Digital Commons Network^™

Structural Study Of Disease Related Proteins, Ayse Sinem Ozyurt

Electronic Theses and Dissertations

The availability of complete sequences for the genomes of many organisms changes the researcher's attention from genome sequencing to finding the function of gene products, the proteins. The three dimensional (3D) structure of a protein is helpful to understand its function, because tertiary structure is more conserved in evolution than sequence. The 3D structures can be found quickly by using high-throughput (HT) methods for protein expression, purification, characterization and structure determination. This process is very challenging in every step. Therefore we selected nearly 200 cancer related proteins as targets to see the difficulties in trying to determine the web predicted …

Physical And Behavioral Complaints In Children With Attention-Deficit/Hyperactivity Disorder (Adhd): Paradoxical Effects Of Methylphenidate, Maria M. Coiro

Electronic Theses and Dissertations

Hypotheses concerning paradoxical, psychostimulant-related side effects experienced by ADHD children were examined in the context of a double-blind, placebo-controlled, within subject (crossover) experimental design. Results revealed that behavioral and physical complaints were significantly higher under baseline relative to placebo and the four methylphenidate (MPH) conditions (5-mg, 10-mg, 15-mg, 20-mg) across three symptom categories: ADHD core/secondary symptoms, symptoms common to all children, and symptoms highly specific to MPH. No significant differences were found among active drug conditions. Implications of these findings for assessing and monitoring potential treatment emergent symptoms in children are discussed.

Choice Of Law For Internet Transactions: The Uneasy Case For Online Consumer Protection, Erin O'Connor

Vanderbilt Law School Faculty Publications

This Essay explores the possibility that the market for online purchases fails to work as efficiently as it can because consumers lack trust in unknown vendors, and it argues that consumer distrust in unknown vendors can and often does take the form of categorical avoidance of other unknown vendors. This avoidance of unknown vendors as a class results from the fact that trust and distrust, as cognitive phenomena, are subject to the same biases and limitations as are other cognitive phenomena. Unknown vendors often are willing to incur some costs to signal their trustworthiness to individual consumers. Unless the other …

Constructing Reality: Social Science And Race Cases, Beverly I. Moran

Vanderbilt Law School Faculty Publications

Dred Scott v. Sanford, Plessy v. Ferguson, Brown v. Board of Education and Grutter v. Bollinger all demonstrate that law alone is not enough to make social change. Instead, lawyers interested in social change must understand the nature of the societies that they attempt to persuade and the language that leads judges to change their ways of thinking. In the early 21st century, the language of persuasion is often the language of social science.

The Effects Of An Academic Support Services Unit On The Grade Point Average For Students Admitted On Probation, Keith Branham

Electronic Theses and Dissertations

The goal of this research was to examine the effects, if any, the programs available from an Academic Support Services unit of a small, private, liberal arts college might have on the grade point averages of students admitted on probation over two major semesters. The assumption was that the students who utilized the services of the Academic Center for Excellence would demonstrate more increases in GPA than students who did not utilize the services. The literature review of this study found that, although there were many factors and student characteristics that could predict and explain student achievement in course work, …

Tunable Liquid Crystal Photonic Devices, Yun-Hsing Fan

Electronic Theses and Dissertations

Liquid crystal (LC)-based adaptive optics are important for information processing, optical interconnections, photonics, integrated optics, and optical communications due to their tunable optical properties. In this dissertation, we describe novel liquid crystal photonic devices and their fabrication methods. The devices presented include inhomogeneous polymer-dispersed liquid crystal (PDLC), polymer network liquid crystals (PNLC) and phase-separated composite film (PSCOF). Liquid crystal/polymer composites could exist in different forms depending on the fabrication conditions. In Chap. 3, we demonstrate a novel nanoscale PDLC device that has inhomogeneous droplet size distribution. In such a PDLC, the inhomogeneous droplet size distribution is obtained by exposing the …

Self-Assembled Supramolecular Structures Of Chiral Phospholipids: Structure, Mechanical Properties And Patterning, Nidhi Mahajan

Electronic Theses and Dissertations

Lipid molecule is well known natural building block to form different supramolecular structures with specific shape, size and functionality. In my thesis work, I have used DC8,9PC 1,2-bis(tricosa-10,12-dinoyl)-sn-glycero-3-phosphocholine), a type of chiral lipid to form the vesicles, tubules and ribbons . By using Atomic Force Microscope, I have studied the morphological features of these particular structures. Also, the mechanical properties of lipid tubules have been studied using AFM. Softlithography has been used to pattern the lipid vesicles and tubules into 2-dimensional and 3-dimensional ordered arrays. The structure of self-assembled hollow spherical vesicles was studied using AFM. The applications of soft …

A Dynamic Model Of The Human/Cooling System/Clothing/Environment System, Zhengxiang Pu

Electronic Theses and Dissertations

The human body compensates well for moderate climatic heat stress, but artificial environments often block or overwhelm physiological defense mechanism. Personal protective equipment (PPE) is one of sources of heat stress. It protects individual from chemical, physical, or biological hazards, but the high thermal insulation and low vapor permeability of PPE may also lead to substantial heat stress. Personal cooling is widely used to alleviate heat stress, especially for those situations where ambient environmental cooling is not economically viable or feasible. It is important to predict the physiological responses of a person wearing PPE with personal cooling to make sure …

System Design And Optimization Of Optical Coherence Tomography, Avni Ceyhun Akcay

Electronic Theses and Dissertations

Optical coherence imaging, including tomography (OCT) and microscopy (OCM), has been a growing research field in biomedical optical imaging in the last decade. In this imaging modality, a broadband light source, thus of short temporal coherence length, is used to perform imaging via interferometry. A challenge in optical coherence imaging, as in any imaging system towards biomedical diagnosis, is the quantification of image quality and optimization of the system components, both a primary focus of this research. We concentrated our efforts on the optimization of the imaging system from two main standpoints: axial point spread function (PSF) and practical steps …

Becoming Transcultural: Filling The Cultural And Communication Gap Within The Black American Community, Quanda Le Boldin

Electronic Theses and Dissertations

The purpose of this study is to define transculturalism by exploring the Black experience through collectivism/individualism, Black identity and the ability to be transcultural. The study included 83 male and female Black American, college students, graduate students and college graduates. The participants answered a 4-part survey that measured collectivism/individualism, Black identity, the ability to be transcultural and minority hardships. Results revealed that the Pre-encounter, Immersion, Emersion and Internalization phases of Black identity are predictors of minority hardships. There were also significant results for the Internalization phase of Black identity and the ability to be transcultural. In conclusion, Black Americans that …

Development And Validation Of The Beile Test Of Information Literacy For Education (B-Tiled), Penny Beile O'Neil

Electronic Theses and Dissertations

Few constituencies exist where it is more important to produce information literate individuals than teacher candidates, yet rarely is it suggested that practitioners entering the field are adequately prepared to teach and model information literacy to their students. As a result, information literacy has been established as a key outcome by a number of teacher education accrediting bodies and professional associations. Corollary to this initiative is the effort to develop valid instruments that assess information literacy skills. Yet, at the time of this dissertation, no rigorously reviewed instruments were uncovered that measure the information literacy skills levels of teacher candidates. …

An Inverse Algorithm To Estimate Thermal Contact Resistance, Jennifer Gill

Electronic Theses and Dissertations

Thermal systems often feature composite regions that are mechanically mated. In general, there exists a significant temperature drop across the interface between such regions which may be composed of similar or different materials. The parameter characterizing this temperature drop is the thermal contact resistance, which is defined as the ratio of the temperature drop to the heat flux normal to the interface. The thermal contact resistance is due to roughness effects between mating surfaces which cause certain regions of the mating surfaces to loose contact thereby creating gaps. In these gap regions, the principal modes of heat transfer are conduction …

Optical Wave Propagation In Discrete Waveguide Arrays, Jared Hudock

Electronic Theses and Dissertations

The propagation dynamics of light in optical waveguide arrays is characteristic of that encountered in discrete systems. As a result, it is possible to engineer the diffraction properties of such structures, which leads to the ability to control the flow of light in ways that are impossible in continuous media. In this work, a detailed theoretical investigation of both linear and nonlinear optical wave propagation in one- and two-dimensional waveguide lattices is presented. The ability to completely overcome the effects of discrete diffraction through the mutual trapping of two orthogonally polarized coherent beams interacting in Kerr nonlinear arrays of birefringent …

Micromachined Electrochemical Sensors For Hydrogen Peroxide And Chlorine Detection, Anjum Mehta

Electronic Theses and Dissertations

Hydrogen peroxide and chlorine detection is critical for many biological and environmental applications. Hydrogen peroxide plays important roles in a variety of fields including plant physiology, medical, environmental and biochemical applications. Its role in plant defense and signal transduction, diseases such as Parkinson's and Alzhemier's, industrial processes such as disinfection and wastewater treatment and biochemical enzymatic reactions is critical. Given the gamut of areas that hydrogen peroxide is a key component of; its detection assumes great importance. Similarly chlorine has long been used as a disinfectant for making drinking water safe, but excessive chlorination is an environmental and health hazard …

Resource Allocation Using Touch And Audition, David Mortimer

Electronic Theses and Dissertations

When people multi-task with inputs that demand attention, processing, andencoding, sensory interference is possible at almost any level. Multiple Resource Theory (MRT) suggests that such interference may be avoided by drawing from separate pools of resources available when using different sensory channels, memory processes, and even different response modes. Thus, there should be advantages in dividing tasks among different sensory channels to tap independent pools of attentional resources. For example, people are better with two tasks using the eye and ear, than when using two auditory or two visual inputs. The majority of the research on MRT involves visual to …

The Use And Development Of Laser Microdissection To Separate Spermatozoa From Epithelial Cells For Str Analysis, Christine Sanders

Electronic Theses and Dissertations

Short Tandem Repeat (STR) analysis has become a valuable tool in identifying the source of biological stains, particularly from the investigation of sexual assault crimes. Difficulties in analysis arise primarily in the interpretation of mixed genotypes when cell separation of the sexual assailant's sperm from the victim's cells is incomplete. The forensic community continues to seek improvements in cell separation methods from mixtures for DNA typing. This report describes the use of laser microdissection (LMD) for the separation of pure populations of spermatozoa from two-donor cell mixtures. In this study, cell separation was demonstrated by microscopic identification of histologically stained …

Coherence Properties Of Optical Near-Fields, Adela Apostol

Electronic Theses and Dissertations

Next generation photonics-based technologies will ultimately rely on novel materials and devices. For this purpose, phenomena at subwavelength scales are being studied to advance both fundamental knowledge and experimental capabilities. In this dissertation, concepts specific to near-field optics and experimental capabilities specific to near-field microscopy are used to investigate various aspects of the statistical properties of random electromagnetic fields in the vicinity of optically inhomogeneous media which emit or scatter radiation. The properties of such fields are being characterized within the frame of the coherence theory. While successful in describing the far-field properties of optical fields, the fundamental results of …

A Comparison Of Character Education Programs And Their Effects On Academic Achievement, Behavior, And Attendance, Beth Berger

Electronic Theses and Dissertations

The purpose of this study was to determine whether significant relationships existed between character education and the number of incidents of crimes and violence, attendance rates, and academic achievement in Florida public schools. Proponents of character education such as Lickona (1991) and Murphy (1998) posited that there was a positive correlation between teaching and practicing the six pillars of character education, and student achievement, and increased attendance. They also posited that there was a negative correlation between character education and incidents of crime and violence. The researcher acquired data in an attempt to determine whether or not the views of …

A Healthy Pregnancy Curriculum For Adolescent Mothers: Participants' Perceptions And Effects On Infants' Birth Weight, Rae Konjoian

Electronic Theses and Dissertations

The purpose of this study was to determine if there are differences in birth weight of infants, tobacco use during pregnancy, and Apgar scores of infants between pregnant adolescents who successfully complete a healthy pregnancy curriculum and those who do not and to further examine the adolescent mothers' perceptions of the major concepts included in a healthy pregnancy curriculum. The study involved the collection and analysis of retrospective data to determine differences in birth weight of infants, tobacco use during pregnancy, and Apgar scores of infants. Additionally, a questionnaire, focus group discussions, and follow-up interviews were conducted with former students …

Consanguinity, Sibling Relationships, And The Default Rules Of Inheritance Law: Reshaping Half-Blood Statutes To Reflect The Evolving Family, Ralph C. Brashier

SMU Law Review

No abstract provided.

Creating Space For Personal Meaning In Schooling, Harro Van Brummelen, Kimberly Franklin, Monika Hilder

International Christian Community of Teacher Educators Journal

This paper suggests possible ways for teachers to develop students’ personal meaning in public school classrooms. We discuss why schools should move beyond a focus on narrow performance standards and help students address the mysteries of life in our universe. We show how a personally meaningful curriculum is an integral one that emphasizes multiple dimensions of knowledge, enduring understandings, and the development of a moral imagination. We conclude that by using four educational keystones (gratitude, justice, imagination, and transcendence) we can educate for personal meaning without imposing our own worldview and belief system on our students.

Engineering A Dimeric Caspase-9: A Re-Evaluation Of The Induced Proximity Model For Caspase Activation, Yang Chao, Eric N. Shiozaki, Srinivasa M. Srinivasula, Robert Fairman

Biology Faculty Scholarship

No abstract provided.

The Subsystems Approach To Genome Annotation And Its Use In The Project To Annotate 1000 Genomes, Ross Overbeek, Tadhg Begley, Ralph M. Butler, Jomuna V. Choudhuri, Han-Yu Chuang, Matthew Cohoon, Valérie De Crécy-Lagard, Naryttza Diaz, Terry Disz, Robert Edwards, Michael Fonstein, Ed D. Frank, Svetlana Gerdes, Elizabeth M. Glass, Alexander Goesmann, Andrew Hanson, Dirk Iwata-Reuyl, Roy Jensen, Neema Jamshidi, Lutz Krause, Michael Kubal, Niels Larsen, Burkhard Linke, Alice C. Mchardy, Folker Meyer, Heiko Neuweger, Gary Olsen, Robert Olson, Andrei Osterman, Vasiliy Portnoy, Gordon D. Pusch, Dmitry A. Rodionov, Christian Rückert, Jason Steiner, Rick Stevens, Ines Thiele, Olga Vassieva, Yuzhen Ye, Olga Zagnitko, Veronika Vonstein

Chemistry Faculty Publications and Presentations

The release of the 1000^th complete microbial genome will occur in the next two to three years. In anticipation of this milestone, the Fellowship for Interpretation of Genomes (FIG) launched the Project to Annotate 1000 Genomes. The project is built around the principle that the key to improved accuracy in high through put annotation technology is to have experts annotate single subsystems over the complete collection of genomes, rather than having an annotation expert attempt to annotate all of the genes in a single genome. Using the subsystems approach, all of the genes implementing the subsystem are analyzed by …

Management Localization And Performance Of Mncs In China : A Contingent Resource-Based View, Shengsheng Huang

Lingnan Theses

Although many foreign invested enterprises (FIEs) and consultants in China put the localization to a strategic level, management localization is still an emerging issue of human resource management in academic research. A few previous studies on management localization focused on the internal efficiency of the subsidiaries or parent-subsidiary relationship. The impact of management localization on the interaction between the subsidiary and local environment has received little attention. Moreover, localization lacks a consistent and valid definition. This thesis attempts to bridge the gap by systematically exploring the strategic impact of management localization. Management localization is defined as substituting expatriate managers with …

The Drosophila Lymph Gland As A Developmental Model Of Hematopoiesis, Seung Hye Jung, Cory J. Evans, Christine Uemura, Utpal Banerjee

Biology Faculty Works

Drosophila hematopoiesis occurs in a specialized organ called the lymph gland. In this systematic analysis of lymph gland structure and gene expression, we define the developmental steps in the maturation of blood cells (hemocytes) from their precursors. In particular, distinct zones of hemocyte maturation, signaling and proliferation in the lymph gland during hematopoietic progression are described. Different stages of hemocyte development have been classified according to marker expression and placed within developmental niches: a medullary zone for quiescent prohemocytes, a cortical zone for maturing hemocytes and a zone called the posterior signaling center for specialized signaling hemocytes. This establishes a …

Transgenic Mouse Model Of Tau Pathology In Astrocytes Leading To Nervous System Degeneration, Deepa V. Dabir

Biology Faculty Works

Filamentous tau inclusions in neurons and glia are neuropathological hallmarks of sporadic and familial tauopathies. Because tau gene mutations are pathogenic for the autosomal dominant tauopathy "frontotemporal dementia and parkinsonism linked to chromosome 17," tau abnormalities are implicated directly in the onset and/or progression of disease. Although filamentous tau aggregates are acknowledged to play roles in degenerative mechanisms resulting in neuron loss, the contributions of glial tau pathology to neurodegeneration remain essentially unexplored. To begin to elucidate the role of glial pathology in tauopathies, we generated a transgenic (Tg) mouse model of astrocytic tau pathology by expressing the human tau …

Through The Back Door : Melungeon Literacies And 21st Century Technologies, Katherine G. Vande Brake

Dissertations, Master's Theses and Master's Reports - Open

The Melungeons, a minority recognized in Southern Appalachia where they settled in the early 1800s, have mixed heritage—European, Mediterranean, Native American, and Sub-Saharan African. Their dark skin and distinctive features have marked them and been the cause of racial persecution both by custom and by law in Appalachia for two centuries. Their marginalization has led to an insider mentality, which I call a “literacy” of Melungeon-ness that affects every facet of their lives.

Just a century ago, while specialized practices such as farming, preserving food, hunting, gathering, and distilling insured survival in the unforgiving mountain environment, few Melungeons could read …

Vegetation And Hydrologic Influences On Carbon And Nitrogen In Subsurface Water Of A Forested Riparian Wetland, Emily B. W. Calhoon

Dissertations, Master's Theses and Master's Reports - Open

Vegetation communities affect carbon and nitrogen dynamics in the subsurface water of mineral wetlands through the quality of their litter, their uptake of nutrients, root exudation and their effects on redox potential. However, vegetation influence on subsurface nutrient dynamics is often overshadowed by the influences of hydrology, soils and geology on nutrient dynamics. The effects of vegetation communities on carbon and nitrogen dynamics are important to consider when managing land that may change vegetation type or quantity so that wetland ecosystem functions can be retained. This study was established to determine the magnitude of the influences and interaction of vegetation …

Rudolf Steiner And The Jewish Question, Peter Staudenmaier

History Faculty Research and Publications

No abstract provided.

Beneficial Reuse And Sustainability: The Fate Of Organic Compounds In The Land-Applied Waste, M. R. Overcash, Ronald C. Sims, J. L. Sims, K. C. Nieman

Biological Engineering Faculty Publications

Land application systems, also referred to as beneficial reuse systems, are engineered systems that have defined and permitted application areas based on site and waste characteristics to determine the land area size requirement. These terrestrial systems have orders of magnitude greater microbial capability and residence time to achieve decomposition and assimilation compared with aquatic systems. In this paper we focus on current information and information needs related to terrestrial fate pathways in land treatment systems. Attention is given to conventional organic chemicals as well as new estrogenic and pharmaceutical chemicals of commerce. Specific terrestrial fate pathways addressed include: decomposition, bound …