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Arbeitspflicht In Postwar Vienna: Punishing Nazis Vs. Expediting Reconstruction, 1945-48, Matthew P. Berg

History

No abstract provided.

Enhancing The Senses: How Technological Advances Shape Our View Of The Law, Steven Goldberg

Georgetown Law Faculty Lectures and Appearances

This memorial lecture was given at West Virginia University, which houses, among other relevant programs, the Biometric Knowledge Center. The lecture surveys the application of a variety of legal topics to biometrics. Covered areas include basic research funding choices, freedom of speech, association and religion, search and seizure, and informational privacy.

Antigen Targeting To Dendritic Cells Elicits Long-Lived T Cell Help For Antibody Responses, Silvia B. Boscardin, Julius C.R. Hafalla, Revati F. Masilamani

Publications

Resistance to several prevalent infectious diseases requires both cellular and humoral immune responses. T cell immunity is initiated by mature dendritic cells (DCs) in lymphoid organs, whereas humoral responses to most antigens require further collaboration between primed, antigen-specific helper T cells and naive or memory B cells. To determine whether antigens delivered to DCs in lymphoid organs induce T cell help for antibody responses, we targeted a carrier protein, ovalbumin (OVA), to DCs in the presence of a maturation stimulus and assayed for antibodies to a hapten, (4-hydroxy-3-nitrophenyl) acetyl (NP), after boosting with OVA-NP. A single DC-targeted immunization elicited long-lived …

Intensified And Protective Cd4+ T Cell Immunity In Mice With Anti-Dendritic Cell Hiv Gag Fusion Antibody Vaccine, Christine Trumpfheller, Jennifer S. Finke, Carolina B. López

Publications

Current human immunodeficiency virus (HIV) vaccine approaches emphasize prime boost strategies comprising multiple doses of DNA vaccine and recombinant viral vectors. We are developing a protein-based approach that directly harnesses principles for generating T cell immunity. Vaccine is delivered to maturing dendritic cells in lymphoid tissue by engineering protein antigen into an antibody to DEC-205, a receptor for antigen presentation. Here we characterize the CD4⁺ T cell immune response to HIV gag and compare efficacy with other vaccine strategies in a single dose. DEC-205-targeted HIV gag p24 or p41 induces stronger CD4⁺ T cell immunity relative to high …

Immunogenicity And Efficacy Of Immunodeficiency Virus-Like Particles Pseudotyped With The G Protein Of Vesicular Stomatitis Virus, Seraphin Kuate, Christiane P. Stahl-Hennig, Heribert Stoiber

Publications

Vaccination with exogenous antigens such as recombinant viral proteins, immunodeficiency virus-derived whole inactivated virus particles, or virus-like particles (VLP) has generally failed to provide sufficient protection in animal models for AIDS. Pseudotyping VLPs with the vesicular stomatitis virus G protein (VSV-G), which is known to mediate entry into dendritic cells, might allow more efficient stimulation of immune responses. Therefore, we pseudotyped noninfectious immunodeficiency virus-like particles with VSV-G and carried out a preliminary screen of their immunogenicity and vaccination efficacy. Incorporation of VSV-G into HIV-1 VLPs led to hundred-fold higher antibody titers to HIV-1 Gag and enhancement of T cell responses …

Dendritic Cell Targeting Of Survivin Protein In A Xenogeneic Form Elicits Strong Cd4+ T Cell Immunity To Mouse Survivin, Anna Charalambous, Margarita Oks, Godwin W. Nchinda

Publications

To determine whether strong CD4⁺ T cell immunity could be induced to a nonmutated self protein that is important for tumorigenesis, we selectively targeted the xenogencic form of survivin, a survival protein overexpressed in tumors, to maturing dendritic cells in lymphoid tissues. Dendritic cell targeting via the DEC205 receptor in the presence of anti-CD40 and poly(I:C) as maturation stimuli, induced strong human and mouse survivin-specific CD4⁺ T cell responses, as determined by IFN-γ, TNF-α, and IL-2 production, as well as the development of lytic MHC class II-restricted T cells and memory. Immunity was enhanced further by depletion of …

Review Of Giorgio Agamben, The Open: Man And Animal, Trans. Kevin Attell., Anat Pick

Bryn Mawr Review of Comparative Literature

Giorgio Agamben, The Open: Man and Animal, trans. Kevin Attell. Stanford: Stanford University Press, 2004. 120 pp. ISBN 0804747377.

Berita Volume Xxx, Number 1 (2006), Ronald Provencher

Berita

Table of Contents

Editor’s notes...1

Corrections... 1

Announcements... 1

Periodicals... 1

Books... 8

Conference Reports...10

Scholarly Opportunities...10

Amnesty International...12

Prospectus...12

Research Staff...12

Developing An Inquiry-Based Physical Science Course For Preservice Elementary Teachers, Zdeslav Hrepic

Faculty Bibliography

Preservice elementary teachers should experience science through inquiry in order to be effective in teaching science. In addition, inquiry as a mode of teaching is mandated by Kansas and National Science Education Standards. As a result of the No Child Left Behind Act, teachers also need to be prepared to include basic skills in reading and mathematics in all instruction. To address these issues, Fort Hays State University (FHSU) is adapting and extending the NSF-developed teacher enhancement materials Operation Primary Physical Science (OPPS) for use in a physical science course for preservice elementary teachers. This paper presents main features of …

Relocating Segregation : The Pea Island Life-Saving Station, Jessica Caldwell

Theses, Dissertations and Capstones

This study examines racial segregation through the lens of the first and only all African-American crew in the history of the United States Life Saving Service (L.S.S.), predecessor to the United States Coast Guard. The all-black Pea Island station, under Richard Etheridge’s leadership, remained the only L.S.S. station with any black surfmen from 1880 until WWII. This study will consider the geography of the station’s location on the Outer Banks of North Carolina, the life of its keeper, Richard Etheridge, and the nature of the Life-Saving Service to show this segregated station provided some benefits to the men who served …

Spectroscopic And Thermodynamic Analysis Of Co Rebinding And Photodissociation From Fe (Ii) Lpo, Dustin Michael Lockney

Theses, Dissertations and Capstones

Lactoperoxidase (LPO) is a heme peroxidase found in tears, milk, saliva, and cervical fluids that has bactericidal activity. The bactericidal nature of LPO is due to its ability to oxidize halides and pseudohalides in the presence of H2O2. Full understanding of the catalytic cycle of LPO requires detailed characterization of the mechanism of ligand binding to the enzyme active site. This includes a dynamic and energetic description of conformational changes associated with heme-ligand interactions. Photoacoustic calorimetry is applied to determine the kinetics and magnitude of reaction volume and enthalpy changes for CO dissociation from CO-LPO. Time-resolved absorption spectroscopy was used …

The Zucker Rat As A Model Of Obesity-Hypertension, Ryan Morrison

Theses, Dissertations and Capstones

Hypertension is a serious health problem that affects approximately 1 in 4 American adults. Most cases are diagnosed as essential hypertension, meaning that the exact cause is unknown. In most patients, however, excess weight is a major contributory factor to the development of essential hypertension. The role of obesity in promoting hypertension is now well documented and has become the foundation for an entire field of research known alternately as obesity-hypertension, obesity-induced hypertension, or obesity-associated hypertension. In this field, rapid advances are being made in our understanding of how obesity and hypertension are linked. A plethora of related risk factors, …

A Mechanistic Study Of The Protective Effects Of S-Adenosyl-L-Methionine Against Hepatotoxicity Of Acetaminophen, Marcus V. Terneus Jr.

Theses, Dissertations and Capstones

Hepatic toxicity is known to be associated with excessive doses of the over-the-counter analgesic, acetaminophen (APAP). APAP overdose is the leading cause of drug-induced liver failure in the United States. APAP hepatotoxicity is dependent on the biotransformation of APAP by cytochrome P450 to the toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI). APAP, when taken in excessive doses, can lead to severe liver damage with the potential to progress to liver failure. Despite substantial efforts in past studies, the mechanism by which APAP induces such damaging effects is not completely understood. Recent discoveries suggest that glutathione (GSH) depletion, protein alkylation and reactive metabolite …

Occurrence And Distribution Of Multi-Antibiotic Resistant Bacteria From The Great Kanawha River, West Virginia, April Dawn Keenan

Theses, Dissertations and Capstones

During the spring and summer of 2004 subsurface mid-channel samples were collected from the Kanawha River and its five primary tributaries (New, Gauley, Elk, Coal and Pocatalico Rivers). The first two objectives of this study were to enumerate bacteria resistant to ciprofloxacin, erythromycin or tetracycline, and test them for multiple resistance to seven commonly used antibiotics. The third objective was to determine the Minimum Inhibitory Concentration (MIC) for seven antibiotics starting at concentrations 20 times the published working concentrations for Gram-negative bacteria. The final objective of this study was to determine if a novel Impact Scoring system incorporating a current …

Natural History And Distribution Of The Upland Chorus Frog, Pseudacris Feriarum Baird, In West Virginia, Jaime Sias

Theses, Dissertations and Capstones

Chapter 1 is a literature review of Pseudacris feriarum, largely based on published P. triseriata Complex species accounts. Chapter 2 presents the natural history of P. feriarum in West Virginia and compares some parameters with other Pseudacris species. Chapter 3 looks at the phenology of a wetland in eastern West Virginia. Chapter 4 examines the current range of P. feriarum and compares it with the historical range in the state. Finally, hypotheses are given as to why Upland Chorus Frogs have declined in West Virginia. All information obtained from this study should be used to create a management plan for …

Protein Kinase C Activity In Mouse Eggs Regulates Gamete Membrane Interaction, Hiroto Akabane

Theses, Dissertations and Capstones

Every mammalian life develops from one cell after fertilization of an egg by the sperm. The molecular pathways governing this event are still poorly understood. Numerous reports indicate that mammalian eggs highly express various protein kinase C (PKC) isoforms. Accordingly, we hypothesize that PKC activity in the egg plays an important role during egg-sperm membrane binding and fusion. In this study, we tested our hypothesis in mouse gametes using two types of PKC inhibitors (calphostin c and staurosporine) and the typical PKC activator, phorbol ester 12-tetradecanoylphorbol-13 acetate (PMA). After treatment with the individual drug, eggs were inseminated with sperm. The …

The Natural History And Thermal Ecology Of A Population Of Spotted Turtles (Clemmys Guttata) And Wood Turtles (Glyptemys Insculpta) In West Virginia, Ariana N. Breisch

Theses, Dissertations and Capstones

An ecological study was conducted from 19 March 2001 to 2 April 2003 on a population of Spotted Turtles (Clemmys guttata) and Wood Turtles (Glyptemys insculpta) in West Virginia. Live-trapping, mark-recapture, radio telemetry and temperature data logging techniques were used to gather information on morphometrics, capture success, movements, home range, behavior, and thermal regime during activity and over-wintering seasons. Twenty-one Spotted Turtles were captured 260 times. Population structure was 42.9% juvenile, 38.1% male, and 19.0% female. Mean home range was 0.52 ha. Fifty Wood Turtles were captured 230 times. Juveniles were 36%, and males and females were 32% each. Mean …

Three-Strikes Legislation And The Evolution Of The Liberal Conception Of Justice, Lisa Dillon

Theses, Dissertations and Capstones

The purpose of this paper is to examine the changing nature of the liberal conception of justice using three-strikes legislation as a basis for comparison. It includes a brief examination of the legal debate surrounding three-strikes legislation, as well as comprehensive tables comparing the content of the laws in several states. The preponderance of the paper explores the evolution of the liberal concept of justice in the works of John Locke, Jeremy Bentham, and John Stuart Mill. It concludes with a discussion of contemporary liberal thought on justice, and more specifically, with an examination of the work of John Rawls …

The Effect Of Substance P On Ovariectomy-Induced Memory Deficits In Rats, Jamie L. Haga

Theses, Dissertations and Capstones

The present experiment was designed to test whether pretreatment with substance P would affect ovariectomy-induced memory deficits in rats for retention in the Morris water maze. Adult female Sprague-Dawley rats were divided to two groups: (1) control (received saline) and (2) experimental group (received substance P). All rats underwent an ovariectomy, as this has been shown to significantly impair spatial reference learning and memory (Monteiro, Matté, Bavaresco, Netto, & Wyse, 2005). Approximately 8 months after surgery, all rats were trained in the Morris water maze in order to evaluate both reference and working memory. Results showed that substance P did …

Thimerosal-Induced Neuritoxicity: Apoptosis Occurs Through A Mitochondrial-Mediated Pathway Via The Jnk Signaling Pathway, Michelle L. Herdman

Theses, Dissertations and Capstones

Thimerosal is an organic mercurial containing an ethylmercury moiety attached to the sulfur atom of thiosalicylate. Since the 1930s, thimerosal has been used as an antiseptic and a preservative in a wide variety of products, including medicinal preparations administered to children and pregnant women. Past exposures to mercurials have indicated that mercury is a neurotoxin, and can also affect the kidney, skin, eyes, and immune system. Additionally, fetuses exposed to mercurials are more susceptible to toxicity because the nervous system is continuously developing. However, despite its widespread use, thimerosal was only studied on a limited basis until the end of …

Regulation Of Biofilm Formation Of Pseudomonas Aeruginosa, Nathaniel Edwards Head

Theses, Dissertations and Capstones

Cystic fibrosis (CF) is the most common, autosomal recessive lethal genetic disease in the Caucasian population, resulting from a malfunctioned cystic fibrosis transmembrane conductance regulator (CFTR) and leading to bacterial lung infections. P. aeruginosa, an opportunistic pathogen, establishes a chronic infection in CF with a phenotype of overproduction of an exopolysaccharide (alginate) due to host-directed mutagenesis. While free-floating planktonic bacteria can be properly cleared from the CF lung, P. aeruginosa, along with alginate production, establishes an infection in the form of a biofilm which supports its survival in nature and in vivo. As a result, genomic structure, …

Watching The Watchdog: Bloggers As The Fifth Estate, Stephen D. Cooper

Communications Faculty Research

This author is inclined to think that social structures which evolve through the voluntary interactions and exchanges among people, such as the blogosphere, tend in general to be more beneficial than structures created through the deliberate exercise of power, however well-intentioned, such as regulatory bureaucracies. That idea cannot be fully explored here. For our purposes, we can simply note that the blogosphere would seem to be a near-perfect instantiation of the ideal discourse.

Romania's New Child Protection Legislation: Change In Intercountry Adoption Law Results In A Human Rights Violation, Carrie A. Rankin

Syracuse Journal of International Law and Commerce

This Note explores and critiques provisions of Law 272 and Law 273, as well as the vulnerable position of Romania's orphaned and abandoned children and Romania's unique challenges to protect them. The remainder of the Introduction maps the history of Romania's orphaned and abandoned children, highlighting the catalysts leading to Romania's need for reform of its child protection laws. Part I traces the drafting process of the new laws, with particular attention on outside influence and how the laws comply with existing international guidelines for inter-country adoption. Part II reveals the devastating consequences the new laws will continue to have …

Is Cost-Benefit Analysis Neutral?, David M. Driesen

College of Law - Faculty Scholarship

Cost-benefit analysis (CBA) owes much of its appeal to its image as a neutral principle for deciding upon the appropriate stringency of environmental, health, and safety regulation. This article examines whether CBA is neutral in effect, i.e. whether it sometimes makes regulations more stringent or regularly leads to weaker health, safety and environmental protection. It also addresses the question of whether CBA offers either an objective value-neutral method or procedural neutrality. This Article shows that CBA has almost always proven anti-environmental in practice and that, in many ways, it is anti-environmental in theory. It examines the practice of the Bush …

Eukaryotic Translation Initiation Factor 5b Activity Regulates Larval Growth Rate And Germline Development In Caenorhabditis Elegans, Xiang Yu, Valarie E. Vought, Barbara Conradt, Eleanor M. Maine

Biology - All Scholarship

In C. elegans, a population of proliferating germ cells is maintained via GLP-1/Notch signaling; in the absence of GLP-1 signaling, germ cells prematurely enter meiosis and differentiate. We previously identified ego (enhancer of glp-1) genes that promote germline proliferation and interact genetically with the GLP-1 signaling pathway. Here, we report that iffb-1 (initiation factor five B) is an ego gene. iffb-1 encodes the sole C. elegans isoform of eukaryotic translation initiation factor 5B, a protein essential for translation. We have used RNA interference and a deletion mutation to determine the developmental consequences of reduced iffb-1 activity. Our data indicate that …

Center For Grassland Studies Newsletters, Winter 2006, Volume 12, No. 1

Center for Grassland Studies: Newsletters

Nitrogen Sequestration and Groundwater Quality Charles Shapiro and Bill Kranz, Haskell Agricultural Laboratory, UNL

Maximize pre-emergence success in turf by Roch Gaussoin, Department of Agronomy and Horticulture, UNL Losing Grasslands and Natural Areas to Development by Richard Sutton, Department of Agronomy and Horticulture, UNL

New Prairie Grasses to Fatten Beef Cattle

Nike Golf Camp in Lincoln This July

The Key 2006, Bowling Green State University

BGSU Key Yearbooks

Bowling Green State University 2006 Key Yearbook

Wera-95: "Vertebrate Pests Of Agriculture, Forestry And Public Lands" 2006 Annual Meeting

Western Region Coordinating Committee for Vertebrate Pests of Agriculture, Forestry, and Public Lands (WCC-95)

Table of Contents ........................................................................... i

2006 Officers.................................................................................... 1

Minutes ........................................................................................... 2

Number and Title of the Regional Project .......................................... 2

Location and Dates of the Meeting ................................................. 2

Convening of Sessions .................................................................... 2

2006 Business Meeting .................................................................. 4

Individual Research Updates and Discussions ................................. 7

Presentation Abstracts ................................................................ 10

Participants/Attendees Names and Addresses ..................................... 17

Technology In The Classroom And Its Impact On Student Understanding Of Mathematical Concepts, Marilyn Weaver

Mathematical and Computing Sciences Masters

Two lesson studies were performed to investigate the impact of technology in the mathematics classroom on student understanding of mathematical concepts. The studies were planned and carried out collaboratively over four days (two days per study) by two eighth grade mathematics teachers in the same building. In the first study, graphing calculator technology was utilized and examined for its ability to engage students and assist in their recognition, visualization, and understanding of linear and nonlinear relationships (including exponential, inverse, and quadratic). The second study employed a computer based mathematical Jeopardy game which students accessed on individual laptop computers from the …

Colorblindness: Invisible Disability, John Stiles

Iowa Science Teachers Journal

In nearly every classroom sits at least one student who is unable to distinguish between certain colors. This incurable, genetic, and sex-linked condition is particularly frustrating in science class, a subject in which color discrimination is frequently required. Teachers are often unaware of this invisible disability, which many "colorblind" students try to keep secret in order to avoid embarrassment. There are a number of modifications a science teacher can make to reduce, or in some instances remove, barriers to learning for colorblind students. In addition, a simple, free test may help identify young children who have color difficulties, so they …