Digital Commons Network^™

Biomarker Discovery Using Targeted Maximum Likelihood Estimation: Application To The Treatment Of Antiretroviral Resistant Hiv Infection, Oliver Bembom, Maya L. Petersen , Soo-Yon Rhee , W. Jeffrey Fessel , Sandra E. Sinisi, Robert W. Shafer, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Researchers in clinical science and bioinformatics frequently aim to learn which of a set of candidate biomarkers is important in determining a given outcome, and to rank the contributions of the candidates accordingly. This article introduces a new approach to research questions of this type, based on targeted maximum likelihood estimation of variable importance measures.

The methodology is illustrated using an example drawn from the treatment of HIV infection. Specifically, given a list of candidate mutations in the protease enzyme of HIV, we aim to discover mutations that reduce clinical virologic response to antiretroviral regimens containing the protease inhibitor lopinavir. …

Synthesis And Structural Characterization Of Two Five Coordinate Aluminum Alkyl And Bis(Trimethylsilyl)Amino Complexes Bearing Acyclic Tetradentate Schiff Bases, C. R. Wade, B. J. Lamprecht, V. W. Day, John A. Belot

Department of Chemistry: Faculty Publications

Two acyclic Schiff-base ligands, bis-5,5′-(1,3-propanediyldiimino)-2,2-dimethyl-4-hexene-3-one and bis-5,5′-(1,3-ethanediyldiimino)- 2,2-dimethyl-4-hexene-3-one, were used to complex homoleptic triethylaluminum and tris[bis(trimethylsilyl)amino]alu minum, respectively. The acid–base reactions proceeded in excellent yields with elimination of ethane or bis(trimethylsilyl)amine during in situ deprotonation of the protio Schiff-base. The colorless aluminum complexes crystallized from n-pentane and were characterized by standard methods including single crystal X-ray diffraction. Polymerization of racemic lactide, with addition of alcohol, yielded PLA with narrow polydispersities but low molecular weights.

2007 Nebraska Guide To Hunting And Public Lands

Nebraska Game and Parks Commission: Publications

Contents:
Permit Requirements. . . . . . . . . . . . . 4
HIP Registration . . . . . . . . . . . . . . . . 6
Hunter Education. . . . . . . . . . . . . . . . 6
Hunter Orange. . . . . . . . . . . . . . . . . . 7
Grouse Hunting Zones, Permits . . . . 7
Nontoxic Shot Requirements. . . . . . . 7
Game Laws . . . . . . …

Interview With Melissa & Rod Volbeda, Willamette Valley Cheese, 2007 (Audio), Melissa Volbeda, Rod Volbeda

All Sustainability History Project Oral Histories

Interview of Melissa and Rod Volbeda by Magda Gaytan on August 6th, 2007.

Willamette Valley Cheese Company tour photos available for download.

An Adaptive Bayesian Approach To Bernoulli-Response Clinical Trials, Andrew W. Stacey

Theses and Dissertations

Traditional clinical trials have been inefficient in their methods of dose finding and dose allocation. In this paper a four-parameter logistic equation is used to model the outcome of Bernoulli-response clinical trials. A Bayesian adaptive design is used to fit the logistic equation to the dose-response curve of Phase II and Phase III clinical trials. Because of inherent restrictions in the logistic model, symmetric candidate densities cannot be used, thereby creating asymmetric jumping rules inside the Markov chain Monte Carlo algorithm. An order restricted Metropolis-Hastings algorithm is implemented to account for these limitations. Modeling clinical trials in a Bayesian framework …

Realizing Live Sequence Charts In System Verilog, Hai H. Wang, Shengchao Qin, Jun Sun, Jin Song Dong

Research Collection School Of Computing and Information Systems

The design of an embedded control system starts with an investigation of properties and behaviors of the process evolving within its environment, and an analysis of the requirement for its safety performance. In early stages, system requirements are often specied as scenarios of behavior using sequence charts for different use cases. This specication must be precise, intuitive and expressive enough to capture different aspects of embedded control systems. As a rather rich and useful extension to the classical message sequence charts, Live Sequence Charts (LSC), which provide a rich collection of constructs for specifying both possible and mandatory behaviors, are …

Gis Assessment Of Environmental Impacts On Urban Forests, Richard Snow, Mary Snow

Publications

No abstract provided.

Summer 2007 Commencement - The University Of Texas Of The Permian Basin, The University Of Texas Permian Basin

UTPB Commencement Programs

Summer 2007 Commencement - August 3, 2007

We Are…Marshall, August 3, 2007, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Critical Thinking Traits Of Top-Tier Experts And Implications For Computer Science Education, Dean Bushey

All Dissertations

A documented shortage of technical leadership and top-tier performers in
computer science jeopardizes the technological edge, security, and economic well-being of the nation. The 2005 President's Information and Technology Advisory Committee (PITAC) Report on competitiveness in computational sciences highlights the major impact of science, technology, and innovation in keeping America competitive in the global marketplace. It stresses the fact that the supply of science, technology, and engineering experts is at the core
of America's technological edge, national competitiveness and security. However, recent data shows that both undergraduate and postgraduate production of computer scientists is falling.

Past research on expert performance …

Estimates Related To The Arithmetic Of Elliptic Curves, Bryan Faulkner

All Dissertations

This dissertation presents results related to two problems in the arithmetic of elliptic curves.
Feng and Xiong equate the nontriviality of the Selmer groups associated with congruent number curves to the presence of certain types of partitions of graphs associated with the prime factorization of n. The triviality of the Selmer groups associated to the congruent number curve implies that the curve has rank zero which in turn implies n is noncongruent. We extend the ideas of Feng and Xiong in order to compute the Selmer groups of congruent number curves.
We prove an average version of a generalization of …

Control Of Nonlinear Mechatronic Systems, Enver Tatlicioglu

All Dissertations

This dissertation is divided into four self-contained chapters. In Chapter 1, an adaptive nonlinear tracking controller for kinematically redundant robot manipulators is presented. Past research efforts have focused on the end-effector tracking control of redundant robots because of their increased dexterity over their non-redundant counterparts. This work utilizes an adaptive full-state feedback quaternion based controller developed in [1] and focuses on the design of a general sub-task controller. This sub-task controller does not affect the position and orientation tracking control objectives, but instead projects a preference on the configuration of the manipulator based on sub-task objectives such as the following: …

Post-Production Separation And Functionalization Of Single-Walled Carbon Nanotubes, Kurukulasuriya Fernando

All Dissertations

ABSTRACT
Single-walled carbon nanotubes (SWNTs) are considered to have many potential applications due to their unique structural, physical, chemical and electronic properties. Because the rigid structure of carbon nanotube determines its toughness in dissolution, the processing capability of carbon nanotube is strongly limited. My carbon nanotube functionalization research was mainly focused on developing innovative methods to functionalize nanotubes with various polymers and large aromatic molecules to make them soluble to study their interesting properties and applications. In this dissertation, different methods for the functionalization and solubilization of carbon nanotubes are described. The co-existence of metallic and semiconducting carbon nanotubes has …

Supernova Injection Of Short-Lived Radionuclides Into The Presolar Cloud: A Feasibility Study, Keith Davis

All Dissertations

Meteorite inclusions show that the early solar system was radioactive with species of short lifetimes compared to the formation time of the solar system. Transporting the radioactive material from the creation site to the formation site of the sun was expected to take enough time that these species should have decayed to nonexistence. Some special series of events seems necessary to speed the process along. Cameron & Truran (1977) suggested that the source of these short-lived radionuclides could have been a supernova. Numerical hydrodynamic studies have shown that slow shockwaves can inject material into a small, dense cloud core. Most …

Upper Limits On Gravitational Wave Emission From 78 Radio Pulsars, B. Abbott, R. Abbott, R. Adhikari, J. Agresti, P. Ajith, B. Allen, R. Amin, S. B. Anderson, W. G. Anderson, M. Arain, M. Araya, H. Armandula, M. Ashley, S. Aston, P. Aufmuth, C. Aulbert, S. Babak, S. Ballmer, H. Bantilan, B. C. Barish, C. Barker, D. Barker, B. Barr, P. Barriga, M. A. Barton, K. Bayer, K. Belczynski, J. Betzwieser, P. T. Beyersdorf, B. Bhawal, I. A. Bilenko, Tiffany Z. Summerscales

Faculty Publications

We present upper limits on the gravitational wave emission from 78 radio pulsars based on data from the third and fourth science runs of the LIGO and GEO 600 gravitational wave detectors. The data from both runs have been combined coherently to maximize sensitivity. For the first time, pulsars within binary (or multiple) systems have been included in the search by taking into account the signal modulation due to their orbits. Our upper limits are therefore the first measured for 56 of these pulsars. For the remaining 22, our results improve on previous upper limits by up to a factor …

Analysis Of The China Factor Effect On The International Dry Bulk Shipping Market, Xiaoxiao Bi

World Maritime University Dissertations

No abstract provided.

Research On The Status Quo And Operational Modes Of Chinese Petrochemical Logistics, Jiajie Hou

World Maritime University Dissertations

No abstract provided.

Research On Competitiveness Of Dalian Port, Zhaobo Xu

World Maritime University Dissertations

No abstract provided.

Study On Xy Group Developing 3pl In The Xiamen Xiangyu Bonded Logistics Park, Wei Zeng

World Maritime University Dissertations

No abstract provided.

Summer Commencement: August 3, 2007, University Of North Dakota

UND Commencement Programs

UND Summer Commencement program from August 3, 2007.

Research On Third Party Chemical Logistics In Shanghai, Yiqing Chen

World Maritime University Dissertations

No abstract provided.

Study On Modern Port Logistics (Mpl) And Forecasting Container Throughput Of Shanghai Port, Jingye Li

World Maritime University Dissertations

No abstract provided.

Study On Grade Evaluation Of Port Shoreline In Jiangsu Province, Wei Li

World Maritime University Dissertations

No abstract provided.

Countermeasures For The Chemicals Transportation Of The Zhangjiagang Port, Qiangqiang Miao

World Maritime University Dissertations

No abstract provided.

The Study On The Vessel Size Of Container Transport In The Yangtze River, Chenchen Peng

World Maritime University Dissertations

No abstract provided.

Research And Analysis On The Competence Of China’S Chemical Shipping Enterprise, Huan Yu

World Maritime University Dissertations

No abstract provided.

Direct Observation Of The Strange B Baryon ΞB-, V. M. Abazov, Kenneth A. Bloom, Gregory R. Snow, D0 Collaboration

Kenneth Bloom Publications

We report the first direct observation of the strange b baryon Ξ_b^-( Ξ_b⁺). We reconstruct the decay Ξ_b^- → J/ψΞ^-, withJ/ψ → μ⁺ μ^-, and Ξ^- → Λ π ^- → p π^-+ π^+- in pp̅ collisions at √s = 1.96 TeV. Using 1.3 fb^-1 of data collected by the D0 detector, we observe 15.2 ± 4.4(stat) _-0.4^+1.9(syst) Ξ_b^- candidates at a mass of 5.774 ± 0.:011(stat) ± 0.015(syst) GeV. The significance of the observed signal …

Mixed Quantum-Classical Molecular Dynamics Study Of A Hydrated Electron And An Investigation Of Temperature Control Algorithms, Janet Aremu-Cole

All Dissertations

The use of classical and quantum mechanics has been employed in this dissertation to study temperature control algorithms and a hydrated electron. A comparison of the effects of four commonly used temperature control algorithms on the energetics and dynamics of liquid water has been executed, in efforts to better understand the non-equipartitioning effects caused by some thermostats. The Berendsen, Andersen, Langevin, and velocity rescaling temperature control algorithms were applied to both dimer and bulk water systems, using the TIP4P water model. The two deterministic thermostats, Berendsen and velocity rescaling, display the 'flying ice cube effect' that had been noticed earlier …

Elementary School Teachers' Understanding Of Essential Topics In Statistics And The Influence Of Assessment Instruments And A Reform Curriculum Upon Their Understanding, Timothy Jacobbe

All Dissertations

With the increased emphasis on statistics at the elementary school level as recommended by the GAISE document, it is important to consider the current status of teachers' understanding of statistics. This study explored teachers' understanding as they implemented new curricula materials which have ten lessons focused on statistical topics at each grade level. These curricula materials provided a medium for discussion that helped reveal whether or not elementary school teachers possess an adequate understanding of essential topics in statistics to implement the standards they are now called upon to teach.
The results of this study indicate that elementary school teachers …

Mesosphere And Lower Thermosphere Neutral Winds Observations Using Rocket-Released Chemical Trails At Poker Flat, Alaska, Tianyu Zhan

All Dissertations

Sounding rocket campaigns ARIA I through ARIA IV, CODA 2, HEX 1, JOULE 1 and JOULE 2 all carried out at Poker Flat Research Range at Alaska, covering the geomagnetic condition from quiet to highly disturbed. Trimethyl aluminum (TMA) were released during the rocket flights to study the mesosphere and lower thermosphere neutral wind at high-latitude region. The results of horizontal neutral wind profiles are presented. The comparison shows that under disturbed condition the wind velocity is stronger and the jet feature at the bottom side of wind maximum with unstable wind shear is lifted to a higher altitude. Under …