Digital Commons Network^™

Identification And Characterization Of A New Tubulin-Binding, Susan L. Mooberry, Kimberly N. Weiderhold, Sivanesan Dakshanamurthy, Ernest Hamel, Edith J. Banner, Anastasia Kharlamova, Jonathan Hempel, John T. Gupton, Milton L. Brown

Chemistry Faculty Publications

We studied the mechanism of action of 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester (JG-03-14) and found that it is a potent microtubule depolymerizer. JG-03-14 caused a dose-dependent loss of cellular microtubules, formation of aberrant mitotic spindles, accumulation of cells in the G₂/M phase of the cell cycle, and Bcl-2 phosphorylation. These events culminated in the initiation of apoptosis, as evidenced by the caspase 3-dependent cleavage of poly(ADP-ribose) polymerase (PARP). JG-03-14 has antiproliferative activity against a wide range of cancer cell lines, with an average IC₅₀ value of 62 nM, and it is a poor substrate for transport …

Introduction To The Symposium, Margaret A. Berger

Journal of Law and Policy

No abstract provided.

A Framework For Assessing Scientific Arguments: Gaps, Relevance And Integrated Evidence, Carl F. Cranor

Journal of Law and Policy

No abstract provided.

Regulating Crime Laboratories: The Impact Of Dna Evidence, Paul C. Giannelli

Journal of Law and Policy

No abstract provided.

Judgement For Judges: What Traditional Statistics Don't Tell You About Causal Claims, Steven N. Goodman

Journal of Law and Policy

No abstract provided.

Determining Disease Causality From Experimental Toxicology Studies, Ronald L. Melnick, John R. Bucher

Journal of Law and Policy

No abstract provided.

The Nature And Necessity Of Scientific Judgement, Douglas L. Weed

Journal of Law and Policy

No abstract provided.

Protectionism, Punishment And Pariahs: Sex Offenders And Residence Restrictions, Meghan S. Towers

Journal of Law and Policy

No abstract provided.

Beyond The Bench: Solutions To Reduce The Disproportionate Number Of Minority Youth In The Family And Criminal Court Systems, Jessica Jean Kastner

Journal of Law and Policy

No abstract provided.

The Relationship Between Parental Divorce And First-Year College Student Adjustment, Jennifer A. Copes

Masters Theses

This study was conducted to investigate the potential relationship between incoming freshmen parental marital status and students' first-year adjustment to college. The PI saw a need for this study because of the lack of previous research directly connecting the two above variables. Numerous researchers have investigated the negative effects of parental divorce; the importance of one's parents during the transition to college has also been well documented. For the purpose of this study, the PI sought to examine a potential link between the two, assuming children of divorce would experience more difficulties adjusting to college life than children from intact …

Investigating Biodiversity: An Economic Analysis Of Global Endangered Species Loss, Kyle Baumgartner

Masters Theses

There has been a rapid increase in interest among economists to examine the economic causes of biodiversity loss. The goal of this thesis is to investigate biodiversity loss using percentage of endangered species across countries for a three year period of time. This is accomplished by developing a series of models to examine the impact of various economic factors on biodiversity loss, in this case using percentage of threatened species as a proxy.

The results indicate that the development of economic growth can impact endangered species loss. The results also demonstrate that there is a relationship between percentage of endangered …

Habitat Use And Overwintering Ecology Of The Northern Watersnake (Nerodia Sipedon) On An Artificial Levee In Central Illinois, Melanie J. Olds

Masters Theses

Several reptile species have populations that are in decline, and anthropogenic habitat loss and alteration are arguably the factors having the greatest impact on these species. More attention has been paid to understanding the activity season habitat needs in snakes than on the habitat requirements for overwintering. I examined the patterns of both activity season and overwintering habitat use by a population of northern watersnakes (Nerodia sipedon) that inhabit an artificial levee in central Illinois. My research objectives were to determine how a population of northern watersnakes uses an artificial levee during the activity season and to determine what type …

The Effects Of An Education Program On Women's Knowledge And Behavior During Menopause, Diana L. Stenger

Masters Theses

The purpose of this study was to determine if women's knowledge of perimenopause, menopause, and related health issues increased after participation in an educational workshop. The first objective was to determine if there was an increase in particip cipants' knowledge of physiological and psychological changes often experienced during perimenopause, menopause, and related health issues. Two further objectives were to determine if women reported learned treatment options and made any behavioral health changes to manage perimenopause, menopause, and related health issues, from attending the educational workshop, during a 3-month follow-up telephone survey. A quasiexperimental pre-test and post-test design involved a purposive …

The Influence Of Internet Pornography On Heterosexual Male University Students' Attitudes Toward Sexuality, Misty Baker

Masters Theses

The purpose of conducting this study was to explore heterosesexual male, Midwestern university students' attitudes regarding internet pornography. This study explored the use of internet pornography, with a specific focus on: a) the age of first exposure to internet pornography; b) the usage characteristics of internet pornography among heterosexual male university students; c) the sexual attitudes and beliefs toward women among heterosexual male university students;and d)the sexual activity history of heterosexual male university students. A 29-item questionnaire was designed by the researcher to explore exposure to internet pornography, sexual behavior, sexual attitudes, and attitudes toward forced sex. Fifty-five participants completed …

An Examination Of The Relationship Between Parental Religiosity And Parent-Adolescent Conflict, Courtney Crane

Masters Theses

While religiosity's influence on family life has been widely examined in studies, little attention has been paid to religiosity's relationships to communication and conflict patterns within the family. The current study examined the relationship between parental religiosity and parent-adolescent conflict. A quantitative, bivariate exploratory survey design was utilized to examine parental religiosity's relationship with parent-adolescent conflict; 28 parents from three religious organizations participated in the study. The results indicated that there is no significant relationship between parental religiosity and quantity of topics discussed with adolescent, indicating parental religiosity does not affect the amount of communication in the parent-adolescent relationship. Parents …

High Stakes Assessments: Influencing Post-School Outcomes For Students With Disabilities, Lynn Holdheide

Masters Theses

Public reports during the last 20 years such as "A Nation at Risk," have criticized students' lack of knowledge and skills upon exit from high school with a diploma. As a result, federal policy initiatives spanning the last decade have focused on raising the nation's education standards. In 2001 the United States Congress enacted the No Child Left Behind Act (NCLB) as a significant education reform agenda to improve the quality of education and enforce accountability in the public schools. Mandates within the NCLB legislation have elevated standardized testing beyond a simple measurement of a student's skills to a broader …

Ain't No Goin' Back: Teaching Mental Disability Law Courses Online, Michael L. Perlin

Articles & Chapters

No abstract provided.

Off The Welfare Rolls And Back Into Poverty: A Look At 11 Years Of Illinois Welfare Reform, Amber Williams

Masters Theses

In 1996, the Republican-lead 104th Congress passed into law the most sweeping welfare reforms the United States had experienced in 60 years. The legislation, the Personal Responsibility and Work Opportunity Reconciliation Act, ended the decades-old Aid to Families with Dependent Children welfare and instituted the Temporary Assistance for Needy Families system. The new system ended entitlements, cut benefits to legal immigrants, set a two-year time limit for people to receive welfare benefits without working, and a five-year lifetime limit. In Illinois, the time limits for receiving cash benefits cut thousands of people off of the welfare rolls in the years …

Putting The Cart Before The Horse: Barriers To Enforcing A Code Of Ethics For Thoroughbred Auctions In The United States, Catharine Altier

Brooklyn Law Review

No abstract provided.

2003-2005 Book Award, Corinne Dempsey, Anne Monius

Journal of Hindu-Christian Studies

Information about the book award winner from the 2006 meeting, Eliza Kent's Converting Women: Gender and Protestant Christianity in Colonial South India.

Book Review: "Spiritual But Not Religious? An Oar Stroke Closer To The Farther Shore", Corinne Dempsey

Journal of Hindu-Christian Studies

A review of Spiritual But Not Religious? An Oar Stroke Closer to the Farther Shore by Reid B. Locklin.

Service Pays: Creating Opportunities By Linking College With Public Service, Ganesh Sitaraman, Elizabeth Warren, Sandy Baum

Vanderbilt Law School Faculty Publications

If college is to be the gateway to security and success, then a new financing mechanism is essential, one that lets students take responsibility for the cost of their own educations without burdening their families unduly, forcing them into career choices that push them out of public service, or mortgaging their futures. Our Service Pays proposal is designed to give every student who wants to work hard a means of paying for college - and to give young people an economically viable option to engage in public service for a few years after college. After describing the high costs of …

Welcome To Hazelton - Illegal Immigrants Beware, Karla M. Mckanders

Vanderbilt Law School Faculty Publications

On July 13, 2006, the city of Hazleton made national news as the first municipality in the country to pass ordinances against illegal immigrants. The majority of municipal legislation that passed regulated the employment of undocumented workers. The ordinances resulted from municipal perceptions that the federal government has failed to enact and enforce comprehensive immigration legislation. Thereafter, several states and municipalities across the country passed ordinances against illegal immigration. Since then, the federal courts have been inundated with lawsuits challenging the validity of municipal ordinances.

This article delves into the profound impact that municipal ordinances that sanction businesses for employing …

Law, Responsibility, And The Brain, Owen D. Jones, Hakwan C. Lau, Dean Mobbs, Christopher D. Frith

Vanderbilt Law School Faculty Publications

This article addresses new developments in neuroscience, and their implications for law. It explores, for example, the relationships between brain injury and violence, as well as the connections between mental disorders and criminal behaviors. It discusses a variety of issues surrounding brain fingerprinting, the use of brain scans for lie detection, and concerns about free will. It considers the possible uses for, and legal implications of, brain-imaging technology. And it also identifies six essential limits on the use of brain imaging in courtroom procedures.

Law, Responsibility, And The Brain, Owen D. Jones, Dean Mobbs, Hakwan C. Lau, Christopher D. Frith

Vanderbilt Law School Faculty Publications

This article addresses new developments in neuroscience, and their implications for law. It explores, for example, the relationships between brain injury and violence, as well as the connections between mental disorders and criminal behaviors. It discusses a variety of issues surrounding brain fingerprinting, the use of brain scans for lie detection, and concerns about free will. It considers the possible uses for, and legal implications of, brain-imaging technology. And it also identifies six essential limits on the use of brain imaging in courtroom procedures.

A Study Of Travel Behavior, Travel Preferences, And Subjective Well-Being Of Older Persons In Hong Kong, Ka Yan, Little Cheng

Lingnan Theses

Demographic ageing of the population is now well established in Hong Kong and, as elsewhere, is raising increasing concerns about the basic needs and the well-being of older persons. Older individuals vary considerably and may try to enhance their well-being in different ways by a range of leisure activities. The gradually improving financial and physical status suggests travel as a potential leisure activity which might enhance individual well-being and quality of life of older persons.

Previous research about travel has mainly involved marketing and sociological perspectives. The market research to date for investigating customer values of tourism and typologies of …

Age Identity And Adjustment Patterns In Later Life : A Qualitative Study Of Retired Secondary School Teachers And Manual Workers In Hong Kong, Kit Ying, Connie Yong

Lingnan Theses

With escalating heterogeneity of the older population due to extending healthy life expectancy, chronological age is decreasingly likely to be an appropriate discriminator of social groups among the diverse population. It may be more fruitful to understand how older people actually feel and live their lives than merely using chronological age as a categorizing variable. Therefore, the present research investigates individual age identity which may provide a more realistic indicator of ageing in the life course. It may also underpin many behavioral phenomena.

Age identity focuses on how an individual perceives himself or herself in terms of age. Previous studies …

Automobile Seatbelt Usage And The Value Of Statistical Life, W. Kip Viscusi, Jahn K. Hakes

Vanderbilt Law School Faculty Publications

This article uses several within-sample tests to assess whether current seatbelt usage decisions are consistent with the stated preferences of survey respondents. The expressed survey values of statistical life are positively associated with the probability of seatbelt usage and are not statistically different from the values of statistical life implied by seatbelt usage decisions, which are in the $1.9 million to $8.4 million range. Seatbelt usage also varies in the expected manner with individual measures of heterogeneous attitudes toward risk, such as smoking status and education. Our evidence on seatbelt usage supports the view that consumers consistently balance expected safety …

Rational Discounting For Regulatory Analysis, W. Kip Viscusi

Vanderbilt Law School Faculty Publications

This Article examines the economic basis for what is termed "rational discounting," which entails full recognition of policy effects over time and exponential discounting at a riskless rate of return. Policies often cannot be ranked unambiguously in terms of their present or future orientation. Both failure to discount and preferential intergenerational discounting generate inconsistencies and economic anomalies. Office of Management and Budget (OMB) discounting guidelines now stipulate more reasonable discount rates than earlier guidelines, but err in permitting open-ended preferential rates for intergenerational effects. This Article presents a methodology for monetizing the value of statistical life for people of different …

The Pardy-Ruhl Dialogue On Ecosystem Management, Part Iv: Narrowing And Sharpening The Questions, J.B. Ruhl

Vanderbilt Law School Faculty Publications

This article, fourth in a five-part dialogue appearing in the Pace ELR, further responds to Professor Bruce Pardy's critique of ecosystem management. I defend ecosystem management, arguing it does not involve the standardless, unbridled administrative discretion Pardy suggests.