Digital Commons Network^™

Trading The Micro-World Of Combinatorial Complexity For The Macro-World Of Protein Interaction Domains, Nikolay M. Borisov, Nick I. Markevitch, Jan B. Hoek, Boris N. Kholodenko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Membrane receptors and proteins involved in signal transduction display numerous binding domains and operate as molecular scaffolds generating a variety of parallel reactions and protein complexes. The resulting combinatorial explosion of the number of feasible chemical species and, hence, different states of a network greatly impedes mechanistic modeling of signaling systems. Here we present novel general principles and identify kinetic requirements that allow us to replace a mechanistic picture of all possible micro-states and transitions by a macro-description of states of separate binding sites of network proteins. This domain-oriented approach dramatically reduces computational models of cellular signaling networks by dissecting …

Causes And Mechanisms, An Interview With Dr. Jeremiah Stamler, Samuel S. Gidding

Department of Pediatrics Faculty Papers

Dr. Jeremiah Stamler began his career in New York City and moved to Chicago in 1947 with his wife Rose, to accept a basic research position with Dr. Louis N. Katz. Early animal studies convinced him of the role of dietary factors, particularly cholesterol and salt, in the etiology of atherosclerotic vascular disease. Because of a strong interest in public health, he began the first of many population based cohort studies in the 1950s that subsequently defined the role of health behaviors (adverse nutrition choices, tobacco use, low physical activity) and associated measurable biologic traits, now called risk factors, in …

Texas Sportsmen And The Conservation Of Bird Life, 1890-1915, Stanley D. Casto

East Texas Historical Journal

No abstract provided.

Judicial Balancing In Times Of Stress: Comparing The American, British, And Israeli Approaches To The War On Terror, Michel Rosenfeld

Cardozo Law Review

No abstract provided.

Ultrastructural Investigation Of The Protective Role Of Folic Acid And Vitamin E Against Toxic Effects Of Valproic Acid On Maternal Liver Tissue During Period Of Gestation, Ozlem P. Baran, Piraye Kervancioglu, Murat Akkus, Yusuf Nergiz

Saudi Medical Journal

No abstract provided.

An Unusual Case Of Colouterine Fistula, Tara C. Sharma, Sonal Bathla, Nirmala Agarwal, Subhash C. Arya, Pragya Ahuja

Saudi Medical Journal

No abstract provided.

Cardiopulmonary Resuscitation In Pregnancy, Farhad Kamrani, Mehdi Khalighimonfared

Saudi Medical Journal

No abstract provided.

A Within-Subjects Validation Of A Group-Administered Timeline Followback For Alcohol Use, Eric R. Pedersen, Joseph W. Labrie

Heads Up!

Objective

The current study uses a within-subjects randomized design with the Timeline Followback (TLFB) method administered in groups or to individuals to determine the equivalence of these methods.

Method

One hundred and four male and female college students who reported drinking at least once in the past 3 months completed the TLFB during a one-on-one interview, as well as in a group setting days apart. The two administrations were counterbalanced among the participants. Drinking variables assessed were drinking days, average drinks, total drinks, and maximum drinks consumed both during a 3-month (90 days) and a 1-month (30 days) period.

Results …

Pakistan - Country Profile Of Cancer And Cancer Control 1995-2004, Yasmin Bhurgri, Asif Bhurgri, Sania Nishter, Ashfaq Ahmed, Ahmed Usman, Shahid Pervez, Naila Kayani, Rashida Ahmed, Sheema H. Hassan, Ahmed Riaz, Hadi Bhurgri, Imtiaz Bashir

Department of Pathology and Laboratory Medicine

No abstract provided.

A New Species And New Records Of Aphodius Illiger (Coleoptera: Scarabaeidae: Aphodiinae) From Mammal Burrows In Nebraska, M. J. Paulsen

University of Nebraska State Museum: Entomology Papers

Direct sampling of rodent burrows in Nebraska resulted in the collection of 16 species of Aphodius Illiger previously unknown from the state, including specimens of four undescribed species. One of these species is described here as new: Aphodius viceversus new species recorded from Nebraska and Kansas. Other Aphodius species recorded from Nebraska for the first time include A. acuminatus Cartwright, . anomaliceps Brown, A. carri Brown, A. criddlei Brown, A. kirni Cartwright, A. kiowensis Gordon and Salsbury, A. magnificens Robinson, A. neodistinctus Brown, A. peculiosus Schmidt, A. punctissimus Brown, A. thomomysi Brown, and A. leptotarsis Brown. Collecting information is summarized …

A Revision Of The Genus Geopsammodius Gordon And Pittino, 1992 (Scarabaeidae: Aphodiinae: Psammodiini), Paul E. Skelley

University of Nebraska State Museum: Entomology Papers

The genus Geopsammodius Gordon and Pittino is revised. Eight new species are described: G. atlantida (Honduras: Atlantida), G. fuscus (Martin Co. and Palm Beach Co., Florida), G. morrisi (eastern Polk Co., Florida), G. ohoopee (Tattnall Co., Georgia), G. rileyi (coastal Louisiana and Texas), G. subpedalis (northern coastal Gulf of Mexico), G. unsidensis (inland Texas), and G. withlacoochee (Citrus Co. and Hernando Co., Florida), bringing the number of described species to 11. A key and illustrations are provided to aid in identification of taxa.

Tools For The Edge: What’S New For Conserving Carnivores, John A. Shivik

United States Department of Agriculture Wildlife Services: Staff Publications

The loss of large carnivores at the edges of parks, preserves, and human habitations threatens the conservation of many species. Thus, effective predation management is a conservation issue, and tools to mitigate conflicts between humans and predators are required. Both disruptive-stimulus (e.g., fladry, Electronic Guards, radio-activated guards) and aversive-stimulus (e.g., electronic training collars, less-than-lethal ammunition) approaches are useful, and technological advances have led to many new, commercially available methods. Evaluating the biological and economic efficiency of these methods is important. However, social and psychological effects should also be considered. The management of animal damage to human property is necessary, and …

Potassium Ion Channels Of Chlorella Viruses Cause Rapid Depolarization Of Host Cells During Infection, Florian Frohns, Anja Kasmann, Detlef Kramer, Britta Schafer, Mario Mehmel, Ming Kang, James L. Van Etten, Sabrina Gazzarrini, Ana Morino, Gerhard Thiel

Department of Plant Pathology: Faculty Publications

revious studies have established that chlorella viruses encode K⁺ channels with different structural and functional properties. In the current study, we exploit the different sensitivities of these channels to Cs⁺ to determine if the membrane depolarization observed during virus infection is caused by the activities of these channels. Infection of Chlorella NC64A with four viruses caused rapid membrane depolarization of similar amplitudes, but with different kinetics. Depolarization was fastest after infection with virus SC-1A (half time [t_1/2], about 9 min) and slowest with virus NY-2A (t_1/2, about 12 min). Cs⁺ inhibited …

Effects Of Moraxella (Branhamella) Ovis Culture Filtrates On Bovine Erythrocytes, Peripheral Mononuclear Cells, And Corneal Epithelial Cells, Henry E. Cerny, Douglas G. Rogers, Jeffrey T. Gray, David R. Smith, Susanne Hinkley

School of Veterinary and Biomedical Sciences: Faculty Publications

Infectious bovine keratoconjunctivitis (IBK) is a highly contagious ocular disease that affects cattle of all ages and that occurs worldwide. Piliated hemolytic Moraxella bovis is recognized as the etiologic agent of IBK. According to data from the Nebraska Veterinary Diagnostic Laboratory System, however, Moraxella (Branhamella) ovis has been isolated with increasing frequency from cattle affected with IBK. The objective of this study was, therefore, to examine M. ovis field isolates for the presence of the putative virulence factors of M. bovis. Culture filtrates from selected M. ovis field isolates demonstrated hemolytic activity on bovine erythrocytes and cytotoxic activity on …

The Effect Of Osteogenic Medium On The Adhesion Of Rat Bone Marrow Stromal Cell To The Hydroxyapatite, Ismet Deliloglu-Gurhan, Ibrahim Tuglu, Hafize S. Vatansever, Feyzan Ozdal-Kurt, Hayati Ekren, Muzaffer Taylan, Bilge H Sen

Saudi Medical Journal

OBJECTIVE: To investigate the adhesive properties of bone marrow stromal cell (BMSC) on the hydroxyapatite (HA) particles and analyze their behavior. METHODS: The study took place in the Department of the Histology and Embryology, Celal Bayar University, Manisa and in the Department of Bioengineering, Ege University, Izmir, Turkey between 2004 and 2005. We cultured BMSC from the mature rat tibia and differentiated to the osteoblasts by osteogenic medium. The BMSCs were subcultured and were taken to the HA substrate. We measured their proliferation capacity and viability with MTT assay using the spectrophotometric method. Furthermore, we identified the osteoblast-like cells by …

Colorectal Carcinoma From Saudi Arabia. Analysis Of Mlh-1, Msh-2 And P53 Genes By Immunohistochemistry And Tissue Microarray Analysis., Khawla S. Al-Kuraya, Prashant P. Bavi, Adnan A. Ezzat, Fouad A. Al-Dayel, Shahab Uddin, Valerie L. Atizado, Naif A. Al-Jomah, Samir S. Amr, Salwa S. Sheikh, Guido Sauter, Ronald Simon

Saudi Medical Journal

OBJECTIVE: To document the incidence and role of p53 and DNA mismatch repair proteins in colorectal carcinomas, and to evaluate the relative frequency of major molecular pathways in colorectal cancers from Saudi Arabia. METHODS: We collected the formalin fixed, paraffin embedded tissues from 154 colorectal tumors (83 patients from King Faisal Specialist Hospital and Research Centre and 71 from Saudi Aramco Dhahran Health Centre) between January 1989 and December 2003. We analyzed the p53 and mismatch repair gene expression (hMSH-2, hMLH-1) by immunohistochemistry in tissue microarray format. RESULTS: Expression loss of at least one mismatch repair gene was found in …

Association Of Hla Class I And Class Ii Alleles With Psoriasis Vulgaris In Turkish Population. Influence Of Type I And Ii Psoriasis, Mustafa Atasoy, Ibrahim Pirim, Omer F. Bayrak, Sevki Ozdemir, Mevlit Ikbal, Teoman Erdem, Akin Aktas

Saudi Medical Journal

OBJECTIVE: To investigate the role of human leukocyte antigen (HLA) in susceptibility to psoriasis vulgaris in the Northeast region of Turkey and to contribute to the data related to HLA and psoriasis. METHODS: The study included 72 unrelated psoriatic patients (43 men and 29 women; aged 11-76 years) admitted to the Dermatology Department, University Research Hospital, Erzurum, Turkey between April 2002 and November 2003. We studied the distribution of HLA class I and II antigens in patients with psoriasis: 72 patients were divided into 2 groups according to the onset of psoriasis before age 40 years with family history (type …

Effects Of Nonstrangulated Small Bowel Obstruction On Intestinal Histology, Insulin-Like Growth Factor-I Level, Antioxidants, And Lipid Peroxidation In Rats, Ismet F. Ozguner, Cagri Savas, Meltem Ozguner, Namik Delibas

Saudi Medical Journal

No abstract provided.

Are The Laws Or Applications Insufficient To Prevent Children From The Hazards Of Corrosive Materials?, Tarik Gunduz, Omur Elcioglu, Huseyin Ilhan

Saudi Medical Journal

No abstract provided.

Peritoneal Tuberculosis Mimicking Ovarian Pathology. A Series Of 11 Cases, Ahmet Kale, Nurten Akdeniz, Levent Akyildiz, Ebru Kale, Talip Gul

Saudi Medical Journal

No abstract provided.

Is There Any Effect Of Age, Gender And Body Mass Index On The Electrocardiographic T-Wave Amplitude In Northern Saudi Arabia?, Naveed D. Mahmood, Abdul S. Khan, Shazia N. Jamil

Saudi Medical Journal

No abstract provided.

Densitometric Analysis Of Dot Blot Assays For Human Immunodeficiency Virus Type 1 And 2 Antibodies, Mehrdad Ravanshad, Fereidoun Mahboudi, Farzaneh Sabahi, Anoshirvan Kazemnejad

Saudi Medical Journal

No abstract provided.

Comparison Of Glycemic Control Of Type 2 Diabetes Between Private Hospital And Governmental Hospital, Abdulrahman A. Al-Shaikh

Saudi Medical Journal

No abstract provided.

Polarity In Plants - Annual Plant Reviews, Volume 12, Steven D. Harris

Department of Plant Pathology: Faculty Publications

Polarity is a fundamental property of all cells. The molecular mechanisms that underlies the establishment and maintenance of cellular polarity have been intensively studied in animal cells and yeast-like fungi. These studies reveal an emerging general principle whereby positional information is relayed to the cytoskeleton and other morphogenetic functions by conserved signaling pathways. Comparatively less attention has been directed toward the molecular basis of polarized growth in plant cells and tissues. This volume, Polarity in Plants, provides a comprehensive review of the topic that should satisfy both hardcore aficionados of plant cell and developmental biology as well as curious investigators …

The National Children's Study, Waukesha Country, Wisconsin, Vanguard Center, Jeanne B. Hewitt, Steven R. Leuthner, Marianne E. Weiss, David Whelan, Leslie Athey, Jane A. Mcelroy, Maureen S. Durkin, Christine E. Cronk

College of Nursing Faculty Research and Publications

The National Children's Study (NCS) is a large, long-term study designed to detect environmental influences on the health and development of children. Waukesha County, Wisconsin, was selected as 1 of 7 "Vanguard Centers" currently funded to finalize and lead the implementation of the study protocol. The authors provide an overview of key design and planning processes that will be used at all NCS Vanguard locations, the specific approaches to be used in the NCS Waukesha Country Vanguard Center, and information about Wisconsin physicians and other health care professionals can become involved in working with the NCS.

Prescription Contraceptives And The Pharmacist's Right To Refuse: Examining The Efficacy Of Conscience Laws, Dennis Rambaud

Cardozo Public Law, Policy & Ethics Journal

The note examines the ethical and legal implications of pharmacists refusing to fill prescriptions for contraceptives based on moral or religious objections. It argues that existing legal protections under Title VII of the Civil Rights Act and professional standards already provide adequate safeguards for pharmacists, rendering additional conscience laws unnecessary. The analysis emphasizes the need to balance pharmacists' rights with patients' access to essential medications, highlighting concerns that conscience laws may hinder patient care without ensuring referrals to alternative providers.

Power-Scavenging Mems Robots, Daniel J. Denninghoff

Theses and Dissertations

This thesis includes the design, modeling, and testing of novel, power-scavenging, biologically inspired MEMS microrobots. Over one hundred 500-μm and 990-μm microrobots with two, four, and eight wings were designed, fabricated, characterized. These microrobots constitute the smallest documented attempt at powered flight. Each microrobot wing is comprised of downward-deflecting, laser-powered thermal actuators made of gold and polysilicon; the microrobots were fabricated in PolyMUMPs® (Polysilicon Multi-User MEMS Processes). Characterization results of the microrobots illustrate how wing-tip deflection can be maximized by optimizing the gold-topolysilicon ratio as well as the dimensions of the actuator-wings. From these results, an optimum actuator-wing configuration was …

Ambient Rivers Monitoring In The Great Bay Estuary Watershed 2005, Natalie Landry, Stephanie Fardy

PREP Reports & Publications

The Department of Environmental Services (DES) received funding from the New Hampshire Estuaries Project (NHEP) to conduct monitoring activities in 2005. The activities described in this report were led by the DES Watershed Assistance Section and involved water monitoring in tidal tributaries. Other DES staff conducted laboratory analyses. These monitoring activities were completed with the overall purpose of improving the understanding of water quality trends. The Department of Environmental Services completed all tasks as planned. This report includes the sample collection information, field and laboratory data, and quality assurance information. Data summaries and interpretations will come at a later time …

Splash: Systematic Proteomics Laboratory Analysis And Storage Hub, Siaw Ling Lo, You Tao, Qingsong Lin, Shashikant B. Joshi, Maxey Chung, Choy Leong Hew

Research Collection School Of Computing and Information Systems

In the field of proteomics, the increasing difficulty to unify the data format, due to the different platforms/instrumentation and laboratory documentation systems, greatly hinders experimental data verification, exchange, and comparison. Therefore, it is essential to establish standard formats for every necessary aspect of proteomics data. One of the recently published data models is the proteomics experiment data repository [Taylor, C. F., Paton, N. W., Garwood, K. L., Kirby, P. D. et al., Nat. Biotechnol. 2003, 21, 247-254]. Compliant with this format, we developed the systematic proteomics laboratory analysis and storage hub (SPLASH) database system as an informatics infrastructure to support …

“Waltzing With The Monster,” Interventions With The Substance-Abusing Adolescent For Pastors, Treatment Providers, And Family, Philip A. Watkins

Doctoral Dissertations and Projects

The biblical story of the "Prodigal Son" is a universal experience made significantly more precarious by the use of mind altering chemicals. A review of the literature reveals that approximately half of all problems impacting American families are caused or exacerbated by the abuse of alcohol or other drugs. This project's focus is the impact of substance abuse on the developing adolescent. Chemical "hijacking" of the brain's pleasure centers and resultant dysfunction is examined. Primary, secondary, and tertiary prevention are discussed. Interventions which facilitate the young person's "homecoming" and implications for the community of faith are integrated.