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Modulation Of Human Neural Stem Cell Differentiation In Alzheimer (App23) Transgenic Mice By Phenserine, Amelia Marutle, Masao Ohmitsu, Mats Nilbratt, Nigel H. Greig, Agneta Nordberg, Kiminobu Sugaya

Faculty Bibliography 2000s

In a previous study, we found that human neural stem cells (HNSCs) exposed to high concentrations of secreted amyloid-precursor protein (sAPP) in vitro differentiated into mainly astrocytes, suggesting that pathological alterations in APP processing during neurodegenerative conditions such as Alzheimer's disease (AD) may prevent neuronal differentiation of HNSCs. Thus, successful neuroplacement therapy for AD may require regulating APP expression to favorable levels to enhance neuronal differentiation of HNSCs. Phenserine, a recently developed cholinesterase inhibitor (ChEI), has been reported to reduce APP levels in vitro and in vivo. In this study, we found reductions of APP and glial fibrillary acidic protein …

Geographical Gradients In Diet Affect Population Dynamics Of Canada Lynx, James D. Roth, John D. Marshall, Dennis L. Murray, David M. Nickerson, Todd D. Steury

Faculty Bibliography 2000s

Geographical gradients in the stability of cyclic populations of herbivores and their predators may relate to the degree of specialization of predators. However, such changes are usually associated with transition from specialist to generalist predator species, rather than from geographical variation in dietary breadth of specialist predators. Canada lynx (Lynx canadensis) and snowshoe hare (Lepus americanus) populations undergo cyclic. fluctuations in northern parts of their range, but cycles are either greatly attenuated or lost altogether in the southern boreal forest where prey diversity is higher. We tested the influence of prey specialization on population cycles by measuring the stable carbon …

Expression Of Cholera Toxin B-Proinsulin Fusion Protein In Lettuce And Tobacco Chloroplasts - Oral Administration Protects Against Development Of Insulitis In Non-Obese Diabetic Mice, Tracey Ruhlman, Raheleh Ahangari, Andrew Devine, Mohtahsem Samsam, Henry Daniell

Faculty Bibliography 2000s

Lettuce and tobacco chloroplast transgenic lines expressing the cholera toxin B subunit-human proinsulin (CTB-Pins) fusion protein were generated. CTB-Pins accumulated up to similar to 16% of total soluble protein (TSP) in tobacco and up to similar to 2.5% of TSP in lettuce. Eight milligrams of powdered tobacco leaf material expressing CTB-Pins or, as negative controls, CTB-green fluorescent protein (CTB-GFP) or interferon-GFP (IFN-GFP), or untransformed leaf, were administered orally, each week for 7 weeks, to 5-week-old female non-obese diabetic (NOD) mice. The pancreas of CTB-Pins-treated mice showed decreased infiltration of cells characteristic of lymphocytes (insulitis); insulin-producing beta-cells in the pancreatic islets …

Selective Chemical Probe Inhibitor Of Stat3, Identified Through Structure-Based Virtual Screening, Induces Antitumor Activity, Khandaker Siddiquee, Shumin Zhang, Wayne C. Guida, Michelle A. Blaskovich, Benjamin Greedy, Harshani R. Lawrence, M. L. Richard Yip, Richard Jove, Mark M. Mclaughlin, Nicholas J. Lawrence, Said M. Sebti, James Turkson

Faculty Bibliography 2000s

S31-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using structure-based virtual screening with a computer model of the Stat3 SH2 domain bound to its Stat3 phosphotyrosine peptide derived from the x-ray crystal structure of the Stat3 beta homodimer. S31-201 inhibits Stat3-Stat3 complex formation and Stat3 DNA-binding and transcriptional activities. Furthermore, S31-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3. Constitutively climerized and active Stat3C and Stat3 SH2 domain rescue tumor cells from S31-201-induced apoptosis. Finally, S31-201 inhibits the expression of …

Ppar Alpha L162v Underlies Variation In Serum Triglycerides And Subcutaneous Fat Volume In Young Males, Julieta Uthurralt, Heather Gordish-Dressman, Meg Bradbury, Carolina Tesi-Rocha, Joseph Devaney, Brennan Harmon, Erica K. Reeves, Cinzia Brandoli, Barbara C. Hansen, Richard L. Seip, Paul D. Thompson, Thomas B. Price, Theodore J. Angelopoulos, Priscilla M. Clarkson, Niall M. Moyna, Linda S. Pescatello, Paul S. Visich, Robert F. Zoeller, Paul M. Gordon, Eric P. Hoffman

Faculty Bibliography 2000s

Background: Of the five sub-phenotypes defining metabolic syndrome, all are known to have strong genetic components ( typically 50 - 80% of population variation). Studies defining genetic predispositions have typically focused on older populations with metabolic syndrome and/or type 2 diabetes. We hypothesized that the study of younger populations would mitigate many confounding variables, and allow us to better define genetic predisposition loci for metabolic syndrome. Methods: We studied 610 young adult volunteers ( average age 24 yrs) for metabolic syndrome markers, and volumetric MRI of upper arm muscle, bone, and fat pre- and post-unilateral resistance training. Results: We found …

Efficacy, Pharmacokinetics, And Metabolism Of Tetrahydroquinoline Inhibitors Of Plasmodium Falciparum Protein Farnesyltransferase, Wesley C. Voorhis, Kasey L. Rivas, Pravin Bendale, Laxman Nallan, Carolyn Hornéy, Lynn K. Barrett, Kevin D. Bauer, Brian P. Smart, Sudha Ankala, Oliver Hucke, Christophe L. M. J. Verlinde, Debopam Chakrabarti, Corey Strickland, Kohei Yokoyama, Frederick S. Buckner, Andrew D. Hamilton, David K. Williams, Louis J. Lombardo, David Floyd, Michael H. Gelb

Faculty Bibliography 2000s

New antimalarials are urgently needed. We have shown that tetrahydroquinoline (THQ) protein farnesyltransferase (PFr) inhibitors (PFTIs) are effective against the Plasmodium falciparum PFr and are effective at killing P. falciparum in vitro. Previously described THQ PFTIs had limitations of poor oral bioavailability and rapid clearance from the circulation of rodents. In this paper, we validate both the Caco-2 cell permeability model for predicting THQ intestinal absorption and the in vitro liver microsome model for predicting THQ clearance in vivo. Incremental improvements in efficacy, oral absorption, and clearance rate were monitored by in vitro tests; and these tests were followed up …

Recognizing Teamwork Activity In Observations Of Embodied Agents, Linus Jan Luotsinen

Electronic Theses and Dissertations

This thesis presents contributions to the theory and practice of team activity recognition. A particular focus of our work was to improve our ability to collect and label representative samples, thus making the team activity recognition more efficient. A second focus of our work is improving the robustness of the recognition process in the presence of noisy and distorted data. The main contributions of this thesis are as follows: We developed a software tool, the Teamwork Scenario Editor (TSE), for the acquisition, segmentation and labeling of teamwork data. Using the TSE we acquired a corpus of labeled team actions both …

An Analysis Of Improving Student Performance Through The Use Of Registered Therapy Dogs Serving As Motivators For Reluctant Read, Julie Paradise

Electronic Theses and Dissertations

This investigation studied the impact of registered therapy dogs assigned to students in order to improve reading skills. The purpose of this study was to determine if children assigned to registered therapy dogs improve significantly in reading achievement and related school performance such as attendance and discipline when compared to students of similar characteristics not assigned to registered therapy dogs. Specifically, the study used data to ascertain whether students assigned to registered therapy dogs improved their reading skills and if these students demonstrated more or less growth than students of similar characteristics not assigned to registered therapy dogs. This study …

Analysis Of Mitochondrial Dna Coding Region Snps By Pyrosequencing, Kyle Robert Carl Parker

Electronic Theses and Dissertations

To date, the use of mitochondrial DNA in forensic analysis has relied on the presence of variations in the control region to differentiate between samples. One problem that this analysis has shown is the occurrence of common Haplogroup H haplotypes or identical sequences. Thus, there is a need to enhance the distinguishing power of this type of analysis. One option has been to investigate the mitochondrial coding region for polymorphisms that could differentiate between samples with identical control region haplotypes. The goal of this study has been to identify polymorphic coding region sites for development in a Pyrosequencing assay that …

The Impact Of Co-Teaching On Student Learning Outcomes In Secondary Social Studies Classrooms Implementing Content Enhancement R, Kimberly Zgonc

Electronic Theses and Dissertations

The purpose of this study was to examine if differences exist in student learning outcomes between students who are instructed in a co-taught or non co-taught environment in secondary social studies classrooms implementing Content Enhancement Routines (CER). This study examined student and teacher data from seventeen matched pairs of co-taught and non co-taught middle and high school general education social studies teachers who participated in professional development in CER and professional development in co-teaching if applicable. Of the 34 participating teachers, 23 were visited by school district personnel to verify implementation of CER. Five co-teaching teams, each consisting of a …

2007 Schroeder Scholar In Residence Lecture The Role Of Science In Health Policy Decision-Making: The Case Of Emergency Contraception, Susan F. Wood

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Criminal Procedure In Perspective, Kit Kinports

Journal of Criminal Law and Criminology

No abstract provided.

Group Think: The Law Of Conspiracy And Collective Reason, Jens David Ohlin

Journal of Criminal Law and Criminology

No abstract provided.

Ky. Waterways Alliance V. Johnson, 426 F. Supp. 2d 612 (W.D. Ky. 2006), Kathleen Brady

Water Law Review

No abstract provided.

The Endangered, Rick Mabrey

Theses

This writing project is a culmination of essays based on my personal experiences as an educator, and an environmentalist. The work illustrates a mindset of abuse and neglect that harms nature, and mistreats children. It offers hope through those who will nurture and not turn their back on the problems of society.

The endangered list no longer singles out animals in the wild. It now includes what is left of the open land, the healthy waterways, and many of the kids I teach.

St. Francis of Assisi said, "Not to hurt our humble brethren is our first duty to them, …

See You Soon: An E-Memoir, Leigh C. Kolb

Theses

This thesis is a creative nonfiction piece, which uses e-mails between two people to create its text. It is in an epistolary style, which historically is a style in which letters, diary entries or newspaper clippings are used to construct a story. Epistolary (which comes from the word "epistle," or letter) novels often are used to show a developing relationship between people, which is precisely what the proceeding piece, See You Soon, aims to do.

The following document is constructed out of thousands of e-mails between the author and her now-husband. The e-mails were weeded through and woven together to …

Cognitively Inspired Anticipatory Adaptation And Associated Learning Mechanisms For Autonomous Agents, A. Negatu, S. Mello, S. Franklin

CCRG Papers

No abstract provided.

The Fine Art Of Monsters In Literature, Charles Garvin

Theses

This thesis will focus on the assimilation of my life experiences that ultimately result in the creation literary monsters. The following introduction defines my development as a writer through explorations of poetry and fiction. Traumatic life experiences as both a child and as an adult, coupled with an excellent education, has augmented my writing style towards literary horror.

A section of poetry comes after the introduction, which is a serious experiment by me to delve into the finer arts of pattern making. The fictional piece, Beyond Road's End, which follows the poetry, is primarily the object of my focus, which …

Mandarin Chinese: An Annotated Bibliography Of Self-Study Materials, Duncan E. Alford

Faculty Publications

The People’s Republic of China is currently the seventh largest economy in the world and is projected to be the largest economy by 2050. Commensurate with its growing economic power, the PRC is using its political power more frequently on the world stage. As a result of these changes, interest in China and its legal system is growing among attorneys and academics. International law librarians similarly are seeing more researchers interested in China, its laws and economy. The principal language of China, Mandarin Chinese, is considered a difficult language to learn. The Foreign Service Institute has rated Mandarin as “exceptionally …

Rojack Revisited As Nightmare Avatar Of I, John, Your Brother (Rev. 1:9), Kevin Lewis

Faculty Publications

No abstract provided.

The Effects Of 17Β-Estradiol And Tamoxifen On Cell Cycle Distribution And F-Actin Expression In Mcf-7 Cells, Kirk Kangaloo, Latoya Jenkins, Nicole Clarke, Samir S. Raychoudhury

Journal of the South Carolina Academy of Science

No abstract provided.

Schweinitz’S Sunflower Helianthus Schweinitzii Torrey And Gray, (Asterales: Asteraceae) In Upper Piedmont South Carolina, Steven E. Fields

Journal of the South Carolina Academy of Science

No abstract provided.

A Listing Of The Flora And Fauna Of Saint Helena Island, South Carolina With Emphasis On Historic Penn Center, Steven E. Fields, Harriet Speer, Joshua S. Castleberry,, Michael W. Hook, Rebecca Hunsucker, David M. Lambert

Journal of the South Carolina Academy of Science

No abstract provided.

2007 Aapp Monograph Series, John Mcfadden, Richard G. Deaner, Moody Crews, Dayna Anne Campbell, A. Taquesa Mcclain, Nancy E. Brown, Vida Mingo, Toby L. Nelson, Melissa B. Pearson, Lisa B. Randle, Fredrick A. Gardin, Valarie A. Mingo, Rex Nobles, Anita M. Rawls, Alexanderia T. Smith, Larry E. Jones Jr., Alvoy L. Bryan Jr.

Monograph Series

The African American Professors Program (AAPP) at the University of South Carolina is proud to publish the seventh edition of its annual monograph series. Furthermore, it is an honor to celebrate the remarkable tenth anniversary of AAPP through these manuscripts. The program recognizes the significance of offering its scholars a venue to engage actively in research and publish papers related thereto. Parallel with the publication of their refereed manuscripts is the opportunity to gain visibility among scholars throughout institutions worldwide.

Scholars who have contributed papers for this monograph are to be commended for adding this responsibility to their academic workload. …

The Effects Of Modern Constitutional Sentencing Law And Natale, Franklin And Abdullah On New Jersey Sentencing Law And Relationship To The Legislative Intent Behind The New Jersey Criminal Sentencing Code, Christopher J. Turano

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

A Manifesto For Visual Legal Realism, Richard K. Sherwin

Loyola of Los Angeles Law Review

No abstract provided.

Identification Of A Novel Domain At The N Terminus Of Caveolin-1 That Controls Rear Polarization Of The Protein And Caveolae Formation, Xing-Hui Sun, Daniel C. Flynn, Vincent Castranova, Lyndell L. Millecchia, Andrew R. Beardsley, Jun Liu

Faculty & Staff Scholarship

No abstract provided.

Prosecutorial Misconduct At Trial: A New Perspective Rooted In Confrontation Clause Jurisprudence, Michael D. Cicchini

Seton Hall Law Review

No abstract provided.

The New York City Police Department's Random Bag Search Policy: Withstanding Fourth Amendment Scrutiny Is Only The First Step In Combating Terrorism, Eugene Kim

Seton Hall Law Review

No abstract provided.

Ghrelin May Be A Universal Peptide In All Living Organisms, Süleyman Aydin

Turkish Journal of Medical Sciences

No abstract provided.