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Oncostatin M Differentially Regulates Cxc Chemokines In Mouse Cardiac Fibroblasts, Pascal J. Lafontant

Biology Faculty publications

Ischemia-reperfusion injury in the heart is characterized by marked infiltration of neutrophils in the myocardial interstitial space. Studies in human, canine, and murine models have revealed oncostatin M (OSM) expression in infiltrating leukocytes. In an effort to assess possible roles of OSM in the myocardium, we used cardiac fibroblasts (mCFs) isolated from adult mouse heart to determine whether recombinant murine OSM regulates the synthesis and release of MIP2/ CXCL2, KC/CXCL1, and LIX/CXCL5, which are three potent neutrophil chemoattractants in the mouse. Our results demonstrate that mCFs express OSM receptors and that, within the IL-6 cytokine family, OSM uniquely induces significant …

The Established Intimin Receptor Tir And The Putative Eucaryotic Intimin Receptors Nucleolin And B1 Integrin Localize At Or Near The Site Of Enterohemorrhagic Escherichia Coli O157:H7 Adherence To Enterocytes In Vivo, James F. Sinclair, Evelyn A. Dean-Nystrom, Alison D. O’Brien

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

For enterohemorrhagic Escherichia coli (EHEC) O157:H7 to adhere tightly to the intestinal epithelium and produce attach and efface (A/E) lesions, the organism must express the adhesin intimin and insert the bacterially encoded translocated intimin receptor Tir into the plasma membrane of the host enterocyte. Additionally, some reports based on tissue culture experiments indicate that intimin has affinity for the eucaryotic proteins nucleolin and β1 integrin. To address the potential biological relevance of these eucaryotic proteins in the infection process in vivo, we sought to compare the proximity of Tir, nucleolin, and β1 integrin to regions of EHEC …

A Child-Centered Approach To Parentage Law, James G. Dwyer

William & Mary Bill of Rights Journal

No abstract provided.

Extension's Role In Homeland Security: A Virginia Perspective, John “Rusty” H. Miller, Robert Grisso, Michael Lambur

Journal of Extension

Virginia Cooperative Extension (VCE) conducted a project designed to determine what role it might play in assisting local governments in dealing with emergency preparedness issues in the aftermath of a manmade disaster resulting from terrorist activity. The project was funded through USDA. Community forums were used to collect viewpoints and perspectives on the unique role VCE could play in providing Homeland Security educational assistance to local governments and key professionals involved in the protection of residents from a terrorist attack. Using this information, VCE has taken steps to position itself to play a key role in addressing this important issue.

Negligence And Nuclear Nonproliferation: Eliminating The Current Liability Barrier To Bilateral U.S.- Russian Nonproliferation Assistance Programs, Patrick F. Speice Jr.

William & Mary Law Review

No abstract provided.

“You’Re My Parent But You’Re Not”: Dialectical Tensions In Stepchildren’S Perceptions About Communicating With The Nonresidential Parent, Dawn O. Braithwaite, Leslie A. Baxter

Department of Communication Studies: Faculty Publications

The nonresidential parent plays a role in the lives of stepchildren and in stepfamily households. The focus of the present study was on the interaction between the nonresidential parent and his/her child who resides as part of a stepfamily household. Grounded in relational dialectics theory, the researchers performed an interpretive analysis of 50 transcribed interviews with college-aged stepchildren. Stepchildren’s perceptions of communication with the nonresidential parent were animated by two contradictions: parenting/nonparenting and openness/closedness. These two contradictions form a totality, interwoven with one another. The parenting/nonparenting contradiction reflected stepchildren’s ambivalence over parenting attempts of nonresidential parents. Stepchildren wanted nonresidential parent …

Farnesol-Induced Apoptosis In Aspergillus Nidulans Reveals A Possible Mechanism For Antagonistic Interactions Between Fungi, Camile P. Semighini, Jacob M. Hornby, Raluca Dumitru, Kenneth W. Nickerson, Steven D. Harris

Department of Plant Pathology: Faculty Publications

The dimorphic fungus Candida albicans secretes farnesol, which acts as a quorum-sensing molecule and prevents the yeast to mycelium conversion. In this study we examined the effect of farnesol in the filamentous fungus Aspergillus nidulans. We show that externally added farnesol has no effect on hyphal morphogenesis; instead, it triggers morphological features characteristic of apoptosis. Additional experiments suggest that mitochondria and reactive oxygen species (ROS) participate in farnesol-induced apoptosis. Moreover, the effects of farnesol appear to be mediated by the FadA heterotrimeric G protein complex. Because A. nidulans does not secrete detectable amounts of farnesol, we propose that it …

Transcriptome Signature Of Virulent And Attenuated Pseudorabies Virus-Infected Rodent Brain, Christina Paulus, Patricia J. Sollars, Gary E. Pickard, Lynn W. Enquist

School of Veterinary and Biomedical Sciences: Faculty Publications

Mammalian alphaherpesviruses normally establish latent infections in ganglia of the peripheral nervous system in their natural hosts. Occasionally, however, these viruses spread to the central nervous system (CNS), where they cause damaging, often fatal, infections. Attenuated alphaherpesvirus derivatives have been used extensively as neuronal circuit tracers in a variety of animal models. Their circuit-specific spread provides a unique paradigm to study the local and global CNS response to infection. Thus, we systematically analyzed the host gene expression profile after acute pseudorabies virus (PRV) infection of the CNS using Affymetrix GeneChip technology. Rats were injected intraocularly with one of three selected …

Acidification Of Soil In A Dry Land Winter Wheat-Sorghum/Corn-Fallow Rotation In The Semiarid U.S. Great Plains, David D. Tarkalson, Jose O. Payero, Gary W. Hergert, Kenneth G. Cassman

Department of Agronomy and Horticulture: Faculty Publications

Soil pH is decreasing in many soils in the semiarid Great Plains of the United States under dry land no-till (NT) cropping systems. This study was conducted to determine the rate of acidification and the causes of the acidification of a soil cropped to a winter wheat (Triticum aestivum L.)-grain sorghum [Sorghum bicolor (L.) Moench]/corn (Zea mays L.)-fallow rotation (W-S/C-F) under NT. The study was conducted from 1989 to 2003 on soil with a long-term history of either continuous NT management [NT(LT)] (1962–2003) or conventional tillage (CT) (1962–1988) then converted to NT [NT(C)] (1989–2003). Nitrogen was applied …

Selachohemecus Benzi N. Sp. (Digenea: Sanguinicolidae) From The Blacktip Shark Carcharhinus Limbatus (Carcharhinidae) In The Northern Gulf Of Mexico, Stephen A. Bullard, Robin M. Overstreet, John K. Carlson

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Selachohemecus benzi Bullard & Overstreet n. sp. infects the heart and kidney of the blacktip shark Carcharhinus limbatus in the northern Gulf of Mexico off Florida and Mississippi, USA. Specimens of S. olsoni Short, 1954, the only congener and only other named blood fluke reported from a chondrichthyan in the Gulf of Mexico, were collected from the heart of the Atlantic sharpnose shark Rhizoprionodon terraenovae from two new localities, Apalachicola Bay, Florida, and Mississippi Sound, Mississippi, USA. The new species differs from S. olsoni by having a larger body (1.4–3.8 mm long), robust tegumental body spines numbering 51–63 along each …

Morphologic Alterations And Immunohistochemical Analysis Of Alpha-Fetoprotein And Cd34 In Chorionic Villi Of Anembryonic Pregnancy, Sevim Aydin, Mehmet Ozeren, Engin Yenilmez, Esin Yulug, Umit Cobanoglu, Haluk Arvas

Saudi Medical Journal

OBJECTIVE: To investigate the morphology of chorionic villi using light and electron microscopy, especially the expression of alpha-fetoprotein (AFP) in trophoblastic cells and the process of maturation and margination vasculogenesis proper using CD34 immunohistochemistry in tissues from the first trimester of pregnancy loss due to anembryonic pregnancy in comparison with embryonic pregnancy. METHODS: The study consisted of 2 groups: 9 patients with anembryonic pregnancies and 9 patients with embryonic pregnancies between 6 and 10 weeks of gestational age registered at the Department of Gynecology and Obstetrics, University Hospital of Karadeniz Technical University, Turkey, from March 2003 to December 2004. We …

Relationship Between Alpha-1 Antitrypsin Deficient Genotypes S And Z And Lung Cancer In Jordanian Lung Cancer Patients, Zeyad J. El-Akawi, Mohamad K. Nusier, Foad E. Zoughool

Saudi Medical Journal

OBJECTIVE: Alpha-1 antitrypsin (alpha1-AT) is a secretory glycoprotein produced mainly in the liver and monocytes. It is the most abundant serine protease inhibitor in human plasma. It predominantly inhibits neutrophil elastase thus, it prevents the breakdown of lung tissue. The deficiency of alpha1-AT is an inherited disorder characterized by reduced serum level of alpha1-AT. Protease inhibitors Z (PiZ) and protease inhibitors S (PiS) are the most common deficient genotypes of alpha1-AT. The aim of this study is to test the relationship between alpha1-AT deficient genotypes S and Z and lung cancer in Jordanian lung cancer patients. METHODS: We obtained the …

Anastomotic Esophageal Leak Due To Taenia Saginata Following Esophagectomy For Esophageal Cancer, Reem M. Baleela, Mohamed Y. Huessain, Mohamed E. Ahmed

Saudi Medical Journal

A 50-year-old female with squamous cell carcinoma of the lower third of the esophagus underwent an esophagectomy via laparotomy and right thoracotomy. She developed a major anastomotic leak on the third postoperative day. The chest tube slipped out on the 10th postoperative day and a segment of Taenia saginata tapeworm came out through the tube drain site and was extracted. She was given praziquantel tablets treatment; after which the leakage dropped dramatically and ceased completely after one week. Patients scheduled for esophagectomy who experienced recurrent abdominal pain in areas endemic with a tapeworm need to be screened for taeniasis before …

Fracture Of The Anterior Iliac Crest Following Autogenous Bone Grafting, Mohammad J. Al-Sayyad, Talat M. Abdulmajeed

Saudi Medical Journal

Anterior iliac crest is the most common donor site for anterior cervical spine surgeries. We searched the literature to summarize the reported fractures of the anterior iliac crest following bone graft harvesting for anterior cervical fusion and documented our experience with such complication. In this account, we report 3 new patients with this rare complication of fracture of the anterior iliac crest following bone graft for anterior cervical fusion. The dual energy x-ray absorptiometry scan was performed in all our patients to assess bone mineral density and all patients had osteoporosis. Non-operative treatment was the method of treatment in our …

Innovative Solutions To Human–Wildlife Conflicts

United States Department of Agriculture Wildlife Services: Staff Publications

Contents

Introduction
Developing Methods
Bird Research Program
Mammal Research Program
Product Development Research Program
Program Support
Wildlife Disease Research Program
Providing Wildlife Services
National Support
International Cooperation
Valuing and Investing in People
2005 Publication Awards
Supporting Student Research
Enhancing Information and Communication
Information Services
Seminars
Meetings, Workshops, and Conference Presentations
Publications

Family Structure, Closeness To Residential And Nonresidential Parents, And Psychological Distress In Early And Middle Adolescence, Christina D. Falci

Department of Sociology: Faculty Publications

American adolescents currently live in a variety of different family structures, with the vast majority of adolescents living in intact, blended, divorced, and never-married families. Previous research shows that family structure correlates both with the quality of parent–adolescent relationships and adolescent psychological distress. The quality of parent–adolescent relationships also correlates with adolescent distress. This research hypothesizes that the observed differences in adolescent distress across family structure might result from differences in the quality of parent–adolescent relationships across family structure. Analyses, using data on 1,443 youth in early and middle adolescence from the National Longitudinal Survey of Youth (NLSY), indicate that …

Treponema Denticola In Disseminating Endodontic Infections, F. Foschi, Jacques Izard, H. Sasaki, V. Sambri, C. Prati, R. Müller, P. Stashenko

Department of Food Science and Technology: Faculty Publications

Treponema denticola is a consensus periodontal pathogen that has recently been associated with endodontic pathology. In this study, the effect of mono-infection of the dental pulp with T. denticola and with polymicrobial “red-complex” organisms (RC) (Porphyromonas gingivalis, Tannerella forsythia, and T. denticola) in inducing disseminating infections in wild-type (WT) and severe-combined-immunodeficiency (SCID) mice was analyzed. After 21 days, a high incidence (5/10) of orofacial abscesses was observed in SCID mice mono-infected with T. denticola, whereas abscesses were rare in SCID mice infected with the red-complex organisms or in wild-type mice. Splenomegaly was …

Nh Department Of Health And Human Services Public Health Laboratories Shellfish Program 2005, Jayne S. Finnigan

PREP Reports & Publications

The Department of Health and Human Services-New Hampshire Public Health Laboratories (DHHS-NHPHL) has continued to carry out various actions providing laboratory analyses for the routine water quality monitoring, “Red Tide” monitoring, and additional testing after rainfall, excess sewage treatment plant, and emergency events. Also, a validation study was performed using non-EPA funds to compare results between the traditional Paralytic Shellfish Poison bioassay and a newer developed test allowed for screening use.

Inside Unlv, Cate Weeks, Shane Bevell, Carol C. Harter, Tony Allen, Diane Russell, Mamie Peers

Inside UNLV

No abstract provided.

Femtosecond Nuclear Motion Of Hcl Probed By Resonant X-Ray Raman Scattering In The Cl 1s Region, Marc Simon, Loic Journel, Stephane Carniato, Richard Taieb, I. Minkov, Faris Gel'mukhanov, P. Salek, H. Agren, Renaud Guillemin, Wayne C. Stolte, A. C. Hudson, Dennis W. Lindle

Chemistry and Biochemistry Faculty Research

Femtosecond dynamics are observed by resonant x-ray Raman scattering (RXS) after excitation along the dissociative Cl 1s→6ơ* resonance of gas-phase HCl. The short core-hole lifetime results in a complete breakdown of the common nondispersive behavior of soft-x-ray transitions between parallel potentials. We evidence a general phenomenon of RXS in the hard-x-ray region: a complete quenching of vibrational broadening. This opens up a unique opportunity for superhigh resolution x-ray spectroscopy beyond vibrational and lifetime limitations.

Regional Economic Indicators: Human Capital And Workforce, Iryna Lendel

All Maxine Goodman Levin School of Urban Affairs Publications

The report is prepared by the Center for Economic Development at Cleveland State University’s Maxine Goodman Levin College of Urban Affairs as a part of the regional indicators project under the Presidential Initiative Program. The study examines human capital and labor force in 36 regions across the country: 32 metropolitan areas of comparable size to the Cleveland metropolitan statistical area (MSA) and three smaller MSAs in Northeast Ohio — Akron,1 Canton, and Youngstown.

Estimating The Long-Term Hydrological Budget Over Heterogeneous Surfaces, Jie Song, M.L. Wesely, D.J. Holdridge, D.R. Cook, J. Klazura

Faculty Articles, Papers, and Other Scholarship

Estimates of the hydrological budget in the Walnut River Watershed (WRW; 5000 km2) of southern Kansas were made with a parameterized subgrid-scale surface (PASS) model for the period 1996–2002. With its subgrid-scale distribution scheme, the PASS model couples surface meteorological observations with satellite remote sensing data to update root-zone available moisture and to simulate surface evapotranspiration rates at high resolution over extended areas. The PASS model is observationally driven, making use of extensive parameterizations of surface properties and processes. Heterogeneities in surface conditions are spatially resolved to an extent determined primarily by the satellite data pixel size. The purpose of …

Lsuhsc Facilities Biweekly Update: February 2006, Lsuhsc Property And Facilities Management

LSUHSC Facilities Biweekly Updates: 2006

LSUHSC Facilities Biweekly Updates from February 10 and 24, 2006.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Woy '06: Spicebush Provides A Salad Bar To Some Caterpillars, W. John Hayden

Biology Faculty Publications

While many wildflower enthusiasts appreciate spicebush (Lindera benzoin), the 2006 Virginia Wildflower of the Year, for its subtle beauty, plant ecologists have found this humble shrub to be a fruitful subject for scientific inquiry. The notes that follow relay just a few of the interesting nuggets that can be gleaned from a cursory study of the scientific literature about this plant.

In Defense Of Regulatory Peer Review, J.B. Ruhl, James Salzman

Vanderbilt Law School Faculty Publications

The debate over application of peer review to the regulatory decisions of administrative agencies has heated up in the last year. Part of the larger and controversial sound science movement, mandating peer review for certain types of agency decisions has recently been championed by the White House and proponents in Congress. Indeed, this past January the Office of Management and Budget finalized guidelines requiring peer review for large classes of agency activities. These initiatives have not gone unchallenged, and a fierce debate has resulted between those who claim peer review will strengthen the scientific basis of agency decisions and those …

Do Cd1-Restricted T Cells Contribute To Antibody-Mediated Immunity Against Mycobacterium Tuberculosis?, Mark L. Lang, Aharona Glatman-Freedman

Dartmouth Scholarship

No abstract provided.

Committee Activities, Hisami Konishi Springer, Anna U, Karen Wei

Journal of East Asian Libraries

No abstract provided.

Translational Regulation Of Nuclear Gene Cox4 Expression By Mitochondrial Content Of Phosphatidylglycerol And Cardiolipin In Saccharomyces Cerevisiae, Xuefeng Su, William Dowhan

Faculty, Staff and Student Publications

Previous results indicated that translation of four mitochondrion-encoded genes and one nucleus-encoded gene (COX4) is repressed in mutants (pgs1Delta) of Saccharomyces cerevisiae lacking phosphatidylglycerol and cardiolipin. COX4 translation was studied here using a mitochondrially targeted green fluorescence protein (mtGFP) fused to the COX4 promoter and its 5' and 3' untranslated regions (UTRs). Lack of mtGFP expression independent of carbon source and strain background was established to be at the translational level. The translational defect was not due to deficiency of mitochondrial respiratory function but was rather caused directly by the lack of phosphatidylglycerol and cardiolipin in mitochondrial membranes. Reintroduction of …

Research With Arctic Peoples: Unique Research Opportunities In Heart, Lung, Blood And Sleep Disorders. Working Group Summary And Recommendations, Sally Smith, Peter Bjerregaard, Hing Man Chan, André Corriveau, Sven Ebbesson, Ruth Etzel, Richard Fabsitz, Hakon Hakonarson, Carl Hild, Elizabeth Nobmann, Jeff Reading, Larisa Tereshchenko, T. Kue Young, Barbara Howard

Open Access Publications

Arctic peoples are spread over eight countries and comprise 3.74 million residents, of whom 9% are indigenous. The Arctic countries include Canada, Finland, Greenland (Denmark), Iceland, Norway, Russia, Sweden and the United States. Although Arctic peoples are very diverse, there are a variety of environmental and health issues that are unique to the Arctic regions, and research exploring these issues offers significant opportunities, as well as challenges. On July 28-29, 2004, the National Heart, Lung, and Blood Institute and the Canadian Institutes of Health Research co-sponsored a working group entitled "Research with Arctic Peoples: Unique Research Opportunities in Heart, Lung, …

Antisense Inhibition Of Cyclin D1 Expression Is Equivalent To Flavopiridol For Radiosensitization Of Zebrafish Embryos, Mary Frances Mcaleer, Kevin T. Duffy, William R. Davidson, Gabor Kari, Adam P. Dicker, Ulrich Rodeck, Eric Wickstrom

Department of Biochemistry and Molecular Biology Faculty Papers

Purpose: Flavopiridol, a small molecule pan-cyclin inhibitor, has been shown to enhance the radiation response of tumor cells both in vitro and in vivo. The clinical utility of flavopiridol, however, is limited by toxicity, previously attributed to pleiotropic inhibitory effects on several targets affecting multiple signal transduction pathways. Here we utilized zebrafish embryos to investigate radiosensitizing effects of flavopiridol in normal tissues.

Methods and Materials: Zebrafish embryos at the 1-4 cell stage were treated with 500 nM flavopiridol or injected with 0.5 pmol antisense hydroxylprolyl-phosphono nucleic acid oligomers to reduce cyclin D1 expression, then subjected to ionizing radiation (IR) or …