Digital Commons Network^™

On The Binding Of N1-Substituted Tryptamines At H5-Ht6 Receptors, Abner Nyamwaro Nyandege

Theses and Dissertations

Serotonin was first discovered in the late 1940s as a vasotonic factor and is now considered a principal neurotransmitter in the nervous system. 5-HT6 receptors are one of the most recently identified members of the serotonin receptor family which consists of seven classes (5-HT1-5-HT7). 5-HT6 receptors are G-protein coupled, positively coupled to an adenylate cyclase second messenger system and are primarily found in the central nervous system (CNS). The exact functional role of 5-HT6 receptors has not been determined, but is implicated to have possible involvement in certain neuropsychiatric disorders and cognition. To investigate the functional role of these receptors, …

Determination Of Size Fractions And Concentrations Of Airborne Particulate Matter Generated From Construction And Demolition Waste Processing Facilities, Jason M. Young

Theses and Dissertations

Construction and Demolition (C&D) processing and recycling facilities accept waste materials that are generated during construction and demolition activities. The processing facility sorts, processes, and transfers the material to another operation. A consequence of these processes is the generation of particulate matter.This study involved quantifying and qualifying airborne particulates at three C&D processing facilities. Active stationary particulate sampling devices were employed to quantify the particle sizes of interest. Results were compared to United States Environmental Protection Agency (EPA) National Ambient Air Quality Standards(NAAQS) and United States Occupational Safety and Health Administration (OSHA)standards.The results from this study are not valid for …

The Art Of Collaboration In The Classroom: Team Teaching Performance, Jenna M. Neilsen

Theses and Dissertations

The Art of Collaboration in the Classroom: Team Teaching Performance is a co-written master's thesis which records our research in the field of team teaching as it relates to theatre education at the university level. It is our intent that this text be used as a tool for helping universities and teachers decide if a collaborative teaching model is right for their courses. A portion of the text is research-based, examining the scholarly writings which have preceded our work. In Chapter 1, we compiled a set of definitions, in the hopes of codifying the language used within this document as …

Transitions: Starting The Second, Full Circle, Mary Colleen Vreeland

Theses and Dissertations

This thesis will focus on the transitional influences that have led me to start the second circle of my professional life. It is an open and honest exploration of the back-story of my life and the academic and professional influences that led me to seek a Master of Fine Arts Degree at Virginia Commonwealth University. With no parallels and therefore no excuses insinuated, I will be open and dissect more of myself as the whole focus of the thesis in hopes of offering clarity to myself and other mature and disabled students seeking to become a better teacher and artist.

Would You Believe Me If I Said I Didn't Need You, Andrew Kozlowski

Theses and Dissertations

This thesis is an attempt to expand upon the ideas that permeate the practice of art making that has developed over the past two years. Art criticism, theory, history, and practice are used to give definition to the boundaries of my ever-shifting body of work. Focusing on the elusive nature of communication in both public and private spheres, these projects range from installation and sculptural work, to web projects, photography, and drawing.

The Encyclopedic Collections Of The Metropolitan Museum Of Art And The Rudolfine Kunstkammer As Expressions Of Power, Jennifer Ashley Pate

Theses and Dissertations

In Western Europe during the sixteenth and seventeenth centuries, collections were created as repositories of art, technology, ethnographic curiosities and natural wonders. Collecting first became a widespread practice among Italian humanists of the late Renaissance who, influenced by the work of Pliny, were driven by the desire to understand the world through the acquisition of universal knowledge. The physical configuration of such encyclopedic projects could be found in the museums created to organize and assimilate the explosion of knowledge experienced during this period.This thesis addresses the social significance of accumulating an encyclopedic collection in the form of a large, public …

Pedagogical Fusion, David Maurice White

Theses and Dissertations

During the five semesters that I have been at VCU I have learned a great deal from the courses that I have been enrolled in but I have learned the most through my experiences as a Teaching Assistant. These experiences have been so valuable because of the wide range of subject areas in which I have been involved and the diverse instructors that I have assisted. Although I hesitate to use the word "problem" I feel that there is a tendency in teacher training for a student to latch onto one professor and model their teaching practices after that one …

An Exploration Of The Influence Of Race And Gender On Sexual Beliefs And Attitudes Of Adolescents, Kristine Marie Vandenberg

Theses and Dissertations

This study explores factors that influence the sexual attitudes and behaviors of adolescents specifically through an examination of social constructs that measure sexual beliefs and attitudes of adolescents and the relationships between race and gender and sexual beliefs and attitudes. As the U.S. has maintained one of the highest rates of unplanned teen pregnancy and births among industrialized nations, schools and community groups have struggled to combat teen pregnancy and worked toward designing effective prevention programs. Through an emphasis either on abstinence or safe sex practices, these programs strive to influence adolescents' sexual behavior. However, studies and reports reveal a …

Induction Of Heme Oxygenase By A Carbon Monoxide-Releasing Molecule, Robert Andrew Kulina

Theses and Dissertations

We have recently demonstrated that heme oxygenase is expressed in both healing wounds and in pressure ulcers. Heme oxygenase has been shown to have important cytoprotective functions in myocardial ischemia-reperfusion injury and organ allograft survival. The cytoprotective effects of heme oxygenase are multifactorial. Besides reducing levels of pro-oxidant heme, heme oxygenase products (bilirubin, carbon monoxide, and iron) have been demonstrated to possess anti-oxidant, anti-inflammatory, anti-apoptotic, and anti-proliferative properties. These properties make heme oxygenase an attractive therapeutic target for the prevention and treatment of chronic wounds. The purpose of this study was two-fold: evaluate the effects of carbon monoxide (CO) on …

The Effect Of A Nominal Fee On Treatment Choices For Children Needing Dental Rehabilitation, D'Audra M. Cole

Theses and Dissertations

Objective: The purpose of the study was to determine if a co-payment resulted in a differential preference for general anesthesia (GA) or oral sedation (OS) and, if so, to examine whether age, the number of appointments, perceived risks of treatment, child's awareness during treatment, or insurance type appeared to play a role in this preference.Methods: Using a cross-sectional survey design, questionnaires were distributed to caregivers of patients in the waiting room of the Virginia Commonwealth University Pediatric Dental Clinic. Two different questionnaires were distributed randomly. Both surveys described a scenario with the need for dental treatment under general anesthesia (GA) …

The Quantitative Genetics Of Neurodevelopment: A Magnetic Resonance Imaging Study Of Childhood And Adolescence, James Eric Schmitt

Theses and Dissertations

Understanding the causes of individual differences in brain structure may give clues about the etiology of cognition, personality, and psychopathology, and also may identify endophenotypes for molecular genetic studies on brain development. We performed a comprehensive statistical genetic study of anatomic neuroimaging data from a large pediatric sample (N=600+) of twins and family members from the Child Psychiatry Branch at the NIMH. These analyses included variance decomposition of structural volumetric endophenotypes at several levels of resolution, voxel-level analysis of cortical thickness, assessment of gene by age interaction, several multivariate genetic analyses, and a search for genetically-mediated brain-behavioral relationships. These analyses …

Toward A New Kinship Constellation, Nellie Helen Frances Appleby

Theses and Dissertations

This thesis attempts to elaborate on my artwork during my graduate studies, while contextualizing it within the framework of the art world and the works of other artists. A main project during this time was to minimize the singular interpretation and framing of a fine art photographic print, while expanding its possibilities of meaning through the addition of important ephemera and objects such as plants, drawings, moving imagery, conversation and the unknown.

Beaut-Ease, Amanda Rae Douglas

Theses and Dissertations

The Beaut-Ease product line consists of several machines that are a hybrid between beauty products and infomercial products. Both industries flourish on a level of falsehood that teeters on the brink of hilarity.

Measuring Hispanic/Latino Satisfaction With Health Services In Chesterfield County, Virginia, Lynell H. Mcclinton

Theses and Dissertations

The objectives of this study were to measure and describe the overall satisfaction of Hispanics/Latinos with services they receive from Chesterfield County's Health Department and compare it to that of African Americans and Caucasians. Also, the objectives were to analyze reasons for different levels of satisfaction, assess the nature and degree of satisfaction with particular services, and suggest implications of the Hispanic/Latino opinions for public policy. While the empirical literature revealed that Hispanics/Latinos experience lower levels of satisfaction with health care services, this study did not provide evidence to support this theory.This is a multi-method non-experimental research design combining a …

Elementary School Principals' Perceptions Of The Instructional Role Of The School Library Media Specialist, Audrey Puckett Church

Theses and Dissertations

Studies conducted in numerous states by various researchers demonstrate that library media specialists who take an active role in the instructional process positively impact student achievement in their schools. Principals are the instructional leaders of their schools, yet the research indicates that they are not knowledgeable regarding the role of the library media specialist. This study explored Virginia elementary school principals' perceptions of the instructional role of the library media specialist, the effect of library schedule on these perceptions, and the origin of these perceptions. Principals who responded to the study strongly endorsed the role of library media specialist as …

Children With Special Needs Oral Health Quality Of Life Survey, Kristin Elizabeth Nelson

Theses and Dissertations

Purpose: The purpose of this study was to asses the oral health quality of life of children with special health care needs. This study examined the effects of oral health conditions on general well-being and family life of these children. A secondary aim of the study was to investigate correlations between specific health care conditions, gender, and age of these children and their global ratings of oral health and well-being.Methods: This study was a cross-sectional design with subjects who are members of the Virginia Care Connection for Children program, based at Virginia Commonwealth University. The oral health quality of life …

Study Of Covalent And Non-Covalent Interactions In Ternary Systems Involving: Metal/Dna-Rna/Protein, Where Metal = Platinum(Ii), Palladium(Ii), Anzellotti I. Atilio

Theses and Dissertations

Ternary systems comprising DNA/RNA, proteins and one (or more) metal ion are generating increased interest due to its biological relevance. The knowledge gained from the study of these systems could provide important clues regarding the precise mechanism for transcription factors, repair proteins and metal complexes with anti-tumoral/anti-viral activities.The interactions occurring among the components of these ternary systems can be broadly grouped into covalent and non-covalent. The first kind of interactions can lead to the irreversible transformation of the components in the system, while the second is thought to be reversible leading to transient states and fluxionality. Both kinds of interaction …

Within And Without, Shane Robert Rocheleau

Theses and Dissertations

Within and Without is a document which illustrates my personal and artistic research into the nature of the postmodern conception of the self: that self is unfixed, multiple, and reactive. It explicates my myriad and explorative approaches to photographic portraiture. Furthermore, it indicates many of my theoretical and artistic references and how I have applied my lessons both as an artist and a researcher to maximize the effect of my concepts within the formal and aesthetic confines of my photographs. Finally, this document explains my own beliefs concerning the nature of self and how a synthesis of my influences has …

Phase Ii Trials Powered To Detect Activity In Tumor Subsets With Retrospective (Or Prospective) Use Of Predictive Markers, Grishma S. Sheth

Theses and Dissertations

Classical phase II trial designs assume a patient population with a homogeneous tumor type and yield an estimate of a stochastic probability of tumor response. Clinically, however, oncology is moving towards identifying patients who are likely to respond to therapy using tumor subtyping based upon predictive markers. Such designs are called targeted designs (Simon, 2004). For a given phase I1 trial predictive markers may be defined prospectively (on the basis of previous results) or identified retrospectively on the basis of analysis of responding and non-responding tumors. For the prospective case we propose two Phase I1 targeted designs in which a) …

Intrapersonal Grief As A Clinical Entity Distinct From Depression: Does It Exist Among A Medically Ill Parkinson's Disease Population?, Rashelle Brown Hayes

Theses and Dissertations

There has been growing support for the idea that complicated grief symptoms following bereavement are independent of symptoms of depression and anxiety. However, the loss of a loved one is not the only or the most frequent type of loss to be encountered. The onset of an insidious medical illness may trigger a mourning process for the lost function or body part that is posited to also involve feelings of grief. While the risk of depression is high among a medical or rehabilitative population, the impact of grief over functional losses has never been empirically investigated as a contributing factor …

Mechanisms Of Accumulation And Biological Consequences Of Polynuclear Platinum Compounds, Peyman Kabolizadeh

Theses and Dissertations

The novel trinuclear complex, BBR3464 has undergone Phase II clinical trials and been shown to have greater cytotoxicity and cellular uptake than clinical anticancer platinum drugs such as cisplatin, oxaliplatin and carboplatin. The clinical efficacy of cisplatin, oxaliplatin and carboplatin is limited due to acquired resistance and dose limiting side effects. The three major pharmacological factors contributing to the intrinsic cytotoxicity of, and cellular resistance to, platinum drugs are (i) cellular uptake and efflux of platinum; (ii) the frequency and nature of Pt-DNA adducts; and (iii) deactivating metabolic reactions with sulfur-containing nucleophiles. Since decreased cellular uptake of platinum drugs is …

A Fugitive Sea, Marian Brunn Smith

Theses and Dissertations

I make images that are fragmented like ominous dreams. Described with sensuous marks of paint, they demand intimacy but reveal vulnerability as they threaten to break apart before the eyes. This thesis examines my journey over the past two years at VCU and describes my artistic beliefs and visions.

Raman Scattering In Gan And Zno, Shinobu Nagata

Theses and Dissertations

The Micro-Raman scattering technique has been used for the study of GaN and ZnO. Capabilities of the Raman technique and existing literature on Raman spectroscopy in GaN and ZnO are reviewed. About 50 GaN and ZnO samples with a wide range of properties are studied. From the analysis of positions of the E2H and A1(LO) phonon modes, biaxial stress and plasmon coupling of the Al(LO) mode are observed and compared to a bulk GaN sample. The stress-related shift rate for the AI(LO) mode in hexagonal GaN is established to be 2.7 ± 0.4 cm-1/GPa through series of GaN with low …

Merging Task-Centered Social Work And Motivational Interviewing In Outpatient Medication Assisted Substance Abuse Treatment: Model Development For Social Work Practice, Andreas Fassler

Theses and Dissertations

To advance social work practice and decrease the research practice gap, this dissertation followed a model development paradigm consisting of several phases. Based on the task-centered model of social work practice and motivational interviewing, a new combined model was construed. The two underlying models were analyzed and synthesized, using technical eclecticism as the integrative approach. The resulting combined model was described by guidelines and manualized. To test the combined model in an applied setting, a study was designed in collaboration with social workers at a substance abuse counseling center. There, the combined model intervention was implemented in an outpatient medication …

The Buried Bodies Case: Alive And Well After Thirty Years, Lisa G. Lerman, Frank H. Armani, Thomas D. Morgan, Monroe H. Freedman

Scholarly Articles

No abstract provided.

Impacts Of Acid Mine Drainage On Carbon Cycling In Receiving Streams, Ernest W. Fonyuy

Doctoral Dissertations

"Field and laboratory investigations of acid mine drainage (AMD) contaminated and uncontaminated waters were conducted in order to determine and model processes and reaction mechanisms that control dissolved inorganic carbon (DIC) transformation and shifts in isotope ratio of DIC (Δ¹³C_DIC). The results show that AMD caused variable pH changes, overall decreases in Fe²⁺, alkalinity, and DIC, and increases in (Δ¹³C_DIC) in receiving streams. AMD caused more than 50 to > 98% seasonal DIC loss in stream water through CO₂ degassing. High DIC losses corresponded to high Fe²⁺ and lower or no HCO₃⁻ in the water samples, because …

An Analysis Of Coaching Efficacy In Volunteer Soccer Coaches, Christopher Lee Kowalski

Dissertations and Theses @ UNI

This purpose of this study was to analyze the relationship between five independent variables and volunteer soccer coaches' overall coaching efficacy as measured by motivation efficacy, character building efficacy, game strategy efficacy, and technique efficacy and five independent variables. The five independent variables explored included the age of a coach, a coach's gender, previous years of coaching experience, participation in a coaching training/licensing/certification program, and previous playing experience.

The study involved 69 participants who coached for the Cedar Valley Youth Soccer Association (CVYSA). The first part of the instrument used to measure coaching efficacy was a questionnaire discussing the various …

The Role Of Spirituality In Women's Leadership At Community Colleges, Carol L. Hedberg

Dissertations and Theses @ UNI

This qualitative research study examined the role of women's leadership in Iowa community colleges. Administrative leaders from community college settings, recommended by their presidents, wrote narratives about effective leadership traits and from these narratives, four women leaders were selected and later interviewed. Key thematic categories were developed from the written and verbal narratives. The resulting data set was then analyzed by a comparative case study approach. Emerging thematic categories were interpreted through the lens of four primary research questions addressing the relationship between gender, spirituality, and authentic leadership.

A plethora of issues surfaced from the data. Issues of gender and …

Approaches To Studying And Study Tactics Of Baccalaureate Nursing Students, Lisa D. Brodersen

Dissertations and Theses @ UNI

This research was designed to describe study approaches and study tactics used by baccalaureate nursing students. Previous inquiry indicates that students will take a Deep, Strategic, or Surface approach to studying and will use specific study tactics to meet the demands of their learning contexts.

The Approaches to Study Skills Inventory for Students (ASSIST) was administered to 174 students in Anatomy and Physiology, Pathophysiology, and Nursing Care of the Adult Client. Failing students were less likely to participate. The ASSIST bad acceptable internal consistency reliability and construct validity. A majority (55%) of students took a Strategic approach to studying; smaller …

Estimating The Economic Impact Of Tourism: A Comparative Analysis Of Albania, Croatia, The Former Yugoslav Republic Of Macedonia And Greece, Arjana Çela

Dissertations and Theses @ UNI

This study assessed the economic impact of tourism on investment, government and imports expenditures in Albania, Croatia, the Former Yugoslav Republic (FYR) of Macedonia, and Greece. The objectives of this study were to develop a model to determine the impacts generated from an incremental change in tourist expenditures in the economy of Albania, Croatia, FYR of Macedonia, and Greece; to estimate the multipliers of the tourism expenditures on investment, government and imports expenditures in Albania, Croatia, FYR of Macedonia, and Greece and to investigate the differences and similarities of the economic impact of tourism between Albania, Croatia, FYR of Macedonia, …