Digital Commons Network^™

Human Glutaminyl Cyclase And Bacterial Zinc Aminopeptidase Share A Common Fold And Active Site, Rachell E. Booth, Simon C. Lovell, Stephanie A. Misquitta, Robert C. Bateman Jr.

Faculty Publications

Background: Glutaminyl cyclase (QC) forms the pyroglutamyl residue at the amino terminus of numerous secretory peptides and proteins. We previously proposed the mammalian QC has some features in common with zinc aminopeptidases. We now have generated a structural model for human QC based on the aminopeptidase fold (pdb code 1AMP) and mutated the apparent active site residues to assess their role in QC catalysis.

Results: The structural model proposed here for human QC, deposited in the protein databank as 1MOI, is supported by a variety of fold prediction programs, by the circular dichroism spectrum, and by the presence …

Flyer News, Vol. 51, No. 28 (Feb. 10, 2004), University Of Dayton

Flyer News

Student-run newspaper of the University of Dayton

Efficient Lactam Synthesis, Kyung Woon Jung, Cheol Hwan Yoon

USF Patents

Lactams, libraries of lactams, and an efficient method of synthesizing a lactam, including a γ-lactam, in which an α-diazoacetamide of the general structure (I) is reacted under conditions promoting intramolecular C—H insertion, for example in the presence of a rhodium salt such as Rhby which means lactams that are precursors in the synthesis of diverse natural and synthetic products, including pyrrolidinone compounds such as lactacystin, pramanicin, kainic acid, statine, AHPPA, and rolipram, are produced.

Method Of Identifying And Treating Invasive Carcinomas (Div.A), Xinqing Chai, Julie Chao, Lee Chao, Limei Chen

UCF Patents

Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell …

The Hilltop 2-10-2004, Hilltop Staff

The Hilltop: 2000 - 2010

No abstract provided.

Mustang Daily, February 9, 2004

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

Minutes February 9, 2004

Minutes

No abstract provided.

Ccu Newsletter, February 9, 2004, Coastal Carolina University

Coastal Carolina University Newsletter

A newsletter for faculty, staff and friends of Coastal Carolina University. Volume 14, Number 3

Arbiter, February 9, Students Of Boise State University

Student Newspapers

No abstract provided.

Commonwealth Times 2004-02-09

Commonwealth Times, 1969-

No abstract provided.

Spartan Daily, February 9, 2004, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 122, Issue 6

Mixture Models For Assessing Differential Expression In Complex Tissues Using Microarray Data, Debashis Ghosh

The University of Michigan Department of Biostatistics Working Paper Series

The use of DNA microarrays has become quite popular in many scientific and medical disciplines, such as in cancer research. One common goal of these studies is to determine which genes are differentially expressed between cancer and healthy tissue, or more generally, between two experimental conditions. A major complication in the molecular profiling of tumors using gene expression data is that the data represent a combination of tumor and normal cells. Much of the methodology developed for assessing differential expression with microarray data has assumed that tissue samples are homogeneous. In this article, we outline a general framework for determining …

Capping Protein Binding To Actin In Yeast: Biochemical Mechanism And Physiological Relevance, Kyoungtae Kim, Atsuko Yamashita, Martin A. Wear, Yuichiro Maéda, John A. Cooper

Open Access Publications

No abstract provided.

Current, February 09, 2004, University Of Missouri-St. Louis

Current (2000s)

No abstract provided.

Gender Equity And Faculty Diversity Focus Of Unh Talk, Sharon Keeler

Media Relations

No abstract provided.

New Species Of Eustomias (Teleostei: Stomiidae) From The Western North Atlantic, With A Review Of The Subgenus Neostomias, Tracey Sutton, Karsten E. Hartel

Marine & Environmental Sciences Faculty Articles

A new species of the deep-sea dragonfish genus Eustomias is described from 14 specimens from the western North Atlantic. This species belongs to the subgenus Neostomias, which is defined principally by the presence of a single pectoral ray, plus one small rudimentary ray. It is unique among members of the subgenus in having a combination of characters that includes a short mental barbel, multiple proximal bulbs on the barbel main stem, and a unique terminal bulb morphology. Analysis of similar species warrants resurrection of Eustomias monodactylus, previously placed in synonymy with Eustomias filifer. A revised key to …

University Of Northern Iowa Faculty Senate Meeting Minutes, Feburary 9, 2004, University Of Northern Iowa. Faculty Senate.

Documents - Faculty Senate

Meeting minutes from the Faculty Senate of the University of Northern Iowa.

Illinois Wesleyan Senior Named To Usa Today Academic Third Team, Stew Salowitz

News and Events (Discontinued Series)

No abstract provided.

Genetic Relationships Between Sex-Specific Traits In Beef Cattle: Mature Weight, Weight Adjusted For Body Condition Score, Height And Body Condition Score Of Cows, And Carcass Traits Of Their Steer Relatives, K. A. Nephawe, L. V. Cundiff, M. E. Dikeman, J. D. Crouse, L. Dale Van Vleck

Department of Animal Science: Faculty Publications

Data from the first four cycles of the Germplasm Evaluation Program at the U.S. Meat Animal Research Center (USMARC) were used to investigate genetic relationships between mature weight (MW, n = 37,710), mature weight adjusted for body condition score (AMW, n = 37,676), mature height (HT, n = 37,123), and BCS (n = 37,676) from 4- to 8-yr old cows (n = 1,800) and carcass traits (n = 4,027) measured on their crossbred paternal half-sib steers. Covariance components among traits were estimated using REML. Carcass traits were adjusted for age at slaughter. Estimates of heritability for hot carcass weight (HCWT); …

Daily Eastern News: February 09, 2004, Eastern Illinois University

February

No abstract provided.

The Collegian (2004-02-09), Sonia Mejia

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 56, No. 18

Monitor Newsletter February 09, 2004, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff

February 9, 2004 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

University Of Northern Iowa Faculty Senate Meeting Agenda, Feburary 9, 2004, University Of Northern Iowa. Faculty Senate.

Documents - Faculty Senate

Meeting agenda from the Faculty Senate of the University of Northern Iowa.

Bjc Today

BJC Today

No abstract provided.

The George-Anne, Georgia Southern University

The George-Anne

• Long-Awaited Writing & Linguistics Major Approved
• News Briefs
• Campus News
• Opinions
• Sports
• Classifieds, Etc

Central Florida Future, Vol. 36 No. 41, February 9, 2004

Central Florida Future

Tuition increase: SGA candidates tackle rising cost of college; Teacher shortage forces scramble; Pricey mural unveiled at Rosen School campus; Teachers working longer hours to stretch budget; Ephedra faces possible ban in March.

Media Advisory, Erin Wetherille

News and Events (Discontinued Series)

No abstract provided.

On The Implementation Of Swarmlinda? A Linda System Based On Swarm Intelligence (Extended Version), Ahmed Charles, Ronaldo Menezes, Robert Tolksdorf

Electrical Engineering and Computer Science Faculty Publications

Natural-forming multi-agent systems (aka Swarms) can grow to enormous sizes and perform seemingly complex tasks without the existence of any centralized control. Their success comes from the fact that agents are simple and the interaction with the environment and neighboring agents is local in nature. In this paper we discuss the implementation of SwarmLinda, a Linda-based system that abstracts Linda concepts in terms of swarm intelligence constructs such as scents and stigmergy. The goal of this implementation is to achieve many characteristics such as scalability, adaptiveness and some level of fault tolerance. This paper describes our initial version of SwarmLinda …

Muc4 Mucin Expression In Human Pancreatic Tumours Is Affected By Organ Environment: The Possible Role Of Tgfbeta2., A. Choudhury, N. Moniaux, A. B. Ulrich, B. M. Schmied, J. Standop, Parviz M. Pour, S. J. Gendler, Michael A. Hollingsworth, J-P Aubert, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

MUC4 is highly expressed in human pancreatic tumours and pancreatic tumour cell lines, but is minimally or not expressed in normal pancreas or chronic pancreatitis. Here, we investigated the aberrant regulation of MUC4 expression in vivo using clonal human pancreatic tumour cells (CD18/HPAF) grown either orthotopically in the pancreas (OT) or ectopically in subcutaneous tissue (SC) in the nude mice. Histological examination of the OT and SC tumours showed moderately differentiated and anaplastic morphology, respectively. The OT tumour cells showed metastases to distant lymph nodes and faster tumour growth (P