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2005

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Jmjd2a Is A Novel N-Cor-Interacting Protein And Is Involved In Repression Of The Human Transcription Factor Achaete Scute-Like Homologue 2 (Ascl2/Hash2), Dianzheng Zhang, Hoguen Yoon, Jiemin Wong Jan 2005

Jmjd2a Is A Novel N-Cor-Interacting Protein And Is Involved In Repression Of The Human Transcription Factor Achaete Scute-Like Homologue 2 (Ascl2/Hash2), Dianzheng Zhang, Hoguen Yoon, Jiemin Wong

PCOM Scholarly Works

Corepressor N-CoR (nuclear receptor corepressor) and the highly related protein SMRT (silencing mediator of retinoid and thyroid hormone receptor) play important roles in different biological processes including proliferation, differentiation, and development. Understanding the biological function of these corepressors requires identification and characterization of their interacting proteins. Here we report the characterization of a novel N-CoR-interacting protein, JMJD2A (previously known as KIAA0677). JMJD2A is an evolutionarily conserved nuclear protein containing many functionally unknown domains. JMJD2A directly interacts with the N-terminal region of N-CoR through a small NID (N-CoR interaction domain) both in vitro and in vivo. Despite its copurification with N-CoR, …

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A Digital Atlas To Characterize The Mouse Brain Transcriptome, James P. Carson, Tao Ju, Hui-Chen Lu, Christina Thaller, Mei Xu, Sarah Pallas, Michael C. Crair, Joe Warren, Wah Chiu, Gregor Eichele Jan 2005

A Digital Atlas To Characterize The Mouse Brain Transcriptome, James P. Carson, Tao Ju, Hui-Chen Lu, Christina Thaller, Mei Xu, Sarah Pallas, Michael C. Crair, Joe Warren, Wah Chiu, Gregor Eichele

PCOM Scholarly Works

Massive amounts of data are being generated in an effort to represent for the brain the expression of all genes at cellular resolution. Critical to exploiting this effort is the ability to place these data into a common frame of reference. Here we have developed a computational method for annotating gene expression patterns in the context of a digital atlas to facilitate custom user queries and comparisons of this type of data. This procedure has been applied to 200 genes in the postnatal mouse brain. As an illustration of utility, we identify candidate genes that may be related to Parkinson …

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Book Notes: The Power To Criminalize: Violence, Inequality And The Law, By Elizabeth Comack And Gillian Balfour, Stefania Arlotto Jan 2005

Book Notes: The Power To Criminalize: Violence, Inequality And The Law, By Elizabeth Comack And Gillian Balfour, Stefania Arlotto

Osgoode Hall Law Journal

No abstract provided.

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Book Review: Unnatural Law: Rethinking Canadian Environmental Law And Policy, By David R. Boyd, Hugh J. Benevides Jan 2005

Book Review: Unnatural Law: Rethinking Canadian Environmental Law And Policy, By David R. Boyd, Hugh J. Benevides

Osgoode Hall Law Journal

No abstract provided.

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Copyright Law And Subject Matter Specificity: The Case Of Computer Software, Stacey Dogan, Joseph Liu Jan 2005

Copyright Law And Subject Matter Specificity: The Case Of Computer Software, Stacey Dogan, Joseph Liu

Faculty Scholarship

Drawing on recent work by Dan Burk and Mark Lemley in the patent context, this paper explores the extent to which courts have adapted pre-existing copyright doctrines to the special case of computer software. We argue that a number of courts have, as has been widely recognized, significantly adapted copyright doctrines to deal with special features of the computer software market. We further argue that these adaptations have, by and large, positively sought to strike a balance between the copyright act's dual goals of incentive and access. Despite this general trend toward adaptation, however, we point to a handful of …

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Privacy And The Criminal Arrestee Or Suspect: In Search Of A Right, In Need Of A Rule, Sadiq Reza Jan 2005

Privacy And The Criminal Arrestee Or Suspect: In Search Of A Right, In Need Of A Rule, Sadiq Reza

Faculty Scholarship

Criminal accusation stigmatizes. Merely having been accused of a crime lasts in the public eye, damaging one's reputation and threatening current and future employment, relationships, social status, and more. But vast numbers of criminal cases are dismissed soon after arrest, and countless accusations are unfounded or unprovable. Nevertheless, police officers and prosecutors routinely name criminal accusees to the public upon arrest or suspicion, with no obligation to publicize a defendant's exoneration, or the dismissal of his case, or a decision not to file charges against him at all. Other individuals caught up in the criminal process enjoy protections against the …

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Good Faith Business Judgment: A Theory Of Rhetoric In Corporate Law Jurisprudence, Sean J. Griffith Jan 2005

Good Faith Business Judgment: A Theory Of Rhetoric In Corporate Law Jurisprudence, Sean J. Griffith

Faculty Scholarship

This Article develops a theory of rhetoric in corporate law jurisprudence. It begins by examining a recent innovation in Delaware case law: the emerging principle of “good faith.” Good faith is an old notion in law generally, but it offers to bring significant change to corporate law, including realignment of the business judgment rule and a shift in the traditional balance between the authority of boards and the accountability of boards to courts. This Article argues, however, that good faith functions as a rhetorical device rather than a substantive standard. That is, it operates as a speech act, a performance, …

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An Examination Of Social Workers' And Other Therapists' Use Of Transference And Countertransference As Therapeutic Tools In Couples Counselling Within The Psychoanalytic Paradigm, Heidi B. Gottlieb Jan 2005

An Examination Of Social Workers' And Other Therapists' Use Of Transference And Countertransference As Therapeutic Tools In Couples Counselling Within The Psychoanalytic Paradigm, Heidi B. Gottlieb

Theses and Dissertations (Comprehensive)

The purpose of this study is to increase knowledge about therapeutic practices on the part of practitioners; specifically, the study asked social workers and other types of therapists who see couples about their awareness of, acknowledgment of, attitude toward, understanding of, and use of the psychoanalytic model and of the concepts of transference and countertransference, and to demonstrate to what extent they accurately comprehend the meaning and potential use of these concepts in their clinical practice. A survey/questionnaire was mailed to a large sample of social workers and other therapists in Ontario, and provided 941 responses. An included vignette gave …

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Application For Historical Plaque, Nashville Christian Institute Jan 2005

Application For Historical Plaque, Nashville Christian Institute

Correspondence and School Documents

The application for a historical plaque to be placed at the remaining building of the Nashville Christian Institute.

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Epistemological Practice And The Internalism/Externalism Debate, James Mcbain Jan 2005

Epistemological Practice And The Internalism/Externalism Debate, James Mcbain

Faculty Submissions

The dialogue between internalists who maintain a belief is a case of knowledge when that which justifies the belief is within the agent’s first-person perspective and externalists who maintain epistemic justification can be in part, or entirely, outside the agent’s first-person perspective has been part of the epistemological literature for some time with one side usually attempting to show how the other side is mistaken. Edward Craig argues the internalist/externalist debate is flawed from the outset. Specifically, both internalism and externalism should be incorporated into the correct analysis of knowledge once we revamp that project. The epistemological project, according to …

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Another Tocqueville, Donald J. Herzog Jan 2005

Another Tocqueville, Donald J. Herzog

Articles

Time for a true confession: I'm skeptical of predictions in social and political life. Talk of causal generalizations and Hempel's covering laws strikes me as science fiction and fantasy in drag; talk of the unfolding of the immanent logic of modernity makes me dyspeptic. I usually think that structural considerations are context, not cause, and that weird combinations of stray contingencies explain what happens. Worse, now I'm called on to predict how political theorists will be discussing democracy ten years hence. Images of herding cats and Brownian motion come to mind. Nonetheless, duty calls. I dust off my crystal ball …

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Legal Durability, Omri Ben-Shahar Jan 2005

Legal Durability, Omri Ben-Shahar

Articles

This paper develops a framework to study the effects of the durability of legal allocation decisions, such as trial outcomes, regulatory enactments and property entitlements. For a party favored by the legal allocation, a more durable decision is also more costly to secure, ex-ante. Thus, it is not the greater durability of the allocation that determines whether the “winner” is better-off, but other factors that are affected by the durability attribute, such as the cost of securing a favorable outcome and the ability of contesting parties to affect this cost. The paper develops conditions under which greater durability is irrelevant, …

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The Silver Lining: The International Tax Provisions Of The American Jobs Creation Act - A Reconsideration, Reuven S. Avi-Yonah Jan 2005

The Silver Lining: The International Tax Provisions Of The American Jobs Creation Act - A Reconsideration, Reuven S. Avi-Yonah

Articles

The American Jobs Creation Act of 2004, passed by the US Congress on 12 October and signed into law by President Bush on 22 October 2004, has been greeted by general dismay by various critics. The Act has been described as overloaded with “pork” and giveaways to special interest groups like tobacco farmers. The critics contend that the only achievement of the Act, the repeal of the “extraterritorial income” (ETI) regime that was ruled by the WTO to be a prohibited export subsidy, is dwarfed by 633 pages of special interest legislation. Even the Bush Administration distanced itself from the …

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The Common Law Power Of The Legislature: Insurer Conversions And Charitable Funds, Jill R. Horwitz, Marion R. Fremont-Smith Jan 2005

The Common Law Power Of The Legislature: Insurer Conversions And Charitable Funds, Jill R. Horwitz, Marion R. Fremont-Smith

Articles

New York's Empire Blue Ccoss and Blue Shield conversion from nonprofic cofor­ profic form has considerable legal significance. Three aspects of the conversion ma.ke checase unique: the role of the scace legislature in directing the disposicion of the conversion assets, che face chac it made itself che primary beneficiary of chose assets, and the actions of che scace attorney general defending the state rather than che public inceresc in che charitable assets. Drawing on several cenruries of common Law rejecting the Legislacive power to direct the disposition of charitable funds, chis article argues chat the legislature lacked power cocontrol che …

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Credible Coercion, Oren Bar-Gill, Omri Ben-Shahar Jan 2005

Credible Coercion, Oren Bar-Gill, Omri Ben-Shahar

Articles

The ideal of individual freedom and autonomy requires that society provide relief against coercion. In the law, this requirement is often translated into rules that operate "postcoercion" to undo the legal consequences of acts and promises extracted under duress. This Article argues that these ex post antiduress measures, rather than helping the coerced party, might in fact hurt her. When coercion is credible-when a credible threat to inflict an even worse outcome underlies the surrender of the coerced party-ex post relief will only induce the strong party to execute the threatened outcome ex ante, without offering the choice to surrender, …

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Learning The Value Of Drugs - Is Rofecoxib A Regulatory Success Story?, Rebecca S. Eisenberg Jan 2005

Learning The Value Of Drugs - Is Rofecoxib A Regulatory Success Story?, Rebecca S. Eisenberg

Articles

Controversy over recent revelations concerning the adverse cardiovascular effects of selective cyclooxygenase- 2 (COX-2) inhibitors has generally been framed as a story of regulatory failure, in which the Food and Drug Administration (FDA) has failed in its mission to protect the public from unsafe products. But this simplistic understanding of the mission of the FDA seems to make failure all but inevitable, if the reliable observation of the risks and benefits of a drug requires rigorous long-term studies. Perhaps in an earlier era the goal of drug regulation was simply to protect the public from poisons. Today, drug regulation guides …

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Do Institutions Matter? The Impact Of The Lead Plaintiff Provision Of The Private Securities Litigation Reform Act, Adam C. Pritchard, Stephen J. Choi, Jill E. Fisch Jan 2005

Do Institutions Matter? The Impact Of The Lead Plaintiff Provision Of The Private Securities Litigation Reform Act, Adam C. Pritchard, Stephen J. Choi, Jill E. Fisch

Articles

When Congress enacted the Private Securities Litigation Reform Act in 1995 ("PSLRA"), the Act's "lead plaintiff' provision was the centerpiece of its efforts to increase investor control over securities fraud class actions. The lead plaintiff provision alters the balance of power between investors and class counsel by creating a presumption that the investor with the largest financial stake in the case will serve as lead plaintiff. The lead plaintiff then chooses class counsel and, at least in theory, negotiates the terms of counsel's compensation. Congress's stated purpose in enacting the lead plaintiff provision was to encourage institutional investors-pension funds, mutual …

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Criminal Law In A Post-Freudian World, Deborah W. Denno Jan 2005

Criminal Law In A Post-Freudian World, Deborah W. Denno

Faculty Scholarship

Freudian psychoanalytic theory has greatly influenced the modern definition of criminal culpability. Indeed, much of the language of key criminal statutes, cases, and psychiatric testimony is framed by psychoanalytic concepts. This impact is particularly evident in the Model Penal Code's mens rea provisions and defenses, which were developed in the 1950s and 1960s, a time of Freudian reign in the United States. For contemporary criminal law, however, this degree of psychoanalytic presence is troublesome. Freudian theory is difficult to apply to group conflicts and legal situations, and the theory emphasizes unconscious (rather than conscious) thoughts. The rising new science of …

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15th Annual Forum On Affordable Housing & Community Development Law: 2006 Michael Scher Award Given To William C. Kelly, Nestor M. Davidson, Leonard A. Zax Jan 2005

15th Annual Forum On Affordable Housing & Community Development Law: 2006 Michael Scher Award Given To William C. Kelly, Nestor M. Davidson, Leonard A. Zax

Faculty Scholarship

No abstract provided.

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Housing First' For The Chronically Homless: Challenges Of A New Service Model, Nestor M. Davidson Jan 2005

Housing First' For The Chronically Homless: Challenges Of A New Service Model, Nestor M. Davidson

Faculty Scholarship

Increasingly in recent years, policymakers have focused their efforts on ending chronic homelessness and, in particular, on individuals grappling with mental illness, substance abuse, and similar challenges. Central to this effort has been the rise of a new model of service provision called Housing First. Housing First reverses the long-standing practice of conditioning housing on compliance with treatment plans or other service requirements, instead providing immediate independent living for chronically homeless individuals with dual or multiple diagnoses and only then making intensive services available. This Commentary reviews this important policy shift and explores some conceptual and practical challenges in moving …

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Rights Myopia In Child Welfare, Clare Huntington Jan 2005

Rights Myopia In Child Welfare, Clare Huntington

Faculty Scholarship

For decades, legal scholars have debated the proper balance of parents' rights and children's rights in the child welfare system. This Article argues that the debate mistakenly privileges rights. Neither parents' rights nor children's rights serve families well because, as implemented, a solely rights-based model of child welfare does not protect the interests of parents or children. Additionally, even if well-implemented, the model still would not serve parents or children because it obscures the important role of poverty in child abuse and neglect and fosters conflict rather than collaboration between the state and families. In lieu of a solely rights-based …

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Law And War: Individual Rights, Executive Authority, And Judicial Power In England During World War I , Rachel Vorspan Jan 2005

Law And War: Individual Rights, Executive Authority, And Judicial Power In England During World War I , Rachel Vorspan

Faculty Scholarship

This Article examines the role of the English courts during World War I, particularly the judicial response to executive infringements on individual liberty. Focusing on the areas of detention, deportation, conscription, and confiscation of property, the Article revises the conventional depiction of the English judiciary during World War I as passive and peripheral. It argues that in four ways the judges were activist and energetic, both in advancing the government's war effort and in promoting their own policies and powers. First, they were judicial warriors, developing innovative legal strategies to legitimize detention and other governmental restrictions on personal. Second, they …

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Structure Of Regulatory Competition In European Corporate Law, The , Martin Gelter Jan 2005

Structure Of Regulatory Competition In European Corporate Law, The , Martin Gelter

Faculty Scholarship

In its opinions in the cases Centros, Uberseering and Inspire Art, the ECJ has begun to open European corporate law for regulaton of competition, as it has been discussed in the US for several ldecades. This article analyses the stuictual conditions of competition on the supply and demand sides of the market for corporate law, and the impact of supranational influence. In doing so, it identifies several factors that have received little attention in the incipient European debate. The supply-side analysis shows that a European Delaware is implausible because of the interdependence of competitive advantages and the incentives to compete. …

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Law And The Rise Of The Firm , Henry Hansmann, Reiner Kraakman, Richard Squire Jan 2005

Law And The Rise Of The Firm , Henry Hansmann, Reiner Kraakman, Richard Squire

Faculty Scholarship

Organizational law empowers firms to hold assets and enter contracts as entities that are legally distinct from their owners and managers. Legal scholars and economists have commented extensively on one form of this partitioning between firms and owners: namely, the rule of limited liability that insulates firm owners from business debts. But a less-noticed form of legal partitioning, which we call "entity shielding," is both economically and historically more significant than limited liability. While limited liability shields owners' personal assets from a firm's creditors, entity shielding protects firm assets from the owners' personal creditors (and from creditors of other business …

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Benthic Fisheries Ecology In A Changing Environment: Unraveling Process To Achieve Prediction, Mark J. Butler Iv Jan 2005

Benthic Fisheries Ecology In A Changing Environment: Unraveling Process To Achieve Prediction, Mark J. Butler Iv

Biological Sciences Faculty Publications

Marine fisheries and the ecosystems that sustain them are increasingly beset by environmental deterioration, and the problem is particularly acute in coastal zones where human Populations are increasing. In the best of circumstances, fishery managers are faced with the multiple, often conflicting, demands of resource users, politicians, and scientists when considering strategies for resource management. A further challenge is that management decisions must be made against a backdrop of a deteriorating environment and the shifting status of coastal ecosystem integrity. Traditional tools for single-species management may be inadequate in these settings. Furthermore. the necessary empirical data to appropriately parameterize models …

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Does A Past Conflict Still Sting? The Influence Of Recall Style And Self-Esteem On The Impact Of Conflict Memories, Huan Jacqueline Ye Jan 2005

Does A Past Conflict Still Sting? The Influence Of Recall Style And Self-Esteem On The Impact Of Conflict Memories, Huan Jacqueline Ye

Theses and Dissertations (Comprehensive)

The current research examined whether the impact of people's past conflicts on their current relationships is associated with (1) the way people think about the conflicts, (2) their self-regard. Specifically, we expected that people's relationships should be more negatively influenced if they recall conflicts in a vivid manner, focusing on "how" the conflicts happened and recalling them in vivid detail, rather than if they recall conflicts in a pallid manner, focusing on "why" the conflict occurred and recalling little detail. We also predicted that past conflicts are more likely to adversely affect the appraisals of the relationships of low self-esteem …

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Biased Forgetting Effects In The Assessment Of Memory For Filled And Empty Intervals: Evidence For The Instructional Failure/Confusion Hypothesis, Stephen Gagne Jan 2005

Biased Forgetting Effects In The Assessment Of Memory For Filled And Empty Intervals: Evidence For The Instructional Failure/Confusion Hypothesis, Stephen Gagne

Theses and Dissertations (Comprehensive)

According to the instructional failure hypothesis, the contextual similarity of the intertrial interval (ITI) and the delay interval (DI) is responsible for the choose-short bias that occurs when memory for filled intervals is tested. This hypothesis may also explain the choose-long bias for empty intervals, if birds confuse an extended DI with a long empty interval. In the present study, pigeons were trained in a within-subjects design to discriminate durations of a filled interval (2-s and 8-s of light), and durations of an empty interval (2-s and 8-s bound by two 1-s light markers). In order to disambiguate the ITI, …

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A Comparison Of Techniques For Measuring Automatic Retrieval In Conceptual Priming, Jennifer C. Major Jan 2005

A Comparison Of Techniques For Measuring Automatic Retrieval In Conceptual Priming, Jennifer C. Major

Theses and Dissertations (Comprehensive)

The speeded response technique has provided pure estimates of automatic retrieval in perceptual memory tasks. The present study was designed to investigate whether pure automatic retrieval could also be evidenced in a conceptual task. Subjects were encouraged to generate category exemplars using strictly automatic retrieval by presenting practice trials that did not allow responding with previously studied items and by encouraging speed of responding. This speeded condition was compared to a baseline condition in which conscious retrieval was not possible and to an explicit condition in which conscious retrieval was required. Average RTs in the speeded condition were the same …

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Experiences And Expectations: What Prompts An Educator To Use Computers In The Classroom?, Craig Ross Jan 2005

Experiences And Expectations: What Prompts An Educator To Use Computers In The Classroom?, Craig Ross

Theses and Dissertations (Comprehensive)

Charged with the task of providing today's youth with the education they need, many school boards across North America have invested large sums of money in computer technology. However, although the technology is being installed in the schools, many educators are not using the technology to its full potential as a learning tool. In the present study, elementary (n = 148) and secondary (n = 150) educators completed one survey which assessed two domains believed to influence an educator's decision to integrate computer technology into his/her classroom. The first domain was comprised of gender and teaching level (elementary versus secondary), …

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Why Do Young Children Forget Where They Learned Information? The Relation Between Source Monitoring, Theory-Of-Mind Understanding And Suggestibility, Angela D. Evans Jan 2005

Why Do Young Children Forget Where They Learned Information? The Relation Between Source Monitoring, Theory-Of-Mind Understanding And Suggestibility, Angela D. Evans

Theses and Dissertations (Comprehensive)

In Study one, Fifty young children (3- to 5- year-olds) watched a video and were then interviewed about the video by a Knowledgeable interviewer, who had watched the video with the children, and a Naive interviewer, who had not seen the video. Children were asked yes/no recognition questions, half of which contained misleading suggestions. After five to seven days, children were asked the same yes/no recognition questions by a third Naïve interviewer. Children then completed a source-monitoring task Followed by three theory-of-mind tests. Study two followed the same methodologies as Study one but with an increased sample size (72 children), …

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