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2006

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Enhancing The Senses: How Technological Advances Shape Our View Of The Law, Steven Goldberg Jan 2006

Enhancing The Senses: How Technological Advances Shape Our View Of The Law, Steven Goldberg

Georgetown Law Faculty Lectures and Appearances

This memorial lecture was given at West Virginia University, which houses, among other relevant programs, the Biometric Knowledge Center. The lecture surveys the application of a variety of legal topics to biometrics. Covered areas include basic research funding choices, freedom of speech, association and religion, search and seizure, and informational privacy.

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Intensified And Protective Cd4+ T Cell Immunity In Mice With Anti-Dendritic Cell Hiv Gag Fusion Antibody Vaccine, Christine Trumpfheller, Jennifer S. Finke, Carolina B. López Jan 2006

Intensified And Protective Cd4+ T Cell Immunity In Mice With Anti-Dendritic Cell Hiv Gag Fusion Antibody Vaccine, Christine Trumpfheller, Jennifer S. Finke, Carolina B. López

Publications

Current human immunodeficiency virus (HIV) vaccine approaches emphasize prime boost strategies comprising multiple doses of DNA vaccine and recombinant viral vectors. We are developing a protein-based approach that directly harnesses principles for generating T cell immunity. Vaccine is delivered to maturing dendritic cells in lymphoid tissue by engineering protein antigen into an antibody to DEC-205, a receptor for antigen presentation. Here we characterize the CD4+ T cell immune response to HIV gag and compare efficacy with other vaccine strategies in a single dose. DEC-205-targeted HIV gag p24 or p41 induces stronger CD4+ T cell immunity relative to high …

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Review Of Giorgio Agamben, The Open: Man And Animal, Trans. Kevin Attell., Anat Pick Jan 2006

Review Of Giorgio Agamben, The Open: Man And Animal, Trans. Kevin Attell., Anat Pick

Bryn Mawr Review of Comparative Literature

Giorgio Agamben, The Open: Man and Animal, trans. Kevin Attell. Stanford: Stanford University Press, 2004. 120 pp. ISBN 0804747377.

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Richard Lifton, 2005, The Rockefeller University Jan 2006

Richard Lifton, 2005, The Rockefeller University

Harvey Society Lectures

Richard P. Lifton. Genetic dissection of human blood pressure variation: common pathways for rare phenotypes

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Aquilegia, Vol. 30 No. 2, April-May 2006: Newsletter Of The Colorado Native Plant Society, Alice Guthrie, Steve Yarbrough, Ken Keefover-Ring Jan 2006

Aquilegia, Vol. 30 No. 2, April-May 2006: Newsletter Of The Colorado Native Plant Society, Alice Guthrie, Steve Yarbrough, Ken Keefover-Ring

Aquilegia - Colorado Native Plant Society

No abstract provided.

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Aquilegia, Vol. 30 No. 5, November-December 2006, Newsletter Of The Colorado Native Plant Society, Kim Regier, Doris Drissgill, David Anderson, Jan Loechell Turner, Carolyn Crawford, Lynn M. Moore, Jan Wingate, Andy Kratz, Bill Weber Jan 2006

Aquilegia, Vol. 30 No. 5, November-December 2006, Newsletter Of The Colorado Native Plant Society, Kim Regier, Doris Drissgill, David Anderson, Jan Loechell Turner, Carolyn Crawford, Lynn M. Moore, Jan Wingate, Andy Kratz, Bill Weber

Aquilegia - Colorado Native Plant Society

No abstract provided.

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Developing An Inquiry-Based Physical Science Course For Preservice Elementary Teachers, Zdeslav Hrepic Jan 2006

Developing An Inquiry-Based Physical Science Course For Preservice Elementary Teachers, Zdeslav Hrepic

Faculty Bibliography

Preservice elementary teachers should experience science through inquiry in order to be effective in teaching science. In addition, inquiry as a mode of teaching is mandated by Kansas and National Science Education Standards. As a result of the No Child Left Behind Act, teachers also need to be prepared to include basic skills in reading and mathematics in all instruction. To address these issues, Fort Hays State University (FHSU) is adapting and extending the NSF-developed teacher enhancement materials Operation Primary Physical Science (OPPS) for use in a physical science course for preservice elementary teachers. This paper presents main features of …

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Chmp1 Is Implicated In The Development Of Pancreatic Tumor Via The Retinoic Acid Signaling Pathway, Juliana Adedayo Akinsete Jan 2006

Chmp1 Is Implicated In The Development Of Pancreatic Tumor Via The Retinoic Acid Signaling Pathway, Juliana Adedayo Akinsete

Theses, Dissertations and Capstones

In the present study, we investigated the involvement of Chmp1 (Chromatin ModifyingProtein 1/Charged Multivesicular body Protein 1) in the development of mousepancreatic acinar tumor cell line. CRL 2151 cell line was transfected with Chmp1/CS2vector to compare growth, morphology and expression of Chmp1, p53 and pp53 (ser37) with control-transfected cells. CRL 2151 cells were treated with all-trans retinoicacid (ATRA) to compare growth, morphology and expression of Chmp1 and p53 withcontrol-treated cells. Strabismus was used as control. Results showed inhibition ofgrowth but no morphological change in transfected cells. Western blot analysis showedthat Chmp1 transfection upregulated the expression of p53, pp53 and Stbm …

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The Effects Of Static Stretching On Vertical Jump Performance, Tom Evans Jan 2006

The Effects Of Static Stretching On Vertical Jump Performance, Tom Evans

Theses, Dissertations and Capstones

The vertical jump can play a significant role for many athletes in various competitive sports. The purpose of this study was to determine the effect that passive static stretching has on various athletes from various sports. The athletes were asked to perform a certain amount of jumps with no stretching routine and a set of jumps with a stretching routine. The results calculated for this study did show to have a statistically significant difference between jumping with stretching and jumping without stretching.

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Spectroscopic And Thermodynamic Analysis Of Co Rebinding And Photodissociation From Fe (Ii) Lpo, Dustin Michael Lockney Jan 2006

Spectroscopic And Thermodynamic Analysis Of Co Rebinding And Photodissociation From Fe (Ii) Lpo, Dustin Michael Lockney

Theses, Dissertations and Capstones

Lactoperoxidase (LPO) is a heme peroxidase found in tears, milk, saliva, and cervical fluids that has bactericidal activity. The bactericidal nature of LPO is due to its ability to oxidize halides and pseudohalides in the presence of H2O2. Full understanding of the catalytic cycle of LPO requires detailed characterization of the mechanism of ligand binding to the enzyme active site. This includes a dynamic and energetic description of conformational changes associated with heme-ligand interactions. Photoacoustic calorimetry is applied to determine the kinetics and magnitude of reaction volume and enthalpy changes for CO dissociation from CO-LPO. Time-resolved absorption spectroscopy was used …

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Thinking Style Differences Of Female College And University Presidents: A National Study, Melanie S. Jones Jan 2006

Thinking Style Differences Of Female College And University Presidents: A National Study, Melanie S. Jones

Theses, Dissertations and Capstones

The purpose of this study was to identify thinking style preferences of female college and university presidents and determine if differences in thinking style exist with regard to the independent variables of Carnegie classification, institutional control, highest academic degree earned, academic background/specialty, age, and total years of presidential experience. The Inquiry Mode Questionnaire (InQ) and a demographic data form were distributed to all 595 female presidents with institutions classified as Associate’s or higher by the Carnegie system. Responses were received from 369 (62.02%), with 328 (55.13%) utilized for data analysis. Descriptive statistics, MANOVA and ANOVA tests were used to address …

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A Comparison Of The Effect Of Single-Sex Versus Mixed-Sex Classes On Middle School Student Achievement, Carol E. Thom Jan 2006

A Comparison Of The Effect Of Single-Sex Versus Mixed-Sex Classes On Middle School Student Achievement, Carol E. Thom

Theses, Dissertations and Capstones

The purpose of this study was to compare the effect of single-sex versus mixedsex classes on middle school student achievement. It was a case study of Stonewall Jackson Middle School in Charleston, West Virginia, an inner-city school with approximately 600 students, of which 30% were minority (mostly black), 30% were special needs, and 70% were classified low socio-economic status (SES). Student WESTEST (West Virginia Educational Standards Test) scores in reading/language arts and math were collected and compared from the school years 2003-2004 and 2004-2005. Each student’s scores from the first year were compared to that same student’s scores from the …

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The Zucker Rat As A Model Of Obesity-Hypertension, Ryan Morrison Jan 2006

The Zucker Rat As A Model Of Obesity-Hypertension, Ryan Morrison

Theses, Dissertations and Capstones

Hypertension is a serious health problem that affects approximately 1 in 4 American adults. Most cases are diagnosed as essential hypertension, meaning that the exact cause is unknown. In most patients, however, excess weight is a major contributory factor to the development of essential hypertension. The role of obesity in promoting hypertension is now well documented and has become the foundation for an entire field of research known alternately as obesity-hypertension, obesity-induced hypertension, or obesity-associated hypertension. In this field, rapid advances are being made in our understanding of how obesity and hypertension are linked. A plethora of related risk factors, …

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A Mechanistic Study Of The Protective Effects Of S-Adenosyl-L-Methionine Against Hepatotoxicity Of Acetaminophen, Marcus V. Terneus Jr. Jan 2006

A Mechanistic Study Of The Protective Effects Of S-Adenosyl-L-Methionine Against Hepatotoxicity Of Acetaminophen, Marcus V. Terneus Jr.

Theses, Dissertations and Capstones

Hepatic toxicity is known to be associated with excessive doses of the over-the-counter analgesic, acetaminophen (APAP). APAP overdose is the leading cause of drug-induced liver failure in the United States. APAP hepatotoxicity is dependent on the biotransformation of APAP by cytochrome P450 to the toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI). APAP, when taken in excessive doses, can lead to severe liver damage with the potential to progress to liver failure. Despite substantial efforts in past studies, the mechanism by which APAP induces such damaging effects is not completely understood. Recent discoveries suggest that glutathione (GSH) depletion, protein alkylation and reactive metabolite …

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Occurrence And Distribution Of Multi-Antibiotic Resistant Bacteria From The Great Kanawha River, West Virginia, April Dawn Keenan Jan 2006

Occurrence And Distribution Of Multi-Antibiotic Resistant Bacteria From The Great Kanawha River, West Virginia, April Dawn Keenan

Theses, Dissertations and Capstones

During the spring and summer of 2004 subsurface mid-channel samples were collected from the Kanawha River and its five primary tributaries (New, Gauley, Elk, Coal and Pocatalico Rivers). The first two objectives of this study were to enumerate bacteria resistant to ciprofloxacin, erythromycin or tetracycline, and test them for multiple resistance to seven commonly used antibiotics. The third objective was to determine the Minimum Inhibitory Concentration (MIC) for seven antibiotics starting at concentrations 20 times the published working concentrations for Gram-negative bacteria. The final objective of this study was to determine if a novel Impact Scoring system incorporating a current …

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Socialization And Attitudes: Effects Of Religion, Political Identification, And Class, 1972-2002, Melissa Kimmel Jan 2006

Socialization And Attitudes: Effects Of Religion, Political Identification, And Class, 1972-2002, Melissa Kimmel

Theses, Dissertations and Capstones

This study analyzes the effects on culture wars attitudes of socialization into religion, political identification, and class on culture war type attitudes. Stepwise OLS and Logistic regression models were used to determine which of the three social institutions would have greatest impact on the attitudes: abortion for reasons beyond one’s control, abortion for willful reasons, capital punishment, prayer in schools, interracial marriage, teaching sex education in schools, homosexuality, premarital sex and extramarital sex. The findings support the theory that religion is the primary social institution involved in the development of culture war attitudes.

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Natural History And Distribution Of The Upland Chorus Frog, Pseudacris Feriarum Baird, In West Virginia, Jaime Sias Jan 2006

Natural History And Distribution Of The Upland Chorus Frog, Pseudacris Feriarum Baird, In West Virginia, Jaime Sias

Theses, Dissertations and Capstones

Chapter 1 is a literature review of Pseudacris feriarum, largely based on published P. triseriata Complex species accounts. Chapter 2 presents the natural history of P. feriarum in West Virginia and compares some parameters with other Pseudacris species. Chapter 3 looks at the phenology of a wetland in eastern West Virginia. Chapter 4 examines the current range of P. feriarum and compares it with the historical range in the state. Finally, hypotheses are given as to why Upland Chorus Frogs have declined in West Virginia. All information obtained from this study should be used to create a management plan for …

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Christina Rossetti, Sarah Grand, And The Expression Of Sexual Liminality In Nineteenth Century Literature, Jennifer Persinger Adams Jan 2006

Christina Rossetti, Sarah Grand, And The Expression Of Sexual Liminality In Nineteenth Century Literature, Jennifer Persinger Adams

Theses, Dissertations and Capstones

This study defines sexual liminality as a transient, threshold moment in which textual characters explore not only their sexual desires, but also their gender identities. During the nineteenth century, social critics reveal that sexuality and gender play a vital role in laws, social practices, and family structure. Thus, when authors such as Christina Rossetti and Sarah Grand produce characters that embark upon introspective journeys of their sexualities against the background of social expectation, one clearly identifies the influence of life upon art. Rossetti’s Prince in The Prince’s Progress and Grand’s Angelica in The Heavenly Twins enter into the realm of …

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Protein Kinase C Activity In Mouse Eggs Regulates Gamete Membrane Interaction, Hiroto Akabane Jan 2006

Protein Kinase C Activity In Mouse Eggs Regulates Gamete Membrane Interaction, Hiroto Akabane

Theses, Dissertations and Capstones

Every mammalian life develops from one cell after fertilization of an egg by the sperm. The molecular pathways governing this event are still poorly understood. Numerous reports indicate that mammalian eggs highly express various protein kinase C (PKC) isoforms. Accordingly, we hypothesize that PKC activity in the egg plays an important role during egg-sperm membrane binding and fusion. In this study, we tested our hypothesis in mouse gametes using two types of PKC inhibitors (calphostin c and staurosporine) and the typical PKC activator, phorbol ester 12-tetradecanoylphorbol-13 acetate (PMA). After treatment with the individual drug, eggs were inseminated with sperm. The …

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The Natural History And Thermal Ecology Of A Population Of Spotted Turtles (Clemmys Guttata) And Wood Turtles (Glyptemys Insculpta) In West Virginia, Ariana N. Breisch Jan 2006

The Natural History And Thermal Ecology Of A Population Of Spotted Turtles (Clemmys Guttata) And Wood Turtles (Glyptemys Insculpta) In West Virginia, Ariana N. Breisch

Theses, Dissertations and Capstones

An ecological study was conducted from 19 March 2001 to 2 April 2003 on a population of Spotted Turtles (Clemmys guttata) and Wood Turtles (Glyptemys insculpta) in West Virginia. Live-trapping, mark-recapture, radio telemetry and temperature data logging techniques were used to gather information on morphometrics, capture success, movements, home range, behavior, and thermal regime during activity and over-wintering seasons. Twenty-one Spotted Turtles were captured 260 times. Population structure was 42.9% juvenile, 38.1% male, and 19.0% female. Mean home range was 0.52 ha. Fifty Wood Turtles were captured 230 times. Juveniles were 36%, and males and females were 32% each. Mean …

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Scanning Probe Microscopy And Oxidation Of Silicon At Breakdown Voltages, Thabo Gcwabaza Jan 2006

Scanning Probe Microscopy And Oxidation Of Silicon At Breakdown Voltages, Thabo Gcwabaza

Theses, Dissertations and Capstones

The growing importance of Scanning Probe Microscopy (SPM) as a tool for nanofabrication is opening many avenues in lithography nano-science. One type of Scanning Probe Lithography involves electrochemistry at the tip/substrate interface. Atomic Force Microscopy (AFM) with conductive tips and substrates was used in our study to both pattern and image those patterns on silicon substrates. Our long-term objective is to design and fabricate micron-scale patterns of nanometer sized spots on silicon chips that can serve as attachment sites for DNA based nano-arrays. In order to fabricate such substrates a study of the underlying electrochemistry was required. A most promising …

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The Effect Of Substance P On Ovariectomy-Induced Memory Deficits In Rats, Jamie L. Haga Jan 2006

The Effect Of Substance P On Ovariectomy-Induced Memory Deficits In Rats, Jamie L. Haga

Theses, Dissertations and Capstones

The present experiment was designed to test whether pretreatment with substance P would affect ovariectomy-induced memory deficits in rats for retention in the Morris water maze. Adult female Sprague-Dawley rats were divided to two groups: (1) control (received saline) and (2) experimental group (received substance P). All rats underwent an ovariectomy, as this has been shown to significantly impair spatial reference learning and memory (Monteiro, Matté, Bavaresco, Netto, & Wyse, 2005). Approximately 8 months after surgery, all rats were trained in the Morris water maze in order to evaluate both reference and working memory. Results showed that substance P did …

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Thimerosal-Induced Neuritoxicity: Apoptosis Occurs Through A Mitochondrial-Mediated Pathway Via The Jnk Signaling Pathway, Michelle L. Herdman Jan 2006

Thimerosal-Induced Neuritoxicity: Apoptosis Occurs Through A Mitochondrial-Mediated Pathway Via The Jnk Signaling Pathway, Michelle L. Herdman

Theses, Dissertations and Capstones

Thimerosal is an organic mercurial containing an ethylmercury moiety attached to the sulfur atom of thiosalicylate. Since the 1930s, thimerosal has been used as an antiseptic and a preservative in a wide variety of products, including medicinal preparations administered to children and pregnant women. Past exposures to mercurials have indicated that mercury is a neurotoxin, and can also affect the kidney, skin, eyes, and immune system. Additionally, fetuses exposed to mercurials are more susceptible to toxicity because the nervous system is continuously developing. However, despite its widespread use, thimerosal was only studied on a limited basis until the end of …

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Regulation Of Biofilm Formation Of Pseudomonas Aeruginosa, Nathaniel Edwards Head Jan 2006

Regulation Of Biofilm Formation Of Pseudomonas Aeruginosa, Nathaniel Edwards Head

Theses, Dissertations and Capstones

Cystic fibrosis (CF) is the most common, autosomal recessive lethal genetic disease in the Caucasian population, resulting from a malfunctioned cystic fibrosis transmembrane conductance regulator (CFTR) and leading to bacterial lung infections. P. aeruginosa, an opportunistic pathogen, establishes a chronic infection in CF with a phenotype of overproduction of an exopolysaccharide (alginate) due to host-directed mutagenesis. While free-floating planktonic bacteria can be properly cleared from the CF lung, P. aeruginosa, along with alginate production, establishes an infection in the form of a biofilm which supports its survival in nature and in vivo. As a result, genomic structure, …

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Determining Biogeochemical Assemblages On The Stony River, Grant County, Wv, Using Fuzzy C-Means And K-Nearest Neighbors Clustering, M. Joseph Hughes Jan 2006

Determining Biogeochemical Assemblages On The Stony River, Grant County, Wv, Using Fuzzy C-Means And K-Nearest Neighbors Clustering, M. Joseph Hughes

Theses, Dissertations and Capstones

Periphyton assemblages were assessed on the Stony River, a high-gradient stream in the Potomac drainage of Grant County, WV. Periphyton samples were collected from nine sites along the mainstem and in two tributaries. Chlorophyll-a, dry weight, taxonomic identifications, and bioaccumulated metals concentrations data were compiled. These data were related to water quality parameters measured at each site during the study. Fuzzy C-means and k-nearest neighbor clustering on the combined, normalized dataset produced similar results. Clustering separated species occurring in each tributary from each other and those dominating the mainstem. Nearly every bioaccumulated metal was associated with one of these tributary …

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Characterization Of The Dna-Binding Properties Of Silent Information Regulator 3 Protein, Cotteka Nichisha Johnson Jan 2006

Characterization Of The Dna-Binding Properties Of Silent Information Regulator 3 Protein, Cotteka Nichisha Johnson

Theses, Dissertations and Capstones

The eukaryotic genome is organized into distinct domains with discrete regulatory potential, influenced by the variation in local chromatin structure. An example of chromatin-mediated consequences on gene expression is mating type determination of yeast Saccharomyces cerevisiae, which depends on silencing of specific gene cassettes. Silencing in yeast involves key proteins, amongst which the Silent Information Regulator (Sir) proteins are essential. Sir1p, Sir2p, and Sir4p are recruited to nucleate silencing events, while Sir3p serves as the pivotal factor in spreading the silent state. This investigation characterizes the DNA binding properties of Sir3p using DNA fragments with varying degrees of inherent flexibility, …

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‘Flex Your Power’: Energy Crises And The Shifting Rhetoric Of The Grid, Anne Marie Todd, A. Wood Jan 2006

‘Flex Your Power’: Energy Crises And The Shifting Rhetoric Of The Grid, Anne Marie Todd, A. Wood

Faculty Publications

In response to widespread power outages, rolling blackouts, and ubiquitous energy debates, this essay considers our relation to energy and the grid that produces it. First, we investigate California's multimedia Flex Your Power campaign, which defines consumers as nodes of the grid to emphasize their responsibility to maintain a stable energy supply. Second, we examine state and national responses to the 2003 blackout in the Northeastern United States, attending to three strategies through which grid administrators sought to impose order, enact hierarchy, and deindividuate power. We propose that the grid invokes personalization at the "local" level and abstraction at the …

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Romania's New Child Protection Legislation: Change In Intercountry Adoption Law Results In A Human Rights Violation, Carrie A. Rankin Jan 2006

Romania's New Child Protection Legislation: Change In Intercountry Adoption Law Results In A Human Rights Violation, Carrie A. Rankin

Syracuse Journal of International Law and Commerce

This Note explores and critiques provisions of Law 272 and Law 273, as well as the vulnerable position of Romania's orphaned and abandoned children and Romania's unique challenges to protect them. The remainder of the Introduction maps the history of Romania's orphaned and abandoned children, highlighting the catalysts leading to Romania's need for reform of its child protection laws. Part I traces the drafting process of the new laws, with particular attention on outside influence and how the laws comply with existing international guidelines for inter-country adoption. Part II reveals the devastating consequences the new laws will continue to have …

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Spring 2006 Jan 2006

Spring 2006

University of Richmond Magazine

No abstract provided.

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Summer 2006 Jan 2006

Summer 2006

University of Richmond Magazine

No abstract provided.

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