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2006

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Roles Of Cyclooxygenase-2 In Microglial Activation And Dopaminergic Cell Death, Rattanavijit Vijitruth Jan 2006

Roles Of Cyclooxygenase-2 In Microglial Activation And Dopaminergic Cell Death, Rattanavijit Vijitruth

University of Kentucky Doctoral Dissertations

Accumulating evidence suggests that inflammation plays an important role in the progression ofParkinson's disease (PD). Among many inflammatory factors found in the PD brain, cyclooxygenase(COX), especially the inducible isoform, COX-2, is believed to be the critical enzyme in theinflammatory response. Induction of COX-2 is also found in an experimental model of PD producedby administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To investigate whetherinhibition of COX-2 by valdecoxib or deficiency in COX-2 could prevent dopaminergic neuronaltoxicity and locomotor activity impairment, we injected MPTP into valdecoxib-treated C57BL/6N miceand COX-2 deficient mice, respectively. Both automated total distance and vertical activitymeasurements of the open-field test were significantly …

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Extending And Enhancing Gt-Itm, Aditya Namjoshi Jan 2006

Extending And Enhancing Gt-Itm, Aditya Namjoshi

University of Kentucky Master's Theses

GT-ITMis a topology generation tool. Since its release GTITMis widely used in the scientific community for network simulations. GTITM is extended to support routing on its topology. The routing algorithm used for interdomain routing attempts to emulate the BGP routing protocol seen on the internet. It uses a policy file if supplied to make routing decisions. An additional functionality provided with the tool is the ability to automatically generate policy file for large graphs.

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Information Technology For Next-Generation Of Surgical Environments, Jesus Caban Jan 2006

Information Technology For Next-Generation Of Surgical Environments, Jesus Caban

University of Kentucky Master's Theses

Minimally invasive surgeries (MIS) are fundamentally constrained by image quality,access to the operative field, and the visualization environment on which thesurgeon relies for real-time information. Although invasive access benefits the patient,it also leads to more challenging procedures, which require better skills andtraining. Endoscopic surgeries rely heavily on 2D interfaces, introducing additionalchallenges due to the loss of depth perception, the lack of 3-Dimensional imaging,and the reduction of degrees of freedom.By using state-of-the-art technology within a distributed computational architecture,it is possible to incorporate multiple sensors, hybrid display devices, and3D visualization algorithms within a exible surgical environment. Such environmentscan assist the surgeon with …

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Investigations Into The Cognitive Abilities Of Alternate Learning Classifier System Architectures, David Alexander Gaines Jan 2006

Investigations Into The Cognitive Abilities Of Alternate Learning Classifier System Architectures, David Alexander Gaines

University of Kentucky Doctoral Dissertations

The Learning Classifier System (LCS) and its descendant, XCS, are promising paradigms for machine learning design and implementation. Whereas LCS allows classifier payoff predictions to guide system performance, XCS focuses on payoff-prediction accuracy instead, allowing it to evolve "optimal" classifier sets in particular applications requiring rational thought. This research examines LCS and XCS performance in artificial situations with broad social/commercial parallels, created using the non-Markov Iterated Prisoner's Dilemma (IPD) game-playing scenario, where the setting is sometimes asymmetric and where irrationality sometimes pays. This research systematically perturbs a "conventional" IPD-playing LCS-based agent until it results in a full-fledged XCS-based agent, contrasting …

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Enhanced Grain Crop Yield Monitor Accuracy Through Sensor Fusion And Post-Processing Algorithms, Matthew Wayne Veal Jan 2006

Enhanced Grain Crop Yield Monitor Accuracy Through Sensor Fusion And Post-Processing Algorithms, Matthew Wayne Veal

University of Kentucky Doctoral Dissertations

Yield monitors have become an indispensable part of precision agriculture systemsbecause of their ability to measure the yield variability. Accurate yield monitor data availabilityis essential for the assessment of farm practices. The current technology of measuring grainyields is prone to errors that can be attributed to mass flow variations caused by the mechanismswithin a grain combine. Because of throughput variations, there are doubts regarding thecorrelation between the mass flow measurement and the actual grain volume produced at aspecific location. Another inaccuracy observed in yield monitor data can be attributed to inexactcut-widths values entered by the machine operator.To effectively address these …

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The Universal Media Book, Shilpi Gupta Jan 2006

The Universal Media Book, Shilpi Gupta

University of Kentucky Master's Theses

We explore the integration of projected imagery with a physical book that acts as a tangible interface to multimedia data. Using a camera and projector pair, a tracking framework is presented wherein the 3D position of planar pages are monitored as they are turned back and forth by a user, and data is correctly warped and projected onto each page at interactive rates to provide the user with an intuitive mixed-reality experience. The book pages are blank, so traditional camera-based approaches to tracking physical features on the display surface do not apply. Instead, in each frame, feature points are independently …

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Physiological And Anatomical Assessment Of Synapses At The Crayfish Neuromuscular Junction, Andrew Fredericks Moser Johnstone Jan 2006

Physiological And Anatomical Assessment Of Synapses At The Crayfish Neuromuscular Junction, Andrew Fredericks Moser Johnstone

University of Kentucky Doctoral Dissertations

The crayfish, Procambarus clarkii, has a multitude of ideal sites in which synaptic transmission may be studied. Its opener muscle, being innervated by a single excitatory neuron is a good model for studying the structure/function of neuromuscular junctions since the preparation is identifiable from animal to animal and the nerve terminals are visible using a vital dye. This allows ease in finding a suitable site to record from in each preparation and offers the ability to relocate it anatomically. Marking a recorded site and rebuilding it through electron microscopy gives good detail of synaptic struture for assesment.In the first of …

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The Gap Between What Taxpayers Want And What Tax Professionals Think They Want: A Reexamination Of Client Expectations And Tax Professional Aggressiveness, Teresa Stephenson Jan 2006

The Gap Between What Taxpayers Want And What Tax Professionals Think They Want: A Reexamination Of Client Expectations And Tax Professional Aggressiveness, Teresa Stephenson

University of Kentucky Doctoral Dissertations

The purpose of this dissertation is to resolve an apparent conflict between the services that tax preparers provide and the tax preparation services taxpayers seek. Some literature demonstrates that tax professionals equate client advocacy with taking aggressive tax positions and minimizing taxes. Other literature suggests taxpayers seek to increase accuracy and reduce the probability of tax audit when they hire a tax professional. This difference is an "expectation gap."The methodology employed to examine this issue is a survey of tax professionals at various levels of expertise. This survey asks tax preparers what they believe motivates their clients to seek professional …

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Solution And Solid State Interactions Between Ionic Π-Systems, Jing Chen Jan 2006

Solution And Solid State Interactions Between Ionic Π-Systems, Jing Chen

University of Kentucky Doctoral Dissertations

Although attractive interactions between π systems (π-π interaction) have been known for many years, understanding of its origin is still incomplete. Quantitative measuring of π-stacking is challenging due to the weak nature of the π-π interaction. This dissertation aims at elucidating a quantitative conformational analysis by NMR ring current anisotropy of an organic compound capable of intramolecular π-stacking in solution and studying charge effects on the stacking of π-systems. This dissertation offers four contributions to the area. (1) A general approach to four-state, conformational analysis based on the magnetic anisotropy of molecules undergoing fast dynamic exchange is described. (2) Study …

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Studies Toward Synthesis Of Polycyclic Polyprenylated Acylphloroglucinols, Roxana Ciochina Jan 2006

Studies Toward Synthesis Of Polycyclic Polyprenylated Acylphloroglucinols, Roxana Ciochina

University of Kentucky Doctoral Dissertations

Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of compounds that reveal intriguing biological activities and interesting and challenging chemical structures. These products are claimed to possess antioxidant, antiviral, and antimitotic properties. Increasing interest is related to their function in the CNS as modulators of neurotransmitters associated to neuronal damaging and depression. All these features make PPAPs targets for synthesis. We decided to focus our own initial efforts in this area on the type A PPAP, nemorosone because we thought that its fairly simple structure relative to other PPAPs would present fewer hurdles as we developed our methodology.In the past decade …

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Molecular Recognition Properties And Kinetic Characterization Of Trans Excision-Splicing Reaction Catalyzed By A Group I Intron-Derived Ribozyme, Joy Sinha Jan 2006

Molecular Recognition Properties And Kinetic Characterization Of Trans Excision-Splicing Reaction Catalyzed By A Group I Intron-Derived Ribozyme, Joy Sinha

University of Kentucky Doctoral Dissertations

Group I introns belong to a class of large RNAs that catalyze their own excision from precursor RNA through a two-step process called self-splicing reaction. These self-splicing introns have often been converted into ribozymes with the ability site specifically cleave RNA molecules. One such ribozyme, derived from a self-splicing Pneumocystis carinii group I intron, has subsequently been shown to sequence specifically excise a segment from an exogenous RNA transcript through trans excision-splicing reaction.The trans excision-splicing reaction requires that the substrate be cleaved at two positions called the 5' and 3' splice sites. The sequence requirements at these splice sites were …

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High Order Shock Capturing Schemes For Hyperbolic Conservation Laws And The Application In Open Channel Flows, Chunfang Chen Jan 2006

High Order Shock Capturing Schemes For Hyperbolic Conservation Laws And The Application In Open Channel Flows, Chunfang Chen

University of Kentucky Doctoral Dissertations

Many applications in engineering practice can be described by thehyperbolic partial differential equations (PDEs). Numerical modeling of this typeof equations often involves large gradients or shocks, which makes it achallenging task for conventional numerical methods to accurately simulate suchsystems. Thus developing accurate and efficient shock capturing numericalschemes becomes important for the study of hyperbolic equations.In this dissertation, a detailed study of the numerical methods for linearand nonlinear unsteady hyperbolic equations was carried out. A new finitedifference shock capturing scheme of finite volume style was developed. Thisscheme is based on the high order Pad?? type compact central finite differencemethod with the …

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Optimal Water Quality Management Strategies For Urban Watersheds Using Macro-Level Simulation Models Linked With Evolutionary Algorithms, Mohammad Tufail Jan 2006

Optimal Water Quality Management Strategies For Urban Watersheds Using Macro-Level Simulation Models Linked With Evolutionary Algorithms, Mohammad Tufail

University of Kentucky Doctoral Dissertations

Urban watershed management poses a very challenging problem due to the varioussources of pollution and there is a need to develop optimal management models that canfacilitate the process of identifying optimal water quality management strategies. Ascreening level, comprehensive, and integrated computational methodology is developedfor the management of point and non-point sources of pollution in urban watersheds. Themethodology is based on linking macro-level water quality simulation models withefficient nonlinear constrained optimization methods for urban watershed management.The use of macro-level simulation models in lieu of the traditional and complexdeductive simulation models is investigated in the optimal management framework forurban watersheds. Two different …

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Co2-Selective Membrane For Fuel Cell Applications, Louei Abdel Raouf El-Azzami Jan 2006

Co2-Selective Membrane For Fuel Cell Applications, Louei Abdel Raouf El-Azzami

University of Kentucky Doctoral Dissertations

We have developed CO2-selective membranes to purified hydrogen and nitrogenfor fuel cell processes. Hydrogen purification impacts other industries such as ammoniaproduction and flue gas purification at reduced costs.Dense chitosan membranes were used for the first time to separate CO2 from amixture of 10% CO2, 10% H2, and 80% N2 at temperatures of 20 – 150oC and feedpressures of 1.5 atm – 5 atm. At 1.5 atm and 20 – 150oC, dry chitosan membranesachieved CO2 permeabilities, CO2/N2 and CO2/H2 separation factors of 0.383 – 24.3barrers, 10.7 – 3.40, and 4.54 – 1.50, respectively. The dry chitosan acted as an ordinarysolution-diffusion membrane: …

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Influence Of Moisture Regime And Tree Species On Nitrogen Cycling And Decomposition Dynamics In Deciduous Forests Of Mammoth Cave National Park, Kentucky, Usa, Eric Fabio Jan 2006

Influence Of Moisture Regime And Tree Species On Nitrogen Cycling And Decomposition Dynamics In Deciduous Forests Of Mammoth Cave National Park, Kentucky, Usa, Eric Fabio

University of Kentucky Master's Theses

The study of biogeochemical cycles and their role in ecosystem function has helped to highlight the impacts of human activities on natural processes. However, our understanding of the effects of nitrogen (N) deposition on forested ecosystems remains limited due to the variable controls on N cycling. Soils, microclimate, and vegetation can influence rates and processes of N cycling, singly or in concert at multiple scales. Understanding how these factors influence N cycling across the landscape will help to elucidate the impacts of N deposition. The objectives of this study were to characterize variation in soils, microclimate and vegetation characteristics, and …

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Habitat Selection Of The Cerulean Warbler In Eastern Kentucky, Patricia J. Hartman Jan 2006

Habitat Selection Of The Cerulean Warbler In Eastern Kentucky, Patricia J. Hartman

University of Kentucky Master's Theses

Successful forest management requires an understanding of the habitat requirements of individual species at multiple spatial scales. The cerulean warbler (Dendroica cerulea) is a neotropical migratory songbird that has recently gained widespread attention as a species of conservation and management concern. It breeds in mature, deciduous forests of eastern North America and has experienced precipitous range-wide declines over the last 40 years. Although Kentucky likely supports one of the largest breeding populations of the species, no information exists on cerulean warbler habitat selection within the state. The overall purpose of this study was to identify important habitat features associated with …

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The Integration Of The Theory Of Planned Behavior, Altruism, And Self-Construal: Implications For Designing Recycling Campaigns In Individualistic And Collectivistic Societies, Rungrat Chaisamrej Jan 2006

The Integration Of The Theory Of Planned Behavior, Altruism, And Self-Construal: Implications For Designing Recycling Campaigns In Individualistic And Collectivistic Societies, Rungrat Chaisamrej

University of Kentucky Doctoral Dissertations

This study was an effort to uncover four major facts: (a) the predictive power ofthe proposed integrated model, which posits the influence of attitudes (ATT), subjectivenorms (SN), perceived behavior control (PBC), altruism, self-construal, and paperrecyclingknowledge on behavioral intentions; (b) the moderating effects ofindividualism-collectivism (I-C) on the attitudes-intentions relationship and thesubjective norms-intentions relationship; (c) the comparison of the predictive power ofthe TPB model and the proposed integrated model; and (d) the relationship between twointentions measures: behavioral intentions and implementation intentions.This cross-sectional research consisted of two phases: the TPB elicitation researchand the main study. Participants were undergraduate students recruited from two majorpublic …

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Fault-Tolerant Distributed Channel Allocation Algorithms For Cellular Networks, Jianchang Yang Jan 2006

Fault-Tolerant Distributed Channel Allocation Algorithms For Cellular Networks, Jianchang Yang

University of Kentucky Doctoral Dissertations

In cellular networks, channels should be allocated efficiently to support communication betweenmobile hosts. In addition, in cellular networks, base stations may fail. Therefore, designing a faulttolerantchannel allocation algorithm is important. That is, the algorithm should tolerate failuresof base stations. Many existing algorithms are neither fault-tolerant nor efficient in allocatingchannels.We propose channel allocation algorithms which are both fault-tolerant and efficient. In theproposed algorithms, to borrow a channel, a base station (or a cell) does not need to get channelusage information from all its interference neighbors. This makes the algorithms fault-tolerant,i.e., the algorithms can tolerate base station failures, and perform well in …

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Petrofabric And Geochemical Analysis Of The Great Smoky -- Snowbird Group Contact, Western Blue Ridge, North Carolina And Tennessee, Kristopher M. Clemons Jan 2006

Petrofabric And Geochemical Analysis Of The Great Smoky -- Snowbird Group Contact, Western Blue Ridge, North Carolina And Tennessee, Kristopher M. Clemons

University of Kentucky Master's Theses

Detailed structural and petrographic analysis of the Greenbrier Fault (GBF) reveal different fold and fabric styles and generations preserved in the Great Smoky Group (GSG) hanging wall and Snowbird Group (SG) footwall. Four planar fabrics (S0, S1, S2, and S3) are completely overprinted within meters of the contact by shear zone-related fabrics. Bedding (S0) is defined by planar laminations in the SG siltstones. S1 is weak, not associated with folding of S0, and defined locally by sub-parallel alignment of biotite. S2 (slaty cleavage) is deflected into a disjunctive planar (in GSG) or continuous planar (in SG) S3 foliation characterized by …

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Optimal Phase Measuring Profilometry Techniques For Static And Dynamic 3d Data Acquisition, Veeraganesh Yalla Jan 2006

Optimal Phase Measuring Profilometry Techniques For Static And Dynamic 3d Data Acquisition, Veeraganesh Yalla

University of Kentucky Doctoral Dissertations

Phase measuring Profilometry (PMP) is an important technique used in 3D data acquisition. Many variations of the PMP technique exist in the research world. The technique involves projecting phase shifted versions of sinusoidal patterns with known frequency. The 3D information is obtained from the amount of phase deviation that the target object introduces in the captured patterns. Using patterns based on single frequency result in projecting a large number of patterns necessary to achieve minimal reconstruction errors. By using more than one frequency, that is multi-frequency, the error is reduced with the same number of total patterns projected as in …

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Citizens On Patrol: Community Policing And The Territorialization Of Public Space In Seattle, Washington, Marcia Rae England Jan 2006

Citizens On Patrol: Community Policing And The Territorialization Of Public Space In Seattle, Washington, Marcia Rae England

University of Kentucky Doctoral Dissertations

This dissertation shows how organizations, including local government and police, and residents within Seattle, Washingtons East Precinct define and police the contours of community, neighborhoods and public space. Under the rubric of public safety, these players create territorial geographies that seek to include only those who fit the narrowly conceived idea of a neighbor. Territoriality is exercised against the social Other in an attempt to build a cohesive community while at the same time excluding those who are seen as different or as non-conformant to acceptable behaviors in the neighborhood. This research provides a framework through which to examine how …

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Effects Of Forest And Grass Vegetation On Fluviokarst Hillslope Hydrology, Bowman's Bend, Kentucky, Linda Leann Martin Jan 2006

Effects Of Forest And Grass Vegetation On Fluviokarst Hillslope Hydrology, Bowman's Bend, Kentucky, Linda Leann Martin

University of Kentucky Doctoral Dissertations

Subsurface solutional pathways make limestone terrains sensitive to changes in soil properties that regulate flows to the epikarst. This study examines biogeomorphic factors responsible for changed water movements and erosion in fluviokarst slopes deforested 200 years ago along the Kentucky River, Kentucky. In this project, infiltration and water content data from forest and fescue grass soil profiles were analyzed within a detailed overview of system factors regulating hillslope hydrology. Results show that grass has growth and rooting characteristics that tend to create a larger volume of lateral water movement in upper soil layers than occurs under forests. This sets up …

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Karl Priebe, Young Woman At The Seashore, 1940, Stephen L. Franzoi Jan 2006

Karl Priebe, Young Woman At The Seashore, 1940, Stephen L. Franzoi

Psychology Faculty Research and Publications

No abstract provided.

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The Smart Bookshelf, Danny Sylvester Crasto Jan 2006

The Smart Bookshelf, Danny Sylvester Crasto

University of Kentucky Master's Theses

The smart bookshelf serves as a test-bed to study environments that are intelligently augmented by projector-camera devices. The system utilizes a camera pair and a projector coupled with an RFID reader to monitor and maintain the state of a real world library shelf. Using a simple calibration scheme, the homography induced by the world plane in which book spines approximately lie is estimated. As books are added to the shelf, a foreground detection algorithm which takes into account the projected information yields new pixels in each view that are then verified using a planar parallax constraint across both cameras to …

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Data Acquisition System For Muon Lifetime Experiment, Sivaram Kumar Battu Jan 2006

Data Acquisition System For Muon Lifetime Experiment, Sivaram Kumar Battu

University of Kentucky Master's Theses

I designed, developed and deployed a data acquisition (DAQ) system to meet the needsof the "??Lan" nuclear physics experiment. The main goal of the experiment is to measurethe positive muon lifetime to a precision of 1 part per million. This represents more thanan order of magnitude increase in precision beyond the current world average. The DAQdesign is motivated by very high data rate this experiment will produce. This experimentis being performed with the proton accelerator at Paul Scherrer Institut in Villigen,Switzerland. I have setup a mock experimental setup at the University of Kentucky. Thedesign and development of the DAQ software …

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Performance Evaluation And Optimization Of The Unstructured Cfd Code Uncle, Saurabh Gupta Jan 2006

Performance Evaluation And Optimization Of The Unstructured Cfd Code Uncle, Saurabh Gupta

University of Kentucky Master's Theses

Numerous advancements made in the field of computational sciences have made CFD a viable solution to the modern day fluid dynamics problems. Progress in computer performance allows us to solve a complex flow field in practical CPU time. Commodity clusters are also gaining popularity as computational research platform for various CFD communities. This research focuses on evaluating and enhancing the performance of an in-house, unstructured, 3D CFD code on modern commodity clusters. The fundamental idea is to tune the codes to optimize the cache behavior of the node on commodity clusters to achieve enhanced code performance. Accordingly, this work presents …

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Detection Of Malingered Mental Retardation, Lili Odom Graue Jan 2006

Detection Of Malingered Mental Retardation, Lili Odom Graue

University of Kentucky Master's Theses

The 2002 Supreme Court decision (Atkins vs. Virginia, 536 U. S. 304), prohibiting the execution of mentally retarded persons, may potentially increase malingering of mental retardation (MR). There is limited research addressing the detection of feigned MR. The present study compared results from tests of intelligence, adaptive functioning, legal/courtroom knowledge, and psychiatric and neurocognitive feigning to determine how effectively these instruments discriminate between MR participants and community volunteers asked to either approach the test honestly (CVH group) or feign, or malinger, MR (CVM group). CVMs suppressed their IQ scores sufficiently to appear MR. CVMs overestimated deficits on individuals with genuine …

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Does Optimism Explain How Religiousness Affects Alcohol Use Among College Students?, Benjamin Lee Collier Jan 2006

Does Optimism Explain How Religiousness Affects Alcohol Use Among College Students?, Benjamin Lee Collier

University of Kentucky Master's Theses

Alcohol use, because of its many negative consequences, is the number one health problem facing college students. Because of this, researchers have looked for factors associated with reduced drinking. Religiousness is one such factor. Religiousness is a complex, multidimensional construct, and while it tends to be negatively associated with alcohol use, research progress has been slow due to the tendency of researchers to poorly operationalize this construct and to design studies that fail to go beyond the bivariate relationship of religiousness and alcohol use. In order to address these shortcomings, this study will assess two dimensions of religiousness, religious commitment/motivation …

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Search For Gravitational Waves From Binary Black Hole Inspirals In Ligo Data, B. P. Abbott, R. Abbott, W. G. Anderson, Mario C. Diaz, Wm. R. Johnston, Soumya Mohanty, Soma Mukherjee, Cristina V. Torres Jan 2006

Search For Gravitational Waves From Binary Black Hole Inspirals In Ligo Data, B. P. Abbott, R. Abbott, W. G. Anderson, Mario C. Diaz, Wm. R. Johnston, Soumya Mohanty, Soma Mukherjee, Cristina V. Torres

Physics & Astronomy Faculty Publications

We report on a search for gravitational waves from binary black hole inspirals in the data from the second science run of the LIGO interferometers. The search focused on binary systems with component masses between 3 and 20M⊙. Optimally oriented binaries with distances up to 1 Mpc could be detected with efficiency of at least 90%. We found no events that could be identified as gravitational waves in the 385.6 hours of data that we searched.

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Ferromagnetic Resonance Investigations On Ga0.965mn0.035as Film, S. Balascuta, X. Liu, D. V. Baxter, J. Carini, T. Wojtowicz, Y. Sasaki, J. Furdyna, Mircea Chipara Jan 2006

Ferromagnetic Resonance Investigations On Ga0.965mn0.035as Film, S. Balascuta, X. Liu, D. V. Baxter, J. Carini, T. Wojtowicz, Y. Sasaki, J. Furdyna, Mircea Chipara

Physics & Astronomy Faculty Publications

Ferromagnetic resonance studies of the temperature dependence of magnetic anisotropies in a Ga0.965Mn0.035As film between 5 and 40K are reported. The in-plane and out-of-the-plane angular dependences of the resonance field were analyzed within the Landau-Lifshitz-Gilbert approach. The second- and fourth-order magnetic anisotropy energies were derived. The temperature dependence of magnetization and of magnetic anisotropy were studied by superconducting quantum interference device and ferromagnetic resonance.

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