Digital Commons Network^™

Systems Analysis Of Circadian Time-Dependent Neuronal Epidermal Growth Factor Receptor Signaling, Daniel E. Zak, Haiping Hao, Rajanikanth Vadigepalli, Gregory M. Miller, Babatunde A. Ogunnaike, James S. Schwaber

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

Identifying the gene regulatory networks governing physiological signal integration remains an important challenge in circadian biology. Epidermal growth factor receptor (EGFR) has been implicated in circadian function and is expressed in the suprachiasmatic nuclei (SCN), the core circadian pacemaker. The transcription networks downstream of EGFR in the SCN are unknown but, by analogy to other SCN inputs, we expect the response to EGFR activation to depend on circadian timing.

Results

We have undertaken a systems-level analysis of EGFR circadian time-dependent signaling in the SCN. We collected gene-expression profiles to study how the SCN response to EGFR activation depends on …

Systems Analysis Of Circadian Time-Dependent Neuronal Epidermal Growth Factor Receptor Signaling, Daniel E. Zak, Haiping Hao, Rajanikanth Vadigepalli, Gregory M. Miller, Babatunde A. Ogunnaike, James S. Schwaber

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

Identifying the gene regulatory networks governing physiological signal integration remains an important challenge in circadian biology. Epidermal growth factor receptor (EGFR) has been implicated in circadian function and is expressed in the suprachiasmatic nuclei (SCN), the core circadian pacemaker. The transcription networks downstream of EGFR in the SCN are unknown but, by analogy to other SCN inputs, we expect the response to EGFR activation to depend on circadian timing.

Results

We have undertaken a systems-level analysis of EGFR circadian time-dependent signaling in the SCN. We collected gene-expression profiles to study how the SCN response to EGFR activation depends on …

Deafdigest: Blue Edition, June 18, 2006, Barry Strassler

DeafDigest Blue 2006

No abstract provided.

Comparison Of Risk Management Policies In Oecd Countries, Reza Lahidji

Geohazards

The Organisation for Economic Cooperation and Development started in 2003 a series of country studies and reviews aimed at assisting its Member countries in evaluating the effectiveness of their risk management systems, notably in terms of their ability to contend with large-scale risks of the future, and at offering them guidance in making the requisite improvements. The project, entitled the OECD Futures Project on Risk Management Policies, focuses on the consistency of risk management policies and on their ability to deal with the challenges, present and future, created by the evolution of the risk landscape.

The Project gathers eight Member …

Integrating Physical Accessibility Of Emergency Establishments Into Earthquake Risk Assessment, Kivanc Ertugay, Sebnem Duzgun

Geohazards

Human being has always been in a continual struggle with disasters. They are mostly sudden and unexpected and cause irreversible damages to human life and property. Disasters are facts of life, but it is always possible to decrease the effects of disasters by preparedness. In disaster case, accessibility is one of the most vital and important components of disaster preparedness and mean the difference between loosing a life or saving a life. That is why emergency accessibility, regardless if it is measured in time, distance, population or any other cost, is the most important variable that decision makers must consider …

Integrated Natural Disaster Risk Assessment: The Socio-Economic Dimension Of Earthquake Risk In The Urban Area, Sibel Kalaycioglu, Helga Rittersberger-Tilic, Kezban Celik, Fatime Günes

Geohazards

Understanding and formulation of risk of a natural disaster requires consideration of every aspect of risk, which can be handled by development of integrated approaches. In such integrated approaches, several discipline’s views are incorporated into risk assessment to see the whole picture. Hence, the risk which can be experienced before and / or after a natural disaster should be a common concern for both natural and social disciplines and should be handled through a interdisciplinary approach. A field research was conducted with 1500 households, selected through stratified random sampling, using the database obtained from the Eskisehir Greater Metropolitan Municipality. Interviews …

Landslide Hazard Assessment At “Sakhalin-2” Main Pipeline Project, S. I. Matsiy, A. P. Sheglov, D. V. Pleshakov

Geohazards

In the given article, 2 various approaches to a landslide hazard assessment are considered. Landslide hazard means probability of a slope failure. The calculations have been carried out using a landslide hazardous section of Sakhalin-2 main pipeline route as an example.

On The Acceptable Risk For Structures Subjected To Geohazards, D. Diamantidis, S. Duzgun, F. Nadim, M. Wöhrle

Geohazards

Geohazards such as earthquakes or landslides represent a major risk to structures. In this contribution risk acceptance criteria for structures subjected to geohazards are reviewed. Especially the implementation of human safety and cost benefit considerations are discussed. Current trends in the definition of target safety criteria for structures subjected to earthquakes and landslides are presented and conclusions regarding codified criteria are drawn.

Tsunami Relief Work - Biopesticide Spray Operations - A Case Study, Kadarkarai Murugan

Geohazards

Tsunami occurred on 26th December, 2004 and in India more than 8000 people were killed due to the massive attack. The worst affected districts in Tamil Nadu were Viz., Velankanni, Nagapattinam and Cuddalore, Tamil Nadu, India. Official sources said that due to massive death of animals and human beings, the public health has been affected/spoiled and it will cause further outbreak of infectious diseases like diarrhea, cholera and mosquito transmitting diseases. After a week there were incidents of outbreak of mosquito transmitting diseases such as malaria, and dengue. Tsunami had caused a mixing of animal debris in the breeding ground …

On Tsunami Risk Assessment For The West Coast Of Thailand, Farrokh Nadim, Thomas Glade

Geohazards

The catastrophic Indian Ocean tsunami of 26 December 2004 raised a number of questions for scientists and politicians on how to deal with the tsunami risk in coastal regions. This paper discusses the challenges in tsunami risk evaluation and presents the results of a tsunami risk mitigation study for the west coast of Thailand. It is argued that a scenario-based approach is particularly well suited for evaluation of the risk posed by tsunamis. The approach consists of considering scenarios of plausible extreme, tsunami-generating events, computing the tsunami inundation levels caused by these events, estimating the possible range of casualties for …

Curricula To Educate The 2020 Mse Engineering Professional: Simple But Powerful Changes In The Way That Mse Is Taught, Linda Vanasupa, Blair London, Katherine C. Chen, Richard Savage

Materials Engineering

National leaders in science and technology sectors speak in unison as they call for engineers who are not only technically competent in their fields, but who possess the abilities to communicate well, to work on teams, to apply systems thinking, to operate in the global business environment, to design within a greater set of constraints (environmental, health and safety, sustainability, economic, societal, political, manufacturability, and ethical). In short, our challenge is to educate an engineering professional who is far more sophisticated than the engineer of the 20^th century. Additionally, challenges brought on by the overuse of natural resources put …

Deafdigest: Gold Edition, June 18, 2006, Barry Strassler

DeafDigest Gold 2006

No abstract provided.

The 1999 Colorado Springs, Colorado Landslides – Federal, State And Local Government Response; Public Involvement; And Future Long-Term Risks And Challenges, Mark W. Squire

Geohazards

In the spring of 1999, heavy rain precipitated landslides in over 12 developed areas in Colorado Springs. The landslide damage and destruction exceeded $80 million dollars. A combined federal, state and local response included active participation by property owners in an open and transparent public process. The resulting federally funded mitigation project was a success, but this can only be considered an interim objective for an inherent serious local problem. Colorado Springs is normally an arid environment but high moisture years, like 1999, can result in activation of new landslides and reactivation of existing landslides. Residential neighborhoods continue to expand …

Embedding Innovation Process And Methodology In Engineering Technology And Business Management And Marketing Courses, W. Andrew Clark, J. Paul Sims, Craig A. Turner, Jon L. Smith

ETSU Faculty Works

For many business segments, true “out of the box” innovation occurs in entrepreneurial companies where the founders aren’t hindered with the research paradigms established by mainstream businesses. The founders of these companies, many times technologists and scientists, see the application of the technology long before potential customers develop an understanding of the capabilities that the new technology can bring to the marketplace. Many times these “new technology ideas” have been developed though modifying an existing dominant design (product or service) to meet an unforeseen market need or through the development of a new design that may become the new industry …

June 17, 2006 (Pages 2945-3076), Pennsylvania Legislative Reference Bureau

Volume 36 (2006)

No abstract provided.

Eastern Washington University Commencement Program, 2006, Eastern Washington University

Commencement Programs

Program for Eastern Washington University's spring commencement in 2006

Governors State University Board Of Trustees Meeting Minutes - June 17, 2006, Board Of Trustees

Board of Trustees Meetings Materials and Recordings

Minutes for the Governors State University Board of Trustees Meeting - June 17, 2006

Level Of Distress And Perception Of Control In Concerned Significant Others Of Substance Abusers, Heather Tonczyczyn

Theses and Dissertations

The purpose of this study is to determine the perception of control and level of distress in Concerned Significant Others (CSO) seeking help for their loved one's drug abuse or dependence; and the effect of Community Reinforcement and Family Training (CRAFT) intervention on CSO's perception of control as a possible mediator of the outcome. Participants were part of a larger treatment study conducted at the Treatment Research Institute and consisted of two significant others of substance abusers. The Shapiro Control Inventory (SCI) and the Drinkers Partners Distress Scale (DPD) were used to assess variables of control and distress at intake, …

Tharon Stevens

African American Funeral Programs

No abstract provided.

Two Sides Of The Same Coin? The Relations Between Prosocial And Physically Aggressive Behaviors, Meredith Mcginley, Gustavo Carlo

Department of Psychology: Faculty Publications

The direct and indirect relations between six types of prosocial behavior and physical aggression were examined. Data were gathered from 252 college students (M age = 21.67 years; 184 women) who completed measures of sympathy, prosocial behavior, and physical aggression. Structural equation modeling revealed that sympathy fully mediated the relations between compliant prosocial behaviors and physical aggression, and partially mediated the relations between altruism and physical aggression and public prosocial behaviors and physical aggression. The fi ndings suggest that the relations between prosocial behaviors and aggression are complex and that prosocial behavior should not be treated as a unitary construct.

Special Meeting, Wku Board Of Regents

Board of Regents Documents

Minutes of WKU Board of Regents special meeting to honor Cornelius Martin, elect officers and approve combined budgets and faculty/staff compensation report.

On The Green Vol. 36 No. 16 June 16, 2006, Gallaudet University

2001-2010

On the Green is an internal publication of Gallaudet College, which later became Gallaudet University. It notified employees of updates around the campus and in the broader community, including new construction and the establishment of new academic programs. Running until 2010, it was supplanted by various forms of online mass communications across multiple audiences.

Age- And Sex-Specific Transformations Of Health Status Measures To Incorporate Death, Ann M. Derleth, Paula Diehr

UW Biostatistics Working Paper Series

Introduction: Measures of health status and physical function do not usually include a specific code for death. This can cause problems in longitudinal studies because analyses limited to survivors may bias the results. One approach is to recode the status variables to include a reasonable value for death. One method that has been used is to replace each scale value with the estimated probability that a person with this value will be “healthy”. “Healthy” has been defined as being above a particular threshold on the variable of interest one year later, or alternatively as being in excellent, very good, or …

Perceptions Of The Impact Of Accountability On The Role Of Principals, James E. Lyons, Bob Algozzine

Education Policy Analysis Archives (EPAA)

Calls for accountability in America’s schools have created increased responsibilities for educational leaders. In this article, we describe and discuss a study of elementary, middle, and high school principals’ perceptions of the state-wide educational accountability program in North Carolina. The respondents indicated that the state’s accountability program has had its greatest impact on how they monitored student achievement, aligned the curriculum to the testing program, provided student remedial or tutorial opportunities, assigned teachers to grades levels or subjects, and protected instructional time. Views of some components, such as measures of school effectiveness, school safety standards, expectations and promotion standards for …

Uab School Of Health Related Professions Renamed, Staff

Browse All News

No abstract provided.

Education Policy Analysis Archives 14/16 , Arizona State University, University Of South Florida

College of Education Publications

Perceptions of the Impact of Accountability on the Role of Principals / James E. Lyons, PhD [and] Bob Algozzine, PhD.

Utb-Tsc Academic Senate Minutes 2006-06-16, University Of Texas At Brownsville And Texas Southmost College. Faculty Senate.

UTB/TSC Faculty Senate Minutes

No abstract provided.

Stat5 Activators Modulate Acyl Coa Oxidase (Aox) Expression In Adipocytes And Stat5a Binds To The Aox Promoter In Vitro, Ann A. Coulter, Jacqueline M. Stephens

Faculty Publications

Growth hormone (GH) diminishes adipose tissue mass in vivo and prolactin (PRL) can also modulate adipocyte metabolism. Both GH and PRL are potent activators of STAT5 and exert a variety of effects on adipocyte gene expression. In this study, we have demonstrated that GH and PRL increase the mRNA of acyl CoA oxidase in 3T3-L1 adipocytes. We also identified seven putative STAT elements in the murine AOX promoter. We observed that GH modulates protein binding to the majority of these promoter elements. However, GH induced very potent binding to -1841 to -1825 of the murine AOX promoter. EMSA supershift analysis …

Alterations In Regional Vascular Geometry Produced By Theoretical Stent Implantation Influence Distributions Of Wall Shear Stress: Analysis Of A Curved Coronary Artery Using 3d Computational Fluid Dynamics Modeling, John F. Ladisa, Lars E. Olson, Douglas Anthony Hettrick, David C. Warltier, Judy R. Kersten, Paul S. Pagel

Biomedical Engineering Faculty Research and Publications

Background

The success of stent implantation in the restoration of blood flow through areas of vascular narrowing is limited by restenosis. Several recent studies have suggested that the local geometric environment created by a deployed stent may influence regional blood flow characteristics and alter distributions of wall shear stress (WSS) after implantation, thereby rendering specific areas of the vessel wall more susceptible to neointimal hyperplasia and restenosis. Stents are most frequently implanted in curved vessels such as the coronary arteries, but most computational studies examining blood flow patterns through stented vessels conducted to date use linear, cylindrical geometric models. It …

Murray Ledger And Times, June 16, 2006, Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.