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Gene Expression Profiles And Clinical Parameters For Survival Prediction In Stage Ii And Iii Colorectal Cancer Patients, Mubeena Begum

USF Tampa Graduate Theses and Dissertations

Prediction of outcome in colorectal cancer (CRC) is currently based on the TNM staging classification; however, histopathological classification alone is insufficient for accurately predicting survival in stage II and III patients. Studies indicate that microarray gene expression profiles can predict survival in CRC. We hypothesize that tumor gene expression in combination with clinical parameters, is a better predictor of outcome in stage II and III colorectal cancers than the TNM stage classification alone. Clinical records and follow-up data were retrospectively reviewed for 58 Stage II and Stage III patients with primary colorectal cancer, who did not receive any neoadjuvant therapy …

Arts In New Directions The Development And Application Of A Construct That Uses The Arts To Promote Transformation And Self-Actualization In Health Care And Education/Therapy, Alexxis Avalon

USF Tampa Graduate Theses and Dissertations

Artistic methods to evoke relaxation, spark creativity, and change self-perceptions are already being used by therapists, educators, and scientists. Interdisciplinary collaborations among researchers are developing to create new paradigms that incorporate the use of arts to empower individuals. By describing various connections between the arts and participants, researchers are looking at the expressive arts (including dance, music, drama, poetry, and visual arts) for transformation and self-actualization.The problem is that no construct is available to describe the transformation, "the conscious move from one deep structure of knowledge to another" (Wilber, 2004), that occurs when using the arts in health care and …

Comparing The Effects Of The Exotic Cactus-Feeding Moth, Cactoblastis Cactorum (Berg) (Lepidoptera: Pyralidae) And A Native Cactus-Feeding Moth, Melitara Prodenialis (Walker) (Lepidoptera: Pyralidae) On Two Species Of Florida Opuntia., Amanda J. Baker

USF Tampa Graduate Theses and Dissertations

Exotic species are a great concern because of the possibility of negative effects once they become established. The exotic cactus moth, Cactoblastis cactorum has a reputation for being detrimental to Opuntia populations throughout Florida and the southeastern United States. Multiple projects are currently underway to attempt to contain and eradicate this species before it can migrate to the Opuntia-rich desert southwest and the agricultural Opuntia fields in the Mexican highlands. These projects have been undertaken without previous studies to determine what negative effects, if any, the moth is having on the common native Opuntia species. This is understandable; since it …

Implications Of Sleep Disorders Symptoms On School Behavior, Academics, And Quality Of Life, Erin Elizabeth Ax

USF Tampa Graduate Theses and Dissertations

Pediatric sleep problems are among the most common yet significant pediatric health issues faced by families. Sleep problems can impact social-emotional and academic functioning of schoolchildren. Once identified, pediatric sleep problems and disorders are treatable with effective and rapid behavioral and medical interventions. The purpose of the current study was to determine the prevalence rates of symptoms of sleep disorders in a diverse school-based sample as well as the relationship between symptoms of sleep disorders and school behavior, academic achievement, and quality of life. The present study examined the relationship between the independent variables of No Sleep Disorders symptoms and …

Adolescent Alcohol Use And Educational Outcomes, Wesley A. Austin

USF Tampa Graduate Theses and Dissertations

There is some controversy over whether adolescent alcohol use has deleterious causal effects on educational outcomes. In particular, does drinking reduce academic performance and school enrollment rates and increase truancy, or does the observed negative correlation between drinking and educational outcomes merely reflect common unobservable factors? This dissertation sheds further light on the issue by estimating the causal impacts of alcohol use on various educational outcomes. Specifically, an instrumental variables model is estimated to study the effects of several drinking measures on grades, school enrollment and absenteeism.

Study Of Laplace And Related Probability Distributions And Their Applications, Gokarna Raj Aryal

USF Tampa Graduate Theses and Dissertations

The aim of the present study is to investigate a probability distribution that can be derived from the laplace probability distribution and can be used to model various real world problems. In the last few decades, there has been a growing interest in the construction of flexible parametric classes of probability distributions. Various forms of the skewed and kurtotic distributions have appeared in the literature for data analysis and modeling. In particular, various forms of the skew laplace distribution have been introduced and applied in several areas including medical science, environmental science, communications, economics, engineering and finance, among others. In …

Crystal Engineering Of Organic Compounds Including Pharmaceuticals, Joanna A. Bis

USF Tampa Graduate Theses and Dissertations

Neutral or charge-assisted hydrogen bonds occurring between organic molecules represent strong and directional forces that mediate the molecular self-assembly into well defined supramolecular architectures. A proper understanding of hydrogen bonding interactions, their types, geometries, and occurrence in supramolecular motifs, is a prerequisite to crystal engineering, i.e. to the rational design of functional solid materials.Multiple-component organic crystals represent ideal systems to study the intermolecular interactions between the constituent molecules that can be pre-selected for their hydrogen bonding sites and geometrical capabilities. In particular, the systematic structural analysis of supramolecular systems that are comprised of simple molecules facilitates the development of strategies …

A Case Study Of A School Implementing A Constructivist Philosophy, Joseph C. Brown

USF Tampa Graduate Theses and Dissertations

Isaacson's (2004) dissertation chronicles the implementation of a constructivist instructional approach at Southwood Elementary School. Southwood's faculty experienced a change of principals, which the Tri-Partite Theory of Organizational Change and Succession, a theory of organizational entropy, predicts could lead to organizational entropy. This study examines the dynamics of the change in principal, as well as Isaacson's recommendation to study teachers' perceptions regarding the maintenance of the constructivist approach. This study answers three questions: 1) Are faculty still using constructivist strategies? 2) What are teacher perceptions regarding the maintenance and support of constructivist philosophy? 3) Is there congruence between what literature …

Regulation Of Transcription And Analysis Of Drug Targets In Lymphoma And Myeloma Cells, Sophia C. E Bolick

USF Tampa Graduate Theses and Dissertations

Hematological malignancies, such as lymphomas and myelomas, have low cure rates or remain refractory to treatment, although advances have been made in treatment regimens for these patients. Questions still remain as to what is occurring in these cells on a molecular level, specifically at the level of gene transcription. The positive regulatory domain I binding factor 1 (PRDI-BF1) has been shown to directly repress genes required for cell proliferation and maintenance of the B cell phenotype, however very little is known as to its regulation. The first study presented in this dissertation demonstrates regulation of the PRDM1 gene occurs primarily …

Teaching Strategies Of Successful College Trombone Professors For Undergraduate Students, Matthew T. Buckmaster

USF Tampa Graduate Theses and Dissertations

This study identified teaching strategies of successful trombone professors for undergraduate trombone students. Participants were three professors at accredited colleges in the United States who had received international awards in the field of trombone pedagogy. A comprehensive interview instrument was administered to each participant in a multiple case studies research design. From the gathered data, a classical content analysis revealed 79 emergent themes from 375 coded passages, with 45 of the emergent themes being commonalities among the three participants. In addition to specific teaching strategies, three meta-themes emerged from an examination of these commonalities: Product Over Process, Individualized Teaching Approaches, …

B-Raf Is An Essential Component Of The Mitotic Machinery Critical For Activation Of Mapk Signaling During Mitosis In Xenopus Egg Extracts, Sergiy I. Borysov

USF Tampa Graduate Theses and Dissertations

Activation of the MAPK cascade during mitosis is critical for spindle assembly and normal mitotic progression. The underlying regulatory mechanisms that control activation of the MEK/MAPK cascade during mitosis are poorly understood. The goal of my dissertation research is to identify the MEK kinase responsible for activation of the MAPK cascade during mitosis and to elucidate the biochemical mechanisms that regulate its activity. In the described herein work I purified and characterized the MEK kinase activity present in M-phase arrested Xenopus egg extracts. I demonstrate that B-Raf is the critical MEK kinase required for activation of the MAPK pathway at …

Statistical Modeling And Assessment Of Software Reliability, Louis Richard Camara

USF Tampa Graduate Theses and Dissertations

The present study is concerned with developing some statistical models to evaluate and analyze software reliability. We have developed the analytical structure of the logistic model to be used for testing and evaluating the reliability of a software package. The proposed model has been shown to be useful in the testing and debugging stages of the developmental process of a software package. It is important that prior to releasing a software package to marketing that we have achieved a target reliability with an acceptable degree of confidence. The proposed model has been evaluated and compared with several existing statistical models …

Enzyme Linked Spectroscopic Assays For Glyoxylate; The Use Of Peptidylglycine Alpha-Amidating Monoxygenase For The Discovery Of Novel Alpha-Amidated Hormones, Sarah Elizabeth Carpenter

USF Tampa Graduate Theses and Dissertations

Peptide hormones are responsible for cellular functions critical to the survival of an organism. Approximately 50% of all known peptide hormones are post-translationally modified at the C-terminus. Enzymatic oxidative conversion of C-terminal glycine extended peptide precursors results in an a-amidated peptide and glyoxylate. Peptidylglycine a-amidating monooxygenase (PAM) is the single known enzyme responsible for catalyzing this reaction. PAM is an O2, Cu(II), and Zn(II) dependent bifunctional enzyme. Initially, PAM hydroxylates the glycyl a-carbon followed by dealkylation of the hydroxylated intermediate to an a-amidated product and glyoxylate. PAM is also responsible for the conversion of glycine extended fatty acids to fatty …

Stabilization Of Marginal Soils Using Recycled Materials, Delfin G. Carreon

USF Tampa Graduate Theses and Dissertations

Marginal soils, including loose sands, soft clays, and organics are not adequate materials for construction projects. These marginal soils do not possess valuable physical properties for construction applications. The current methods for remediation of these weak soils such as stone columns, vibro-compaction, etc. are typically expensive. Waste materials such as scrap tires, ash, and wastewater sludge, offer a cheaper method for stabilizing marginal soils. As an added benefit, utilizing waste materials in soil stabilization applications keeps these materials from being dumped into landfills, thereby saving already depleting landfill space. Included in this report is an extensive investigation into the current …

Cloning And Analysis Of Putative Collagenases Of The U32 Family In Streptococcus Mutans And Streptococcus Agalactiae (Group B Streptococci), Valerie Carson

USF Tampa Graduate Theses and Dissertations

Analysis of the genomic sequences of Streptococcus mutans UA159 and Group B Streptococcus (GBS) strains Streptococcus agalactiae NEM316 and S. agalactiae 2603V/R indicated the presence of two putative collagenase genes in each organism. smcol1 from S. mutans was previously cloned and analyzed and the results indicated that the enzyme belonged to the U32 family of collagenases/peptidases. This enzyme shares homology with the prtC of Porphyromonas gingivalis, one of the principal examples of the U32 family of peptidases. Considering the potential role of these enzymes in the pathogenicity of P. gingivalis (periodontitis or gum disease), GBS (premature rupture of the amniochorionic …

Cue Reactivity And The Role Of Social Alcohol Expectancies In The College-Aged Drinking Population, Ashlee C. Carter

USF Tampa Graduate Theses and Dissertations

Research has shown alcohol expectancies to be critically important in understanding maladaptive drinking patterns within alcohol use disorders. Alcohol expectancies, thought to be automatically elicited in the presence of environmental alcohol-related cues, represent both cognitive and affective associations with drinking behavior. However, the automatic and affective properties of alcohol expectancies have not yet been thoroughly measured in the literature. Psychophysiological measures, including skin conductance, heart rate, and the acoustic startle response in particular, offer a uniquely powerful set of indices for the automatic affective processing of alcohol-related cues.

Therefore, the present study was designed to examine how alcohol expectancies moderate …

The Hearing Abilities Of Elasmobranch Fishes, Brandon M. Casper

USF Tampa Graduate Theses and Dissertations

The hearing abilities of elasmobranch fishes were examined in response to several types of stimuli using auditory evoked potentials (AEP). Audiograms were acquired for the nurse shark, Ginglymostoma cirratum, the yellow stingray, Urobatis jamaicensis, in a controlled environment using a monopole underwater speaker. A dipole stimulus was used to measure the hearing thresholds of the horn shark, Heterodontus francisi, and the white-spotted bamboo shark, Chiloscyllium plagiosum. The dipole experiments yielded much lower thresholds than any other experiment, suggesting that this type of sound specifically stimulated the macula neglecta by creating a strong velocity flow above the head of the shark. …

Folk Wiki: The Shared Traditions Of Folk Music And The Wiki Way, Phillip Mark Chamberlin

USF Tampa Graduate Theses and Dissertations

Wiki is often perceived as representing a revolutionary break from conventional notions of authorship, writing, and textual history. Dialogues concerning Wiki tend to ignore the characteristics that Wiki shares with earlier forms of collaboration, particularly folk music. In both Wiki and folk music, content is often collectively shared and authored, even if specific individuals create and change the content. Many collaborators are anonymous, quasi-anonymous, or pseudo-anonymous, but the perception of this anonymity is, in both genres, problematic. Second, both Wiki documents and folk songs exist in the "Eternal Now," a seemingly perpetual state that makes these texts available for addition, …

The Effects Of Multimedia Annotations On L2 Vocabulary Immediate Recall And Reading Comprehension: A Comparative Study Of Text-Picture And Audio-Picture Annotations Under Incidental And Intentional Learning Conditions, Zhaohui Chen

USF Tampa Graduate Theses and Dissertations

This dissertation investigated the effects of multimedia annotation on L2 vocabulary learning and reading comprehension. The overarching objective of this study was to compare the effects of text-picture annotation and audio-picture annotation on L2 vocabulary immediate recall and reading comprehension. This study also sought to examine the different effects under incidental and intentional learning conditions. The participants were 78 intermediate adult ESL learners from three universities in northwest U.S. The participants read an Internet-based English text. Twenty target words, annotated in either text-picture or audio-picture, were embedded in the reading text. The participants accessed the annotations by clicking on the …

Monitoring Water Quality In Tampa Bay: Coupling In Situ And Remote Sensing, Zhiqiang Chen

USF Tampa Graduate Theses and Dissertations

Water quality in Tampa Bay was examined using concurrent in situ and satellite remote sensing observations. Chlorophyll and suspended sediment concentrations showed large short-term variability, primarily driven by tide and wind forcing. Superimposed on these high frequency variations were recurrent phytoplankton blooms stimulated by decreases in turbidity 1-2 days after wind-induced bottom sediment resuspension events; the blooms were particularly strong if neap tides occurred after the wind events. The in situ data show that observations once per month are inadequate to sample short-term variability and that therefore the current monthly water quality surveys may have uncertainties of -50 to 200% …

Genetic Variation In The Chloroplast Genome Of A Newly Described Aster Species, Chrysopsis Delaneyi, Justine Ann Clark

USF Tampa Graduate Theses and Dissertations

The genus Chrysopsis (Asteraceae) contains eleven species native to Florida, including the newly described species, Chrysopsis delaneyi. Populations of this endemic plant species inhabit the Lake Wales Ridge (LWR) and the Atlantic Ridge (AR) of the Florida peninsula. Differences in morphology have been demonstrated within C. delaneyi, based on their locations. My objective was to determine the relationships between the LWR and the AR populations by analysis of chloroplast sequence and nuclear sequence variation. Approximately 160 samples of C. delaneyi and its sister species C. scabrella have been collected from fifteen sites throughout Florida. Six single base differences were detected, …

Performance Based Design Of Degrading Structures, Mouchir Chenouda

USF Tampa Graduate Theses and Dissertations

Seismic code provisions are now adopting performance-based methodologies, where structures are designed to satisfy multiple performance objectives. Most codes rely on approximate methods to predict the desired seismic demand parameters. Most of these methods are based on simple SDOF models, and do not take into account neither MDOF nor degradation effects, which are major factors influencing structural behavior under earthquake excitations. More importantly, most of these models can not predict collapse explicitly under severe seismic loads. This research presents a newly developed model that incorporates degradation effects into seismic analysis of structures. A new energy-based approach is used to define …

Traumatic Loss And Transformative Life Experiences: The Lived Experience Of Green Cross Traumatologists Deployed To The New York City World Trade Center Disaster, Carron C. Cherrie

USF Tampa Graduate Theses and Dissertations

This exploratory study examines the lived experience of Green Cross traumatologists deployed to the New York City World Trade Center disaster. The deployment took place five days after the terrorist attacks on September 11, 2001. The author was a member of a ten member advance team that provided crisis stabilization services to an international union in Lower Manhattan. Disaster Mental Health Services and community outreach were provided for a month. The purpose of the study was to describe in an anthropologically holistic perspective the lived experience of traumatologists, who as Americans were also affected by the terrorist disaster. Thirty-one traumatologists …

The Influence Of Performance Background On Instrumentalists’ Ability To Discriminate And Label Cornet And Trumpet Timbre, Gary Compton

USF Tampa Graduate Theses and Dissertations

This study was an examination of timbre discrimination and labeling, with specific consideration of the soprano-brass timbres of cornets and trumpets. This study sought to determine whether instrumentalists differed in their ability to label and discriminate cornet and trumpet timbres, and whether these abilities were influenced by the instrumentalists' performing instrument and years of playing experience. Wind, brass and percussion players (n=100) from existing instrumental groups in the Tampa Bay area participated in the study. These groups were collegiate trumpet majors from a large public university school of music, a collegiate wind ensemble from a private university, and a brass …

Behavioral And Auditory Evoked Potential (Aep) Hearing Measurements In Odontocete Cetaceans, Mandy Lee Hill Cook

USF Tampa Graduate Theses and Dissertations

Bottlenose dolphins (Tursiops truncatus) and other odontocete cetaceans rely on sound for communication, navigation, and foraging. Therefore, hearing is one of their primary sensory modalities. Both natural and anthropogenic noise in the marine environment could mask the ability of free-ranging dolphins to detect sounds, and chronic noise exposure could cause permanent hearing losses. In addition, several mass strandings of odontocete cetaceans, especially beaked whales, have been correlated with military exercises involving mid-frequency sonar, highlighting unknowns regarding hearing sensitivity in these animals.Auditory evoked potential (AEP) methods are attractive over traditional behavioral methods for measuring the hearing of marine mammals because they …

The Association Of Head Circumference With Selected Cognitive Outcomes In Older Adults In Charlotte County, Florida, Cathleen Copenhaver

USF Tampa Graduate Theses and Dissertations

OBJECTIVE: The brain reserve hypothesis was examined in a secondary analysis of cross-sectional data from a community-based sample of 468 older adults residing in Charlotte County, Florida. The objective of the analysis was to determine the association between head circumference and eight cognitive outcomes and to assess any potential effect modification of existing associations by Apolipoprotein E (APOE) genotype. METHODS: Cognitive outcomes include scores from the Modified Mini-Mental State Exam (3MS), the Hopkins Verbal Learning Test-Revised (HVLT-R), Stroop Color-Word Test, Trail-Making Test A and B, and a word-stem completion task measuring implicit memory. Descriptive statistics were calculated for each variable. …

Herbivory By Leaf Miners On Florida Scrub Oaks, Tatiana Cornelissen

USF Tampa Graduate Theses and Dissertations

This study investigated effects of plant quality and natural enemies on the abundance and survivorship of several leaf miner species on Florida scrub oaks over several ecological scales. Three oak species (Quercus laevis, Q. geminata, and Q. myrtifolia) and four leafminer species (Acrocercops albinatella, Brachys tesselatus, Stilbosis quadripustulatus, and Cameraria sp. nova) were the main focus of five separate studies, addressing effects of bottom-up and top-down factors at regional, local, and individual scales. At the regional scale, it was observed that Cameraria sp. nova was aggregated into sites, and sites closer to …

A Descriptive Analysis Of The Relationship Between Specific Teacher Characteristics And Teacher Efficacy In Florida’S Low-Performing Public High Schools, Pamela S. Craig

USF Tampa Graduate Theses and Dissertations

This study was designed to collect data to determine the specific characteristics (gender, level and area of degree status, certification status, pedagogical training, gender, number of years of teaching experience, number of years teaching at the current school, and courses currently taught) of language arts teachers at Florida's low-performing pubic high schools and compare these characteristics to teachers' sense of efficacy (the extent to which teachers' believe they have the ability to bring about changes in student achievement independent of the student's background, behaviors, or motivation level). A total of 615 teachers representing 84 schools in 36 districts participated in …

Risk And Protective Factors Related To Resilience In Adolescents In An Alternative Education Program, Kelly M. Crawford

USF Tampa Graduate Theses and Dissertations

Using a multivariate correlational design, this study was designed to determine the degree to which selected risk and protective factors were related to resilience in an at-risk student population. A total of 12 individual, family and external risk and protective factors were identified and data were collected from 142 6th through 11th grade students in an alternative education program for individuals who had committed severe behavioral infractions. A series of multiple regression analyses were conducted using three outcome variables: a rating of students' resilient behavior, number of behavior referrals in the students' records, and standardized reading achievement scores. Five percent …

Some Problems On Products Of Random Matrices, Edgardo S. Cureg

USF Tampa Graduate Theses and Dissertations

We consider three problems in this dissertation, all under the unifying theme of random matrix products. The first and second problems are concerned with weak convergence in stochastic matrices and circulant matrices, respectively, and the third is concerned with the numerical calculation of the Lyapunov exponent associated with some random Fibonacci sequences. Stochastic matrices are nonnegative matrices whose row sums are all equal to 1. They are most commonly encountered as transition matrices of Markov chains. Circulant matrices, on the other hand, are matrices where each row after the first is just the previous row cyclically shifted to the right …