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How Exposures To Biologics Influence The Induction And Incidence Of Asthma, Darryl C. Zeldin, Peyton Eggleston, Martin Chapman, Giovanni Piedimonte, Harard Renz, David Peden

Faculty & Staff Scholarship

A number of environmental factors can affect the development and severity of allergy and asthma; however, it can be argued that the most significant inhaled agents that modulate the development of these conditions are biologics. Sensitization to environmental allergens is an important risk factor for the development of asthma. Innate immune responses are often mediated by receptors on mononuclear cells whose primary ligands arise from microorganisms. Many pathogens, especially viruses, target epithelial cells and affect the host immune response to those pathogens. The acquired immune response to an allergen is influenced by the nature of the innate immune system. Products …

A Novel Role For 3, 4-Dichloropropionanilide (Dcpa) In The Inhibition Of Prostate Cancer Cell Migration, Proliferation, And Hypoxia-Inducible Factor 1alpha Expression, Bing-Hua Jiang, Ling-Zhi Liu, Rosana Schafer, Daniel C. Flynn, John B. Barnett

Faculty & Staff Scholarship

Background

The amide class compound, 3, 4-dichloropropionanilide (DCPA) is known to affect multiple signaling pathways in lymphocyte and macrophage including the inhibition of NF-κB ability. However, little is known about the effect of DCPA in cancer cells. Hypoxia-inducible factor 1 (HIF-1) regulates the expression of many genes including vascular endothelial growth factor (VEGF), heme oxygenase 1, inducible nitric oxide synthase, aldolase, enolase, and lactate dehydrogenase A. HIF-1 expression is associated with tumorigenesis and angiogenesis.

Methods

We used Transwell assay to study cell migration, and used immunoblotting to study specific protein expression in the cells.

Results

In this report, we demonstrate …

Nucleolin Links To Arsenic-Induced Stabilization Of Gadd45Α Mrna, Yadong Zhang, Deepak Bhatia, Hongfeng Xia, Vince Castranova, Xianglin Shi, Fei Chen

Faculty & Staff Scholarship

The present study shows that arsenic induces GADD45α (growth arrest and DNA damage inducible gene 45α) mainly through post-transcriptional mechanism. Treatment of the human bronchial epithelial cell line, BEAS-2B, with arsenic(III) chloride (As 3+ ) resulted in a significant increase in GADD45α protein and mRNA. However, As 3+ only exhibited a marginal effect on the transcription of the GADD45α gene. The accumulation of GADD45α mRNA is largely achieved by the stabilization of GADD45α mRNA in the cellular response to As 3+ . As 3+ is able to induce binding of mRNA stabilizing proteins, nucleolin and less potently, HuR, to the …

Red-Tide–Associated Mass Mortality In 2005 Of The Sand Dollars Encope Aberrans, Encope Michelini, And Mellita Tenuis (Echinodermata: Echinoidea) On The Central Florida Gulf Coast Shelf, John M. Lawrence, Janessa Cobb, James P. Swigart

Gulf of Mexico Science

In March 2005, populations of Encope aberrans and E. michelini found at 20-m depth (ca. 27 km west of Captiva Island) and of Mellita tenuis at 6.5-m depth (ca. 7 km west of Egmont Key) were studied to calculate density and size frequency distribution. All individuals were alive. A red tide occurred on the central Florida Gulf Coast shelf during the summer. In Sept., all individuals in these populations were dead. Dead individuals had lost their spines and were gray but intact, indicating recent death. On the same date, all E. michelini and E. aberrans were alive in a population …

Review: Sharks, Skates, And Rays Of The Gulf Of Mexico: A Field Guide By Glenn R. Parsons, Steve Branstetter

Gulf of Mexico Science

Sharks, Skates, and Rays of the Gulf of Mexico: A Field Guide. 2006. Glenn R. Parsons, University Press of Mississippi, Jackson, Mississippi 39211. 165 pages. Web address: www.upress.state.ms.us. Flexibind, ISBN 1-57806-827-4, US$ 25.

Irish Renaissance (Chapter Seven Of Other Renaissances: A New Approach To World Literature), Kathleen A. Heininge

Faculty Publications - Department of English

Excerpt: "Critics have several names for the movement that took place in Ireland at the turn of the twentieth century. Each name seems to suggest a different interpretation of the events at that time, and each interpretation, in turn, reflects a different idea of Ireland’s relationship with the rest of the world. The Irish Revival, a term most often used to discuss the literary movement, implies that the greatness of a people can be resuscitated after it has been nearly lost, and is thus a term in keeping with a nationalist agenda. The Celtic Twilight, a term coined by W. …

In Love With Life: An American Dream Of A Luxembourger, Edmond Israel, Raymond Flammant, Center For Christian Jewish Understanding

Sacred Heart University Press Books

Based on the author's La vie, passionnément. French edition published in 2004 by Editions Saint Paul, Luxembourg.

On cover and title page: Pampered child, Refugee, Factory Worker, International Banker: New Thinking.

The unprecedented problems that challenge most of our major institutions and our traditional ways of doing things are so new that few of us have the courage or even the capacity to consider them. Yet Edmond Israel enthusiastically relishes the opportunity to think differently and boldly about how to hold our problems together in creative tension and wrestle with them until moral and efficient solutions can be found. …

Trademark Searching Tools And Strategies: Questions For The New Millennium, Jon R. Cavicchi

Law Faculty Scholarship

The intent of this discussion is to raise questions about trademark searching which will be discussed in future issues of IDEA. I will lead you through the questions raised by my journey through primarily legal literature in treatises and periodicals on the Lexis and Westlaw platforms.

Legality Of Age Restrictions In The Nba And Nfl, Michael Mccann, Joseph S. Rosen

Law Faculty Scholarship

This essay examines age eligibility rules in the National Football League (NFL) and the National Basketball Association (NBA), offers analysis of related antitrust and labor law issues, and shares perspective on underlying policies. As a matter of background, the NFL and the NBA are the only major sports organizations that prohibit players from entrance until a prescribed period after high school graduation. Major League Baseball, the National Hockey League, NASCAR, professional tennis, professional golf, and professional boxing have no such rules. Individuals can also partake in professional acting, theater, music, and other entertainment professions without satisfying a period after high …

It’S Not About The Money: The Role Of Preferences, Cognitive Biases And Heuristics Among Professional Athletes, Michael Mccann

Law Faculty Scholarship

Professional athletes are often regarded as selfish, greedy, and out-of-touch with regular people. They hire agents who are vilified for negotiating employment contracts that occasionally yield compensation in excess of national gross domestic products. Professional athletes are thus commonly assumed to most value economic remuneration, rather than the love of the game or some other intangible, romanticized inclination.

Lending credibility to this intuition is the rational actor model, a law and economic precept which presupposes that when individuals are presented with a set of choices, they rationally weigh costs and benefits, and select the course of action that maximizes their …

The Reckless Pursuit Of Dominion: A Situational Analysis Of The Nba And Diminishing Player Autonomy, Michael Mccann

Law Faculty Scholarship

This Article examines required genetic testing of NBA players from a situational vantage point, integrating socio-psychological, legal, and ethical analyses. The core argument may be expressed as follows: required genetic testing of NBA players appears consistent with a broader and largely deleterious agenda by the NBA to control players. Since implementation of the rookie wage scale in 1995 through the recent imposition of a paternalistic player dress code, the NBA has increasingly usurped player autonomy. The NBA's capacity to do so largely rests in its adroit manipulation of the situational influences that influence fans and media. For instance, because of …

Social Psychology, Calamities, And Sports Law, Michael Mccann

Law Faculty Scholarship

This Article examines the role of situational pressures, fundamental attribution errors, and legal frameworks in how professional sports actors respond to the threat and occurrence of calamities. Both natural and manmade threats to American health are likely to rise over the next decade. Such threats may include catastrophic weather, natural disasters, terrorist attacks, and communicable disease pandemics. In response to these threats, professional sports leagues, professional athletes, fans, and media might engage in unprecedented behavior. Consider, for instance, increasingly-devastating weather patterns, and how they might animate leagues to relocate franchises to cities with more favorable forecasts. The same outcome might …

A Feeling Of Unease About Privacy Law, Ann Bartow

Law Faculty Scholarship

This essay responds to Daniel Solove's recent article, A Taxonomy of Privacy. I have read many of Daniel Solove's privacy-related writings, and he has made many important scholarly contributions to the field. As with his previous works about privacy and the law, it is an interesting and substantive piece of work. Where it falls short, in my estimation, is in failing to label and categorize the very real harms of privacy invasions in an adequately compelling manner. Most commentators agree that compromising a person's privacy will chill certain behaviors and change others, but a powerful list of the reasons why …

Application Of The 1996 Nrc To Protein And Energy Nutrition Of Range Cattle, H. H. Patterson, D. C. Adams, T. J. Klopfenstein, G. P. Lardy

Department of Animal Science: Faculty Publications

Based on applications of the 1996 National Research Council (NRC) Nutrient Requirement of Beef Cattle (2000 update) model at our laboratories and on use of the model to evaluate published literature, it is our assessment that the NRC model (Level 1) represents an advancement in nutrient requirements of grazing cattle. We evaluated 8 published studies (35 treatment observations) to compare observed changes in body condition score (BCS) to those predicted by the NRC model, and to develop criteria to help with application of the model to range cattle nutrition. When in vitro organic matter disappearance (IVOMD) of grazed diets was …

Annual Report Of The Officers Of The Town Of Piermont, New Hampshire For The Year Ending December 31, 2005., Piermont Town Representatives

Piermont, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Conserving The King: Inverting The Origin Story Of The Annapurna Conservation Area Project Of Nepal, Kenneth D. Croes

HIMALAYA, the Journal of the Association for Nepal and Himalayan Studies

No abstract provided.

Kharka Of The Ghunsa Valley In The Kanchenjunga Conservation Area In Eastern Nepal Himalaya: Diverse Locations Of Campsites Used By Yak/Yak-Cattle Hybrid Herders, Naho Ikeda

HIMALAYA, the Journal of the Association for Nepal and Himalayan Studies

No abstract provided.

35th Annual Conference On South Asia

HIMALAYA, the Journal of the Association for Nepal and Himalayan Studies

No abstract provided.

Process Modeling For Simulation, John Ryan, Cathal Heavey

Articles

This paper discusses shortfalls in relation to the requirements gathering phases of simulation. While many developments have taken place around supporting the model coding task of simulation, there are few tools available to assist in the requirements gathering phase. This is surprising as it has been reported by several researchers that the requirements phase can absorb twice as much resources as the coding phase. There are numerous process modeling tools available (over 100) that can and have been used to support the requirements phase of simulation. This paper provides a selective review of some of the most important in relation …

2005 Cancer Care Annual Report, Children's Mercy Hospital

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Hospital, Kansas City MO, a pediatric medical center, with a focus on neuroblastoma.

Southern Adventist University Undergraduate Catalog 2006-2007, Southern Adventist University

Catalog, Undergraduate

Southern Adventist University's undergraduate catalog for the academic year 2006-2007.

Variation In The U.S. Photoperiod Insensitive Sorghum Collection For Chemical And Nutritional Traits, Tisha L. Hooks, Jeffrey F. Pedersen, D. B. Marx, K. P. Vogel

Department of Statistics: Faculty Publications

Screening germplasm for chemical and nutritional content can be expensive and time consuming. Near infrared spectroscopy (NIRS) and application of geostatistical models can make screening more efficient. The objectives of this study were to utilize these technologies to: (i) generate chemical and nutritional values for the U.S. photoperiod insensitive sorghum collection, (ii) describe variability for those traits, (iii) identify accessions in the highest and lowest 1% for each trait, and (iv) describe relationships among the accessions. Accessions were grown at Ithaca, NE, during 2001 and 2002. Samples of grain were scanned and NIRS equations developed for starch, fat, crude protein, …

Trans-10, Cis-12 Conjugated Linoleic Acid Causes Inflammation And Delipidation Of White Adipose Tissue In Mice: A Microarray And Histological Analysis, P. Christopher Larosa, Jess L. Miner, Yuannan Xia, You Zhou, Stephen D. Kachman, Michael Fromm

Department of Statistics: Faculty Publications

A combined histological and microarray analysis of the white adipose tissue (WAT) of mice fed trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) was performed to better define functional responses. Mice fed t10c12 CLA for 14 days lost 85% of WAT mass, 95% of adipocyte lipid droplet volume, and 15 or 47% of the number of adipocytes and total cells, respectively. Microarray profiling of replicated pools (n = 2 per day x diet) of control and treated mice (n = 140) at seven time points after 1–17 days of t10c12 CLA feeding found between 2,682 and 4,216 …

Pregnancy Rate And First-Service Conception Rate In Angus Heifers, J. Minick Bormann, L. R. Totir, Stephen D. Kachman, R. L. Fernando, D. E. Wilson

Department of Statistics: Faculty Publications

The objective of this project was to determine the genetic control of conception rate, or pregnancy percentage in Angus beef heifers. Producers from 6 herds in 5 states provided 3,144 heifer records that included breeding dates, breeding contemporary groups, service sires, and pregnancy check information. Two hundred fourteen sires of the heifers were represented; with 104 sires having less than 5 progeny, and 14 sires having greater than 50 progeny. These data were combined with performance and pedigree information, including actual and adjusted birth weights, weaning weights, and yearling weights, from the American Angus Association database. Heifer pregnancy rate varied …

Nesadsu Alumni Newsletter, No. 10, Spring 2006, Suffolk University

Advancement and Alumni Newsletters

No abstract provided.

Besafe - American Indian, Alaska Native, And Native Hawaiian Model Book, Nmaetc Staff

National Minority AIDS Education and Training Center Publications

Softback cultural competency book detailing the BESAFE model for American Indian, Alaska Native, and Native Hawaiian populations, 6.75 inches by 9.5 inches.

City Of Portsmouth, New Hampshire Annual Report Fy 2006 July 1, 2005- June 30, 2006., Portsmouth Town Representatives

Portsmouth, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Renaissance 2006, University Of Rhode Island

URI Yearbooks

This is a digitized, downloadable version of the University of Rhode Island yearbook.

Non-Native Invasive Marine Species In Maine, A Report To The Maine State Legislature, Marine Resources Committee And Natural Resources Committee, Peter E. Thayer, James F. Stahlnecker

Publications

No abstract provided.

Seasonal Variation In Mussel Byssal Thread Mechanics, Gretchen M. Moeser, Emily Carrington

Biological Sciences Faculty Publications

The blue mussel, Mytilus edulis, attaches itself to the substrate by producing a radially arranged complex of collagenous byssal threads. The strength of byssal attachment, or tenacity, has been shown to vary seasonally on Rhode Island shores, increasing twofold in spring in comparison with fall. It was previously assumed that this seasonality was due to increased thread production following periods of increased wave action; however, recent findings do not support this view. As an alternate hypothesis, this study evaluates the contribution of seasonal changes in the material properties of byssal threads to an annual cycle in mussel attachment …