Digital Commons Network^™

The Case For Selection At Ccr5-Δ32, Pardis C. Sabeti, Emily Walsh, Steve F. Schaffner, Patrick Varilly, Ben Fry, Holli B. Hutcheson, Mike Cullen, Tarjei S. Mikkelsen, Jessica Roy, Nick Patterson, Richard Cooper, David Reich, David Altshuler, Stephen O'Brien, Eric S. Lander

Faculty Publications

The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Δ32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Δ32 arose within the past 1,000 y and rose to its present high frequency (5%-14%) in Europe as a result of strong positive selection, perhaps by such selective agents as the bubonic plague or smallpox during the Middle Ages. This hypothesis was based on several lines of evidence, including the absence of the allele outside of Europe and long-range linkage disequilibrium at the locus. We reevaluated this evidence with the benefit of much denser genetic …

Lsu In The Eye Of The Storm: A University Model For Disaster Response, Renée Bacher, Teresa Devlin, Kristine Calongne, Joshua Duplechain, Stephanie Pertuit

LSU Press Published Books

No abstract provided.

The Role Of Cuticular Pheromones In Courtship Conditioning Of Drosophila Males, Kathleen King Siwicki, Paul Nicholas Riccio , '05, Lisa Ladewski , '02, F. Marcillac, L. Dartevelle, Stephanie Alexis Cross , '04, J.-F. Ferveur

Biology Faculty Works

Courtship conditioning is an associative learning paradigm in Drosophila melanogaster, wherein male courtship behavior is modified by experience with unreceptive, previously mated females. While the training experience with mated females involves multiple sensory and behavioral interactions, we hypothesized that female cuticular hydrocarbons function as a specific chemosensory conditioned stimulus in this learning paradigm. The effects of training with mated females were determined in courtship tests with either wild-type virgin females as courtship targets, or with target flies of different genotypes that express distinct Cuticular hydrocarbon (CH) profiles. Results of tests with female targets that lacked the normal CH profile, and …

First Force, William A. Edmundson

Faculty Publications By Year

No abstract provided.

A Bayesian Subset Analysis Of Sensory Evaluation Data, Balgobin Nandram

Journal of Modern Applied Statistical Methods

In social sciences it is easy to carry out sensory experiments using say a J-point hedonic scale. One major problem with the J-point hedonic scale is that a conversion from the category scales to numeric scores might not be sensible because the panelists generally view increments on the hedonic scale as psychologically unequal. In the current problem several products are rated by a set of panelists on the J-point hedonic scale. One objective is to select the best subset of products and to assess the quality of the products by estimating the mean and standard deviation response …

Selection Of Independent Binary Features Using Probabilities: An Example From Veterinary Medicine, Ludmila I. Kuncheva, Zoë S.J. Hoare, Peter D. Cockcroft

Journal of Modern Applied Statistical Methods

Supervised classification into c mutually exclusive classes based on n binary features is considered. The only information available is an n×c table with probabilities. Knowing that the best d features are not the d best, simulations were run for 4 feature selection methods and an application to diagnosing BSE in cattle and Scrapie in sheep is presented.

Training Statisticians To Be Alert To The Dangers Of Misapplying Statistical Methods, Vance W. Berger

Journal of Modern Applied Statistical Methods

Statisticians are faced with a variety of challenges. Their ability to cope successfully with these challenges depends, in large part, on the quality of their training. It is not the purpose of this article to present a comprehensive training plan that will overhaul the standard curriculum a statistician might follow under current training regimens (i.e., in a degree program). Rather, the objective is to point out important areas that appear to be under-represented in standard curricula and correspondingly overlooked too often in practice. The hope is that these areas might be better integrated into the training of the next generation …

Power Of The T Test For Normal And Mixed Normal Distributions, Marilyn S. Thompson, Samuel B. Green, Yi-Hsin Chen, Shawn Stockford, Wen-Juo Lo

Journal of Modern Applied Statistical Methods

Previous research suggests that the power of the independent-samples t test decreases when population distributions are mixed normal rather than normal, and that robust methods have superior power under these conditions. However, under some conditions, the power for the independent-samples t test can be greater when the population distributions for the independent groups are mixed normal rather than normal. The implications of these results are discussed.

End Matter, Jmasm Editors

Journal of Modern Applied Statistical Methods

No abstract provided.

Second-Order Accurate Inference On Simple, Partial, And Multiple Correlations, Robert J. Boik, Ben Haaland

Journal of Modern Applied Statistical Methods

This article develops confidence interval procedures for functions of simple, partial, and squared multiple correlation coefficients. It is assumed that the observed multivariate data represent a random sample from a distribution that possesses infinite moments, but there is no requirement that the distribution be normal. The coverage error of conventional one-sided large sample intervals decreases at rate 1√n as n increases, where n is an index of sample size. The coverage error of the proposed intervals decreases at rate 1/n as n increases. The results of a simulation study that evaluates the performance of the proposed intervals is …

A Method For Analyzing Unreplicated Experiments Using Information On The Intraclass Correlation Coefficient, Jamis J. Perrett

Journal of Modern Applied Statistical Methods

Many studies are performed on units that cannot be replicated; however, there is often an abundance of subsampling. By placing a reasonable upper bound on the intraclass correlation coefficient (ICC), it is possible to carry out classical tests of significance that have conservative levels of significance.

Ab/Ba Crossover Trials - Binary Outcome, James F. Reed Iii

Journal of Modern Applied Statistical Methods

On occasion, the response to treatment in an AB/BA crossover trial is measured on a binary variable - success or failure. It is assumed that response to treatment is measured on an outcome variable with (+) representing a treatment success and a (-) representing a treatment failure. Traditionally, three tests for comparing treatment effect have been used (McNemar’s, Mainland-Gart, and Prescott’s). An issue arises concerning treatment comparisons when there may be a residual effect (carryover effect) of a previous treatment affecting the current treatment. A general consensus as to which procedure is preferable is debatable. However, if both group and …

Brief In Opposition - Lummi Nation V. Samish Indian Tribe, Docket No. 05-445 (546 U.S. 1090 (2006))

Lummi Nation v. Samish Indian Tribe, Docket No. 05-445 (546 U.S. 1090 (2006))

No abstract provided.

Monastic Life Of A Federal Distric Judge, The, Colleen Mcmahon

Missouri Law Review

There is no one on earch more monk-like than a federal district judge. As a result, there is no one on earth who more surely needs to have some understanding of core monastic virtures in order to do the job well.

Justice Harry Blackmun And The Phenomenon Of Judicial Preference Change, Theodore W. Ruger

Missouri Law Review

We are fond of putting our judges into neat adjectival boxes, particularly when they sit on the Supreme Court. These typologies often reflect perceived attitudinal or ideological preferences; some Justices are called "liberal" or "conservative" or "moderate," or occasionally some hyphenated combination thereof. Or the labels might seek to capture variations in jurisprudential philosophy or method, such as "formalist," "pragmatist," "originalist," "textualist," or "minimalist." No Justice is immune from this classification game, and the subject of this symposium is an apt example. From the moment of his nomination by President Nixon in 1970, Harry A. Blackmun attracted a bevy of …

Did Roe V. Wade Pass The Arbitrary And Capricious Test, Daniel A. Farber

Missouri Law Review

Justice Blackmun sat on 3,653 cases during his twenty-four terms on the Supreme Court, yet he will surely be best remembered for his role in one case, Roe v. Wade. Seldom has a judicial decision been more controversial. True, many opinions are harshly criticized. But the criticisms of Roe were distinctive. According to critics, Roe was not merely bad law, in some sense it was not law at all. One particularly outspoken critic recently calls Roe "perhaps the most indefensible 'constitutional' decision ever reached by this Court to date' as well as "manifestly and atrociously contrary to the Constitution."

Which One Here Is Not Like The Others - No Third-Party Standing For Lawyers To Assert Indigent Criminal Defendants' Right To Counsel On Appeal, Courtney C. Stirrat

Missouri Law Review

In Kowalski v. Tesmer, the Supreme Court held that attorneys lack standing to assert the rights of indigent criminal defendants.1t The Court's application of its prudential rules of standing presents great concern, as it leaves thirty years of precedent in doubt. This Note examines the parameters of the Court's prudential standing requirements and the great shift in thirdparty standing after Kowalski.1

Daily Eastern News: November 01, 2005, Eastern Illinois University

November

No abstract provided.

Particular Solutions For Axisymmetric Helmholtz-Type Operators, A.S. Muleshkov, M.A. Golberg, C.S. Chen

Faculty Publications

In this paper, we consider the solution of the axisymmetric heat equation with axisymmetric data in an axisymmetric domain in R-3. To solve this problem, we remove the time-dependence by various transform or time-stepping methods. This converts the problem to one of a sequence of modified inhomogeneous Helmholtz equations. Generalizing previous work, we consider solving these equations by boundary-type methods. In order to do this, one needs to subtract off a particular solution, so that one obtains a sequence of modified homogeneous Helmholtz equations. We do this by modifying the usual Dual Reciprocity Method (DRM) and approximating the right-hand sides …

The Progressive Critique Of The Current Socio-Legal Landscape: Corporations And Racial Justice, Cheryl I. Harris

Seattle Journal for Social Justice

No abstract provided.

Corporations And The Public Purpose: Restoring The Balance, Charlie Cray, Lee Drutman

Seattle Journal for Social Justice

No abstract provided.

Crafting Qualitative Research Articles On Marriages And Families, Sarah H. Matthews

Sociology & Criminology Faculty Publications

This paper aims to assist those who do qualitative research in the field of marriage and family to reduce the number of rejections received in response to article submissions. Recurring shortcomings identified by reviewers and suggestions made to authors about revising papers are organized using headings traditionally used in a research article—introduction and literature review, method, results, and discussion. Considerations stemming from the fact that data on marriages and families are produced largely through interviews also are addressed.

Accounting Conservatism And Managerial Incentives, Young Koan Kwon

Research Collection School Of Accountancy

There are two sources of agency costs under moral hazard: (1) distortions in incentive contracts and (2) implementation of suboptimal decisions. In the accounting literature, the relation between conservative accounting and agency costs of type (1) has received considerable attention (cf. Watts 2002). However, little appears to be known about the effects of accounting conservatism on agency costs of type (2) or trade-offs between agency costs of types (1) and (2). The purpose of this study is to examine this void. In a principal-agent setting in which the principal motivates the agent to expend effort using accounting earnings, this study …

A Nonlinear Dynamic Approach For Evaluating Postural Control, James T. Cavanaugh, Kevin M. Guskiewicz, Nikolaos Stergiou

Journal Articles

Recent research suggests that traditional biomechanical models of postural stability do not fully characterise the nonlinear properties of postural control. In sports medicine, this limitation is manifest in the postural steadiness assessment approach, which may not be sufficient for detecting the presence of subtle physiological change after injury. The limitation is especially relevant given that return-to-play decisions are being made based on assessment results. This update first reviews the theoretical foundation and limitations of the traditional postural stability paradigm. It then offers, using the clinical example of athletes recovering from cerebral concussion, an alternative theoretical proposition for measuring changes in …

Excessive Tibial Rotation During High-Demand Activities Is Not Restored By Anterior Cruciate Ligament Reconstruction, Stavros Ristanis, Nikolaos Stergiou, Kostas Patras, Haris S. Vasiliadis, Giannis Giakas, Anastasios D. Georgoulis

Journal Articles

Purpose: Recent in vitro research has suggested that anterior cruciate ligament (ACL) reconstruction does not restore control of tibial rotation. The purpose of this study was to explore these findings in vivo and investigate rotational knee stability during landing and subsequent pivoting. Such an activity places higher demands on the knee, almost similar to those found during high-level sports.

Type of Study: Case control series study.

Methods: We assessed 11 patients who had undergone ACL reconstruction with the same arthroscopic technique using a bone–patellar tendon–bone graft, 11 ACL-deficient subjects who had sustained the injury more than 1 year prior to …

A Discretized Approach To Flexibly Fit Generalized Lambda Distributions To Data, Steve Su

Journal of Modern Applied Statistical Methods

This article presents a flexible approach to fit statistical distribution to data. It optimizes the bin-width of data histogram to find a suitable generalized lambda distribution. In addition to the default optimization, this approach provides additional flexibility akin to the concepts of loess and kernel smoothing, which allow the users to determine the amount of details they would like to smooth over the data. The approach presented in this article will allow users to visually compare and choose the parameters of generalized lambda distribution that best suit their purposes of study.

A Single, Powerful, Nonparametric Statistic For Continuous-Data Telecommunications Parity Testing, J. D. Opdyke

Journal of Modern Applied Statistical Methods

Since the enactment of the Telecommunications Act of 1996, extensive expert testimony has justified use of the modified t statistic (Brownie et al., 1990) for performing two-sample hypothesis tests comparing Bell companies’ CLEC and ILEC performance measurement data (known as parity testing). However, Opdyke (Telecommunications Policy, 2004) demonstrated this statistic to be potentially manipulable and to have literally zero power to detect inferior CLEC service provision under a wide range of relevant data conditions. This article develops a single, nonparametric statistic that is easily implemented (i.e., not computationally intensive) and typically provides dramatic power gains over the modified t while …

Testing Goodness Of Fit Of The Geometric Distribution: An Application To Human Fecundability Data, Sudhir R. Paul

Journal of Modern Applied Statistical Methods

A measure of reproduction in human fecundability studies is the number of menstrual cycles required to achieve pregnancy which is assumed to follow a geometric distribution with parameter p. Tests of heterogeneity in the fecundability data through goodness of fit tests of the geometric distribution are developed, along with a likelihood ratio test statistic and a score test statistic. Simulations show both are liberal, and empirical level of the likelihood ratio statistic is larger than that of the score test statistic. A power comparison shows that the likelihood ratio test has a power advantage. A bootstrap p-value procedure using the …

Estimation Of Process Variances In Robust Parameter Designs, T. K. Mak, Fassil Nebebe

Journal of Modern Applied Statistical Methods

The modeling of variation through interactions is appealing in crossed array design as it leads to greater robustness to certain type of model misspecification. As an alternative to signal-to-noise analysis, a new, systematic method based on Taguchi type crossed array design is given. It is shown in this article that when fractional factorial design is used for the outer array, the crossed array design is not robust to the presence of noise-noise interactions and a method of rectifying the problem is suggested.

Simulation Procedure In Periodic Cancer Screening Trials, Ioana Barnicescu, Ricolindo L. Cariño

Journal of Modern Applied Statistical Methods

A general simulation procedure is described to validate model fitting algorithms for complex likelihood functions that are utilized in periodic cancer screening trials. Although screening programs have existed for a few decades, there are still many unsolved problems, such as how age or hormone affects the screening sensitivity, the sojourn time in the preclinical state, and the transition probability from diseasefree state to the preclinical state. Simulations are needed to check reliability or validity of the likelihood function combined with the associated effect functions. One bottleneck in the simulation procedure is the very time consuming calculations of the maximum likelihood …