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2007

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C-Jun N-Terminal Kinase Inhibitor Sp600125 Modulates The Period Of Mammalian Circadian Rhythms, M. Chansard, P. Molyneux, K. Nomura, Mary E. Harrington, C. Fukuhara Mar 2007

C-Jun N-Terminal Kinase Inhibitor Sp600125 Modulates The Period Of Mammalian Circadian Rhythms, M. Chansard, P. Molyneux, K. Nomura, Mary E. Harrington, C. Fukuhara

Psychology: Faculty Publications

Circadian rhythms are endogenous cycles with periods close to, but not exactly equal to, 24 h. In mammals, circadian rhythms are generated in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as several peripheral cell types, such as fibroblasts. Protein kinases are key regulators of the circadian molecular machinery. We investigated the role of the c-Jun N-terminal kinases (JNK), which belong to the mitogen-activated protein kinases family, in the regulation of circadian rhythms. In rat-1 fibroblasts, the p46 kDa, but not the p54 kDa, isoforms of JNK expressed circadian rhythms in phosphorylation. The JNK-inhibitor SP600125 dose-dependently extended the period …

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Poetry: Chapbooks To Slams Mar 2007

Poetry: Chapbooks To Slams

News Releases

No abstract provided.

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Tandem Repeat Regions Within The Burkholderia Pseudomallei Genome And Their Application For High Resolution Genotyping, Richard A. Robison, Jana M. U'Ren, James M. Schupp, Talima Pearson, Heidie Hornstra, Christine L. Friedman Clark, Kimothy L. Smith, Rebecca R. Leadem Daugherty, Shane D. Rhoton, Ben Leadem, Shalamar Georgia, Michelle Cardon, Lynn Y. Huynh, David Deshazer, Steven P. Harvey, Daniel Gal, Mark J. Mayo, David Wagner, Bart J. Currie, Paul Keim Mar 2007

Tandem Repeat Regions Within The Burkholderia Pseudomallei Genome And Their Application For High Resolution Genotyping, Richard A. Robison, Jana M. U'Ren, James M. Schupp, Talima Pearson, Heidie Hornstra, Christine L. Friedman Clark, Kimothy L. Smith, Rebecca R. Leadem Daugherty, Shane D. Rhoton, Ben Leadem, Shalamar Georgia, Michelle Cardon, Lynn Y. Huynh, David Deshazer, Steven P. Harvey, Daniel Gal, Mark J. Mayo, David Wagner, Bart J. Currie, Paul Keim

Faculty Publications

The facultative, intracellular bacterium Burkholderia pseudomalle is the causative agent of melioidosis, a serious infectious disease of humans and animals. We identified and categorized tandem repeat arrays and their distribution throughout the genome of B. pseudomallei strain K96243 in order to develop a genetic typing method for B. pseudomallei. We then screened 104 of the potentially polymorphic loci across a diverse panel of 31 isolates including B. pseudomallei, B. mallei and B. thailandensis in order to identify loci with varying degrees of polymorphism. A subset of these tandem repeat arrays were subsequently developed into a multiple-locus VNTR analysis to examine …

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The New Hampshire, Vol. 96 [97], No. 40 (March 30, 2007), The New Hampshire Mar 2007

The New Hampshire, Vol. 96 [97], No. 40 (March 30, 2007), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 96, but it is the 97th volume in the series. This was corrected in pencil.

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Assessment Of Blood Vessel Mimics With Optical Coherence Tomography, Garret T. Bonnema, Kristen O'Halloran Cardinal, James B. Mcnally, Stuart K. Williams, Jennifer K. Barton Mar 2007

Assessment Of Blood Vessel Mimics With Optical Coherence Tomography, Garret T. Bonnema, Kristen O'Halloran Cardinal, James B. Mcnally, Stuart K. Williams, Jennifer K. Barton

Biomedical Engineering

Optical coherence tomography (OCT) is an imaging mo-dality that enables assessment of tissue structural characteristics. Studies have indicated that OCT is a useful method to assess both blood vessel morphology and the response of a vessel to a deployed stent. We evaluated the ability of OCT to visualize the cellular lining of a tissue-engineered blood vessel mimic (BVM) and the response of this lining to a bare metal stent. We develop a side-firing endoscope that obtains intraluminal, longitudinal scans within the sterile bioreactor environment, enabling time-serial assessment. Seventeen BVMs are imaged with the endoscopic OCT system. The BVMs are then …

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Restraint-Induced Corticosterone Secretion And Hypothalamic Crh Mrna Expression Are Augmented During Acute Withdrawal From Chronic Cocaine Administration, John R. Mantsch, Sarah Taves, Tayyiba Khan, Eric S. Katz, Tanveer Sajan, Lee C. Tang, William E. Cullinan, Dana R. Ziegler Mar 2007

Restraint-Induced Corticosterone Secretion And Hypothalamic Crh Mrna Expression Are Augmented During Acute Withdrawal From Chronic Cocaine Administration, John R. Mantsch, Sarah Taves, Tayyiba Khan, Eric S. Katz, Tanveer Sajan, Lee C. Tang, William E. Cullinan, Dana R. Ziegler

Biomedical Sciences Faculty Research and Publications

Stress responses during cocaine withdrawal likely contribute to drug relapse and may be intensified as a consequence of prior cocaine use. The present study examined changes in stressor-induced activation of the hypothalamic–pituitary–adrenal (HPA) axis during acute withdrawal from chronic cocaine administration. Adult male Sprague–Dawley rats received daily administration of cocaine (30 mg/kg, i.p.) or saline for 14 days. Twenty-four hours after the last injection, rats in each group were sacrificed under stress-free conditions or following 30 min of immobilization. Plasma corticosterone (CORT) was measured in trunk-blood using radioimmunoassay, corticotropin-releasing hormone (CRH) mRNA levels in the paraventricularnucleus (PVN) of the hypothalamus …

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Utilization Of Passive Acoustic Tracking To Determine Artificial Habitat Use And Movement Of Nurse Sharks, Ginglymostoma Cirratum, Michael Palozzola Mar 2007

Utilization Of Passive Acoustic Tracking To Determine Artificial Habitat Use And Movement Of Nurse Sharks, Ginglymostoma Cirratum, Michael Palozzola

Undergraduate Student Symposium

The ecological characteristics of many cryptic and evasive marine vertebrates, such as sharks, are widely unknown, largely, due to the inability to efficiently monitor and track them over extended periods of time. Recent advances in ultrasonic acoustic telemetry now allow scientists to collect data on these highly elusive predators more efficiently then ever before. Marine animals, such as the nurse shark, Ginglymostoma cirratum, have been observed at artificial reefs, such as sunken vessels, but how long they spend at or near these habitats is unknown. This research aims to determine the habitat use of the nurse shark, Ginglymostoma cirratum …

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The Synthesis Of Building Blocks For Metal-Organic Frameworks (Mof): Potential For Gaseous Fuel Storage, Richard C. Wheeler Mar 2007

The Synthesis Of Building Blocks For Metal-Organic Frameworks (Mof): Potential For Gaseous Fuel Storage, Richard C. Wheeler

Undergraduate Student Symposium

There is currently considerable interest in the use of hydrogen as an energy transport medium. While hydrogen provides clean combustion, storage and transport raises complex engineering challenges, resulting in potentially expensive design restraints. Current research indicates that transition metal complexes of mononucleating ligands, such as 1,3-bis(pyridylimino)benz(f)isoindoline (NBAII), spontaneously form uniform channels in the crystalline matrix that may be suitable for hydrogen storage. Furthermore, the alteration of the ligand substituents may yield the ability to tailor the shape and size of the crystalline channel to optimize the geometric configuration. Specifically, the x-ray crystallography of the divalent copper complex of NBAII indicates …

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The Effects Of Academic Stress On Immune Functioning, Maureen Green, Lara Murphy Mar 2007

The Effects Of Academic Stress On Immune Functioning, Maureen Green, Lara Murphy

Undergraduate Student Symposium

Stress associated with academic examinations is thought to cause immunosuppression in students. However, it is currently unclear whether the immunosupression associated with academic pressure is related to increases in the stress hormone, cortisol. Indeed, it is possible that factors independent of cortisol may control the emotional and immune response. In the current study, we were interested in untangling the complex relationship between academic stress and immunusupression through comparing both subjective and objective measures of academic stress and immune functioning. Students were assessed before, during, and after an academic examination period. During each assessment, self-reported subjective reports of stress were collected …

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Online Professional Basketball Statistics Tracker, Allen Furmanski Mar 2007

Online Professional Basketball Statistics Tracker, Allen Furmanski

Undergraduate Student Symposium

The world of professional basketball is more than just a sport – it’s a business. As with any business, the goal is to maximize productivity by continually making changes to improve efficiency. The purpose of this program is to allow the coaches of a professional basketball team to obtain optimal efficiency by providing them with the tools to monitor all aspects of their team. From determining the leaders in various categories such as 3- point field goals and steals to displaying success percentages of various offenses and defenses, the primary goal is to give the team’s coaching staff absolute control …

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Dissonant Composition: Gender Inequalities In Music, Greg Kyriakakis Mar 2007

Dissonant Composition: Gender Inequalities In Music, Greg Kyriakakis

Undergraduate Student Symposium

Gender constructions are inescapable in society; it is therefore understandable that inequities have permeated the realm of classical and popular music. From the types of instruments young children decide to study to the composition of modern rock bands, gender roles and expectations have helped shape the state of music. Women who further their study in music predominantly learn from the works of male artists, influencing the female musicians’ style while crippling personal creativity. Even the body of the performer plays a role in the type of instrument studied; female vocalists rely on their body to produce sound while male musicians …

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Attraction On The Basis Of Relationship Status, Laxmi Lalwani, Luciana Ortiz Mar 2007

Attraction On The Basis Of Relationship Status, Laxmi Lalwani, Luciana Ortiz

Undergraduate Student Symposium

Research has shown that the criteria women use to evaluate men’s attractiveness shift across the menstrual cycle (Gangestad & Thornhill, 1998). For example, when women are in the fertile phase of their cycle, they report greater attraction to men who display high intrasexual competitiveness (Gangestad, Simpson, Cousins, Garver-Apgar, & Christensen, 2004). We propose to examine female college students’ attraction to men based on the phase of their cycle and the men’s relationship status. In a between- participants design, female college students will either be told that a male confederate is single or in a relationship. We will then ask the …

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Methicillin Resistant Staphylococcus Aureus (Mrsa) Prevalence, Awareness, And Prevention In The Athletic Setting, Deirdre Foisy Mar 2007

Methicillin Resistant Staphylococcus Aureus (Mrsa) Prevalence, Awareness, And Prevention In The Athletic Setting, Deirdre Foisy

Undergraduate Student Symposium

To examine the current prevalence, awareness and prevention of Methicillin Resistant Staphylococcus aureus (MRSA) utilizing an online survey and sending it nationwide to Certified Athletic Trainers. Methicillin Resistant Staphylococcus aureus(MRSA) is an emerging resistant form of bacteria which is becoming more apparent in the athletic population. Few studies have assessed the prevalence among athletes and the efficiency of athletic trainers and sports medicine professionals with the identification of the signs and symptoms associated with MRSA; an easily transmitted form of bacteria. To assess the prevalence of MRSA among the collegiate athletic population and the efficiency of athletic trainers and sports …

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Journeys In Love, Iva Christina Marc Mar 2007

Journeys In Love, Iva Christina Marc

Undergraduate Student Symposium

The name of my film is Journeys in Love. The theme of the film details the processes we go through in the name of love. The purpose of this film is to embrace the ups and downs within a relationship and show how love continually provides the healing necessary to bring people back together. My principle cast members are Roslie Laurent and Ray D. Pollock. My crewmembers are Jonathan Marc and Roger Casanova.

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John F. Kennedy’S Inaugural Address, Marsha Mitchell Mar 2007

John F. Kennedy’S Inaugural Address, Marsha Mitchell

Undergraduate Student Symposium

John F. Kennedy’s inaugural address is one of the greatest historical speeches in American history. It was written in 1960, and is quite often quoted, utilized for declamation and evaluated publicly by many individuals. President John F. Kennedy delivered this famous speech on January 20, 1960 after being victorious in the presidential election. It was then he gave hope to the American people; and it is often considered that hope is like a river, and President Kennedy was the river that flowed at that particular time, bringing with it life and productivity to the American public. This speech is considered …

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Forearm Injury In A Female Collegiate Rower: Case Study, Priscilla Rashida Dobbs Mar 2007

Forearm Injury In A Female Collegiate Rower: Case Study, Priscilla Rashida Dobbs

Undergraduate Student Symposium

The topic of this project is to examine a forearm injury sustained by a female collegiate rower. The final diagnosis, based on MRI and X-ray testing, was Left Forearm Pain with a Grade I Flexor Carpi Ulnaris Strain, though initial signs and symptoms led the sports medicine team to suspect more serious injuries. The athlete received conservative treatment and rehabilitation exercises were initiated, aimed at restoring full strength and function. The certified athletic trainer and athletic training student observed a “mass” over the anterior forearm during the initial evaluation. The defect was more prominent with wrist and finger flexion; however, …

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Effect Of Ginkgo Biloba On Short-Term Memory, Tommy Gaertner Mar 2007

Effect Of Ginkgo Biloba On Short-Term Memory, Tommy Gaertner

Undergraduate Student Symposium

Ginkgo biloba has been used for thousands of years in traditional Chinese medicine to improve vascular and cognitive functioning. Ginkgo biloba is widely prescribed for the prevention and treatment of dementia in Europe. In addition to having a direct effect on cognitive functions of live laboratory mice, the extract of Ginkgo biloba also increases production of a neurological chemical responsible for enhancing cognitive performance. However, many scientists have pointed out these results are based upon limited research and have expressed the need for additional studies. This study will investigate short-term effects of Ginkgo biloba on healthy individuals. If Ginkgo biloba …

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Effects Of Newly Developed Anticancer Drugs Against Gi101aluc Mammary Tumor Implanted In Athymic Nude Mice, Ambreen F. Parvez, Frantz Etienne Mar 2007

Effects Of Newly Developed Anticancer Drugs Against Gi101aluc Mammary Tumor Implanted In Athymic Nude Mice, Ambreen F. Parvez, Frantz Etienne

Undergraduate Student Symposium

The purpose of this research is screening anti-cancer drugs using tumor bearing animals. To achieve this, we used a mammary tumor cell line GI-101A that was developed from a metastatic breast tumor xenograft. The GI-101A cell line had been previously transfected to express the luciferase gene (GI-101Aluc). Luciferase expression in the tumor cells enables the imaging of tumors in a molecular imager rather than performing surgery. For drug screening analysis, twenty-four athymic nude mice were implanted subcutaneously with GI-101Aluc cells. The animals were rested for 3 weeks after implantation for establishing tumor growth. During this period their weight and tumor …

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Effect Of Professional Sports On Local Economies, Jordan Smith, Wael Sankar Mar 2007

Effect Of Professional Sports On Local Economies, Jordan Smith, Wael Sankar

Undergraduate Student Symposium

In today’s world economy there are several factors affecting local economies. One major social interest is sport. Owners of major league sports teams have agreed that the buildings of new facilities are a necessity if a team is to remain financially viable, and competitive. New arenas and ball parks have sprung up around the country funded in some part by public dollars. Subsidizing stadiums is the idea of a local government taking taxes from local citizens to help to pay for the facilities. The belief that subsidizing stadiums helps in supporting other businesses in the surrounding areas, has made these …

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Analysis Of Interactions Between Candida Albicans And Staphylococcus Aaureus In Mixed Species Biofilms, Yi Jey Lin, Fabio Vogel Mar 2007

Analysis Of Interactions Between Candida Albicans And Staphylococcus Aaureus In Mixed Species Biofilms, Yi Jey Lin, Fabio Vogel

Undergraduate Student Symposium

Biofilms are multicellular communities of microorganisms that characteristically attach to some surface, produce and encase themselves within a thick polysaccharide matrix, and resist physical insults and treatment with anti-microbial drugs. To date, most biofilm studies have focused on pure biofilms consisting of a single species rather than more natural biofilms that contain multiple species of bacteria and fungi. The studies described here focus on characterizing the physical interactions between a bacterium (Staphylococcus aureus) and fungus (Candida albicans) in the context of a mixed biofilm. Both of these organisms are common human pathogens that cause a variety …

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Analysis Of Elie Wiesel’S “Perils Of Indifference”, Natasha M. Antonovich Mar 2007

Analysis Of Elie Wiesel’S “Perils Of Indifference”, Natasha M. Antonovich

Undergraduate Student Symposium

Elie Wiesel grew up in the Carpathian Mountains during the rise of Nazi Germany. As a boy he survived four concentration camps, and when he was freed, moved to France. He then began to write about his experience in the Holocaust, and from his works, became an icon of peace. In 1999, Wiesel spoke at the Millennium Lecture Series where he discussed the indifference that has plagued the world both in the past and in the current moment. This speech was analyzed using Aristotle’s Modes of Persuasion which is based on how the speaker uses ethos, pathos, and logos. It …

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Aids: An African Epidemic, Christina Bethea Mar 2007

Aids: An African Epidemic, Christina Bethea

Undergraduate Student Symposium

Every year in Africa, millions of adults and children are infected with AIDS. This disease is the number one killer in Africa, even outweighing malaria. AIDS has infected over 39 million Africans in total. Additionally, despite the fact that it holds only 10 percent of the population, 90 percent of the world’s AIDS orphans are on this continent. Obviously, this disease threatens the African life expectancy, dropping it from 66 to 33 years of age. It cuts off workers in their prime, thus affecting many of Africa’s businesses and making Sub-Saharan Africa’s GDP suffer. Unfortunately, if the African market suffers …

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The Rising Cost Of Obesity In The United States, Sarah Siddiqui, Jenet George, Yesenia Camero Mar 2007

The Rising Cost Of Obesity In The United States, Sarah Siddiqui, Jenet George, Yesenia Camero

Undergraduate Student Symposium

The purpose of this study is to determine to what extent the costs of obesity have increased over the past decade within the United States. Data implies that obesity has undergone a rapid increase among the U.S. population resulting in significant escalation of health care spending. The studies reviewed focused primarily on obesity as it relates to age, race, gender, as well as the veteran population. The research focused on the effect of obesity-related illnesses such as diabetes, dyslipidemia, and hypertension among these groups. Studies suggest that health care intervention at an early stage can have a significant impact on …

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The Role Of Chaperones In Prion Infection, Prerna Alfa Thomas Mar 2007

The Role Of Chaperones In Prion Infection, Prerna Alfa Thomas

Undergraduate Student Symposium

Prions are infectious proteins that cause neurodegenerative diseases called transmissible spongiform encephalopathy which affect several species, including humans. Chaperones are molecules that bind to the nascent peptide chain and fold the polypeptide chain into its secondary or tertiary structure. Prions affect the protein folding machinery or molecular chaperones of the cell which might lead to the formation of aggregates. The goal of this literature review is to highlight several functions of chaperones in prion infection, to draw attention that prions could be misfolded molecular chaperones, and to indicate the therapeutic applications of chaperones in prion infection.

Chaperones may perform a …

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The Ballerina In The Box, Amy Harvey Mar 2007

The Ballerina In The Box, Amy Harvey

Undergraduate Student Symposium

When read for the first time, this poem seems to be about one of those beautiful little jewelry boxes little girls receive as a gift from a loved one; the kind that have a spinning plastic ballerina in them. However, at second glance the reader might notice that it is actually about the insecurities of being alone. This poem is an allegory of an experience of its author.

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The Formation Of A New Gadolinium Dendrimer And Its Potential Use As An Mri Contrast Agent, Karoline Korah Mar 2007

The Formation Of A New Gadolinium Dendrimer And Its Potential Use As An Mri Contrast Agent, Karoline Korah

Undergraduate Student Symposium

The search for a magnetic resonance imaging (MRI) contrast agent that enhances the images of the body’s bloodstream, tissues, or organs is currently continued. There are several known gadolinium compounds that are used as MRI agents. The use of dendrimers as an MRI contrast agent is being investigated, but the recent focus on the applications of dendrimers allows much of the developments of research to be fairly new. This research project will involve creating a new gadolinium compound and studying the possibility of using it as an MRI contrast agent. In this research project, several compounds have been synthesized. This …

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The American Dream: Support The Dream Act, Myra Rafi Mar 2007

The American Dream: Support The Dream Act, Myra Rafi

Undergraduate Student Symposium

Every day, many young and eager students face barriers to obtaining a college education. They are prohibited from working, driving, and applying for the financial assistance that so many other young, soon-to-be college students can have. Unfortunately, this is the life many undocumented students lead. After graduating from high school, these students have no options for working toward the futures they have dreamt of. However, there is an option, a prospect that may help them to achieve their dreams: it is the Development Relief Education for Alien Minors Act: the DREAM Act. This bipartisan legislation was proposed by no less …

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Seeing It Through: An Overview Of Retinal Degeneration And Future Treatments, Michael Au Mar 2007

Seeing It Through: An Overview Of Retinal Degeneration And Future Treatments, Michael Au

Undergraduate Student Symposium

Degenerative retinal diseases are, to date, largely untreatable – a shortcoming born of the complexity of the nervous system and our finite understanding. Retinitis pigmentosa (a group of inherited eye disease of the retina) scuttles about the family tree relatively unchecked, slowly and silently impairing vision in 1.5 million people worldwide. Comparatively, macular degeneration, an age-related kin of retinitis pigmentosa, afflicts sufferers on a magnitude of roughly 20 diagnoses per hour within the United States alone. Such degenerative diseases almost always culminate in the death of rod and cone photoreceptor cells along with the accompanying loss of visual capacity. This …

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Synthesis Of New Ruthenium (Ii) Complex With A Long Excited State Lifetime For Its Use As A Dna Probing Biosensor, Terry-Ann Dawes Mar 2007

Synthesis Of New Ruthenium (Ii) Complex With A Long Excited State Lifetime For Its Use As A Dna Probing Biosensor, Terry-Ann Dawes

Undergraduate Student Symposium

Due to the degree of instrumentation needed for DNA diagnostic and colorimetric procedures, it has become considerably expensive for the public and independent laboratories to conduct research on genetic diseases and to probe DNA. Even though myriad technologies are available for detection and measurement of modified target molecules, cell and DNA probing techniques are involved and complex processes. Current methods of chemiluminescence by metal-ligand complexes (such as those with ruthenium) have proven to be ineffective because luminescent lifetimes are extremely short. Hence, the primary focus of this research is to synthesize novel ruthenium-ligand complexes that will have enhanced emission lifetimes. …

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Recovery Of Branching Coral In Devil’S Crown, Galapagos Islands, Following El Niño Impacts, Kristen Taylor Mar 2007

Recovery Of Branching Coral In Devil’S Crown, Galapagos Islands, Following El Niño Impacts, Kristen Taylor

Undergraduate Student Symposium

In 1982-83 a severe El Niño-Southern Oscillation (ENSO) event killed 95% of the scleractinian coral in the Galapagos Islands, Ecuador, with over 99% coral mortality reported at the study site, Devil’s Crown. Also at this site, a reef composed primarily of the branching coral Pocillopora spp. was lost from primary and secondary biological disturbances associated with ENSO. For the subsequent 11 years Pocillopora was not observed there, however 5 colonies were seen in May, 1995. The number and size of colonies was monitored from 1995-2004. Projected surface areas were determined using two methods: direct measure during snorkel surveys using a …

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