Digital Commons Network^™

Taking Biologics For Granted? Takings, Trade Secrets, And Off-Patent Biological Products, Andrew Wasson

Duke Law & Technology Review

Biologics are complex medicines which are often genetically engineered, and which are sure to play an important role in curing some of humankind's worst diseases. Not surprisingly, generic companies want a part of the biologic market. The FDA believes that it has the authority to approve off-patent versions of biologics that were originally regulated under the Food, Drug & Cosmetic Act, but in order to effectively do so the FDA would have to rely on findings based on data produced by the brand name companies. This iBrief examines whether the FDA's reliance on previous findings would give rise to a …

Design And Simulation Of A Permanent-Magnet Electromagnetic Aircraft Launcher, Dean Patterson, Antonello Monti, Charles W. Brice, Roger A. Dougal, Robert O. Pettus, Srinivas Dhulipala, Dilip Chandra Kovuri, Tiziana Bertoncelli

Faculty Publications

This paper describes the basic design, refinement, and verification using finite-element analysis, and operational simulation using the Virtual Test Bed, of a linear machine for an electromagnetic aircraft launcher, for the aircraft carrier of the future. Choices of basic machine format and procedures for determining basic dimensions are presented. A detailed design for a permanent-magnet version is presented, and wound-field coil and induction machine versions are briefly discussed. The long armature-short field geometry is justified, and in particular the impact of this geometry on the scale of the power electronic drive system is examined.

A New Paradigm For Implementing Ecologically – Based Participatory Ipm In A Global Context: The Ipm Crsp Model, E. A. Heinrichs

Department of Entomology: Faculty Publications

Integrated Pest Management (IPM) is a key component in the development of sustainable agro ecosystems. The Integrated Pest Management Collaborative Research Support Program (IPM CRSP) is a USAID funded project that is a consortium of U.S. universities working with host country national programs and other stakeholders to promote IPM globally. The IPM CRSP model is based on a Participatory Integrated Pest Management (PIPM) process that has as its goals to help reduce: agricultural losses due to pests, damage to natural eco-systems including loss of biodiversity, and pollution and contamination of food and water supplies. The IPM CRSP participatory model is …

Invasive Iguanas As Airstrike Harzards At Luis Munoz Marin International Airport, San Juan, Puerto Rico, Richard M. Engeman, Henry T. Smith, Bernice Constantin

United States Department of Agriculture Wildlife Services: Staff Publications

Green iguanas are large lizards exotic to Puerto Rico, but abundant around Luis Munoz Marin International Airport (SJU) in metropolitan San Juan, where we assessed their potential as an airstrike hazard. During our two rnonth sanipling period, operatio~iso il portions of (he airfielJ hdJ Lu be hdltcJ 011 s io~~ ~ d s i ujluot, t" l i ~l )d~ i j~. ~ ~ byi t ~ d iguana incursions to aircraft traffic areas. All 5 records of collisions with iguanas in the FAA airstrike database were from SJU. Body size comparisons between mature iguanas and terrestrial mammals known as …

Wildlife Population Monitoring: Some Practical Considerations, Gary W. Witmer

United States Department of Agriculture Wildlife Services: Staff Publications

The accurate estimation of wildlife population density is difficult and requires considerable investment of resources and time. Population indices are easier to obtain but are influenced by many unknowns and the relationships to actual population densities are usually unclear. Wildlife biologists, whether in the public or private sector, often find themselves in difficult situations where a resource manager or landowner wants good information, quickly, at low cost, and without clear objectives. In many situations, in addition to establishing clear objectives, a budget and timeframe, a biologist must understand and deal with the reality of many logistical concerns that will make …

Conducting Qualitative Research On Desertification In Western Lesvos, Greece, Theodoros Iosifides, Theodoros Politidis

The Qualitative Report

The main aim of this article is to present some critical methodological strategies employed in a qualitative research study on local socioeconomic development and desertification in western Lesvos, Greece. Through in-depth qualitative interviews with local producers in western Lesvos, Greece, an effort was made to identify and analyze the links between the local socioeconomic trajectory and environmental marginality. The article concerns the justification of the choice of qualitative investigation on the matter, the main methodological strategies employed in the field, and the basic data analysis processes. In particular, we discuss the gradual development of a coding framework and a conceptual …

Using Genome Scans Of Dna Polymorphism To Infer Adaptive Population Divergence, Jay F. Storz

Jay F. Storz Publications

Elucidating the genetic basis of adaptive population divergence is a goal of central importance in evolutionary biology. In principle, it should be possible to identify chromosomal regions involved in adaptive divergence by screening genome-wide patterns of DNA polymorphism to detect the locus-specific signature of positive directional selection. In the case of spatially separated populations that inhabit different environments or sympatric populations that exploit different ecological niches, it is possible to identify loci that underlie divergently selected traits by comparing relative levels of differentiation among large numbers of unlinked markers. In this review I first address the question of whether diversifying …

Effect Of Cholesterol Diet On Reproductive Function In Male Albino Rats, Hameed N. Bataineh, Mohamad K. Nusier

Saudi Medical Journal

OBJECTIVE: The present study was carried out to investigate the effect of cholesterol diet (400 mg/kg body weight) for 60 days on gonadal function in albino rats. METHODS: The study was conducted in the Animal House Unit at Jordan University of Science and Technology, School of Medicine, Irbid, Jordan between October 2003 and February 2004. Adult male and female albino rats of Sprague Dawley strain were raised under controlled temperature and light. Male rats were divided into: a) control group - rats receiving vehicle (olive oil) for 60 days and treatment group - rats receiving cholesterol diet for a reproductive …

Age-Related Changes In Human Tendo Calcaneus Collagen Fibrils, Mustafa F. Sargon, Korhan Ozlu, Fuad Oken

Saudi Medical Journal

OBJECTIVE: The ruptures of tendo calcaneus often occur between the age of 30 - 45 years as described by several textbooks. It is also described that some diseases and drugs are said to be responsible in the etiology; however, there are no studies related with the detailed histological structure of collagen fibrils found in the tendon in the age groups of humans. In view thereof, this study was aimed to obtain further information on the etiology and to find an answer regarding the frequency of the ruptures occurring between the age of 30 - 45 years in humans. METHODS: In …

Contribution Study Of Visceral Leishmaniasis In Syria, Samar Al-Nahhas, Maha Shaaban, Lana Hammoud

Saudi Medical Journal

No abstract provided.

Vitiligo And Human Herpesvirus 6. Is There A Relationship?, Ali K. Adiloglu, Pinar Y. Basak, Rabia Can, Vahide B. Akkaya

Saudi Medical Journal

No abstract provided.

Hotline Press Newspaper- March 1,2005 Vol 22 No 31, Hotline Press Newspaper

Hotline Press Newspaper 2005

No abstract provided.

The Formal State Action Doctrine And Free Speech Analysis, John Fee

North Carolina Law Review

No abstract provided.

Gamma Sigma Delta Newsletter - Nebraska Chapter, Issue #29, March 2005

Gamma Sigma Delta, Nebraska Chapter: Newsletters

CONTENTS:
PRESIDENT’S MESSAGE
2005 GAMMA SIGMA DELTA CALENDAR OF EVENTS
GAMMA SIGMA DELTA Award Recipients
GAMMA SIGMA DELTA Inductees
MEMBERSHIP COORDINATOR WELCOMES NEW MEMBERS
2005 ANNUAL DUES NOTICE FOR NEBRASKA CHAPTER
GAMMA SIGMA DELTA MEMBERSHIP RENEWAL FORM
Merit Award Nomination
Teaching Award Nomination
Research Award Nomination
Extension Award Nomination
GAMMA SIGMA DELTA COMMITTEES, 2004-2005

Recalling Why Corporate Officers Are Fiduciaries, Lyman P.Q. Johnson, David Millon

William & Mary Law Review

No abstract provided.

The Prairie Naturalist, Volume 37, No. 1, March 2005

The Prairie Naturalist

LESSER PRAIRIE-CHICKEN USE OF HARVESTED CORN FIELDS DURING FALL AND WINTER IN SOUTHWESTERN KANSAS, G. C. Salter, R. J. Robel, and K. E. Kemp 1

DAPHNIA LUMHOLTZI, AN EXOTIC ZOOPLANKTON, INVADING A NEBRASKA RESERVOIR B. C. Peterson, N. J. Fryda, K. D. Koupal, and W. W. Hoback 11

COMPARISON OF MICROCLIMATE AT GRASSLAND BIRD NESTS WITH DIFFERENT SUBSTRATES, K. M. Suedkamp Wells and S. D. Fuhlendorf 21

FACTORS INFLUENCING PERSISTENCE OF WHITEFOOTED MICE, B. R. McMillan, G. A. Kaufman, and D. W. Kaufman 29

NOTES

RECORDS OF THE EASTERN RED BAT ON THE NORTHERN FRONT RANGE OF COLORADO, …

Records Of The Eastern Red Bat On The Northern Front Range Of Colorado, Daniel J. Neubaum

The Prairie Naturalist

Although common in deciduous forest throughout the Midwest and east-central states, the eastern red bat (Lasiurus borealis) is rare in Colorado (Armstrong et al. 1994, Fitzgerald et al. 1994). However, this species has the potential to extend its range because belts of eastern deciduous forest habitat have expanded across western prairies and reached the Front Range of Colorado over the last 100 years (Knopf 1986). The eastern red bat ranges from Canada southward across the United States to northeastern New Mexico with most records occurring east of the Continental Divide (Hall 1981, Shump and Shump 1982, Cryan 2003). …

Lesser Prairie-Chicken Use Of Harvested Corn Fields During Fall And Winter In Southwestern Kansas, Gregory C. Salter, Robert J. Robel, Kenneth E. Kemp

The Prairie Naturalist

The lesser prairie-chicken (Tympanuchus pallidicinctus) has declined in numbers in Kansas primarily due to the conversion of sand sagebrush (Artemisia .filifolia) prairie to cropland. The lesser prairie-chicken in Finney County, Kansas exists primarily in large fragments of sand sagebrush prairie, and it forages during fall and winter on waste grain in harvested com (Zea mays) fields adjacent to prairie fragments. We used radio-telemetry to monitor lesser prairie chicken locations and found no significant relationship between numbers of bird locations and amounts of waste grain on the ground in harvested com fields. Even the harvested …

Honoring The Elders: Interviews With Two Lakota Men, Deborah E. Bowen

The Journal of Sociology & Social Welfare

The beliefs that honoring the elders, commitment to family, and the connectedness to all creation are paramount are intrinsic to Lakota culture. Two Lakota elders, Albert White Hat, Sr. and Sylvan White Hat, Sr. are interviewed for this article. They express their concerns with major social justice issues, and offer hope for future generations of Lakota children. A strengths-based perspective of social work practice is compared to traditional Lakota customs and practices.

The Octofoil, March/April 2005, Ninth Infantry Division Association

The Octofoil

The Octofoil is the offical publication of the Ninth Infantry Division Association, Inc., an organization formed by the officers and men of the 9th Infantry Division in order to perpetuate the memory of fallen comrades, preserve the esprit de corps of the Division, promote peace and serve as an information bureau about the 9th Infantry Division. The Association is made up of 9th Infantry veterans from WWII and Vietnam, spouses, widows and lineal descendants.

Privacy And The Debate Over Same-Sex Marriage Versus Unions, Vincent J. Samar

DePaul Law Review

No abstract provided.

Surveillance And The Self: Privacy, Identity, And Technology , Richard Warner

DePaul Law Review

No abstract provided.

Doors, Envelopes, And Encryption: The Uncertain Role Of Precautions In Fourth Amendment Law, Lee Tien

DePaul Law Review

No abstract provided.

Psychological Evaluations: Their Use And Misuse In Illinois Abuse And Neglect Cases, Marjory E. Deward

DePaul Law Review

No abstract provided.

Investigation Of Bottom Fishing Impacts On Benthic Structure Using Multibeam Sonar, Sidescan And Video, Mashkoor A. Malik, Larry A. Mayer

Center for Coastal and Ocean Mapping

Bottom fishing gear is known to alter benthic structure, however changes in the shape of the sea floor are often too subtle to be detected by acoustic remote sensing. Nonetheless, long linear features were observed during a recent high-resolution multibeam sonar survey of Jeffreys Ledge, a prominent fishing ground in Gulf of Maine, located about 50 km from Portsmouth, NH. These marks, which have a relief of only few centimeters, are presumed to be caused by bottom dredging gear used in the area for scallop and clam fisheries. The extraction of these small features from a noisy data set (including …

Circumferential Vascular Deformation After Stent Implantation Alters Wall Shear Stress Evaluated With Time-Dependent 3d Computational Fluid Dynamics Models, John F. Ladisa, Lars E. Olson, Ismail Guler, Douglas Anthony Hettrick, Judy R. Kersten, David C. Warltier, Paul S. Pagel

Biomedical Engineering Faculty Research and Publications

The success of vascular stents in the restoration of blood flow is limited by restenosis. Recent data generated from computational fluid dynamics (CFD) models suggest that stent geometry may cause local alterations in wall shear stress (WSS) that have been associated with neointimal hyperplasia and subsequent restenosis. However, previous CFD studies have ignored histological evidence of vascular straightening between circumferential stent struts. We tested the hypothesis that consideration of stent-induced vascular deformation may more accurately predict alterations in indexes of WSS that may subsequently account for histological findings after stenting. We further tested the hypothesis that the severity of these …

Antegrade Iliac Artery Stent Implantation For The Temporal And Spatial Examination Of Stent-Induced Neointimal Hyperplasia And Alterations In Regional Fluid Dynamics, John F. Ladisa, Heidi T. Meier, Lars E. Olson, Judy R. Kersten, David C. Warltier, Paul S. Pagel

Biomedical Engineering Faculty Research and Publications

Neointimal hyperplasia remains an important problem after stent implantation. Previous investigations examining vascular responses to stent implantation and effects of drugs have used a retrograde deployment approach that may inadvertently alter the local fluid dynamics surrounding the stent. We present a model of antegrade iliac artery stent implantation that facilitates the analysis of stent-induced alterations in neointimal hyperplasia and wall shear stress in vivo. Methods: Stent delivery catheters were inserted through the left carotid artery in anesthetized rabbits (n=37). Catheters were advanced under fluoroscopic guidance to the distal iliac arteries, where the stent was deployed. Hemotoxylin and eosin …

The Effect Of Culture Media And Culture Time On The In Vitro Maturation Of Domestic Cat Oocytes, Ruttachuk Rungsiwiwut, Ampika Thongphagdee, Pranee Numchaisrika, Sudsan Sirivaidayapong, Mongkol Techakumphu

The Thai Journal of Veterinary Medicine

Culture media and culture time play important roles in meiotic competence and in vitro development of domestic cats oocytes. This experiment was designed to investigate the effects of culture media (M199 versus DMEM) on the in vitro maturation of domestic cat oocytes, after culturing for 24, 36 and 48 h. Domestic cat ovaries were obtained from routine ovariohysterectomy at an animal hospital, cooled to 4oC and transferred immediately to the laboratory. The oocytes were collected by slicing ovaries in the collecting medium. Five to ten cumulus oocyte complexes (COCs) were cultured in small drops of 50 μl of M199 or …

Towards An Establishment Theory Of Gay Personhood, Jeffrey A. Kershaw

Vanderbilt Law Review

Homosexuality refers to relations between men or between women who experience an exclusive or predominant sexual attraction toward persons of the same sex. It has taken a great variety of forms through the centuries and in different cultures. Its psychological genesis remains largely unexplained. Basing itself on Sacred Scripture, which presents homosexual acts as acts of grave depravity, tradition has always declared that "homosexual acts are intrinsically disordered." They are contrary to the natural law. They close the sexual act to the gift of life. They do not proceed from a genuine affective and sexual complementarity. Under no circumstances can …

Orbit Estimation Algorithms For A Microsatellite Rendezvous With A Non-Cooperative Target, John P. Heslin

Theses and Dissertations

This study investigated the minimum requirements to establish a satellite tracking system architecture for a microsatellite to rendezvous with a non-cooperative target satellite. A prototype optical tracking system was reviewed with emphasis on a proposed tactical employment that could be used by technologically unsophisticated state or non-state adversaries. With the tracking system architecture selected, simulated tracking data was processed with a Non-Linear Least Squares batch orbit estimation algorithm and a Bayes sequential orbit determination filter to update the target satellite's state vector.