Digital Commons Network^™

Error Models For Microarray Intensities, Wolfgang Huber, Anja Von Heydebreck, Martin Vingron

Bioconductor Project Working Papers

We derive the additive-multiplicative error model for microarray intensities, and describe two applications. For the detection of differentially expressed genes, we obtain a statistic whose variance is approximately independent of the mean intensity. For the post hoc calibration (normalization) of data with respect to experimental factors, we describe a method for parameter estimation.

Carbon Fiber For Air Filtration, Marit Jagtoyen, Francis J. Derbyshire, Rosemary Anne Alexander Derbyshire

Center for Applied Energy Research Faculty Patents

Described are filters containing free-activated carbon fibers or activated carbon fibers in the form of a composite used for filtering a variety of contaminants, including pathogens, from air. These filters can provide effective and efficient removal of contaminants from air, requiring only short contact time between the air being filtered and the filter itself, with only a minimum pressure drop across the filter. The characteristics of these filters allow for effective filtration with only thin filter layers being required. The process of filtering air utilizing these filters is also disclosed.

Identification Of Novel Small Molecule Inhibitors Of Core-Binding Factor Dimerization By Computational Screening Against Nmr Molecular Ensemble, Ryan H. Lilien, Mohini Sridharan, Bruce R. Donald

Computer Science Technical Reports

The long development process of novel pharmaceutical compounds begins with the identification of a lead inhibitor compound. Computational screening to identify those ligands, or small molecules, most likely to inhibit a target protein may benefit the pharmaceutical development process by reducing the time required to identify a lead compound. Typically, computational ligand screening utilizes high-resolution structural models of both the protein and ligand to fit or `dock' each member of a ligand database into the binding site of the protein. Ligands are then ranked by the number and quality of interactions formed in the predicted protein-ligand complex. It is currently …

Respecting Human Life In 21st Century America: A Moral Perspective To Extend Civil Rights To The Unborn From Creation To Natural Death, Charles I. Lugosi

Saint Louis University Law Journal

No abstract provided.

Could A Cia Or Fbi Agent Be Quartered In Your House During A War On Terrorism, Iraq Or North Korea?, Christopher J. Schmidt

Saint Louis University Law Journal

No abstract provided.

Confronting The Impending Public Health Workforce Crisis In America: Perspectives From Academia And Public Health Practice.

Florida Public Health Review

No abstract provided.

Treatment Of Breast Cancer, Delbert Miles, Elena Goun, Krasnych Pertrovna, Pimenova Valentinovna, Solodnikov Yurjevich

UCF Patents

Compounds of the class of 4-oxo-butenoic acid derivatives are disclosed along with the surprising use property of these compounds as a anti-tumor agents in humans against breast carcinoma, which include: 2-(N'-Fluoren-9-ylidene-hydrazino)5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester (OF-06), 1-(2,4-Dimethyl-phenyl)-2,4-dihydroxy-3-(4-methyl-benzoyl)-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester (1F-07), 4-(4-Methoxy-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid (3F-10), 4-(4-Chloro-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid ethyl ester (3F-11), 2-Hydroxy-4-oxo-4-(2,3,5,6-tetrafluoro-4-methoxy-phenyl)-but-2-enoic acid (3F-15), and 4,4-Dihydroxy-5-(4-methyl-benzoyl)-2-phenyl-2,4-dihydro-pyrazol-3-one (3F-16) as well as some novel derivatives of these compounds claimed (see Table 2). The invention also encompasses a class of the compounds with the novel property of anti-tumor activity against human breast cancer, which includes the following compounds 4-(4-Ethoxy-phenyl)-2-(N'-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-butyric acid methyl ester (OF-13); 2-{N'-[1-(4-Chloro-phenyl)-ethylidene]-hydrazino}-4-oxo-4-phenyl-but-2-enoic acid methyl …

Independent- Mar. 9, 2004, Andrea Zelinski

The Independent (1988-present)

No abstract provided.

The Tumor Suppressor Lkb1 Kinase Directly Activates Amp-Activated Kinase And Regulates Apoptosis In Response To Energy Stress, Reuben J. Shaw, Monica Kosmatka, Nabeel Bardeesy, Rebecca L. Hurley, Lee A. Witters, Ronald A. Depinho, Lewis C. Cantley

Dartmouth Scholarship

AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP ratio. Essential to activation of AMPK is its phosphorylation at Thr-172 by an upstream kinase, AMPKK, whose identity in mammalian cells has remained elusive. Here we present biochemical and genetic evidence indicating that the LKB1 serine/threonine kinase, the gene inactivated in the Peutz-Jeghers familial cancer syndrome, is the dominant regulator of AMPK activation in several mammalian cell types. We show that LKB1 directly phosphorylates Thr-172 of AMPKalpha in vitro and activates its …

Hearing Loss And Retarded Cochlear Development In Mice Lacking Type 2 Iodothyronine Deiodinase, Lily Ng, Richard J. Goodyear, Chad A. Woods, Mark J. Schneider

Dartmouth Scholarship

The later stages of cochlear differentiation and the developmental onset of hearing require thyroid hormone. Although thyroid hormone receptors (TRs) are a prerequisite for this process, it is likely that other factors modify TR activity during cochlear development. The mouse cochlea expresses type 2 deiodinase (D2), an enzyme that converts thyroxine, the main form of thyroid hormone in the circulation, into 3,5,3'-triiodothyronine (T3) the major ligand for TRs. Here, we show that D2-deficient mice have circulating thyroid hormone levels that would normally be adequate to allow hearing to develop but they exhibit an auditory phenotype similar to that caused by …

Montana Kaimin, March 9, 2004, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula. Pages 1 and 12 are missing.

University Of New Mexico Board Of Regents Minutes For March 08, 2004, University Of New Mexico Board Of Regents

Board of Regents Meeting Minutes

Minutes from the March 08, 2004 Board of Regents Meeting

Volume 3, Issue 5, St. Norbert College

Assessment News (campus only)

Assessment News was a newsletter out of the Office of Institutional Effectiveness from 2002 to 2013. Almost all are archived here as open access, but some are designated campus only.

Grand Valley Forum, Volume 028, Number 29, March 8, 2004, Grand Valley State University

2003-2004, Volume 28

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Commonwealth Times 2004-03-08

Commonwealth Times, 1969-

No abstract provided.

Ccu Newsletter, March 8, 2004, Coastal Carolina University

Coastal Carolina University Newsletter

A newsletter for faculty, staff and friends of Coastal Carolina University. Volume 14, Number 5

Daily Eastern News: March 08, 2004, Eastern Illinois University

March

No abstract provided.

The Collegian (2004-03-08), Sonia Mejia

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 56, No. 22

March 8, 2004 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

The Cohesion Protein Ord Is Required For Homologue Bias During Meiotic Recombination, Hayley A. Webber, Louisa Howard, Sharon E. Bickel

Dartmouth Scholarship

During meiosis, sister chromatid cohesion is required for normal levels of homologous recombination, although how cohesion regulates exchange is not understood. Null mutations in orientation disruptor (ord) ablate arm and centromeric cohesion during Drosophila meiosis and severely reduce homologous crossovers in mutant oocytes. We show that ORD protein localizes along oocyte chromosomes during the stages in which recombination occurs. Although synaptonemal complex (SC) components initially associate with synapsed homologues in ord mutants, their localization is severely disrupted during pachytene progression, and normal tripartite SC is not visible by electron microscopy. In ord germaria, meiotic double strand breaks appear …

Bjc Today

BJC Today

No abstract provided.

The George-Anne, Georgia Southern University

The George-Anne

• Perdue: HOPE Plan May Not Prevent Future Cuts
• Campus Calendar
• News Briefs
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Extra-Pair Fertilization, Mate Choice And Genetic Similarity In The Mexican Jay (Aphelocoma Ultramarina), John Andrew Eimes

Theses

Inbreeding depression should select for the ability of females to avoid inbreeding or minimize its effects. We tested for a relationship between genetic similarity of social pairs and the occurrence of extra-pair fertilization (EPF) in the Mexican jay (Aphelocoma ultramarina), a bird species with known inbreeding depression and a high EPF rate (Brown and Brown 1998, Li and Brown 2000). Multi-locus minisatellite and microsatellite DNA fingerprinting were used to detect extra-pair young and measure genetic similarity between social parents. We found that 15 of 38 (39%) nests had at least one EPF and 21 of 115 (18%) young …

Gender Socialization In Latino/A Families: Results From Two Retrospective Studies, Marcela Raffaelli, Lenna L. Ontai

Department of Psychology: Faculty Publications

In this article, we present findings from 2 studies designed to explore gender-related socialization in Latino/a families. In Study 1, 22 adult Latinas (ages 20–45) completed in-depth interviews. In Study 2, 166 Latino/a college students (58% women; M age 21.4 years) completed self-report surveys. Study 1 findings suggest that many Latino/a parents socialize their daughters in ways that are marked by “traditional” gender-related expectations and messages. Results of Study 2, which included descriptive analyses and the creation of scales to explore family correlates of gender-related socialization, support and expand these findings. Male and female respondents described different experiences of household …

Toward A New Theory Of Notice And Deterrence, Dru Stevenson

ExpressO

This article sets forth a new model of “notice” and deterrence that helps explain some long-standing contradictions in the literature on deterrence. Nearly all the work in the area of criminal law and deterrence has included an assumption that would-be offenders know the laws and the threatened sanctions, and therefore adjust their behavior in light of these disincentives. The fact that most people seem to be ignorant of the exact boundaries of the rules, and ignorant of the sanctions, presents an enormous conceptual problem for the classic model of deterrence. This new model presents an alternative mechanism for deterrence based …

On The Green Vol. 34 No. 9 March 5, 2004, Gallaudet University

2001-2010

On the Green is an internal publication of Gallaudet College, which later became Gallaudet University. It notified employees of updates around the campus and in the broader community, including new construction and the establishment of new academic programs. Running until 2010, it was supplanted by various forms of online mass communications across multiple audiences.

Spartan Daily, March 5, 2004, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 122, Issue 25

Sandspur, Vol 110, No 18, March 05, 2004, Rollins College

The Rollins Sandspur

Rollins College student newspaper, written by the students and published at Rollins College. The Sandspur started as a literary journal.

The Courier, Volume 37, Issue 17, March 5, 2004, The Courier, College Of Dupage

The Courier

Stories:

Improvement Project Under Way In BIC

Readership Program Successful So Far

Three Students Compete For Trustee Position

Parking Lot Study Points

Protecting Your Privacy

Drama And Trauma In Guantanamo

Answers To Identity, Mortality Sought (“Mere Mortals”)

Lady Chaps Head To Nationals (Basketball)

Swim Team Seeks Victory At National Competition

People:

Craig Blanchfield

Michael Pogwizd

Michael Mack

Mike Perkins

Andrew Carroll

The Tiger Vol. 97 Issue 19 2004-03-05, Clemson University

Tiger Newspapers

No abstract provided.