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Articles 871 - 900 of 12893
Full-Text Articles in Entire DC Network
Central Florida Future, Vol. 39 No. 36, November 15, 2006
Central Florida Future, Vol. 39 No. 36, November 15, 2006
Central Florida Future
No abstract provided.
Multiple Domains In Siz Sumo Ligases Contribute To Substrate Selectivity., Alison Reindle, Irina Belichenko, Gwendolyn R Bylebyl, Xiaole L Chen, Nishant Gandhi, Erica S Johnson
Multiple Domains In Siz Sumo Ligases Contribute To Substrate Selectivity., Alison Reindle, Irina Belichenko, Gwendolyn R Bylebyl, Xiaole L Chen, Nishant Gandhi, Erica S Johnson
Department of Biochemistry and Molecular Biology Faculty Papers
Saccharomyces cerevisiae contains two Siz/PIAS SUMO E3 ligases, Siz1 and Siz2/Nfi1, and one other known ligase, Mms21. Although ubiquitin ligases are highly substrate-specific, the degree to which SUMO ligases target distinct sets of substrates is unknown. Here we show that although Siz1 and Siz2 each have unique substrates in vivo, sumoylation of many substrates can be stimulated by either protein. Furthermore, in the absence of both Siz proteins, many of the same substrates are still sumoylated at low levels. Some of this residual sumoylation depends on MMS21. Siz1 targets its unique substrates through at least two distinct domains. Sumoylation of …
Proteomic Identification Of In Vivo Substrates For Matrix Metalloproteinases 2 And 9 Reveals A Mechanism For Resolution Of Inflammation, Kendra J Greenlee, David B Corry, David A Engler, Risë K Matsunami, Philippe Tessier, Richard G Cook, Zena Werb, Farrah Kheradmand
Proteomic Identification Of In Vivo Substrates For Matrix Metalloproteinases 2 And 9 Reveals A Mechanism For Resolution Of Inflammation, Kendra J Greenlee, David B Corry, David A Engler, Risë K Matsunami, Philippe Tessier, Richard G Cook, Zena Werb, Farrah Kheradmand
Faculty, Staff and Student Publications
Clearance of allergic inflammatory cells from the lung through matrix metalloproteinases (MMPs) is necessary to prevent lethal asphyxiation, but mechanistic insight into this essential homeostatic process is lacking. In this study, we have used a proteomics approach to determine how MMPs promote egression of lung inflammatory cells through the airway. MMP2- and MMP9-dependent cleavage of individual Th2 chemokines modulated their chemotactic activity; however, the net effect of complementing bronchoalveolar lavage fluid of allergen-challenged MMP2(-/-)/MMP9(-/-) mice with active MMP2 and MMP9 was to markedly enhance its overall chemotactic activity. In the bronchoalveolar fluid of MMP2(-/-)/MMP9(-/-) allergic mice, we identified several chemotactic …
11-14-2006 Swim Moving To Weekday At Swosu, Southwestern Oklahoma State University
11-14-2006 Swim Moving To Weekday At Swosu, Southwestern Oklahoma State University
THE BARK ARCHIVE 2006
Southwestern Oklahoma State University’s interscholastic meet, which is Oklahoma’s longest-running academic contest, will be held on a new day of the week starting in 2007 on the Weatherford campus.
Chemistry Multiple Course Revisions Form 11/14/2006, Curriculum Committee
Chemistry Multiple Course Revisions Form 11/14/2006, Curriculum Committee
Curriculum Committee Reports
No abstract provided.
The Bates Student - Volume 136 Number 08 - November 14, 2006, Bates College
The Bates Student - Volume 136 Number 08 - November 14, 2006, Bates College
The Bates Student
No abstract provided.
11-14-06 (The Liberty Champion, Volume 24, Issue 10)
11-14-06 (The Liberty Champion, Volume 24, Issue 10)
2006 -- 2007
No abstract provided.
Volume 44, Number 25: November 14, 2006, University Of North Dakota
Volume 44, Number 25: November 14, 2006, University Of North Dakota
University Letter Archive
No abstract provided.
Biol1111 Course Proposal, Curriculum Committee
Biol1111 Course Proposal, Curriculum Committee
Curriculum Committee Reports
No abstract provided.
Mustang Daily, November 14, 2006
Mustang Daily, November 14, 2006
Cal Poly Student Newspaper
Student newspaper of California Polytechnic State University, San Luis Obispo, CA.
Capillary Electrophoresis Of Proteins With Selective On-Line Affinity Monoliths, Jenny Marcela Armenta Blanco
Capillary Electrophoresis Of Proteins With Selective On-Line Affinity Monoliths, Jenny Marcela Armenta Blanco
Theses and Dissertations
The analysis of proteins in biological fluids by capillary electrophoresis (CE) is of interest in clinical chemistry. However, due to low analyte concentrations and poor concentration limits of detection (CLOD), protein analysis by this technique is frequently challenging. Coupling preconcentration techniques with CE greatly improves the CLOD. An on-line preconcentration-CE method that can selectively preconcentrate any protein for which an antibody is available would be very useful for the analysis of low abundance proteins and would establish CE as a major tool in biomarker discovery. To accomplish this, an on-line protein G monolithic preconcentrator CE system for enrichment and separation …
The Daily Egyptian, November 14, 2006, Daily Egyptian Staff
The Daily Egyptian, November 14, 2006, Daily Egyptian Staff
November 2006
No abstract provided.
Use Of Xenopus Laevis Oocytes A Microincubators, Sergei Paylian
Use Of Xenopus Laevis Oocytes A Microincubators, Sergei Paylian
USF Patents
The present invention concerns methods for de-differentiation and stabilize cells, such as progenitor cells, by introducing the cells into the cytoplasm of host oocytes, such as Xenopus laevis oocytes. Advantageously, this method obviates the need for any nuclear transfer procedure, which is known to disrupt the chromosomal architecture of donor and recipient cells. The present invention also concerns host oocytes encapsulating cells that have been introduced into their cytoplasm. The present invention also concerns cells that have been removed from the host oocytes.
Rhob As A Suppressor Of Cancer Cell Growth, Cell Transformation, And Metastasis, Said M. Sebti
Rhob As A Suppressor Of Cancer Cell Growth, Cell Transformation, And Metastasis, Said M. Sebti
USF Patents
The present invention concerns the use of the protein RhoB and its variants to inhibit cancer cell growth, migration, invasion, metastasis, malignant cell transformation, and/or to modulate oncogenic signaling, wherein introducing RhoB directly, or indirectly via a nucleic acid sequence encoding RhoB, into a malignantly transformed cell or a cancerous cell decreases phosphorylation of Erk and Akt proteins inhibiting the PI3-kinase/Akt cell survival pathway and promoting apoptotic cell death. In one aspect, the compositions and methods of the present invention are used to inhibit the malignant transformation of cells by the oncogenes H-Ras, N-Ras, K-Ras, EGFR, or ErbB2, or to …
Genetic Engineering Of Plant Chloroplasts, Henry Daniell, Bruce Mcfadden
Genetic Engineering Of Plant Chloroplasts, Henry Daniell, Bruce Mcfadden
UCF Patents
Novel chimeric constructions and methods for their use are provided for expression of exogenous genes in a plant chloroplast. Particularly, expression is achieved by the use of a chloroplast or bacterial 5' untranslated region in the expression cassette. The expression cassette may be integrated into the chloroplast genome by the use of chloroplast DNA flanking sequences, or may replicate autonomously if provided with a chloroplast origin of replication. Plants and cells containing the transformed chloroplasts are also provided. The constructs may be used with both monocotyledenous and dicotyledenous chloroplasts.
The Hilltop 11-14-2006, Hilltop Staff
The Bg News November 14, 2006, Bowling Green State University
The Bg News November 14, 2006, Bowling Green State University
BG News (Student Newspaper)
The BGSU campus student newspaper. November 14, 2006. Volume 97-Issue 59.
Model Ford, Gleaves Whitney
Montana Kaimin, November 14, 2006, Students Of The University Of Montana, Missoula
Montana Kaimin, November 14, 2006, Students Of The University Of Montana, Missoula
Montana Kaimin, 1898-present
Student newspaper of the University of Montana, Missoula. Pages 3-5, and 7 are missing.
Insights Into Transcription Enhancer Factor 1 (Tef-1) Activity From The Solution Structure Of The Tea Domain, Asokan Anbanandam, Diana C Albarado, Catherine T Nguyen, Georg Halder, Xiaolian Gao, Sudha Veeraraghavan
Insights Into Transcription Enhancer Factor 1 (Tef-1) Activity From The Solution Structure Of The Tea Domain, Asokan Anbanandam, Diana C Albarado, Catherine T Nguyen, Georg Halder, Xiaolian Gao, Sudha Veeraraghavan
Faculty, Staff and Student Publications
Transcription enhancer factor 1 is essential for cardiac, skeletal, and smooth muscle development and uses its N-terminal TEA domain (TEAD) to bind M-CAT elements. Here, we present the first structure of TEAD and show that it is a three-helix bundle with a homeodomain fold. Structural data reveal how TEAD binds DNA. Using structure-function correlations, we find that the L1 loop is essential for cooperative loading of TEAD molecules on to tandemly duplicated M-CAT sites. Furthermore, using a microarray chip-based assay, we establish that known binding sites of the full-length protein are only a subset of DNA elements recognized by TEAD. …
Adolescent Mothers: Youth In Need Of Developmentally Appropriate Services, Patricia Arlyne Zimmerman
Adolescent Mothers: Youth In Need Of Developmentally Appropriate Services, Patricia Arlyne Zimmerman
Dissertations and Theses
This research examines the childhood abuse and maltreatment experiences of adolescent mothers (age 14 to 17) to investigate if these experiences have hindered their socioemotional development and consequently, their parenting behaviors and attitudes. Data were gathered using four standardized self-report instruments: the Child Trauma Questionnaire (CTQ), the Trauma Symptom Checklist for Children (TSCC), the BarOn Emotional Quotient Inventory-Youth Version (EQi-YV), and the Adult Adolescent Parenting Inventory (AAPI-2). Two additional questionnaires were developed to gather demographic and social service information to add to the knowledge base of the field, and to examine what (if any) developmentally focused services young mothers may …
Intellectual Property And Competition – Human Economic Universals, Wolfgang Fikentscher
Intellectual Property And Competition – Human Economic Universals, Wolfgang Fikentscher
The Gruter Institute Working Papers on Law, Economics, and Evolutionary Biology
My contribution to this workshop is an approach to answering the question whether property, in particular intellectual property, and competition for the acquisition of such property, are innate building blocks of human behavior “deep in our brain” and inherited characteristics of our human nature, or whether they are cultural attitudes and abilities which we have to learn because we are not born with it. In the first case we would call them human universals, in the second cultural specificities. Also, a way has to be shown how we can know the one or the other.
Trust, Paul Joseph Zak
Trust, Paul Joseph Zak
The Gruter Institute Working Papers on Law, Economics, and Evolutionary Biology
Trust pervades every aspect of our daily lives, from business transactions to dealings with loved-ones, yet why we trust others in some instances but not others is little understood. At an aggregate level, surveys of trustworthiness show enormous differences across countries, from 3% in Brazil to 65% in Norway. This article reports on new research that has characterized the legal, social, economic, and environmental factors that cause trust to be high or low. It also reports on laboratory experiments that demonstrate that trust has a neurophysiological basis. This research shows that low trust is a fundamental cause of poverty, but …
Grand Valley Forum, Volume 031, Number 16, November 13, 2006, Grand Valley State University
Grand Valley Forum, Volume 031, Number 16, November 13, 2006, Grand Valley State University
2006-2007, Volume 31
Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.
Peters, Ann, Betty Schmoll, And Nancy Janssens Interview For The Miami Valley College Of Nursing And Health Oral History Project, Donna M. Curry, Carol Holdcraft, Ann Peters, Betty Schmoll, Nancy Janssens
Peters, Ann, Betty Schmoll, And Nancy Janssens Interview For The Miami Valley College Of Nursing And Health Oral History Project, Donna M. Curry, Carol Holdcraft, Ann Peters, Betty Schmoll, Nancy Janssens
Wright State University - Miami Valley College of Nursing and Health Oral History Project
Donna Miles Curry and Carol Holdcraft interviewed Ann Peters, Betty Schmoll, and Nancy Janssens in the first group interview for the oral history project on November 13, 2006. In this interview they discussed the struggles and hurdles they faced while applying and beginning their nursing school in addition to their careers.
Spartan Daily, November 13, 2006, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, November 13, 2006, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily (School of Journalism and Mass Communications)
Volume 127, Issue 44
Soluble Amyloid Oligomers Increase Bilayer Conductance By Altering Dielectric Structure, Yuri Sokolov, J. Ashot Kozak, Rakez Kayed, Alexandr Chanturiya, Charles G. Glabe, James E. Hall
Soluble Amyloid Oligomers Increase Bilayer Conductance By Altering Dielectric Structure, Yuri Sokolov, J. Ashot Kozak, Rakez Kayed, Alexandr Chanturiya, Charles G. Glabe, James E. Hall
Neuroscience, Cell Biology & Physiology Faculty Publications
The amyloid hypothesis of Alzheimer's toxicity has undergone a resurgence with increasing evidence that it is not amyloid fibrils but a smaller oligomeric species that produces the deleterious results. In this paper we address the mechanism of this toxicity. Only oligomers increase the conductance of lipid bilayers and patch-clamped mammalian cells, producing almost identical current-voltage curves in both preparations. Oligomers increase the conductance of the bare bilayer, the cation conductance induced by nonactin, and the anion conductance induced by tetraphenyl borate. Negative charge reduces the sensitivity of the membrane to amyloid, but cholesterol has little effect. In contrast, the area …
November 13, 2006, James Madison University
November 13, 2006, James Madison University
The Breeze, 2000-2009
The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.
The Daily Gamecock, Monday, November 13, 2006, University Of South Carolina, Office Of Student Media
The Daily Gamecock, Monday, November 13, 2006, University Of South Carolina, Office Of Student Media
November
No abstract provided.
The Collegian (2006-11-13), Isis Lopez
The Collegian (2006-11-13), Isis Lopez
UTB/TSC Archives - The Collegian [Newspaper]
Vol. 59, No. 13