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2007

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The Effects Of Eicu Technology On Clinical Outcomes Of Icu Patients: Analysis Of The Relationship Of Patient, Hospital, And Unit Characteristics To Proximal And Distal Outcomes, Michelle G. Chandler Jan 2007

The Effects Of Eicu Technology On Clinical Outcomes Of Icu Patients: Analysis Of The Relationship Of Patient, Hospital, And Unit Characteristics To Proximal And Distal Outcomes, Michelle G. Chandler

Electronic Theses and Dissertations

Each year approximately five million people are treated in the nation's intensive care units making intensive care one of the most expensive components of the U.S. healthcare system. Of these patients, 400,000-500,000 will die annually giving the ICU the distinction of having the highest rate of mortality and complications in the hospital setting. Studies have demonstrated that one in ten patients who die each day in ICUs might survive if intensivists were present to manage clinical care and direct treatment plans (Randolph & Pronovost, 2002; Dimick, Pronovost, Heitmiller & Lipsett, 2001; Pronovost et al., 2002). The utilization of supplemental remote …

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Understanding The Low Temperature Electrical Propertiesof Nanocrystalline Sno2 For Gas Sensor Applications, Christina Drake Jan 2007

Understanding The Low Temperature Electrical Propertiesof Nanocrystalline Sno2 For Gas Sensor Applications, Christina Drake

Electronic Theses and Dissertations

Nanocrystalline metal/metal oxide is an important class of transparent and electronic materials due to its potential use in many applications, including gas sensors. At the nanoscale, many of the phenomena observed that give nanocrystalline semiconducting oxide enhanced performance as a gas sensor material over other conventional engineering materials is still poorly understood. This study is aimed at understanding the low temperature electrical and chemical properties of nanocrystalline SnO2 that makes it suitable for room temperature gas detectors. Studies were carried out in order to understand how various synthesis methods affect the surfaces on the nano-oxides, interactions of a target gas …

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Parameter Estimation Using Sensor Fusion And Model Updating, Kevin Francoforte Jan 2007

Parameter Estimation Using Sensor Fusion And Model Updating, Kevin Francoforte

Electronic Theses and Dissertations

Engineers and infrastructure owners have to manage an aging civil infrastructure in the US. Engineers have the opportunity to analyze structures using finite element models (FEM), and often base their engineering decisions on the outcome of the results. Ultimately, the success of these decisions is directly related to the accuracy of the finite element model in representing the real-life structure. Improper assumptions in the model such as member properties or connections, can lead to inaccurate results. A major source of modeling error in many finite element models of existing structures is due to improper representation of the boundary conditions. In …

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Environmental Security In The Global Capitalist System: A World-Systems Approach And Study Of Panama, Mark Allen Freeman Jan 2007

Environmental Security In The Global Capitalist System: A World-Systems Approach And Study Of Panama, Mark Allen Freeman

Electronic Theses and Dissertations

The current global capitalist system is at odds with environmental protection and the protection of indigenous people that are directly linked to the land on which they live. In environmental security literature, many have argued that, theoretically and functionally, it is possible to link national security with environmental security. However possible this may be on paper, in practice, the global capitalist system prevents this from becoming a reality. Using a world-systems approach, this thesis will show that core countries seeking to expand capital by tapping into new markets, locating new sources of raw materials and even forming strategic military partnerships …

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Decision-Maker Trade-Offs In Multiple Response Surface Optimization, Alicia Hawkins Jan 2007

Decision-Maker Trade-Offs In Multiple Response Surface Optimization, Alicia Hawkins

Electronic Theses and Dissertations

The focus of this dissertation is on improving decision-maker trade-offs and the development of a new constrained methodology for multiple response surface optimization. There are three key components of the research: development of the necessary conditions and assumptions associated with constrained multiple response surface optimization methodologies; development of a new constrained multiple response surface methodology; and demonstration of the new method. The necessary conditions for and assumptions associated with constrained multiple response surface optimization methods were identified and found to be less restrictive than requirements previously described in the literature. The conditions and assumptions required for a constrained method to …

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A Microeconomic Model Of Healthcare Systems: From Theoretical To Practical, Jesse Helligso Jan 2007

A Microeconomic Model Of Healthcare Systems: From Theoretical To Practical, Jesse Helligso

Electronic Theses and Dissertations

This thesis is a microeconomic market analysis of healthcare systems. Different countries use various forms for financing and providing healthcare, and the effects of market forces on the quality, access and economic efficiency of these divergent healthcare markets is the primary subject. The purpose of this thesis is to describe the forces working in the healthcare market. Free-market healthcare systems allow medical providers to become price-setters. Price-setting by medical providers creates an economically inefficient system which decreases public access to healthcare but creates a high quality system. Single-payer systems make government the price-setter which creates a system in which medical …

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Sex-Biased Parasitism And The Reproductive Costs Of Parasites In A Social African Ground Squirrel, Melissa Ann Hillegass Jan 2007

Sex-Biased Parasitism And The Reproductive Costs Of Parasites In A Social African Ground Squirrel, Melissa Ann Hillegass

Electronic Theses and Dissertations

Vertebrate males frequently carry higher numbers of parasites than females. This bias in parasite loads could be a consequence of sexual selection. Grouping species are also assumed to be afflicted with larger numbers of parasites than solitary animals and associated costs of this parasitism could vary with group size or structure. I examined sex-biased parasitism and the influence of group size on parasite loads in Cape ground squirrels (Xerus inauris), a highly social species that occurs in the arid regions of southern Africa. Males carried three times as many ectoparasites as females, but females harbored nearly three times more endoparasites …

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Peter Safar: Father Of Modern Cardiopulmonary Resuscitation, Louis J. Acierno, L. Timothy Worrell Jan 2007

Peter Safar: Father Of Modern Cardiopulmonary Resuscitation, Louis J. Acierno, L. Timothy Worrell

Faculty Bibliography 2000s

No abstract provided.

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Toward A Formula-Based Model For Academic Library Funding: Statistical Significance And Implications Of A Model Based Upon Institutional Characteristics, Frank R. Allen, Mark Dickie Jan 2007

Toward A Formula-Based Model For Academic Library Funding: Statistical Significance And Implications Of A Model Based Upon Institutional Characteristics, Frank R. Allen, Mark Dickie

Faculty Bibliography 2000s

This study tests the hypothesis that a positive relationship exists between academic library funding (dependent variable) and selected institutional variables taken as indicators of the demand for library services at the university (enrollment, number of doctoral programs, doctoral degrees awarded, number of faculty, select other institutional characteristics). The research employs 11 years of longitudinal data from 113 members of the Association of Research Libraries to create a multiple regression model. Empirical results indicate that operational indicators of the demand for library services are positively associated with funding, and most of the associations are statistically significant at the five percent level …

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Field Production And Functional Evaluation Of Chloroplast-Derived Interferon-Alpha 2b, Philip A. Arlen, Regina Falconer, Sri Cherukumili, Amy Cole, Alexander M. Cole, Karen K. Oishi, Henry Daniell Jan 2007

Field Production And Functional Evaluation Of Chloroplast-Derived Interferon-Alpha 2b, Philip A. Arlen, Regina Falconer, Sri Cherukumili, Amy Cole, Alexander M. Cole, Karen K. Oishi, Henry Daniell

Faculty Bibliography 2000s

Type I interferons (IFNs) inhibit viral replication and cell growth and enhance the immune response, and therefore have many clinical applications. IFN-alpha 2b ranks third in world market use for a biopharmaceutical, behind only insulin and erythropoietin. The average annual cost of IFN-alpha 2b for the treatment of hepatitis C infection is $26 000, and is therefore unavailable to the majority of patients in developing countries. Therefore, we expressed IFN-alpha 2b in tobacco chloroplasts, and transgenic lines were grown in the field after obtaining United States Department of Agriculture Animal and Plant Health Inspection Service (USDA-APHIS) approval. Stable, site-specific integration …

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Intravenous Immunoglobulin (Ivig) Protects The Brain Against Experimental Stroke By Preventing Complement-Mediated Neuronal Cell Death, Thiruma V. Arumugam, Sung-Chun Tang, Justin D. Lathia, Aiwu Cheng, Mohamed R. Mughal, Srinivasulu Chigurupati, Tim Magnus, Sic L. Chan, Dong-Gyu Jo, Xin Ouyang, David P. Fairlie, Daniel N. Granger, Alexander Vortmeyer, Milan Basta, Mark P. Mattson Jan 2007

Intravenous Immunoglobulin (Ivig) Protects The Brain Against Experimental Stroke By Preventing Complement-Mediated Neuronal Cell Death, Thiruma V. Arumugam, Sung-Chun Tang, Justin D. Lathia, Aiwu Cheng, Mohamed R. Mughal, Srinivasulu Chigurupati, Tim Magnus, Sic L. Chan, Dong-Gyu Jo, Xin Ouyang, David P. Fairlie, Daniel N. Granger, Alexander Vortmeyer, Milan Basta, Mark P. Mattson

Faculty Bibliography 2000s

Stroke is among the three leading causes of death worldwide and the most frequent cause of permanent disability. Brain ischemia induces an inflammatory response involving activated complement fragments. Here we show that i.v. Ig (IVIG) treatment, which scavenges complement fragments, protects brain cells against the deleterious effects of experimental ischemia and reperfusion (I/R) and prevents I/R-induced mortality in mice. Animals administered IVIG either 30 min before ischemia or after 3 h of reperfusion exhibited a 50-60% reduction of brain infarct size and a 2- to 3-fold improvement of the functional outcome. Even a single low dose of IVIG given after …

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The Effects Of Year-Round Irrigation On Landscape Plant Quality And Health In Ohio, Heath Caldwell, Karen Mancl, Martin F. Quigley, Malcolm Pirnie Inc. Jan 2007

The Effects Of Year-Round Irrigation On Landscape Plant Quality And Health In Ohio, Heath Caldwell, Karen Mancl, Martin F. Quigley, Malcolm Pirnie Inc.

Faculty Bibliography 2000s

Deep (over 165 cm), permeable, unsaturated soil is needed to treat and dispose of wastewater through septic systems. In Ohio, only 6.4% of the state's land area is suited for septic systems for wastewater treatment. Soils with shallow depth to a limiting condition, between 30 and 60 cm, represent 49% of Ohio's land area. In these areas onsite wastewater treatment systems could be followed by irrigation on the lot to disperse the treated wastewater. Several months each year in Ohio reach subfreezing temperatures, making year-round irrigation a challenge. The objective of this research was to examine the feasibility of year-round …

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Stable Expression Of Gal/Galnac Lectin Of Entamoeba Histolytica In Transgenic Chloroplasts And Immunogenicity In Mice Towards Vaccine Development For Amoebiasis, Seethamahalakshmi Chebolu, Henry Daniell Jan 2007

Stable Expression Of Gal/Galnac Lectin Of Entamoeba Histolytica In Transgenic Chloroplasts And Immunogenicity In Mice Towards Vaccine Development For Amoebiasis, Seethamahalakshmi Chebolu, Henry Daniell

Faculty Bibliography 2000s

Chloroplast genetic engineering offers several advantages, including high levels of transgene expression, transgene containment via maternal inheritance and multigene engineering in a single transformation event. Entamoeba histolytica infects 50 million people, causing about 100 000 deaths annually, but there is no approved vaccine against this pathogen. LecA, a potential target for blocking amoebiasis, was expressed for the first time in transgenic plants. Stable transgene integration into chloroplast genomes and homoplasmy were confirmed by polymerase chain reaction and Southern blot analyses. LecA expression was evaluated by Western blots and quantified by enzyme-linked immunosorbent assay (up to 6.3% of total soluble protein …

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Lunar Surface: Dust Dynamics And Regolith Mechanics, J. E. Colwell, S. Batiste, M. Horányi, S. Robertson, S. Sture Jan 2007

Lunar Surface: Dust Dynamics And Regolith Mechanics, J. E. Colwell, S. Batiste, M. Horányi, S. Robertson, S. Sture

Faculty Bibliography 2000s

The lunar surface is characterized by a collisionally evolved regolith resulting from meteoroid bombardment. This lunar soil consists of highly angular particles in a broad, approximately power law size distribution, with impact-generated glasses. The regolith becomes densified and difficult to excavate when subjected to lunar quakes or, eventually, manned and unmanned activity on the surface. Solar radiation and the solar wind produce a plasma sheath near the lunar surface. Lunar grains acquire charge in this environment and can exhibit unusual behavior, including levitation and transport across the surface because of electric fields in the plasma sheath. The fine component of …

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Elevated Soil Lead: Statistical Modeling And Apportionment Of Contributions From Lead-Based Paint And Leaded Gasoline, R. Dennis Cook, Liqiang Ni Jan 2007

Elevated Soil Lead: Statistical Modeling And Apportionment Of Contributions From Lead-Based Paint And Leaded Gasoline, R. Dennis Cook, Liqiang Ni

Faculty Bibliography 2000s

While it is widely accepted that lead-based paint and leaded gasoline are primary sources of elevated concentrations of lead in residential soils, conclusions regarding their relative contributions are mixed and generally study specific. We develop a novel nonlinear regression for soil lead concentrations over time. It is argued that this methodology provides useful insights into the partitioning of the average soil lead concentration by source and time over large residential areas. The methodology is Used to investigate soil lead concentrations from the 1987 Minnesota Lead Study and the 1990 National Lead Survey. Potential litigation issues are disscussed briefly.

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Accd6, A Member Of The Fas Ii Locus, Is A Functional Carboxyltransferase Subunit Of The Acyl-Coenzyme A Carboxylase In Mycobacterium Tuberculosis, Jaiyanth Daniel, Tae-Jin Oh, Chang-Muk Lee, Pappachan E. Kolattukudy Jan 2007

Accd6, A Member Of The Fas Ii Locus, Is A Functional Carboxyltransferase Subunit Of The Acyl-Coenzyme A Carboxylase In Mycobacterium Tuberculosis, Jaiyanth Daniel, Tae-Jin Oh, Chang-Muk Lee, Pappachan E. Kolattukudy

Faculty Bibliography 2000s

The Mycobacterium tuberculosis acyl-coenzyme A (CoA) carboxylases provide the building blocks for de novo fatty acid biosynthesis by fatty acid synthase I (FAS 1) and for the elongation of FAS I end products by the FAS 11 complex to produce meromycolic acids. The M. tuberculosis genome contains three biotin carboxylase subunits (AccA1 to -3) and six carboxyltransferase subunits (AccD1 to -6), with accD6 located in a genetic locus that contains members of the FAS 11 complex. We found by quantitative real-time PCR analysis that the transcripts of accA3, accD4, accD5, and accD6 are expressed at high levels during the exponential …

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Analysis Of 81 Genes From 64 Plastid Genomes Resolves Relationships In Angiosperms And Identifies Genome-Scale Evolutionary Patterns, Robert K. Jansen, Zhengqiu Cai, Linda A. Raubeson, Henry Daniell, Claude W. Depamphilis, James Leebens-Mack, Kai F. Müller, Mary Guisinger-Bellian, Rosemarie C. Haberle, Anne K. Hansen, Timothy W. Chumley, Seung-Bum Lee, Rhiannon Peery, Joel R. Mcneal, Jennifer V. Kuehl, Jeffrey L. Boore Jan 2007

Analysis Of 81 Genes From 64 Plastid Genomes Resolves Relationships In Angiosperms And Identifies Genome-Scale Evolutionary Patterns, Robert K. Jansen, Zhengqiu Cai, Linda A. Raubeson, Henry Daniell, Claude W. Depamphilis, James Leebens-Mack, Kai F. Müller, Mary Guisinger-Bellian, Rosemarie C. Haberle, Anne K. Hansen, Timothy W. Chumley, Seung-Bum Lee, Rhiannon Peery, Joel R. Mcneal, Jennifer V. Kuehl, Jeffrey L. Boore

Faculty Bibliography 2000s

Angiosperms are the largest and most successful clade of land plants with > 250,000 species distributed in nearly every terrestrial habitat. Many phylogenetic studies have been based on DNA sequences of one to several genes, but, despite decades of intensive efforts, relationships among early diverging lineages and several of the major clades remain either incompletely resolved or weakly supported. We performed phylogenetic analyses of 81 plastid genes in 64 sequenced genomes, including 13 new genomes, to estimate relationships among the major angiosperm clades, and the resulting trees are used to examine the evolution of gene and intron content. Phylogenetic trees from …

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Comparative Mitochondrial Genomics Of Snakes: Extraordinary Substitution Rate Dynamics And Functionality Of The Duplicate Control Region, Zhi J. Jiang, Todd A. Castoe, Christopher C. Austin, Matthew D. Herron, Frank T. Burbrink, Jimmy A. Mcguire, Christopher L. Parkinson, David D. Pollock Jan 2007

Comparative Mitochondrial Genomics Of Snakes: Extraordinary Substitution Rate Dynamics And Functionality Of The Duplicate Control Region, Zhi J. Jiang, Todd A. Castoe, Christopher C. Austin, Matthew D. Herron, Frank T. Burbrink, Jimmy A. Mcguire, Christopher L. Parkinson, David D. Pollock

Faculty Bibliography 2000s

Background: The mitochondrial genomes of snakes are characterized by an overall evolutionary rate that appears to be one of the most accelerated among vertebrates. They also possess other unusual features, including short tRNAs and other genes, and a duplicated control region that has been stably maintained since it originated more than 70 million years ago. Here, we provide a detailed analysis of evolutionary dynamics in snake mitochondrial genomes to better understand the basis of these extreme characteristics, and to explore the relationship between mitochondrial genome molecular evolution, genome architecture, and molecular function. We sequenced complete mitochondrial genomes from Slowinski's corn …

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Advances In Homeland Security Series, Naim Kapucu Jan 2007

Advances In Homeland Security Series, Naim Kapucu

Faculty Bibliography 2000s

This is a book review article for the Advances in Homeland Security Series by Purdue University. The series consist of two volumes. Volume one is entitled The Science of Homeland Security. Volume two is entitled Guiding Future Homeland Security Policy. Amass F. S., Bhunia, A. K, Chaturvedi, A. L., Dolk, D. R., Peeta, S., and Atallah, M. J. Advances in Homeland Security Series: The Science of Homeland Security (Volume 1), West Lafayette, IN: Perdue University Press, 2006 227 pp, introduction, notes, bibliography, index (hardcover). Amass F. S., Chaturvedi, A. L., and Peeta, S. Advances in Homeland Security Series: Guiding Future …

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Logistics And Staging Areas In Managing Disasters And Emergencies, Naim Kapucu, Wendell C. Lawther, Sommer Pattison Jan 2007

Logistics And Staging Areas In Managing Disasters And Emergencies, Naim Kapucu, Wendell C. Lawther, Sommer Pattison

Faculty Bibliography 2000s

Emergency management is often evaluated and improved after the occurrence of a disaster, especially in the case of preparedness. This paper discusses the importance of logistics planning and operation as it relates to disaster preparedness. The selection of field logistics sites such as staging areas, prior to the occurrence of a natural or man-made disaster, is a crucial step in emergency planning and management. Selection can be aided and kept consistent by pre-identifying state and county-level guidelines for staging areas. This paper reviews state and county criteria for the pre-selection of staging areas and discusses supporting logistical operations in disaster …

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Role Of Crkii In Fc Gamma Receptor-Mediated Phagocytosis, Warren L. Lee, Gabriela Cosio, Keith Ireton, Sergio Grinstein Jan 2007

Role Of Crkii In Fc Gamma Receptor-Mediated Phagocytosis, Warren L. Lee, Gabriela Cosio, Keith Ireton, Sergio Grinstein

Faculty Bibliography 2000s

Phagocytosis of IgG-opsonized pathogens by Fc gamma receptors requires extensive remodeling of the actin cytoskeleton, a process regulated by the small GTPase Rac. Vav was thought to be the guanine nucleotide exchange factor responsible for the activation of Rac, but recent evidence indicates that Fc gamma receptor-mediated phagocytosis is unaffected in macrophages lacking all three isoforms of Vav. We therefore tested whether another GEF, DOCK180, participates in Fc gamma receptor-initiated phagocytosis. DOCK180 associates with the adaptor protein Crk, which mediates recruitment of the GEF to sites of tyrosine phosphorylation. CrkII and DOCK180 were found to accumulate at the phagocytic cup. …

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Specific Grb2-Mediated Interactions Regulate Clathrin-Dependent Endocytosis Of The Cmet-Tyrosine Kinase, Ning Li, Marta Lorinczi, Keith Ireton, Lisa A. Elferink Jan 2007

Specific Grb2-Mediated Interactions Regulate Clathrin-Dependent Endocytosis Of The Cmet-Tyrosine Kinase, Ning Li, Marta Lorinczi, Keith Ireton, Lisa A. Elferink

Faculty Bibliography 2000s

Lysosomal degradation of the receptor-tyrosine kinase cMet requires receptor ubiquitination by the E3 ubiquitin ligase Cbl followed by clathrin-dependent internalization. A role for Cbl as an adaptor for cMet internalization has been previously reported. However, the requirement for Cbl ubiquitin ligase activity in this process and its mode of recruitment to cMet has yet to be determined. Cbl can directly bind cMet at phosphotyrosine 1003 or indirectly via Grb2 to phosphotyrosine 1356 in the multisubstrate binding domain of cMet. The direct binding of Cbl with cMet is critical for receptor degradation and not receptor internalization. Here we show a strict …

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Modulation Of Human Neural Stem Cell Differentiation In Alzheimer (App23) Transgenic Mice By Phenserine, Amelia Marutle, Masao Ohmitsu, Mats Nilbratt, Nigel H. Greig, Agneta Nordberg, Kiminobu Sugaya Jan 2007

Modulation Of Human Neural Stem Cell Differentiation In Alzheimer (App23) Transgenic Mice By Phenserine, Amelia Marutle, Masao Ohmitsu, Mats Nilbratt, Nigel H. Greig, Agneta Nordberg, Kiminobu Sugaya

Faculty Bibliography 2000s

In a previous study, we found that human neural stem cells (HNSCs) exposed to high concentrations of secreted amyloid-precursor protein (sAPP) in vitro differentiated into mainly astrocytes, suggesting that pathological alterations in APP processing during neurodegenerative conditions such as Alzheimer's disease (AD) may prevent neuronal differentiation of HNSCs. Thus, successful neuroplacement therapy for AD may require regulating APP expression to favorable levels to enhance neuronal differentiation of HNSCs. Phenserine, a recently developed cholinesterase inhibitor (ChEI), has been reported to reduce APP levels in vitro and in vivo. In this study, we found reductions of APP and glial fibrillary acidic protein …

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Invariant Resolution Dynamic Focus Ocm Based On Liquid Crystal Lens, S. Murali, K. S. Lee, J. P. Rolland Jan 2007

Invariant Resolution Dynamic Focus Ocm Based On Liquid Crystal Lens, S. Murali, K. S. Lee, J. P. Rolland

Faculty Bibliography 2000s

A primary limitation of optical coherence microscopy is the lack of sufficient lateral resolution over a usable imaging volume for diagnostic applications, even with high-numerical aperture imaging optics. In this paper, we first motivate the benefit of refocusing at multiple depths in a highly scattering biological sample using optical coherence microscopy, which experimentally shows invariant 2.5 mu m axial and 6.5 mu m lateral resolution throughout the sample. We then present the optical system design of a hand-held probe with the advanced capability to dynamically focus with no moving parts to a depth of 2 mm in skin-equivalent tissue at …

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Expression Of Cholera Toxin B-Proinsulin Fusion Protein In Lettuce And Tobacco Chloroplasts - Oral Administration Protects Against Development Of Insulitis In Non-Obese Diabetic Mice, Tracey Ruhlman, Raheleh Ahangari, Andrew Devine, Mohtahsem Samsam, Henry Daniell Jan 2007

Expression Of Cholera Toxin B-Proinsulin Fusion Protein In Lettuce And Tobacco Chloroplasts - Oral Administration Protects Against Development Of Insulitis In Non-Obese Diabetic Mice, Tracey Ruhlman, Raheleh Ahangari, Andrew Devine, Mohtahsem Samsam, Henry Daniell

Faculty Bibliography 2000s

Lettuce and tobacco chloroplast transgenic lines expressing the cholera toxin B subunit-human proinsulin (CTB-Pins) fusion protein were generated. CTB-Pins accumulated up to similar to 16% of total soluble protein (TSP) in tobacco and up to similar to 2.5% of TSP in lettuce. Eight milligrams of powdered tobacco leaf material expressing CTB-Pins or, as negative controls, CTB-green fluorescent protein (CTB-GFP) or interferon-GFP (IFN-GFP), or untransformed leaf, were administered orally, each week for 7 weeks, to 5-week-old female non-obese diabetic (NOD) mice. The pancreas of CTB-Pins-treated mice showed decreased infiltration of cells characteristic of lymphocytes (insulitis); insulin-producing beta-cells in the pancreatic islets …

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The Complete Nucleotide Sequence Of The Coffee (Coffea Arabica L.) Chloroplast Genome: Organization And Implications For Biotechnology And Phylogenetic Relationships Amongst Angiosperms, Nalapalli Samson, Michael G. Bausher, Seung-Bum Lee, Robert K. Jansen, Henry Daniell Jan 2007

The Complete Nucleotide Sequence Of The Coffee (Coffea Arabica L.) Chloroplast Genome: Organization And Implications For Biotechnology And Phylogenetic Relationships Amongst Angiosperms, Nalapalli Samson, Michael G. Bausher, Seung-Bum Lee, Robert K. Jansen, Henry Daniell

Faculty Bibliography 2000s

The chloroplast genome sequence of Coffea arabica L., the first sequenced member of the fourth largest family of angiosperms, Rubiaceae, is reported. The genome is 155 189 bp in length, including a pair of inverted repeats of 25 943 bp. Of the 130 genes present, 112 are distinct and 18 are duplicated in the inverted repeat. The coding region comprises 79 protein genes, 29 transfer RNA genes, four ribosomal RNA genes and 18 genes containing introns (three with three exons). Repeat analysis revealed five direct and three inverted repeats of 30 bp or longer with a sequence identity of 90% …

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Hospital Outpatient Perceptions Of The Physical Environment Of Waiting Areas: The Role Of Patient Characteristics On Atmospherics In One Academic Medical Center, Chun-Yen Tsai, Mu-Chia Wang, Wei-Tsen Liao, Jui-Heng Lu, Pi-Hung Sun, Blossom Yen-Ju Lin, Gerald-Mark Breen Jan 2007

Hospital Outpatient Perceptions Of The Physical Environment Of Waiting Areas: The Role Of Patient Characteristics On Atmospherics In One Academic Medical Center, Chun-Yen Tsai, Mu-Chia Wang, Wei-Tsen Liao, Jui-Heng Lu, Pi-Hung Sun, Blossom Yen-Ju Lin, Gerald-Mark Breen

Faculty Bibliography 2000s

Background: This study examines hospital outpatient perceptions of the physical environment of the outpatient waiting areas in one medical center. The relationship of patient characteristics and their perceptions and needs for the outpatient waiting areas are also examined. Method: The examined medical center consists of five main buildings which house seventeen primary waiting areas for the outpatient clinics of nine medical specialties: 1) Internal Medicine; 2) Surgery; 3) Ophthalmology; 4) Obstetrics-Gynecology and Pediatrics; 5) Chinese Medicine; 6) Otolaryngology; 7) Orthopedics; 8) Family Medicine; and 9) Dermatology. A 15-item structured questionnaire was developed to rate patient satisfaction covering the four dimensions …

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Ppar Alpha L162v Underlies Variation In Serum Triglycerides And Subcutaneous Fat Volume In Young Males, Julieta Uthurralt, Heather Gordish-Dressman, Meg Bradbury, Carolina Tesi-Rocha, Joseph Devaney, Brennan Harmon, Erica K. Reeves, Cinzia Brandoli, Barbara C. Hansen, Richard L. Seip, Paul D. Thompson, Thomas B. Price, Theodore J. Angelopoulos, Priscilla M. Clarkson, Niall M. Moyna, Linda S. Pescatello, Paul S. Visich, Robert F. Zoeller, Paul M. Gordon, Eric P. Hoffman Jan 2007

Ppar Alpha L162v Underlies Variation In Serum Triglycerides And Subcutaneous Fat Volume In Young Males, Julieta Uthurralt, Heather Gordish-Dressman, Meg Bradbury, Carolina Tesi-Rocha, Joseph Devaney, Brennan Harmon, Erica K. Reeves, Cinzia Brandoli, Barbara C. Hansen, Richard L. Seip, Paul D. Thompson, Thomas B. Price, Theodore J. Angelopoulos, Priscilla M. Clarkson, Niall M. Moyna, Linda S. Pescatello, Paul S. Visich, Robert F. Zoeller, Paul M. Gordon, Eric P. Hoffman

Faculty Bibliography 2000s

Background: Of the five sub-phenotypes defining metabolic syndrome, all are known to have strong genetic components ( typically 50 - 80% of population variation). Studies defining genetic predispositions have typically focused on older populations with metabolic syndrome and/or type 2 diabetes. We hypothesized that the study of younger populations would mitigate many confounding variables, and allow us to better define genetic predisposition loci for metabolic syndrome. Methods: We studied 610 young adult volunteers ( average age 24 yrs) for metabolic syndrome markers, and volumetric MRI of upper arm muscle, bone, and fat pre- and post-unilateral resistance training. Results: We found …

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Efficacy, Pharmacokinetics, And Metabolism Of Tetrahydroquinoline Inhibitors Of Plasmodium Falciparum Protein Farnesyltransferase, Wesley C. Voorhis, Kasey L. Rivas, Pravin Bendale, Laxman Nallan, Carolyn Hornéy, Lynn K. Barrett, Kevin D. Bauer, Brian P. Smart, Sudha Ankala, Oliver Hucke, Christophe L. M. J. Verlinde, Debopam Chakrabarti, Corey Strickland, Kohei Yokoyama, Frederick S. Buckner, Andrew D. Hamilton, David K. Williams, Louis J. Lombardo, David Floyd, Michael H. Gelb Jan 2007

Efficacy, Pharmacokinetics, And Metabolism Of Tetrahydroquinoline Inhibitors Of Plasmodium Falciparum Protein Farnesyltransferase, Wesley C. Voorhis, Kasey L. Rivas, Pravin Bendale, Laxman Nallan, Carolyn Hornéy, Lynn K. Barrett, Kevin D. Bauer, Brian P. Smart, Sudha Ankala, Oliver Hucke, Christophe L. M. J. Verlinde, Debopam Chakrabarti, Corey Strickland, Kohei Yokoyama, Frederick S. Buckner, Andrew D. Hamilton, David K. Williams, Louis J. Lombardo, David Floyd, Michael H. Gelb

Faculty Bibliography 2000s

New antimalarials are urgently needed. We have shown that tetrahydroquinoline (THQ) protein farnesyltransferase (PFr) inhibitors (PFTIs) are effective against the Plasmodium falciparum PFr and are effective at killing P. falciparum in vitro. Previously described THQ PFTIs had limitations of poor oral bioavailability and rapid clearance from the circulation of rodents. In this paper, we validate both the Caco-2 cell permeability model for predicting THQ intestinal absorption and the in vitro liver microsome model for predicting THQ clearance in vivo. Incremental improvements in efficacy, oral absorption, and clearance rate were monitored by in vitro tests; and these tests were followed up …

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Recognizing Teamwork Activity In Observations Of Embodied Agents, Linus Jan Luotsinen Jan 2007

Recognizing Teamwork Activity In Observations Of Embodied Agents, Linus Jan Luotsinen

Electronic Theses and Dissertations

This thesis presents contributions to the theory and practice of team activity recognition. A particular focus of our work was to improve our ability to collect and label representative samples, thus making the team activity recognition more efficient. A second focus of our work is improving the robustness of the recognition process in the presence of noisy and distorted data. The main contributions of this thesis are as follows: We developed a software tool, the Teamwork Scenario Editor (TSE), for the acquisition, segmentation and labeling of teamwork data. Using the TSE we acquired a corpus of labeled team actions both …

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