Digital Commons Network^™

A Domain-Oriented Approach To The Reduction Of Combinatorial Complexity In Signal Transduction Networks, Holger Conzelmann, Julio Saez-Rodriguez, Thomas Sauter, Boris N. Kholodenko Phd, Dsci, Ernst D. Gilles

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background:

Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinatorial explosion of different states generated by feasible molecular species. The number of possible species grows exponentially with the number of different docking sites and can easily reach several millions. Models accounting for this combinatorial variety become impractical for many applications.

Results:

Our results show that under realistic assumptions on domain interactions, the dynamics of signaling pathways can be exactly described by reduced, hierarchically structured models. The method presented here provides a rigorous way to …

Transport Of E. Coli In Egyptian Agricultural Soils As A Result Of Reclaimed Wastewater Use For Irrigation, Aimen Badawy

Archived Theses and Dissertations

Limited water resources are one of the main constraints to socio-economic development and even a source of insecurity at national and regional levels. The increasing demand for water in the agricultural sector stimulated the use of reclaimed wastewater for irrigation. Comprehending health and environment risks resulting from contaminants that may often be associated with reclaimed wastewater will lead to the sustainable use of this resource, as well as the conservation of other water resources.

In the present study the fate and transport of one important wastewater constituent, namely E. Coli bacteria, in three Egyptian soils of typical agricultural use was …

Uneven Distribution Of Mhc Class Ii Epitopes Within The Influenza Virus, Sherry R. Crowe, Shannon C. Miller, Pamela S. Adams, Richard Dutton, Allen G. Harmsen, Frances E. Lund, Troy D. Randall, Deborah M. Brown, Susan Swain, David L. Woodland

Nebraska Center for Virology: Faculty Publications

The identification of T cell epitopes is crucial for the understanding of the host immune response during infection. While much is known about the MHC class I-restricted response following influenza virus infection of C57BL/6 mice, with over 16 CD8 epitopes identified to date, less is known about the MHC class II-restricted response. Currently, only a few I-A^b-restricted T helper epitopes have been identified. Therefore, several important questions remain about how many class II epitopes exist in this system and whether these epitopes are evenly distributed within the most abundant viral proteins. In order to address these questions, we …

Taxonomy Of Short-Tailed Shrews (Genus Blarina) In Florida, Russell A. Benedict, Hugh H. Genoways, Jerry R. Choate

University of Nebraska State Museum: Mammalogy Papers

Three nominal taxa of short-tailed shrews historically were recognized in Florida: Blarina carolinensis carolinensis in the north, Blarina carolinensis peninsulae on the southern peninsula, and Blarina carolinensis shermani in the vicinity of Fort Myers. The taxonomy of these shrews is complex, and researchers have suggested they may represent one, two, or even three species. To assess relationships among these taxa, we measured eight cranial characters on 363 specimens from Florida and used discriminant function analysis to characterize the mensural features of reference samples and to assign unknown specimens to a particular taxon. The reference sample of shermani averaged 7.8% larger …

Presentation To Outside Las Vegas Foundation January 23, 2006, Public Lands Institute

Presentations (PLI)

The Public Lands Institute is dedicated to strengthening the national fabric that is essential for the protection, conservation, and management of public lands.

In collaboration with federal, state, and non-profit partners, we are:

• creating new knowledge
• advancing technology
• improving education
• engaging the public to become involved in conservation and stewardship.

Teaching And Researching "The Politics Of Race" In A Majority White Institution, Byron D. Orey

Department of Political Science: Faculty Publications

In this chapter, I outline some of the challenges faced by people of color who teach at traditional white institutions (TWIs). In addition, I offer proposed remedies to address such challenges. Given that the primary foci of Research I universities are research, teaching, and service (generally in that order), this chapter places special emphasis on these categories.

I first suggest that departments attempting to diversify their faculty consider hiring more than one person of color. While I was contemplating whether to accept my current job, I was contacted by a woman of color who told me that she had just …

Explanation, Human Nature, And Tort Theory, Jeffery L. Johnson

ExpressO

The article argues that, as they are usually stated, corrective justice theories of torts and economic efficiency theories fail to contradict one another. Thus, although the literature typically sees these approaches as doing conceptual battle, it takes a good deal of philosophical analysis to discover a theoretical framework from which to assess one perspective as superior to the other. Indeed, in many cases the corrective justice scholar appears to be talking past the economic lawyer, and vice versa.

The article then goes on to suggest that the one perspective from which we can see a genuine conflict between the explanations …

Coupling Between Lysozyme And Trehalose Dynamics: Microscopic Insights From Molecular-Dynamics Simulations, Taner E. Dirama, Joseph E. Curtis, Gustavo A. Carri, Alexei P. Sokolov

College of Polymer Science and Polymer Engineering

We have carried out molecular-dynamics simulations on fully flexible all-atom models of the protein lysozyme immersed in trehalose, an effective biopreservative, with the purpose of exploring the nature and extent of the dynamical coupling between them. Our study shows a strong coupling over a wide range of temperatures. We found that the onset of anharmonic behavior was dictated by changes in the dynamics and relaxation processes in the trehalose glass. The physical origin of protein-trehalose coupling was traced to the hydrogen bonds formed at the interface between the protein and the solvent. Moreover, protein-solvent hydrogen bonding was found to control …

Clinical Perspectives Of Emerging Pathogens In Bleeding Disorders, Jamie Siegel

Department of Medicine Faculty Papers

As a result of immunological and nucleic-acid screening of plasma donations for transfusion-transmissible viruses, and the incorporation of viral reduction processes during plasma fractionation, coagulation-factor concentrates (CFC) are now judged safe in terms of many known infectious agents, including hepatitis B and C viruses, HIV, and human T-cell lymphotropic virus. However, emerging pathogens could pose future threats, particularly those with blood-borne stages that are resistant to viral-inactivation steps in the manufacturing process, such as non-lipid-coated viruses. As outlined in this Review, better understanding of infectious diseases allows challenges from newly described agents of potential concern in the future to be …

01-20-2006 Volunteers Needed For Recycling Project, Southwestern Oklahoma State University

THE BARK ARCHIVE 2006

SWOSU organizations that are heading up a “Recycling Awareness” project on January 26 are seeking students to help hand out fliers to area businesses and residences.

Volume 43, Number 20: January 20, 2006, University Of North Dakota

University Letter Archive

No abstract provided.

Washington University Record, January 20, 2006

Washington University Record

No abstract provided.

Using Species Richness To Estimate Benthic Sampling Effort, Robert M. Cerrato, Nicole P. Maher

School of Marine & Atmospheric Sciences Faculty Publications

In planning marine benthic grab sampling, there is a need to determine the number of faunal samples that should be collected to guarantee than an adequate amount of data is available to identify and describe faunal community structure. We suggest that an estimate of species richness can serve as the basis for the determining sample size. An appropriate criterion might be, for example, to set sample size within an environmentally and biologically homogenous area large enough such that at least 70% of the species that are present are collected. The goal of present study is to identify an appropriate species …

The Murray State News, January 20, 2006, The Murray State News

Murray State University Collection

No abstract provided.

Dr. Hayes Is Black History Month Speaker, University Relations

Campus News Archive

Dr. Tyrone Hayes, a biology professor at the University of California, Berkeley, will present the Black History Month keynote, “From Boyhood Curiosity to Scientific Discovery,” at 7:30 p.m. Wednesday, Feb. 1, in Edson Auditorium.

Characterization Of The Role Of Sox9 In Cartilage-Specific Gene Regulation, Mary Ann Genzer

Theses and Dissertations

Although advances have been made toward understanding the complex mechanisms that regulate the process of DNA transcription, the specific mechanisms of activation for many individual genes remain unknown. In this study, we focus on the role the transcription factor SOX9 plays in activating cartilage-specific genes, specifically Col9a1 and Cartilage Link Protein (CRTL1). Previously, enhancers of these genes containing single SOX9 binding sites were shown to be activated through SOX9 binding. However, the hypothesis was made that in cartilage-specific genes dimeric SOX9, as opposed to monomeric SOX9, is necessary for activation. We identified a putative binding site adjacent to each of …

University Of Dayton To Help Local Hospitals Address Critical Shortage Of Physical Therapists In Dayton Region

News Releases

News release announces that the University of Dayton's board of trustees today approved a doctor of physical therapy degree that will educate students for well-paying jobs in a growing health care field and help alleviate a shortage of physical therapists in the Dayton region.

Power Signal Analysis Of Channel Current Signal Using Hmm-Em And Time Domain Fsa, Anand Prabhakaran

LSU New Orleans Theses and Dissertations

The Nanopore Detector using á-hemolysin channel transcribes kinetics of a single molecule along the nanometer-scale pore. The transcribed data is represented by electrical measurements. We present accurate and computationally inexpensive tools to analyze single molecule kinetics. The HMM-EM level projection method de-noises data, retaining the transitions with very high precision. This approach doesn't require input number of levels. Another advantage is the minimal tuning required. The levels are then identified using Finite State Automata (FSAs). Spike Detector algorithm analyzes spikes characterizing behavior of molecule in pore. No commercial tools available are capable of analyzing spikes in presence of noise. The …

Investigation Of Different Video Compression Schemes Using Neural Networks, Prem Kovvuri

LSU New Orleans Theses and Dissertations

Image/Video compression has great significance in the communication of motion pictures and still images. The need for compression has resulted in the development of various techniques including transform coding, vector quantization and neural networks. this thesis neural network based methods are investigated to achieve good compression ratios while maintaining the image quality. Parts of this investigation include motion detection, and weight retraining. An adaptive technique is employed to improve the video frame quality for a given compression ratio by frequently updating the weights obtained from training. More specifically, weight retraining is performed only when the error exceeds a given threshold …

Deer-Vehicle Accident Hotspots In Northwest Clackamas County, Oregon, Linda K. Anderson

Dissertations and Theses

Road-kill of wildlife is common on Portland, Oregon's suburban fringe where development has increased road densities and traffic volume in rural areas. I identify the spatial and temporal patterns of black-tailed deer (Odocoileus hemionus columbianus) deer-vehicle accidents (DVA) at the suburban/rural interface of developing northwest Clackamas County using deer carcass pickup reports for county maintained roads for 1997-2004 and Oregon Department of Transportation deer-vehicle accident reports for 1996-2004. No black-tailed deer DVA models exist in the literature.

DVA increased 121% from 1997 to 1999 followed by a 26% decline by 2004. The initial DVA increase appears related to …

Soundings 2006-01-20 (V.18 No.17), N/A N/A

Soundings

No abstract provided.

Sediment Transport And Pathogen Indicator Modeling In Lake Pontchartrain, Chandra Sekhar Chilmakui

LSU New Orleans Theses and Dissertations

A nested three dimensional numerical modeling application was developed to determine the fate of pathogen indicators in Lake Pontchartrain discharged from its tributaries. To accomplish this, Estuarine, coastal and ocean model with sediment (ECOMSED) was implemented to simulate various processes that would determine the fate and transport of fecal coliform bacteria in the lake. The processes included hydrodynamics, waves, sediment transport, and the decay and transport of the fecal coliforms. Wind and tidal effects were accounted along with the freshwater inflows. All the components of the modeling application were calibrated and validated using measured data sets. Field measurements of the …

Synthesis Of Molecular Baskets And Introduction Of Inward Facing Functionality, Zachary Laughery

LSU New Orleans Theses and Dissertations

As a first step to producing a shape selective catalysts or enzyme mimic, two preorganized host molecules were synthesized. Binding studies of the two hosts with a variety of guests in three solvents demonstrated that an important driving force in the association was the formation of C-H???X-R hydrogen bonds (X = halogen). A deuterated host was utilized to further examine the formation of the C-H???X-R hydrogen bonds. In an effort to place functionality in the hydrophobic pocket of these hosts, two methods were developed. The first utilized directed ortho metallation to place electrophiles above and/or directed into the cavity. Perlithiation …

The Role Of Emotion In The Aggressive Behavior Of Juvenile Offenders, Katherine Aucoin

LSU New Orleans Theses and Dissertations

This study examined the roles of emotion regulation, negative emotional reactivity, callous-unemotional traits, and socioemotional competence (i.e., identity, self-esteem, communication skills, work orientation, empathy) in overt aggression in a sample of detained juvenile offenders. Clusters were formed based on type and level of overt aggression exhibited: reactive, proactive/reactive, and low aggression. The proactive/reactive distinction failed to provide differential relationships with dependent variables when compared to an overall level of overt aggression. Results indicate that adolescents high in overall overt aggression exhibit higher levels of callousunemotional traits and negative reactivity, as well as lower levels of selfconcept and self-esteem when compared …

Meeting Minutes: January 19, 2006, Dan B. Lutz

UNL Emeriti Association: Meeting Minutes

No abstract provided.

Council On Academic Affairs Minutes, Jan 19, 2006, Eastern Kentucky University

Council on Academic Affairs

No abstract provided.

Minutes, Arts & Sciences Academic Affairs Committee Meeting, Thursday, January 19, 2006, Arts & Sciences Academic Affairs Committee

Academic Affairs Committee Minutes

No abstract provided.

The Setonian, January 19, 2006, Seton Hall University

2006

No abstract provided.

Observer, Central Washington University

Student Newspaper

Student newspaper for Central Washington University for January 19, 2006

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.