Digital Commons Network^™

Multiple Testing To Establish Superiority/Equivalence Of A New Treatment Compared With K Standard Treatments For Unbalanced Designs, Koon Shing Kwong, Siu Hung Cheung, Wai-Sum Chan

Research Collection School Of Economics

In clinical studies, multiple superiority/equivalence testing procedures can be applied to classify a new treatment as superior, equivalent (same therapeutic effect), or inferior to each set of standard treatments. Previous stepwise approaches (Dunnett and Tamhane, 1997, Statistics in Medicine 16, 2489–2506; Kwong, 2001, Journal of Statistical Planning and Inference 97, 359–366) are only appropriate for balanced designs. Unfortunately, the construction of similar tests for unbalanced designs is far more complex, with two major difficulties: (i) the ordering of test statistics for superiority may not be the same as the ordering of test statistics for equivalence; and (ii) the correlation structure …

Agreeing To Disagree: Security Council Resolution 1441 And Intentional Ambiguity, Michael Byers

Faculty Scholarship

No abstract provided.

Mining In Irian Jaya: How Citizens Should Think About Environmental Justice, Jeremy Bendik-Keymer

Faculty Scholarship

"All around me are the facts of my life. But I can't see them, because the way I think gets in the way." I am making a case for environmental justice. We'll explore how questioning our lives and actions helps us grasp environmental justice. I believe environmental justice calls many of us to conceive of our lives in new ways so that we can become true ecological citizens. First, relations between humans and lands need to be articulated, and we need to think of our lives in spatially, temporally and ecologically extended ways. This paper is intended initially as an …

University Of San Diego News Print Media Coverage 2004.06, University Of San Diego Office Of Public Relations

Print Media Coverage (1947-2009)

Printed clippings housed in folders with a table of contents arranged by topic.

The Impact Of Species Concept On Biodiversity Studies, Keith A. Crandall, Paul-Michael Agapow, Olaf R. P. Bininda-Emonds, John L. Gittleman, Georgina M. Mace, Jonathon C. Marshall, Andy Purvis

Faculty Publications

Species are defined using a variety of different operational techniques. While discussion of the various methodologies has previously been restricted mostly to taxonomists, the demarcation of species is also crucial for conservation biology. Unfortunately, different methods of diagnosing species can arrive at different entities. Most prominently, it is widely thought that use of a phylogenetic species concept may lead to recognition of a far greater number of much less inclusive units. As a result, studies of the same group of organisms can produce not only different species identities but also different species range and number of individuals. To assess the …

Assessing The Gender Component In Coronary Heart Disease; A Comparative Analysis Of Osteopathic And Allopathic Rural Physicians' Medical Approaches To Diagnosing And Treating Female Coronary Heart Disease, Victoria S. Curtis

Dissertations

Heart disease is the number one killer among women in the United States. This dissertation examines how the knowledge base of rural physicians affects his/her approach to diagnosing female heart disease. It compares the knowledge base of doctors trained in osteopathic medicine with doctors trained in allopathic medicine to determine if knowledge base affects how women are diagnosed in comparison with men. Current data suggests that a male model of recognized heart symptoms is most often used to diagnose heart disease, that women and men experience different cardiac symptoms, and those physicians more often overlook and/or misdiagnose women presenting with …

Multi-Trophic Level Interactions In A Cassava-Maize Mixed Cropping System In The Humid Tropics Of West Africa, F. Schulthess, A. Chabi-Olaye, S. Gounou

All Peer-Reviewed Publications

Multi-trophic level interactions in a mixed crop, involving cassava and maize, were studied in derived-savanna in Benin, West Africa. Two trials were planted, one during the short rainy season two months before onset of the dry season and one during the long rainy season in spring. Key pests under study on maize were the noctuid Sesamia calamistis Hampson and the pyralids Eldana saccharina Walker and Mussidia nigrivenella Ragonot, and on cassava, the exotic mealybug, Phenacoccus manihoti Matile-Ferrero and its encyrtid parasitoid Apoanagyrus lopezi De Santis. Both crops received insecticide treatments to assess the crop loss by a pest species. On …

New Techniques For Improving Biological Data Quality Through Information Integration, Katherine Grace Herbert

Dissertations

As databases become more pervasive through the biological sciences, various data quality concerns are emerging. Biological databases tend to develop data quality issues regarding data legacy, data uniformity and data duplication. Due to the nature of this data, each of these problems is non-trivial and can cause many problems for the database. For biological data to be corrected and standardized, methods and frameworks must be developed to handle both structural and traditional data.

The BIG-AJAX framework has been developed for solving these problems through both data cleaning and data integration. This framework exploits declarative data cleaning and exploratory data mining …

Optimization Studies Of Thermal Bimorph Cantilevers, Electrostatic Torsion Actuators And Variable Capacitors, Wuyong Peng

Dissertations

In this dissertation, theoretical analyses and optimization studies are given for three kinds of MEMS devices: thermal bimorph cantilevers, electrostatic torsion actuators, and variable capacitors. Calculation, simulation, and experimental data are used to confirm the device behavior and demonstrate the application of the design approaches.

For thermal bimorph cantilevers, an analytical model is presented which allows theoretical analysis and quantitative optimization of the performance based on material properties and device dimensions. Bimorph cantilevers are divided into two categories for deflection optimization: either the total thickness is constant, or the cantilever has one constant and one variable layer thickness. The optimum …

Non-Parametric Algorithms For Evaluating Gene Expression In Cancer Using Dna Microarray Technology, Virginie Aris

Dissertations

Microarray technology has transformed the field of cancer biology by enabling the simultaneous evaluation of tens of thousands mRNA expression levels in a single experiment. This technology has been applied to medical science in order to find gene expression markers that cluster diseased and normal tissues, genes affected by treatments, and gene network interactions. All methods of microarray data analysis can be summarized as a study of differential gene expression. This study addresses three questions, 1) the roles of selectively expressed genes for the classification of cancer, 2) issues of accounting for both experimental and biological noise, and 3) issues …

An Approximate Search Engine For Structure, Huiyuan Shan

Dissertations

As the size of structural databases grows, the need for efficiently searching these databases arises. Thanks to previous and ongoing research, searching by attribute-value and by text has become commonplace in these databases. However, searching by topological or physical structure, especially for large databases and especially for approximate matches, is still an art.

In this dissertation, efficient search techniques are presented for retrieving trees from a database that are similar to a given query tree. Rooted ordered labeled trees, rooted unordered labeled trees and free trees are considered. Ordered labeled trees are trees in which each node has a label …

Mobile Agent Based Distributed Network Management : Modeling, Methodologies And Applications, Jian Ye

Dissertations

The explosive growth of the Internet and the continued dramatic increase for all wireless services are fueling the demand for increased capacity, data rates, support of multimedia services, and support for different Quality of Services (QoS) requirements for different classes of services. Furthermore future communication networks will be strongly characterized by heterogeneity. In order to meet the objectives of instant adaptability to the users' requirements and of interoperability and seamless operation within the heterogeneous networking environments, flexibility in terms of network and resource management will be a key design issue. The new emerging technology of mobile agent (MA) has arisen …

Mixing Enhancement By Dual Speed Rotating Stirrer, Arnaud Goullet

Dissertations

Stirring is a well-known means of fluid mixing due to the emergence of complex patterns in the flow, even at low Reynolds numbers. In this work, we consider a stirrer rotating along a circular trajectory at constant speed. The fluid flow, considered incompressible, inviscid and two dimensional (in a circular container), is modeled by a point vortex model consisting of a vortex rotating in a circular container at constant angular speed. The mixing problem is addressed by considering the Hamiltonian form of the advection equations formulated in a frame of reference moving with the vortex. The dynamics of passive fluid …

Wetlands Evaluation Project, Joyce El Kouarti

PREP Reports & Publications

This New Hampshire Estuaries Project (NHEP) grant funded a study to identify and evaluate significant wetlands within the six towns that comprise Moose Mountains Regional Greenways (MMRG): Brookfield, Farmington, Middleton, Milton, New Durham and Wakefield. The goals of the study were to heighten awareness of the wetland areas in each town, educate Conservation Commission members and key town officials of the functional values of each selected wetland, and provide educational outreach toward the preservation of the quality of these wetlands using proven planning tools such as outright land purchase, easements, master planning, Prime Wetland designation in zoning, wetlands of special …

Novel Internally-Staged Ultrafiltration For Protein Purification, Meredith Ann Feins

Dissertations

A new ultrafiltration technique based on a multimembrane stack has been developed to fractionate proteins closer in molecular weight than conventionally possible. The technique is illustrated here by obtaining a pure protein product from a binary protein mixture. By employing membranes in series using the same membrane without any gaskets or spacers in-between, ultrafiltration is carried out to separate two proteins relatively close in molecular weight. Flat membranes, of the same molecular weight cutoff (MWCO) 30,000 or 100,000, are stacked together in the desired number, and ultrafiltration takes place. The membrane rejection of a protein is amplified with each additional …

Nonlinear Long-Wave Interfacial Stability Of Two-Layer Gas-Liquid Flow, Tetyana Segin

Dissertations

The flow of two immiscible viscous fluids in a thin inclined channel is considered, in either a cocurrent or countercurrent regime. Following the air-water case, which is found in a variety of engineering systems, we allow the upper fluid to be either compressible or incompressible. The disparity of the length scales and the density and viscosity ratios of the two fluids is exploited through a lubrication approximation of the conservation of mass and the Navier-Stokes equations. As a result of this long-wave theory, a coupled nonlinear system of partial differential equations is obtained that describes the evolution of the interfacial …

Does Rural High School Education Influence College Outcomes? A Longitudinal Study Using A Cohort Of U.S. High School Seniors, Christopher S. Snyder

Morehead State Theses and Dissertations

A thesis presented to the faculty of the Caudill College of Humanities at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Arts by Christopher S. Snyder on May 31, 2004.

May 31, 2004 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

The View Finder: Discovering My Artist Path Through Photography, Ivy Frances

Critical and Creative Thinking Capstones Collection

This is a personal narrative of how I applied Critical and Creative Thinking skills to photography and, in the process, found my artistic self. As a young girl, I was an emerging artist under the tutelage of creative parents. I took photographs of my family and of the beautiful landscape where we lived. Tragedy struck my child’s world twice; first, when my father died, and a second time when developers destroyed the natural areas where I played. These events shut down my inner awareness, stunted my growth as a risk taker and the artist in me went dormant. The Critical …

Beyond The Happy Sheets! Evaluating Learning In Information Skills Teaching, Richard German, Jane Barton, Nick Joint

Proceedings of the IATUL Conferences

This paper reviews three years of data measuring students' immediate reactions to a computer-assisted learning package in information skills and reports on work in progress to establish a more comprehensive programme of evaluation which will assess the medium term impact on learning of both the courseware itself and the way the courseware is delivered to students. The GAELS courseware was developed in the late 1990s as part of a collaborative project between the Universities of Glasgow and Strathclyde, with funding from the Scottish Higher Education Funding Council. The courseware was designed to teach higher level information skills and was initially …

Fabrication Of Nanofiber Scaffolds By Electrospinning And It's Potential For Tissue Engineering, Shobana Shanmugasundaram

Theses

Electrospinning is a fabrication process that uses an electric field to control the deposition of polymer fibers on to a target substrate. This electrospinning strategy can be used to fabricate fibrous polymer mats composed of fiber diameters ranging from several microns down to tens of nanometers. This study assesses the potential of electrospinning, as an alternative scaffold fabrication technique for tissue engineering applications. In this study, electrospinning is adapted to produce tissue-engineering scaffolds of two different size ranges composed of non-woven poly-L-lactide (PLLA) nanofibers and as a first study, the potential use of these scaffolds as tissue engineering scaffolds was …

Case Studies In Disassembly Process Planning, Riteshkumar Dhimmar

Theses

The rapid advancement in technology started in last century and still continuing resulted in decreased life cycle of electronic products. It also resulted in increased product disposal rate and filling land fill space faster causing shortage of such space and consequently creates major environmental problems. So, since couple of decade environmental concern has focused on production process and environmental regulations imposed by government has watched industrial pollution. With government regulations to control environmental problems; consumers are also aware of adverse effects of product disposal forcing manufacturer to become more responsible for safe product disposal and recycling of used product.

A …

Analysis Of Molecular Conformations Using Relative Planes, Deepa S. Pai

Theses

Ring substructures of a drug usually participate actively in binding to the receptor. It is necessary to study the spatial relationship of these molecular recognition features in order to determine the pharmacophore of the drug. This is a particularly difficult problem when the drug is a flexible molecule with many energetically accessible conformations.

In this research an innovative approach to calculate the relative displacement and orientation of every possible pair of rings in a given molecule was designed, tested, and implemented in the "Planes" program. Planes were defined from each of the ring substructures and the displacement and rotation of …

Evaluation Of Effect Of Extrusion Process Variables On Mechanical Properties Of Extruded Collagen Tubes And Effect Of Post Extrusion Treatments, Mayank K. Patel

Theses

This study evaluated the effect of extrusion process variable on mechanical properties of extruded collagen tubes made using a specialized extruder, made by ZOKO Corporation of Czechoslovakia. Three extrusion variables were considered; extrusion speed, linear draw rate and rotation speed. Using Taguchi L₄ matrix, a design of experiment (DOE) was run. Two mechanical properties, wall thickness and estimated elastic modulus, were considered as response of this DOE. Data was analyzed statically to evaluate the effect of extrusion variables on both these properties. Result of this study showed that linear draw rate of the extrusion process has the highest influence …

Random Search Conformational Analysis Of Piperazine And Piperadine Analogs Of Gbr12909 : Implicit Aqueous Solvation Effects, William A. Roosma

Theses

The object of this work was to study the effect of solvent on the conformational potential energy surface (PES) of GBR12909 analogs. Local minima on the PES's were found by the Random Search algorithm using the Sybyl molecular modeling package from Tripos, Inc., and an implicit solvent model. Two force-field/charge models were employed in the analysis: the Tripos force field with Gasteiger-Huckel charges and the MMFF94 force field with MMFF94 charges.

The effect of solvent on the location of minima in multi-dimensional torsional angle space was studied by comparison to the vacuum phase results. Minima were plotted in torsional angle …

Biomimetic Sensor For In-Vivo Applications, Daya I. Sooryadas

Theses

The development of sensitive specific devices (e.g., molecular sensors) for the detection, diagnosis and monitoring of diseases, drug discovery, environmental detection of pollutants and/or biological agents has been an active area of research. A molecular sensor is a biomolecule or biomimetic molecule that performs two distinct functions in detecting target molecules. The sensor molecule recognizes a target molecule and specifically binds to it. This specific binding generates a signal in response to the event of target binding that can be then detected. The long term vision of this thesis research work is to develop a specific recognition ligand for detecting …

Measurement Of The Effectiveness Of Enhanced External Counterpulsation On Heart Rate Variability For Patients With Myocardial Ischemia, Kripa Jayaraman

Theses

This thesis is a study to measure the changes in heart rate variability due to the activity of the autonomic nervous system caused by the Enhanced External Counterpulsation treatment. The treatment is a non surgical, mechanical procedure that can reduce the symptoms of angina or Congestive Heart Failure, presumably by stimulating the opening, or formation of, small branches of blood vessels (collaterals) to create a natural bypass around narrowed or blocked arteries. It has been proved that rhythms can be markers of normal functional states. Even in the absence of external perturbations, the normal heartbeat is not characterized by clockwise …

Mathematical Modeling And Simulation Of Human Motion Using 3-Dimensional, Multi-Segment Coupled Pendulum System : Derivation Of A Generalized Formula For Equations Of Motion, Loay Ahmed-Wasfe Al-Zube

Theses

The use of mathematical models to investigate the dynamics of human movement relies on two approaches: forward dynamics and inverse dynamics. In this investigation a new modeling approach called the Boundary Method is outlined. This method addresses some of the disadvantages of both the forward and the inverse approach. The method yields as output both a set of potential movement solutions to a given motor task and the net muscular impulses required to produce those movements. The input to the boundary method is a finite and adjustable number of critical target body configurations. In each phase of the motion that …

An In Vitro Evaluation Of Tyrosine Derived Polyarylates And Polycarbonate As Polymeric Scaffold For Human Mesenchymal Stem Cells Osteogenic Differentiation, Manish Suresh Godbole

Theses

Human mesenchymal stem cells (hMSCs) obtained from the adult bone marrow are multipotential cells that are capable of differentiating along several lineages. They are readily available and abundant source of cells in the field of tissue engineering. For their use in treating certain connective tissue defect or disorders, their success depends at minimum on the use of scaffolds that support differentiation. Therefore , this thesis details a study that systematically evaluated hMSC differentiation on materials that exhibit gradual range in surface properties as a first study for selecting materials as potential scaffolds. Polycarbonates and polyarylates have combinatorial libraries that exhibit …

Osha Laboratory Safety Standard 29 Cfr 1910.1450 And Achieving Compliance In The Microelectronic Laboratory, Danielle M. Digironimo

Theses

This thesis is a practical application of occupational exposures to hazardous substances in a microelectronics laboratory. The Occupational Safety and Health Administration (OSHA) standard for the safety in laboratories is (29 CFR 1910.1450). The application is a demonstration of the implementation of the standard in a university setting. Hazards that exist in laboratory settings are very complex and the task of providing a safe workplace can become increasingly complicated. A laboratory can and does impose different health and safety concerns that a standard industrial workplace setting might not have. The need for a laboratory safety standard program to be implemented …