis Of The Cat Genome, J. U. Pontius, James C. Mullikin, Douglas R. Smith, Agencourt Bioscience Corporation, Kerstin Lindblad-Toh, Sante Gnerre, Michele Clamp, Jean Chang, R. Stephens, Beena A. Neelam, Natalia Volfovsky, Alejandro A. Schaffer, R. Agarwala, Kristina Narfstrom, William J. Murphy, Urs Giger, Alfred L. Roca, Agostinho Antunes, Marilyn Menotti-Raymond, Naoya Yuhki, Jill Pecon-Slattery, Warren E. Johnson, Guillaume Bourque, Glenn Tesler, Nisc Comparative Sequencing Program, Stephen J. O'Brien

Biology Faculty Articles

The genome sequence (1.9-fold coverage) of an inbred Abyssinian domestic cat was assembled, mapped, and annotated with a comparative approach that involved cross-reference to annotated genome assemblies of six mammals (human, chimpanzee, mouse, rat, dog, and cow). The results resolved chromosomal positions for 663,480 contigs, 20,285 putative feline gene orthologs, and 133,499 conserved sequence blocks (CSBs). Additional annotated features include repetitive elements, endogenous retroviral sequences, nuclear mitochondrial (numt) sequences, micro-RNAs, and evolutionary breakpoints that suggest historic balancing of translocation and inversion incidences in distinct mammalian lineages. Large numbers of single nucleotide polymorphisms (SNPs), deletion insertion polymorphisms (DIPs), and …

Is It A European Car Or A Japanese Car? An Erp Study Of Diagnostic Information Use In Visual Expertise, Assaf Harel, Shlomo Bentin

Psychology Faculty Publications

No abstract provided.

Introduction To The 2007 Editors’ Symposium: Informational Privacy: Philosophical Foundations And Legal Implications, Larry Alexander

San Diego Law Review

The outstanding collection of articles and comments thereon that follows this Introduction constitutes the 2007 Editors' Symposium of the San Diego Law Review. This year's theme is: "Informational Privacy: Philosophical Foundations and Legal Implications."

Observer, Central Washington University

Student Newspaper

Student newspaper for Central Washington University for November 1, 2007

A Mutant Dec-1 Transgene Induces Dominant Female Sterility In Drosophila Melanogaster, Daniel K. Spangenberg, Gail L. Waring

Biological Sciences Faculty Research and Publications

The Drosophila dec-1 gene produces three proproteins required for female fertility and eggshell assembly. The three proproteins are distinguished by their C termini. Fc106, the most abundant proprotein, is cleaved within the vitelline membrane to three mature derivatives in a developmentally regulated manner. To define sequences within fc106 that are critical for its function, we created wild-type and mutant versions of an fc106 cDNA transgene. The functional consequences of the mutations were assessed in dec-1⁴, a female-sterile splicing mutant that does not produce the fc106 isoform. The fertility of dec-1⁴ females was restored by the introduction of …

The Pacifican November 1, 2007, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.

2007 November 13 Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes No. 6, November 13, 2007

2007 November 27 Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes No. 7, November 27, 2007

Sporophytic Inbreeding Depression In Mosses Occurs In A Species With Separate Sexes But Not In A Species With Combined Sexes, Philip J. Taylor, Sarah M. Eppley, Linley K. Jesson

Biology Faculty Publications and Presentations

Inbreeding depression is a critical factor countering the evolution of inbreeding and thus potentially shaping the evolution of plant sexual systems. Current theory predicts that inbreeding depression could have important evolutionary consequences, even in haploid-dominant organisms. To date, no data have been reported on inbreeding depression in moss species. Here, we present data on the magnitude of inbreeding depression in sporophytic traits of moss species with contrasting breeding systems. In eratodon purpureus (Ditrichaceae), a moss species with separate sexes, self-fertilizations between sibling gametophytes (intergametophytic selfing) significantly reduced fitness in two of four traits quantified, with seta length and capsule length …