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Dna Binding Specificity Of Mu Transcription Factor C And Crystallization Of C : Dna Complex, Karthik Shanmugantham

Theses and Dissertations (ETD)

The lytic cycle of phage Mu is regulated by a transcriptional cascade consisting of early, middle and late transcription. The Mor protein is an activator of the middle promoter Pm and is encoded by the last gene of the early transcript. The C protein is an activator of the four late promoters Plys, PI, PP, and Pmom and is expressed from the middle transcript. Both Mor and C proteins bind an imperfect dyad-symmetry element just upstream and overlapping the –35 region of Pm and Plys respectively. The main aims of this study was, (1) To understand the binding specificity of …

Synthesis Of Novel Sulfonamide-Based Calpain Inhibitors And Their Potential As Anti-Tumor Agents, Jin Xu

Theses and Dissertations (ETD)

Calpain is a class of intracellular cytoplasmic cysteine proteases.1 The enzyme participates in different intracellular signaling pathways that are mediated by Ca2+.2 The two major isoforms of calpain universally distributed in most mammalian tissues are calpain 1 (µ-calpain) and calpain 2 (m-calpain). The exact in vivo function of the enzyme is not clear, but calpain has been implicated in a variety of physiological and pathological conditions,3 such as cancer, stroke, cardiac ischaemia, muscular dystrophy, cataract and Alzheimer’s disease. Calpain inhibitors are therefore of interest as therapeutic agents and as biomedical tools.

Several potent calpain inhibitors isolated from natural sources as …

Longitudinal Tracking Of Cytokines After Acute Exposure To Tuberculosis: Association Of Distinct Cytokine Patterns With Protection And Disease Development, Rabia Hussain, Najeeha Talat, Firdaus Shahid, Ghaffar Dawood

Department of Pathology and Laboratory Medicine

Household contacts (HCs) of patients with tuberculosis (TB) are at higher risk of infection as well as the development of active disease. Longitudinal tracking of antigen-specific cytokines after acute exposure may significantly advance our understanding of the dynamic changes in cytokine patterns associated with disease establishment. To achieve this objective, we carried out a prospective cohort study with healthy HCs after exposure to TB. The patterns of cytokines (gamma interferon [IFN-gamma] and interleukin 10 [IL-10]) in response to mycobacterial antigens (culture filtrate [CF] proteins) and nonspecific mitogens (phytohemagglutinin [PHA] and lipopolysaccharide [LPS]) were assessed at 0, 6, 12, and 24 …

The Complete Genome Sequence And Analysis Of The Epsilonproteobacterium Arcobacter Butzleri, William G. Miller, Craig T. Parker, Mark Rubenfield, George L. Mendz, Marc Msm Wo, David W. Ussery, John F. Stolz, Tim T. Binneweis, Peter F. Hallin, Guilin Wang, Joel A. Malek, Andrea Rogosin, Larry H. Stanker, Robert E. Mandrell

Medical Papers and Journal Articles

Arcobacter butzleri is a member of the epsilon subdivision of the Proteobacteria and a close taxonomic relative of established pathogens, such as Campylobacter jejuni and Helicobacter pylori. Here we present the complete genome sequence of the human clinical isolate, A. butzleri strain RM4018.

Methodology/Principal Findings: Arcobacter butzleri is a member of the Campylobacteraceae, but the majority of its proteome is most similar to those of Sulfuromonas denitrificans and Wolinella succinogenes, both members of the Helicobacteraceae, and those of the deep-sea vent Epsilonproteobacteria Sulfurovum and Nitratiruptor. In addition, many of the genes and pathways described here, …

Impairments In Inhibition Or Cognitive Control In Psychological Disorders, Paula T. Hertel

Psychology Faculty Research

Contributions to this special issue of Applied & Preventive Psychology richly elucidate connections between a variety of psychological disorders and performance in a number of tasks that are used to reason about inhibitory deficits. This commentary calls attention to the different uses of the concept of inhibition - vernacular, neural, operational, and theoretical - and suggests that the term cognitive control avoids claims about dampened memory representations that are difficult to support. Central findings from the reviews are summarized; evidence concerning suppression-induced forgetting is featured and directions to foster application are discussed.

The Lens Of Faith, Donald J. Lococo

Verbum

In lieu of an abstract, below is the essay's first paragraph.

"For seven years during the nineties, I taught a course at St. Michael’s College in the University of Toronto called Christianity and Science. It served as an introduction to the science division of the Christianity and Culture Program. In that context, it illustrated the essential relationship that Christianity has had to the development of the modern disciplines of natural science out of the ancient and Medieval discipline of natural philosophy. It was a full-year course. The first semester introduced to the students a lesson that many did not …

Full Issue, No Author

Verbum

This is the full issue of Volume 5, Issue 1 of Verbum, published in Fall 2007 by the REST Club at St. John Fisher College. Articles from this issue are available as separate PDFs at http://fisherpub.sjfc.edu/verbum/vol5/iss1/

Learner-Centered Assignments In Computer Literacy, Martha E. Myers, Meg C. Murray, Mario Guimaraes, Debra B. Geist

Faculty Articles

Literacy is a concept that is understood to be the identifier of an educated populace. In today's world, literacy includes computer literacy, as well as language and quantitative literacy. This paper describes exercises developed to improve first year students' computer literacy through more learner-centered engagement. Exercises are designed to support learner-centered goals of independent and responsible learners, appropriate breadth and depth of content, teacher as facilitator, and assessment woven into learning. Exercise topics include purchase of a personal computer, basic logic via spreadsheets, an annotated bibliography built with electronic resources, and an integrated assignment customized by and for each student.

Jurisdiction In Outer Space: Challenges Of Private Individuals In Space, P. J. Blount

Journal of Space Law

No abstract provided.

Bibliography: Space Law And Relevant Publications, P. J. Blount

Journal of Space Law

No abstract provided.

Front Matter, Journal Editors

Journal of Space Law

Includes table of contents.

Foreword, Joanne Irene Gabrynowicz

Journal of Space Law

No abstract provided.

Call For Papers, Journal Editors

Journal of Space Law

No abstract provided.

Patent Rights Under Space Act Agreements And Procurement Contracts: A Comparison By The Examination Of Nasa’S Commercial Orbital Transportation Services (Cots), Tiphany Baker Dickerson

Journal of Space Law

No abstract provided.

Space Tourism Activities: Emerging Challenges To Air And Space Law?, Stephan Hobe, Gérardine Meishan Goh, Julia Neumann

Journal of Space Law

No abstract provided.

A Study Of Aerospace Legislation Of China, Qi Yongliang

Journal of Space Law

No abstract provided.

National Space Legislation In Mainland China, Yun Zhao

Journal of Space Law

No abstract provided.

Chinese Law: Registration, Launching And Licensing Space Objects, China University Of Political Science And Law. Faculty Of International Law, University Of Mississippi. National Center For Remote Sensing, Air, And Space Law

Journal of Space Law

Chinese Law: Registration, Launching and Licensing Space Objects: 1) Order No. 6 of the Commission of Science, Technology, and Industry for National Defense and the Ministry of Foreign Affairs of the People’s Republic of China, 8 February 2001; Annex: National Registration Form of Space Objects 2) Order No. 12 of the Commission of Science, Technology, and Industry for National Defense of the People’s Republic of China, 21 November 2002; Annex: Application Form for Licensing the Project of Launching Civil Space Objects

Japanese Law: Geospatial Information Utilization Promotion Bill Of May 30, 2007, Journal Editors

Journal of Space Law

No abstract provided.

Direito E Política Na Era Espacial: Podemos Ser Mais Justos No Espaço De Que Na Terra? (Law And Policy In The Space Age: Can We Be More Just [Or Equitable] In Space Than On Earth?) By José Monserrat Filho, Sylvia Ospina

Journal of Space Law

No abstract provided.

Interpreting The Fourteenth Amendment: Two Don'ts And Three Dos, Garrett Epps

All Faculty Scholarship

A sophisticated reading of the legislative record of the framing of the Fourteenth Amendment can provide courts and scholars with some general interpretive principles to guide their application of the Amendment to current legal problems. The author argues that two common legal conceptions about the Amendment are, in fact, misconceptions. The first is that the Amendment was chiefly concerned with the immediate situation of freed slaves in the former slave states. Instead, he argues, the legislative record suggests that the framers were broadly concerned with the rights not only of freed slaves but also of foreign-born immigrants in the North …

Defending Truth: Legal And Psychological Aspects Of Holocaust Denial, Kenneth Lasson

All Faculty Scholarship

From the still-burning embers of the Holocaust we have come once again to learn the terrible truth, that the power of Evil still lurks among the nations of the world, and cannot be underestimated. Nor can the effect of the spoken and written word, which in modern times must be taken in tandem with the violence of terrorism. Part I describes the background and nature of Holocaust denial, tracing the Nazis' adoption of a plan for the A "Final Solution of the Jewish Problem" through the post-War Nuremberg Trials to the present day. Part II examines the tension between free …

Connecting The Dots: Nonresident Vacationer Characteristics Of Popular Travel Corridors, Christine Oschell, Lee Rademaker, Norma Nickerson

Institute for Tourism and Recreation Research Publications

This report highlights travel corridors and characteristics of Montana vacationers. Seven distinct groups of people based on their entry and exit points to Montana emerged from the data. Each group is described in terms of demographics, attractions to the state, activities engaged in while visiting and how many of each group visited Montana by quarter.

Keeping “Every Catholic Child In A Catholic School” During The Great Depression, 1933-1939, Ann Marie Ryan

Journal of Catholic Education

The quest for state and federal aid for Catholic schools is not new. Concerns regarding excessive entanglement, mission dilution, and external control have been voiced for decades. A particularly instructive historical period on this issue is the era of the Great Depression. Because of widespread economic hardship across sectors, Catholic leaders were active and engaged in the politics of federal and state aid for schools and experienced both success and failure.

Educational Leadership For Social Justice: Enhancing The Ethical Dimension Of Educational Leadership, Susan Toft Everson, Leslie Hazle Bussey

Journal of Catholic Education

Much criticism has been levied in recent years on professional preparation programs in schools of education offering the Doctor of Education (Ed.D.) degree. This article chronicles the attempt of one Jesuit university to respond to that criticism in designing a professional degree with an ethical focus on social justice.

Brothers Of The Christian School, Luke Salm

Journal of Catholic Education

The Brothers of the Christian Schools, popularly known in the United States as Christian Brothers, have made numerous significant contributions to the development of Catholic education. Building and staffing schools, colleges, and orphanages, producing textbooks and catechetical materials, advocating for the poor, and creating new models of Catholic education are among their many successes. Manhattan College, St. Mary’s Press, and San Miguel Schools are all products of this community of Catholic educators.

The United States: The Role Of The Brothers Of Holy Cross, Philip C. Armstrong

Journal of Catholic Education

The Congregation of Holy Cross, the founding religious community behind the University of Notre Dame, had its origin in the ranks of diocesan clergy in France. This article chronicles the early history of the congregation, struggles between priests and its brothers, and its movement into the ministry of Catholic education.

Arkansas Soybean Performance Tests 2007, D. G. Dombek, R. D. Bond, I. L. Eldridge, R. M. Pryor

Arkansas Agricultural Experiment Station Research Series

Soybean cultivar performance tests are conducted each year in Arkansas by the University of Arkansas Division of Agriculture. The tests provide information to companies developing cultivars and/or marketing seed within the State, and aid the Arkansas Cooperative Extension Service in formulating cultivar recommendations for soybean producers.

Can Collective Action And Capacity Building Reduce Vulnerability Among Settled Pastoralists?, D. Layne Coppock, Solomon Desta, Getachew Gebru, Seyoum Tezera

Environment and Society Faculty Publications

In 2001 PARIMA and her partners began to create collective-action groups among illiterate, settled pastoralists in southern Ethiopia. These groups—dominated by women—focused on savings-led microfinance, small business, and livestock marketing to increase incomes and diversify livelihoods. Fifty-nine groups with over 2,100 members were formed using intensive capacity- building methods. After six years we wanted to compare group members with their neighbors who never participated in the PARIMA program. We surveyed 180 individuals from groups and paired control (traditional) communities. Respondents were asked to assess the extent that they perceived positive, negative, or no change in their lives over the past …

Diffusion Of Collective-Action Innovations Among Pastoralists In Liben District, Ethiopia, D. Layne Coppock, Solomon Desta, Getachew Gebru, Getachew Kassa, Seyoum Tezera

Environment and Society Faculty Publications

In 2001 PARIMA and her partners began to create collective-action groups among illiterate, settled pastoralists in Ethiopia. These groups—soon dominated by women—focused on savings-led microfinance, small business activity, and livestock marketing to increase incomes and diversify livelihoods. Fifty-nine groups with over 2,100 members were formed using intensive training methods, and they have subsequently merged into legally recognized cooperatives. We regard this approach as successful and sustainable. We were curious, however, if “the word has spread” and collective-action has spontaneously arisen beyond our immediate project area. Preliminary findings from recent surveys of settlements in Liben District indicate that diffusion of collective-action …