Digital Commons Network^™

The Effect And Chronic Acute Pre-Treatment With Methylphenidate On Recovery Of Cognitive Function Following Experimental Traumatic Brain Injury In Rats, Katharine Coryell Eakin

Theses and Dissertations

Adolescent and young adult males are at a higher risk for traumatic brain injury (TBI) compared to the general population. Diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) is also more prevalent for males in these age groups. The most commonly prescribed medication for ADHD is methylphenidate (MPH). Based on the increase in the number of new diagnoses of ADHD and the number of children who continue taking MPH into adulthood, it is important to evaluate how chronic or acute MPH administered prior to injury may influence recovery following TBI. In both studies, cognitive abilities of male Sprague-Dawley rats were assessed …

Out Of Body, Alessandra Lee Michelle Torres

Theses and Dissertations

This thesis explores the evolution of Alessandra Torres's work, from her early performances and installations, to her latest work with surrogate bodies, as she challenges the relationship between artist and their creation, body and object, and audience and art. Examining the work of artists such as Cindy Sherman, Rebecca Horn and Marina Abramovic, Torres explores the transformative capabilities of interactive sculpture and live performance. Join Ms. Torres as she transforms herself into everything from a paintbrush to a serpent, in her ongoing exploration of the body's ability to adapt and evolve.

Stature And Criminal Behavior, Rebecca J. Fish

Theses and Dissertations

Minorities are significantly overrepresented in America's prison population, and many studies have been conducted to determine possible causes for such a disparity. Few of these studies, however, have examined small stature as a potential contributor to criminal behavior. This study examines the relationship between criminal behavior and stature among American males. The heights, weights, stature scores (a function of the product of height and weight) and the body mass indices of criminals are examined as a whole, as well as by subgroup based on race, locality, and nature of the crime committed. The average weight of the male criminal population …

Assessing Epidermal Growth Factor Expression In The Rodent Hippocampus Following Traumatic Brain Injury, Janice Mabutas Daus

Theses and Dissertations

Hippocampal neurons are vulnerable to injury, as indicated by the prevalence of learning and memory deficits following traumatic brain injury. Research indicates that proliferation of neural precursor cells increases following brain injury, which implies that there is an endogenous response in the hippocampus to replenish neurons and restore cognitive function. Studies show that mitogenic growth factors may drive this proliferative response; one of which is epidermal growth factor. Because adults and the elderly manifest the most enduring deficits following TBI, it is critical to investigate how EGF expression following injury may relate to injury-induced cell proliferation and the degree of …

Natural Selection, Jeffrey A. Vick

Theses and Dissertations

My thesis work is about imagination. I use the collaborative efforts of the viewer's mind and my sculptures, or specimens, to make associations of real life animals. I feel this engages the viewer and in turn invites them to inspect the work on closer level. This is my ultimate goal in the work, to take hold of the viewer's curiosity and have them examine the work on a closer level.

Functional Redistribution Of Hippocampal Cannabinoid Cb1 Receptors In The Rat Pilocarpine Model Of Acquired Epilepsy, Katherine Winslow Falenski

Theses and Dissertations

Cannabinoids, such as the marijuana derivative Δ9-THC, are known to have CBl receptor-mediated anticonvulsant effects in several animal models of seizures and epilepsy, including the rat pilocarpine model of acquired epilepsy. However, the distribution of CBl receptor expression and function in brains of epileptic rats has not been characterized. Therefore, this dissertation was initiated to evaluate the effect of epileptogenesis on the distribution and function of the endogenous CBI receptor system in the rat pilocarpine model, a well-established model of acquired temporal lobe epilepsy. Using immunohistochemistry, we demonstrated that chronically epileptic rats exhibit a unique, long-term, and specific redistribution of …

Acquisition And Retention Of Bacterial Spores (Bacillus Atrophaeus) By Eight Insect Species, Kieron Marie Torres

Theses and Dissertations

Acquisition and retention of spores of an anthrax surrogate, Bacillus atrophaeus Nakamura ("BG") were evaluated in eight insect species. Species included: house cricket (Acheta domesticus L.), German cockroach (Blatella germanica L.), common house fly (Musca domestics L.), blue bottle fly (Calliphora vomitoria L.), hairy rove beetle Creophilus maxillosus L.), yellow mealworm (Tenebrio molitor L.), common paper wasps (Polistes exclamans exclamans Viereck), red paper wasps (Polistes Carolina L.), red harvester ant (Pogonymyrmex barbatus Smith). Individual insects were offered BG-treated food and sacrificed at specified time intervals following one, two or three meals. Resulting samples were surface-washed five consecutive times then homogenized …

Raubeaux Scientician, Joe W. Grant Iii

Theses and Dissertations

The works contained in "Raubeaux Scientician" are about a triadic relationship between people, science, and art. The obsessions, of individuals and the apparent change brought about by their physical presence guide my artistic research. I am awestruck at the capabilities of the individual to overcome conventional thought and through creative action yield a new vision. Some of the people I am fascinated by put forth theories and inventions that continue to affect myriad aspects of our world today. Among those at the forefront are, Robert Oppenheimer, and Edward Teller. Their contributions to science and mathematics remain almost unmatched. These and …

Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, And Non-Specific Inflammatory Responses, Brian Joseph Kelley

Theses and Dissertations

A significant component of diffuse brain injury (DBI) is diffuse axonal injury (DAI) which is responsible for the morbidity and mortality associated with this condition. DAI and its experimental counterpart traumatic axonal injury (TAI) result in scattered microscopic pathology characterized by focal impairment of axonal transport leading to progressive swelling and delayed axotomy. DBI-mediated perisomatic axotomy does not result in acute neuronal death suggesting that delayed axotomy was responsible for this unanticipated response. To evaluate this hypothesis, we examined the spatiotemporal progression of DBI-mediated perisomatic TAI. LM / TEM identified impaired axonal transport within 15 - 30 min post-injury. Perisomatic …

Novel Characteristics Of Murine Bone Marrow-Derived Macrophages And Human Macrophage-Like Cells, George Tharwat Georges

Theses and Dissertations

These studies provide evidence for novel properties of macrophages derived from bone marrow stem cells. In study 1, treatment of activated mouse bone marrow-derived macrophages (BMM) with either catecholamine synthesis inhibitors (α-methyl-para-tyrosine and fusaric acid) or the β2 adrenergic receptor antagonist ICI 118,551 demonstrated that BMM produce catecholamines. The catecholamines modulated macrophage cytokine production through autocrine actions on adrenergic receptors. In study II, undifferentiated human bone marrow cells were incubated in 30% mouse L929 fibroblast conditioned medium and generated adherent cells within three days. The cells were clearly identifiable as macrophages based on surface proteins and phagocytic activity but produced …

The Assistant Director, Stephanie R. Hanna

Theses and Dissertations

My thesis addresses the role of the assistant director within the realm of today's American theatre. I determine who the assistant director is in today's theatre, what qualities they need to possess, and how a director can use an assistant director most effectively. To come to these conclusions, I analyze my experiences as an assistant director and a director over the last four years, as well as conduct interviews with directors and assistant directors currently working in professional and academic.

Fostering Imaginative Expression In Elementary Art Students: A Descriptive Study Of Teacher Strategies, Julia Robinson Bargo

Theses and Dissertations

The students in my elementary art classes did not seem to be creating for themselves. They seemed to have the understanding there was only one correct answer in art class, and the art teacher knew what that answer was. By way of research I have found ways to create an atmosphere in my art room that promotes imagination and self expression in children, thus fostering a free and creative reaction from my students. Through understanding how and why one uses their imagination, an art teacher can enhance a student's ability to build and use his or her knowledge base. I …

Ige Production Regulation Via Cd23 Stalk Engagement And Cell Cycle Stimulation, Timothy Hays Caven

Theses and Dissertations

CD23, the low affinity receptor for IgE, is expressed mainly on B cells and has been shown to regulate IgE production. Previously, recombinant mouse and human CD23 were constructed with a trimerizing isoleucine zipper motif attached in frame to the N-terminus of the entire extracellular CD23 (lz-ECCD23). The goal was to examine the role of the necessity of the CD23 stalk for binding IgE. Using PCR-based mutagenesis to delete the majority of the stalk, binding to IgE was lost. Further studies examined the effect of lz-ECCD23 in preventing IgE from binding FcεRI and therefore acting as a therapeutic agent. It …

The Expression And Function Of Wilms' Tumor 1 In Malignant Glioma, Aaron J. Clark

Theses and Dissertations

The Wilms' tumor 1 gene is overexpressed in many types of cancer and is associated with poor prognosis and resistance to anti-cancer therapies. In vitro studies in non-glioma cells types have demonstrated that WTl plays a role in increased proliferation, resistance to apoptosis, and increased cellular invasion. We aimed to thoroughly characterize the expression pattern of Wilms' tumor 1 in human malignant glioma and discern its function in this complex disease process. We screened a large sample of established human malignant glioma cell lines and glioma tissue specimens of all grades for WT1 expression. The majority of cell lines and …

Little Paintings, Robert William Land

Theses and Dissertations

Little Paintings is a document that describes the creation, influences and process of two films, "Betty Creek" and "New Berlin". The films are personal responses to my experiences growing-up and living in the Southern United States. The Thesis illustrates the influences of painters such as Jimmie Lee Sudduth and Willie Jinks and how their raw painting methods inspire the development of my films using a tactile approach to filmmaking.

A Model For Studying Vasogenic Brain Edema, Anshu Shukla

Theses and Dissertations

Convection-enhanced delivery (CED) is a proven method for targeted drug delivery to the brain that circumvents the blood-brain barrier (BBB). Little study has been conducted in understanding CED in pathological brain states. This is of importance when dealing with chemotherapeutic agent delivery to brain tumors, where vasogenic edema (VE) exists. The current study aims to characterize a model of VE suitable for studying CED.VE was produced in the right hemisphere of the rat brain using multiple infusions of hyperosmotic mannitol (0.25mL/kg/s over 30 seconds) delivered through the right internal carotid artery. Magnetic resonance imaging (MRI) revealed consistent edema formation and …

Frame Of Mind, Jeffrey Brooks Warden

Theses and Dissertations

The creative process offers me an escape and tranquility worthy of sharing. When creating art, I reflect on the people, places, and things that move me. I convey my frame of mind through the brush to the canvas. The result is intense strokes of color that deliver clarity of emotion for others to experience. The intention of my work is to share a world that satisfies the eyes, mind, and soul. There is something about each piece that I hope will keep the viewer returning to absorb, contemplate, and enjoy.

Autocrine Effects Of Catecholamines On Macrophage Release Of Interleukin-6 (Il-6), Shaunta D. Poe

Theses and Dissertations

Effects of norepinephrine (NE) on macrophage cytokine release are complex because the cells have both α2 and β2 adrenergic receptors, which mediate opposing actions. Furthermore, β2-adrenergic agonists are reported to have both stimulatory and inhibitory effects on interleukin-6 (IL-6). This study was designed to clarify the autocrine role of macrophage-derived NE on IL-6 production in activated peritoneal macrophages. Effects of NE on IL-6 production in the RAW264.7 macrophage cell-line also were investigated. Treatment of activated peritoneal macrophages with endotoxin, the α2-adrenergic antagonists yohimbine or RS79948 revealed that the α2-adrenergic receptor mediates a stimulatory autocrine action of catecholamines on IL-6 production. …

Shared Reading In A Second Grade Classroom, Trisha L. Dietrich

Theses and Dissertations

No abstract provided.

Rehabilitating The "Mystery Passage": An Examination Of The Supreme Court's Anthropology Using The Personalistic Norm Explicit In The Philosophy Of Karol Wojtyla, Michael A. Scaperlanda

Faculty Articles

No abstract provided.

Evaluating The Impact Of Peer Review And Participation Awareness In An Online Collaborative Document Authoring Environment, Greg Baatard

Theses : Honours

Online Learning Environments (OLEs) have been widely adopted by higher education facilities, offering distance education with the potential to support the social and collaborative aspects deemed crucial to modern constructivist pedagogy. Groupware, a form of software which aims to facilitate group work, has been the subject of much research, from both educational and enterprise perspectives. This research introduced Reportal, an online groupware system designed to facilitate the collaborative authoring of a document. Reportal's peer review and participation awareness features were the focus of this research, and their impact was measured against the elements of online collaboration, a typology established by …

A Model For Successful Teamwork, Mohamed Bakir

Theses : Honours

Increasingly, there have been greater expectations from industry and employers that universities in Australian focus on developing student generic skills, core competencies or graduate attributes. As a result, key skills included in the mission statements of most universities tend to include higher-level aims relating to critical thinking, lifelong learning and teamwork. These generic skills and others, are considered essential for successful work place practice and universities are constantly being called upon to produce graduates that can show these skills. This is not an easy task, and universities are trying different approaches to try and satisfy these needs, e.g. e-portfolios and …

East O' The Sun And West O' The Moon: The Construction Of National Identity In Norwegian Fashion Photography, Anne-Britt Kjoensburg

Theses : Honours

This exegesis compliments my photographic project which was to produce a body of work that explores Norwegian identity through fashion using myths and iconography to communicate Norwegian-ness, and depicts the Norwegian lifestyle in a surprising and humorous way. My aim has been to find out if there is any distinctive aesthetic approach/style that constructs, defines and reproduces Norwegian identity, and if Norwegian fashion photography is being influenced by the resurgence of interest in Norwegian style. I have looked at how humans use fashion as a technique to construct various identities rather than a mask that covers the self and how …

That's Freakin' Sweet: The Collecting Of Family Guy, Matthew Knight

Theses : Honours

The animated series Family Guy (1999-2006) has been cancelled twice and resurrected twice mainly because of the efforts of viewers. It is worth asking, however; why has Family Guy attained a level of fanaticism that repeatedly rescues it from permanent cancellation? Arguably, the Family Guy audience is made up predominantly of members of generation y and as such, the way they view the program and their relationship to it will differ to that of previous generations. In short, Family Guy was cancelled due to poor ratings, however, these ratings were a result of erratic scheduling that was not conducive to …

Applying Principles Of Information Design To Help Parents Accept Babies With Down Syndrome, Anita Eradla

Theses and Dissertations

My creative project is a system of resource materials designed for parents and expecting parents to promote acceptance of babies with Down syndrome. This project is also a study of information architecture and icon development, and an opportunity to study the universal and emotive qualities of an iconic system.

Changing Students Valuing Of Moral Education: From Pain To Gain: A Case Of Curtin University Of Technology. Curtin University Of Technology, Malaysia., Azlin Hj Alwi

EDU-COM International Conference

Everyone recognizes the need for educating youngsters about the importance of moral values, in today‘s complex world. Teaching moral values to youngsters is easy. However, to make them value what they learnt is not. In Malaysia, Moral Education is a subject is introduced in the primary school and is continued further at the university level as a strategy to ensure that all students are able to discern right from wrong and make ethical decisions. The question raised is, how can we ensure that the knowledge acquired form the subject is internalized, with long lasting benefits to them? One approach is …

Initiating Community Engagement For Enhancing Preservice Teacher Education, Peter Hudson, Sue Hudson

EDU-COM International Conference

Facilitating community engagement in education is promoted and emphasised in university policies and strategic plans. How can a university facilitate innovations to develop collaborative partnerships with its community? This paper presents leadership processes for initiating community engagement with an Australian university and highlights examples of innovations in Science Education for Sustainable Living (SESL) with preservice teachers‘ reflections on their teaching practices. Data collection included observations of practice, interviews, minutes of meetings, and written correspondence with a wide range of participants (i.e., senior QUT staff, lecturers, preservice teachers, principals, school executives and teachers, and other community members). A four-step process for …

The Design Of An Undergraduate Degree Program In Computer & Digital Forensics, Gary C. Kessler, Michael E. Schirling

Journal of Digital Forensics, Security and Law

Champlain College formally started an undergraduate degree program in Computer & Digital Forensics in 2003. The underlying goals were that the program be multidisciplinary, bringing together the law, computer technology, and the basics of digital investigations; would be available as on online and oncampus offering; and would have a process-oriented focus. Success of this program has largely been due to working closely with practitioners, maintaining activity in events related to both industry and academia, and flexibility to respond to ever-changing needs. This paper provides an overview of how this program was conceived, developed, and implemented; its evolution over time; and …

The Antiviral Action Of Common Household Disinfectants And Antiseptics Against Murine Hepatitis Virus, Christine Bernadette Dellanno

Theses, Dissertations and Culminating Projects

The 2003 outbreak of Severe Acute Respiratory Syndrome (SARS) infected over 8,000 people and killed 784 leaving many questions concerning the effectiveness of common household disinfectants and antiseptics at preventing viral transmission. In order to determine how well standard disinfectants and detergents were at eliminating viral particles from surfaces, the antiviral action of triclosan, pine oil, bleach, chloroxylenol and quaternary ammonium compound/ethanol based products were assayed against Murine Hepatitis Virus (MHV), a virus genetically similar to SARS. Using the Environmental Protection Agency (EPA) guidelines for the virucidal assay, it was determined that alkyl dimethyl benzyl ammonium saccharinate in 79% ethanol …

Attenuation Of Acute Rejection In A Rat Liver Transplantation Model By A Liver-Targeted Dextran Prodrug Of Methylprednisolone, Anjaneya Chimalakonda, Donald L. Montgomery, Jon A. Weidanz, Imam H. Shaik, Justin H. Nguyen, John J. Lemasters, Eiji Kobayashi, Reza Mehvar

Pharmacy Faculty Articles and Research

Background. The use of methylprednisolone (MP) and other corticosteroids for the treatment of acute liver allograft rejection is associated with severe toxicities in nontarget tissues. Therefore, selective delivery of NIP to the liver may improve its efficacy and alleviate its side effects. We investigated the effects of a novel liver-targeted dextran prodrug of MP (DMP) in an orthotopic rat liver transplantation (OLT) model.

Methods. The model consisted of a high responder rejection strain combination (Dark Agouti donors and Lewis recipients). Liver recipients were intravenously administered saline or a single subtherapeutic dose of MP (5 mg/kg) as the parent …