Digital Commons Network^™

Effects Of Novel Synthetic Nucleosides As Anti-Tumor Agents On Human Acute Promyelocytic Leukemia Cell Line (Hl-60), Salma Awad Merghani Mahmoud

Theses

Nucleosides and their analogs are considered a clinically proven class of therapeutic agents possessing anticancer and antiviral activity. Several trifluoromethyl-substituted pyrazole N-nucleosides (coded NIA, NIIA and NIIA) and their nucleobases were synthesized and tested for the ability to induce apoptosis in acute human promyelocytic cell line (HL-60). The growth and proliferation of HL-60 was more effectively inhibited by NIA, NIIA and their nucleobases compared to NIIIA and its nucleobase. In addition, DNA fragmentation was detected in a concentration-dependent manner as a result of nucleosides treatment. A caspase-3-dependent apoptosis was observed based on the Western blot analysis of poly-ADP-ribose polymerase (PARP) …

Expression Of Tumor Suppressor Genes During Breast Cancer Progression In The Rat, Wafa Saqer Rashid Abdullah Aldhaheri

Theses

Breast cancer is the most common type of cancer and the leading cause of cancer deaths among women in the United Arab Emirates and all over the world. Although many factors contribute to the high incidence of breast cancer, a considerable number of cases are related to environmental factors. In this study, breast cancer was induced in female rats using a single dose, 80 mg/kg body wt, of the environmental carcinogen 7,12- dimethylbenz[a]anthracene (DMBA). The aim was to characterize some of the early cellular and molecular changes that occur during breast cancer development in the DMBA-treated rat model. Mammary gland …

Effects Of Medicinal Plants On Lead Induced Toxicity Of Biotransformation And Redox Cycling Enzymes, Yusra Saif Khalfan Al Dhaheri

Theses

All organisms including humans are constantly and unavoidably exposed to foreign chemicals (xenobiotics), which include both manufactured and natural molecules such as pollutants and plant metabolites. One such alarming pollutant is lead as it is constantly produced from automobiles exhaust products and food containers. It has been documented that lead, as the major heavy metal pollutant in the air, has notable effects on nervous systems and efficiency of several enzymes.

There are some natural products such as medicinal plants that might have antagonistic effects against such pollutants. Several medicinal plants are used as traditional remedies for many ailments without knowing …

In-Use Emission Measurements Of Snowmobiles And Snowcoaches In Yellowstone National Park, Gary A. Bishop, Daniel A. Burgard, Thomas R. Dalton, Donald H. Stedman

Fuel Efficiency Automobile Test Publications

No abstract provided.

Editorial

Contemporary Aesthetics (Journal Archive)

No abstract provided.

Notices

Contemporary Aesthetics (Journal Archive)

No abstract provided.

Fact And Fiction: Writing The Difference Between Suicide And Death, John Carvalho

Contemporary Aesthetics (Journal Archive)

Did Michel Foucault die of AIDS or did he kill himself? Did he knowingly infect others in the bath houses in San Francisco or was he unaware that he was ill and of how less-than-safe sex could spread the same virus that infected him? What did he know about AIDS/HIV and what do we know about what he knew? Answers to these questions are ambiguous. This is due, in part, to the culture of homosexuality and the cultural response to AIDS/HIV at the time. It is also due to the conflicting reports about what Foucault knew, and when, in the …

A Phenomenological Aesthetic Of Cinematic 'Worlds', Christopher Yates

Contemporary Aesthetics (Journal Archive)

Contemporary film aesthetics is beset by difficulties arising from the medium itself and the bewildering itinerary of film theory. Inspired by Martin Heidegger's hermeneutical vision in "On the Origin of the Work of Art" (1935), my essay seeks to overcome this paralysis by grounding the aesthetic value of cinematic art in its ability to "disclose the world" through a convergence of artist and viewer intentionalities. Stanley Cavell has gone far by exploring a corresponding "natural relation" between philosophy and cinema, but his work assumes an ontological discourse without an appropriate phenomenological method. I contend that Mikel Dufrenne's phenomenology of aesthetic …

Reflections On An Aesthetics Of Touch, Smell And Taste, Mădălina Diaconu

Contemporary Aesthetics (Journal Archive)

Modern aesthetics regards sight and hearing as the only senses which were able to produce art. Touch, smell and taste might offer pleasant stimuli, but can never achieve the status of art objects. What are the arguments for this rejection, and are they still sustainable? This paper focuses on the general and specific difficulties of forming an aesthetics of touch, smell and taste; some can be overcome, while others are still waiting for a proper answer. At the same time, artistic movements, as well as changes in recent discussions of the aesthetics of everyday life prove the necessity of extending …

Paradoxes And Puzzles: Appreciating Gardens And Urban Nature, Stephanie Ross

Contemporary Aesthetics (Journal Archive)

To explore our appreciation of gardens and urban nature, I propose a recursive definition of original or wild nature together with guidelines for discerning degrees of naturalness. Arguing (contra Robert Elliott) that nature can be restored as well as degraded, I characterize four varieties of urban nature - interrupted, altered, constructed, and virtual. I build on Stan Godlovitch's comments about scale to suggest two modes of appreciation - macroscopic and fine-focused. I close by discussing some particular examples - parks, environmental art, gardens - and drawing some conclusions for the appreciation of vernacular gardens.[1]

Wittgenstein And Haydn On Understanding Music, Yael Kaduri

Contemporary Aesthetics (Journal Archive)

Wittgenstein's remarks about music have motivated philosophers to build a comprehensive picture of his philosophy of music, concentrating on the central issues of musical meaning. It is often claimed that, according to Wittgenstein, understanding music consist in grasping the internal relationships between musical events. Musical practice, however, is naturally saturated with what philosophers often call extra-musical meanings. The present study, by considering a musical issue in Haydn's instrumental music, attempts to show that musical language games in the Wittgensteinian sense involve explanations of music that enhance the listener's ability to understand music by broadening his musical competence. Nevertheless, constituting understanding …

Realism And The Riddle Of Style, Catharine Abell

Contemporary Aesthetics (Journal Archive)

No abstract provided.

Symposium On Pictorial Realism

Contemporary Aesthetics (Journal Archive)

No abstract provided.

Depiction And The Sense Of Reality, John Armstrong

Contemporary Aesthetics (Journal Archive)

No abstract provided.

The Perceptual Constraints On Pictorial Realism, Jennifer Mcmahon

Contemporary Aesthetics (Journal Archive)

No abstract provided.

Development Of Electroanalytical Methods For The Determination Of Sialic Acid As A Biomarker For Cancer, Khawla Ali Rashid Al-Tayyari

Theses

Sialic acid (SA) is a general term for a family composed of 43 derivatives of neuraminic acid. Whereas N-acetylneuraminic acid (NANA) is the most commonly occurring sialic acid in human. There has been a great interest in the determination of SA in humans because variations in SA level was linked to different medical conditions and diseases. In particular, serum SA are elevated in several types of cancers. SA also exists in Erythropoietin (EPO), a hormone, which induces the production of red blood cells and hence used in the treatment of anemia.

Although of the great physiological significance of SA …

Assessment Of The Effectiveness Of Available Pollution Control Technologies In Reducing Phenol Level At Enoc Refinery Wastewater Treatment Plant, Waddah Shihab Ghanim Al Hashemi

Theses

Phenols are present in discharge effluents of many heavy industries such as refineries. They are regulated and monitored by environmental authorities. Emirates National Oil Company (ENOC) processes condensate oil and produces wastewater that is treated at the ENOC Processing Company's (EPCL-refinery) wastewater treatment plant (ETP) through the use of physical, chemical and biological treatment processes. This study provides an in-depth description of the unit processes employed to treat the different waste streams generated at the EPCL refinery and identifies the different types of phenols which are formulated in the processes. Characterization of phenol level at EPCL-ETP and assessment of the …

A Study Of Factors Influencing The Occurrence Of Algae Bloom (Hab) Along The Abu Dhabi Coast, Uae., Buthaina Salem Saeed Al Qubaisi

Theses

During last few years, the frequency of Harmful Algal Bloom (HAB) has increased worldwide. The occurrence of HAB in the Gulf region has only recently been recorded in the United Arab Emirates (UAE). Specifically, these occurrences have not been thoroughly investigated. This phenomena, was found to be associated with the increase in nutrient load, depletion of oxygen and a significant decrease in fish populations that is caused by a bloom of a certain phytoplankton species, results in economic and social problems. Therefore, the Environment Agency-Abu Dhabi (EAD) has decided to conduct a study on different aspects of this phenomenon of …

Fabrication Of Array Microstructures By Localized Electro-Deposition, Nidal Khalaf Alshwawreh

Theses

Localized Electro-Deposition (LED) is now highly receiving scientists and researchers attention for its advantages over conventional fabrication techniques. These advantages include simplicity of the setup thus reducing the overall fabrication cost, capability of producing 2D and 3D high aspect ratio microstructures and its ability to fabricate microstructures from various raw materials. Efforts now are taking place in order to standardize the fabrication by LED to develop a commercial setup that is capable of producing complex microstructures which, in tum, can be integrated in different applications including microelectronics, microelectrochemical systems (MEMS) and sensors applications. The standardization process is performed by studying …

Date Palm (Phoenix Dactylifera L.) Tissue Culture: Type Of Contamination And Improvement Of Disinfestation Techniques, Mouza Nasser Al-Shamisi

Theses

Date palm (Phoenix dactylifera L.) cultivation in the United Arab Emirates (UAE) is considered one of the most important economic supports for the agricultural sector. Propagation of date palm by offshoots cannot satisfy the increasing demand of date palm trees, and high propagation rate can only be achieved using tissue culture techniques. However, one of the major problems of this technique is the failure of producing aseptic cultures, yielding to the loss of the explants at the initiation phase.

The objectives of this study were to develop a reliable disinfection technique of date palm explants at the initiation …