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Training And Implementation Guide For Pathway Definition, Risk Analysis And Risk Prioritization

National Invasive Species Council

The purpose of pathway risk analysis is to provide scientific analyses and policy recommendations in support of U.S. National Invasive Species Council’s Management Plan. These analyses and recommendations must comply with the Plan’s mandates to:

• ensure Federal efforts are coordinated and effective

• promote action and partnership at local, State, tribal and ecosystem levels

• identify recommendations for international cooperation; and,

• facilitate networks to document, monitor and prioritize invasive species pathways

Though many definitions for invasive species and pathways may exist, we are defining these terms as they relate to Federal regulatory functions. Definitions are recounted, below:

Invasive …

Risk Factors Associated With The Prevalence Of Tuberculosis-Like Lesions In Fenced Wild Boar And Red Deer In South Central Spain, Joaquin Vicente, Ursula Hofle, Joseba M. Garrido, Isabel G. Fernandez-De-Mera, Pelayo Acevedo, Ramon Juste, Marta Barral, Christian Gortazar

Michigan Bovine Tuberculosis Bibliography and Database

In recent decades the management of large game mammals has become increasingly intensive in south central Spain (SCS), resulting in complex epidemiological scenarios for disease maintenance, and has probably impeded schemes to eradicate tuberculosis (TB) in domestic livestock. We conducted an analysis of risk factors which investigated associations between the pattern of tuberculosis-like lesions (TBL) in wild boar (Sus scrofa) and red deer (Cervus elaphus) across 19 hunting estates from SCS and an extensive set of variables related to game management, land use and habitat structure. The aggregation of wild boar at artificial watering sites was …

Effects Of A Hurricane On Fish Parasites, Robin M. Overstreet

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Hurricanes, also called tropical cyclones, can dramatically affect life along their paths, including a temporary losing or reducing in number of parasites of fishes. Hurricane Katrina in the northern Gulf of Mexico in August 2005 provides many examples involving humans and both terrestrial and aquatic animals and plants. Fishes do not provide much of an indicator of hurricane activity because most species quickly repopulate the area. Fish parasites, however, serve as a good indicator of the overall biodiversity and environmental health. The reasons for the noted absence or reduction of parasites in fishes are many, and specific parasites provide indications …

Space–Time Zero-Inflated Count Models Of Harbor Seals, Jay M. Ver Hoef, John K. Jansen

United States Department of Commerce: Staff Publications

Environmental data are spatial, temporal, and often come with many zeros. In this paper, we included space–time random effects in zero-inflated Poisson (ZIP) and ‘hurdle’ models to investigate haulout patterns of harbor seals on glacial ice. The data consisted of counts, for 18 dates on a lattice grid of samples, of harbor seals hauled out on glacial ice in Disenchantment Bay, near Yakutat, Alaska. A hurdle model is similar to a ZIP model except it does not mix zeros from the binary and count processes. Both models can be used for zero-inflated data, and we compared space–time ZIP and hurdle …

Neglect Of Plasmodium Vivax Malaria, J. Kevin Baird

United States Navy: Publications

Plasmodium vivax infects 130–435 million of the 2.6 billion people living at risk of infection. Recent studies suggest that vivax malaria can become lethal in a similar way to severe falciparum malaria. First-line therapies remain unchanged after 50 years. Despite evidence of failing chloroquine efficacy, little work has assessed the problem or explored alternative therapies. Primaquine treatment, the only therapeutic option against relapse, might also be failing. No licensed primary chemoprophylactic agent protects travelers from relapse. Misdiagnosis of species now affects clinical decisions resulting in inadequate therapy for P. falciparum and P. vivax. All of these factors demonstrate the …

Genetically Attenuated Plasmodium Berghei Liver Stages Induce Sterile Protracted Protection That Is Mediated By Major Histocompatibility Complex Class I–Dependent Interferon-Y–Producing Cd8+ T Cells, Ousman Jobe, Joanne Lumsden, Ann-Kristin Mueller, Jackie Williams, Hilda Silva-Rivera, Stefan H. I. Kappe, Robert J. Schwenk, Kai Matuschewski, Urszula Krzych

United States Army: Publications

At present, radiation-attenuated plasmodia sporozoites (y-spz) is the only vaccine that induces sterile and lasting protection in malaria-naive humans and laboratory rodents. However, g-spz are not without risks. For example, the heterogeneity of the y-spz could explain occasional breakthrough infections. To avoid this possibility, we constructed a double-knockout P. berghei parasite by removing 2 genes, UIS3 and UIS4, that are up-regulated in infective spz.We evaluated the double-knockout Pbuis3(-)/4(-) parasites for protective efficacy and the contribution of CD8+ T cells to protection. Pbuis3(-)/4(-) spz induced sterile and protracted protection in C57BL/6 mice. Protection was linked to CD8+ …

Factors Influencing Movement Probabilities Of Big Brown Bats (Eptesicus Fuscus) In Buildings, Laura E. Ellison, Thomas J. O’Shea, Daniel J. Neubaum, Richard Bowen

United States Geological Survey: Staff Publications

We investigated movements of female big brown bats (Eptesicus fuscus) roosting in maternity colonies in buildings in Fort Collins, Colorado (USA), during the summers of 2002, 2003, and 2005. This behavior can be of public health concern where bats that may carry diseases (e.g., rabies) move among buildings occupied by people. We used passive integrated transponders (PIT tags) to mark individual bats and hoop PIT readers at emergence points to passively monitor the use of building roosts by marked adult females on a daily basis during the lactation phase of reproduction. Multi-strata models were used to examine movements …

Anti-Infective Agents From The Terrestrial Plants Zanthoxylum Monophyllum (Lam.) P. Wilson And Sorocea Muriculata Miq. Against Pathogenic Fungi, Methicillin-Resistant Staphylococcus Aureus And Plasmodium Falciparum, Raquel Rodr├¡Guez Guzm├Ín

Electronic Theses and Dissertations

No abstract provided.

Positioning For Acceptance: How Women With Hiv Infection Manage Their Relationships, Mary Kozy

Electronic Theses and Dissertations

Even though the number of women with Human Immunodeficiency Virus (HIV) grows annually, medical treatment has rendered this illness a chronic but manageable disease. Nurses must expand their knowledge beyond issues of survival and end of life care and focus on ways to maintain health and well being in this population. The works of Miller (1986) and Gilligan (1993) underscore the significance of relationships in the emotional well being of women. Issues of stigma, sexual transmission and ill health render HIV infection a threat to social relationships. Published literature exists that explores aspects of relationship such as social support, motherhood …

The Politics Of Medical Syncretism In The Ghanaian National Healthcare System, Mark Morrison

Electronic Theses and Dissertations

Efforts to create public policy integrating traditional/indigenous medical practices and practitioners into national healthcare strategies are currently being pursued in a variety of nations in the Africa region. The purpose of this research is to present a historical case study of the social and political factors associated with the passage of the Traditional Medicine Practice Act of 2000 in the West African nation of Ghana. Research methodology included conducting a thorough examination of available archival and secondary data as well as an abbreviated interview series (N=5). Research findings suggest that significant factors associated with Ghanaian medical revivalism were the role …

When Is It Permissable To Dismiss A Family Who Refuses Vaccinces? Legal, Ethical And Public Health Perspectives, Beth Halperin, Ryan Melnychuk, Jocelyn Downie, Noni Macdonald

Articles, Book Chapters, & Popular Press

Although immunization is one of the most important health inter- ventions of the 20th century, cases of infectious disease continue to occur. There are parents who refuse immunization for their children, creating a dilemma for the primary care physician who must consider the best interest of the individual child as well as that of the commu- nity. Some physicians, when faced with parents who refuse immuniza- tion on behalf of their children, choose to dismiss these families from their practice. Given the existing shortage of primary care physicians across Canada, this decision to dismiss families based on vaccine refusal has …

Out Of "Dark Backrooms And Sheds", Marguerite Maher M.Ed

Electronic Journal for Inclusive Education

Commitment to a single, inclusive education system has been the aspiration of reform in education in a democratic South Africa as articulated in White Paper 6: Special needs education: Building an inclusive education and training system (Department of Education, 2001, referred to hereafter as White Paper 6). Within a ‘barriers to learning’ approach to inclusive education, progress is being made with improved facilities and the implementation of AIDS awareness programmes. Managing the transition towards an inclusive education system has proved challenging in some areas, however, and the specific provision in policy documents directed towards children with disabilities is behind schedule. …

Social Contagion Of Violence, Jeffrey A. Fagan, Deanna L. Wilkinson, Garth Davies

Faculty Scholarship

In this chapter, we assess whether the roller-coaster pattern of homicides in New York City beginning in 1985 fits a contagion model and identify mechanisms of social contagion that predict its spread across social and physical space. This framework for interpreting the homicide trends as an epidemic includes two perspectives. First, the sharp rise and fall are indicative of a nonlinear pattern in which the phenomenon spreads at a rate far beyond what would be predicted by exposure to some external factor and declines in a similar pattern in which the reduction from year to year exceeds what might be …

Design, Synthesis, And Evaluation Of 10-N-Substituted Acridones As Novel Chemosensitizers In Plasmodium Falciparum, Jane X. Kelly, Martin J. Smilkstein, Roland A. Cooper, Kristin D. Lane, Robert A. Johnson, Aaron Janowsky, Rozalia A. Dodean, David J. Hinrichs, Rolf Winter, Michael Riscoe

Biological Sciences Faculty Publications

A series of novel 10-N-substituted acridones, bearing alkyl side chains with tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for the ability to enhance the potency of quinoline drugs against multidrug-resistant (MDR) Plasmodium falciparum malaria parasites. A number of acridone derivatives, with side chains bridged three or more carbon atoms apart between the ring nitrogen and terminal nitrogen, demonstrated chloroquine (CQ)-chemosensitizing activity against the MDR strain of P. falciparum (Dd2). Isobolograrn analysis revealed that selected candidates demonstrated significant synergy with CQ in the CQ-resistant (CQR) parasite Dd2 but only additive (or indifferent) interaction in the CQ-sensitive …

Outlook Magazine, Winter 2007

Outlook Magazine

No abstract provided.

Outlook Magazine, Summer 2007

Outlook Magazine

No abstract provided.

Sovereignty And Humanity: Reality And Possibility, Hans Corell

Denver Journal of International Law & Policy

No abstract provided.

Outlook Magazine, Fall 2007

Outlook Magazine

No abstract provided.

Globalization: Health Challenges For Multinational Corporations, Yann Meunier

Journal of International Business and Law

No abstract provided.

Meningitis Revealing Pancreatic Carcinoma, Mounir T. Grira, Haifa M. Ben Jemaa, Turkia M. Lammouchi, Sofien A. Benammou

Neurosciences

Meningeal carcinomatosis is an uncommon metastatic complication of systemic solid tumors. The diagnosis is based on the presence of malignant cells in the cerebrospinal fluid. The sensibility of cerebrospinal fluid testing in detecting the neoplastic cells improves when repeating lumbar punctures. Magnetic resonance imaging could help in establishing the diagnosis. The prognosis of carcinomatous meningitis is poor, especially when the primitive neoplasm is initially unknown. We report the case of a patient presenting with sudden bilateral visual decrease, headaches, and vomiting. Signs of meningeal irritation were found. Cerebrospinal fluid analysis showed malignant cells consistent with an adenocarcinoma. Abdominal echography and …

Lessons Learned From The 1918-1919 Influenza Pandemic In Minneapolis And St. Paul, Minnesota, Miles Q. Ott, Shelly F. Shaw, Richard N. Danila, Ruth Lynfield

Statistical and Data Sciences: Faculty Publications

No abstract provided.

Hypoxic Induction And The Role Of Hifs In The Activation Of Luciferase Constitutive Reporters In Placental Stem Cells, Diane Michelle Doran

Browse all Theses and Dissertations

Hypoxia is critically important to the development of the embryo and placenta. Proper placental development is critical for normal fetal growth and embryonic survival. Abnormal placental development has been implicated in numerous obstetric complications, including preeclampsia, which affects about 7% of all pregnancies and can be fatal for both mother and baby. Rodent and murine trophoblast stem cells differentiate into three distinct cell lineages: giant cells, spongiotrophoblasts, and labyrinthine cells, which form different layers and have different functions within the placenta. Recent studies in our laboratory have focused on the invasive giant cell layer using the rodent Rcho-1 choriocarcinoma stem …

On A Multinational Assessment Of Rotavirus Disease In Europe, David O. Matson

Community & Environmental Health Faculty Publications

Rotaviruses were discovered in the 1960s in animals and in the 1970s in humans; the latter discovery was made by an intrepid group who performed duodenal biopsies on children with acute gastroenteritis (AGE) [1]. By the late 1970s, data already clearly indicated that rotavirus was the cause of the annual winter peak of AGE affecting young children, as well as a frequent cause of severe gastroenteritis in various animal species (e.g., [2–5]). Use of the retrospectroscope clarified or left as tantalizing the suggestion that rotaviruses were the cause of the annual “winter vomiting syndrome” first described in children in 1910 …

Project Echo: Linking University Specialists With Rural And Prison-Based Clinicians To Improve Care For People With Chronic Hepatitis C In New Mexico, Sanjeev Arora, Karla Thornton, Steven M. Jenkusky, Brooke Parish, Joseph V. Scaletti

Project ECHO Bibliography

Project Extension for Community Healthcare Outcomes (Project ECHO) is a telemedicine and distance-learning program designed to improve access to quality health care for New Mexicans with hepatitis C. Project ECHO links health-care providers from rural clinics, the Indian Health Service, and prisons with specialists at the University of New Mexico. At weekly clinics, partners present and discuss patients with hepatitis C with specialists. Partners can receive continuing education credits for participating. Since June 2003, 173 hepatitis C clinics have been conducted with 1,843 case presentations. Partners have received 390 hours of training and 2,997 hours of continuing education credits. And …

Mutations In Transmembrane Domains 1, 4 And 9 Of The Plasmodium Falciparum Chloroquine Resistance Transporter Alter Susceptibility To Chloroquine, Quinine And Quinidine, Roland A. Cooper, Kristan D. Lane, Bingbing Deng, Jianbing Mu, Jigar J. Patel, Thomas E. Wellems, Xinzhuan Su, Michael T. Ferdig

Biological Sciences Faculty Publications

Mutations in the Plasmodium falciparum chloroquine (CQ) resistance transporter (PfCRT) can result in verapamil-reversible CQ resistance and altered susceptibility to other antimalarials. PfCRT contains 10 membrane-spanning domains and is found in the digestive vacuole (DV) membrane of intraerythrocytic parasites. The mechanism by which PfCRT mediates CQ resistance is unclear although it is associated with decreased accumulation of drug within the DV. On the permissive background of the P. falciparum 106/1(K76) parasite line, we used single-step drug selection to generate isogenic clones containing unique pfcrt point mutations that resulted in amino acid changes in PfCRT transmembrane domains 1 (C72R, K76N, K76I …

Tissue And Life Stage Distribution Of A Defensin-Like Gene In The Lone Star Tick Amblyomma Americanum, S. Michelle Todd, Daniel E. Sonenshine, Wayne L. Hynes

Biological Sciences Faculty Publications

The transcript sequence of the Amblyomma americanum Linnaeus (Acari: Ixodidae) defensin, termed amercin (amn), was ascertained and a 219-bp amn coding region identified. The gene encodes a 72-amino acid prepropeptide with a putative 37-amino acid mature peptide. This gene shows little similarity to either of the defensins from Amblyomma hebraeum Koch, the only other Amblyomma species for which a defensin has been described. Sequence comparisons with other tick defensins reveal amn to be shorter (6 bp or 2 amino acids) than the Ixodes scapularis Linnaeus (Acari: Ixodidae) and Dermacentor variabilis (Say) (Acari: Ixodidae) defensin sequences. The amercin prepropeptide …

Anticipating Pandemic Avian Influenza: Why The Federal And State Preparedness Plans Are For The Birds, Hillary R. Ahle

DePaul Journal of Health Care Law

No abstract provided.

Hiv-Positive Inmates Released From Nevada’S Prisons In 2001: Results From Matching Health Division And Corrections’ Databases, Paul G. Devereux, Kristen Clements-Nolle, Sharon Clodfelter, Jessey Bargmann-Losche, Miguel Feroro, Wei Yang

Nevada Journal of Public Health

It is estimated that about one quarter of all HIV-infected individuals in the United States are released from a correctional facility each year. To better understand the needs of inmates with HIV exiting the prison system, a partnership with the Nevada State Health Division (NSHD), the Nevada Department of Corrections (DOC), and the University of Nevada, Reno School of Public Health was formed to examine this population using information contained in existing databases. An analysis of DOC data matched with the data from the HIV/AIDS Reporting System (HARS) maintained by the NSHD identified 2,802 HIV-negative inmates (2,451 males and 350 …

Field Production And Functional Evaluation Of Chloroplast-Derived Interferon-Alpha 2b, Philip A. Arlen, Regina Falconer, Sri Cherukumili, Amy Cole, Alexander M. Cole, Karen K. Oishi, Henry Daniell

Faculty Bibliography 2000s

Type I interferons (IFNs) inhibit viral replication and cell growth and enhance the immune response, and therefore have many clinical applications. IFN-alpha 2b ranks third in world market use for a biopharmaceutical, behind only insulin and erythropoietin. The average annual cost of IFN-alpha 2b for the treatment of hepatitis C infection is $26 000, and is therefore unavailable to the majority of patients in developing countries. Therefore, we expressed IFN-alpha 2b in tobacco chloroplasts, and transgenic lines were grown in the field after obtaining United States Department of Agriculture Animal and Plant Health Inspection Service (USDA-APHIS) approval. Stable, site-specific integration …

Sharp Estimates On Minimum Travelling Wave Speed Of Reaction Diffusion Systems Modelling Autocatalysis, Xinfu Chen, Yuanwei Qi

Faculty Bibliography 2000s

This article studies propagating wave fronts in an isothermal chemical reaction A + 2B - > 3B involving two chemical species, a reactant A and an autocatalyst B, whose diffusion coefficients, D-A and D-B, are unequal due to different molecular weights and/or sizes. Explicit bounds v(*) and v* that depend on D-B/D-A are derived such that there is a unique travelling wave of every speed v > = v* and there does not exist any travelling wave of speed v < v*. New to the literature, it is shown that v(*) proportional to v* proportional to D-B/D-A when D-B = v(min). Estimates on v(min) significantly improve those of early works. The framework is built upon general isothermal autocatalytic chemical reactions A + nB - > (n + 1)B of arbitrary order n > = 1.