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2002

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Ga And Gby Require Distinct Src-Dependent Pathways To Activate Rap1 And Ras, John M. Schmitt, Philip J. S. Stork Jan 2002

Ga And Gby Require Distinct Src-Dependent Pathways To Activate Rap1 And Ras, John M. Schmitt, Philip J. S. Stork

Faculty Publications - Department of Biological & Molecular Science

No abstract provided.

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Activation Of Central Melanocortin Pathways By Fenfluramlne, Lora K. Heisler, Michael A. Cowley, Laurence H. Tecott, Wei Fan, Malcolm J. Low, James L. Smart, Marcelo Rubinstein, Jeffrey B. Tatro, Jacob N. Marcus, Henne Holstege, Charlotte E. Lee, Roger D. Cone, Joel K. Elmquist Jan 2002

Activation Of Central Melanocortin Pathways By Fenfluramlne, Lora K. Heisler, Michael A. Cowley, Laurence H. Tecott, Wei Fan, Malcolm J. Low, James L. Smart, Marcelo Rubinstein, Jeffrey B. Tatro, Jacob N. Marcus, Henne Holstege, Charlotte E. Lee, Roger D. Cone, Joel K. Elmquist

Faculty Publications - Department of Biological & Molecular Science

D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to …

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A Complex, Cross-Taxon, Chemical Releaser Of Antipredator Behavior In Amphibians, Dale M. Madison, Aaron M. Sullivan, John C. Maerz, James H. Mcdarby, Jason R. Rohr Jan 2002

A Complex, Cross-Taxon, Chemical Releaser Of Antipredator Behavior In Amphibians, Dale M. Madison, Aaron M. Sullivan, John C. Maerz, James H. Mcdarby, Jason R. Rohr

Faculty Publications - Department of Biological & Molecular Science

Prey species show diverse antipredator responses to chemical cues signaling predation threat. Among terrestrial vertebrates, the red-backed salamander, Plethodon cinereus, is an important species in the study of these chemical defenses. During the day and early evening, this species avoids rinses from garter snakes, Thamnophis sirtalis, independent of snake diet, but late at night, avoids only those rinses from garter snakes that have recently eaten P. cinereus. We tested whether the selective, late-night response requires the ingestion or injury of salamanders. In three experiments, we tested P. cinereus for their responses to separate or combined rinses from salamanders (undisturbed, distressed, …

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Sex Differences And Seasonal Trade-Offs In Response To Injured And Non-Injured Conspecifics In Red-Spotted Newts, Notophthalmus Viridescens, Jason R. Rohr, Dale M. Madison, Aaron M. Sullivan Jan 2002

Sex Differences And Seasonal Trade-Offs In Response To Injured And Non-Injured Conspecifics In Red-Spotted Newts, Notophthalmus Viridescens, Jason R. Rohr, Dale M. Madison, Aaron M. Sullivan

Faculty Publications - Department of Biological & Molecular Science

Injured prey often release alarm chemicals that induce antipredator behaviors in conspecifics. Injured or killed prey most likely release a wide array of chemicals in addition to alarm substances, such as sexual pheromones, which could enhance or compromise antipredator responses. Thus, damage-release cues provide an excellent opportunity to examine the influence of seasonally fluctuating sexual pheromones on antipredator behaviors. We used a series of laboratory and field experiments and meta-analysis to examine seasonal changes and sex differences in the response of red-spot-ted newts, Notophthalmus viridescens, to the odor of non-injured conspecifics and conspecific tissue extracts, the latter of which presumably …

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The Ontogeny Of Chemically-Mediated Antipredator Behaviours In Newts (Notophthalmus Viridescens): Responses To Injured And Non-Injured Conspecifics, Aaron M. Sullivan, Jason R. Rohr, Dale M. Madison Jan 2002

The Ontogeny Of Chemically-Mediated Antipredator Behaviours In Newts (Notophthalmus Viridescens): Responses To Injured And Non-Injured Conspecifics, Aaron M. Sullivan, Jason R. Rohr, Dale M. Madison

Faculty Publications - Department of Biological & Molecular Science

Responses to alarm chemicals from injured prey may influence predation risk and foraging success of receivers and senders, while learning can influence the strength of these responses. Thus, it is important to know when in ontogeny prey produce and detect alarm substances and how learning shapes their response, but surprisingly little is known about either of these topics. We assessed when in the life of red-spotted newts, Notophthalmus viridescens, alarm chemicals are produced and detected by comparing adult versus eft (terrestrial juveniles) and larval responses to rinses and tissue extracts from individuals in each life-history stage. To evaluate the influence …

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Positive Parenting And Negative Contributions: Why Payment Of Child Support Should Not Be Regarded As Dissipation Of Marital Assets, Laura W. Morgan Jan 2002

Positive Parenting And Negative Contributions: Why Payment Of Child Support Should Not Be Regarded As Dissipation Of Marital Assets, Laura W. Morgan

New Mexico Law Review

No abstract provided.

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Marital Acts, Morality, And The Right To Privacy, Mark Strasser Jan 2002

Marital Acts, Morality, And The Right To Privacy, Mark Strasser

New Mexico Law Review

No abstract provided.

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Civil Procedure - Collateral Estoppel As A Bar To Post-Divorce Litigation Of Paternity - Tedford V. Gregory, Meghan R. Dimond Jan 2002

Civil Procedure - Collateral Estoppel As A Bar To Post-Divorce Litigation Of Paternity - Tedford V. Gregory, Meghan R. Dimond

New Mexico Law Review

No abstract provided.

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The Regulation And Function Of Inositol Phosphorylceramide Synthase In The Yeast Saccharomyces Cerevisiae, Angeleah Arlene Browdy Jan 2002

The Regulation And Function Of Inositol Phosphorylceramide Synthase In The Yeast Saccharomyces Cerevisiae, Angeleah Arlene Browdy

Open Access Dissertations

IPC Synthase has been shown to be an essential membrane bound enzyme in yeast that catalyzes the transfer of PI to ceramide to yield the primary sphingolipid found in yeast, Inositolphosphorylceramide. A biochemical approach was taken to investigate the biological factors that regulate IC synthase activity in order to better understand the sphingolipid synthesis. A highly purified IPC synthase was purified over 1000-fold from the yeast Saccharomyces cerevisiae by a procedure that included Triton X-100 solubilization, as well as a series of ion exchange and hydrophobic column chromatography steps. The highly purified enzyme fraction contained three major bands at 45, …

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Functional Characterization Of The Pregnane X Receptor, He Zhang Jan 2002

Functional Characterization Of The Pregnane X Receptor, He Zhang

Open Access Dissertations

Cytochrome P450 3A enzymes (CYP3A) are involved in the metabolism of two thirds of drugs and other xenobiotics, and highly induced by structurally diverse xenobiotics. Induction of CYP3A causes many drug-drug interactions, and an orphan nuclear receptor, the pregnane X receptor (PXR) is established to mediate the induction of CYP3A in mouse and human. Structurally, the PXR has a N-terminal uncharacterized domain, a conserved DNA binding domain (DBD) and a diverse C-terminal ligand binding domain (LBD). The purpose of the studies described in this dissertation is to characterize the role of the N-terminal domain and the LBD in PXR-mediated signaling …

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The Egyptian Pharmaceutical Industry After Trips — A Practitioner's View, Nermien Al-Ali Jan 2002

The Egyptian Pharmaceutical Industry After Trips — A Practitioner's View, Nermien Al-Ali

Fordham International Law Journal

The pharmaceutical industry in Egypt is the largest in the Middle East and North Africa (“MENA”) region, and one that has attracted foreign investment despite the fact that Egyptian law has not always provided pharmaceuticals with patent protection. The situation changed with the signing of the Agreement on Trade-Related Aspects of Intellectual Property Rights (“TRIPS agreement” or “TRIPS”), strengthening the interest of the U.S. and other pharmaceutical companies in increasing their investment in Egypt. The Egyptian pharmaceutical industry is currently undergoing many changes spurred by the implementation of TRIPS and the globalization of trade. Many of these changes can be …

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The Challenges Of Fighting Global Organized Crime In Latin America, Luz Estella Nagle Jan 2002

The Challenges Of Fighting Global Organized Crime In Latin America, Luz Estella Nagle

Fordham International Law Journal

This Article examines organized crime in Iberoamerica. It also examines the international mechanisms implemented to combat it, specifically the 1988 United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances, the 1996 Organization of American States Inter-American Convention against Corruption of 1996, and the United Nations Convention on Transnational Organized Crime of 2000. It then examines whether these efforts have been successful or unsuccessful, and whether multilateral instruments are a formidable tool in the war against international organized crime or merely toothless tigers.

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Watershed Down: The Ups And Downs Of Watershed Management In The Southwest, Kara Gillon Jan 2002

Watershed Down: The Ups And Downs Of Watershed Management In The Southwest, Kara Gillon

Water Law Review

No abstract provided.

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Wisconsin V. Epa: Tribal Empowerment And State Powerlessness Under 518(E) Of The Clean Water Act, Paul M. Drucker Jan 2002

Wisconsin V. Epa: Tribal Empowerment And State Powerlessness Under 518(E) Of The Clean Water Act, Paul M. Drucker

Water Law Review

No abstract provided.

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An Environmental Water Account: The California Experience, Alf W. Brandt Jan 2002

An Environmental Water Account: The California Experience, Alf W. Brandt

Water Law Review

No abstract provided.

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Strengthening Sustainable Development In Regional Inter-Governmental Governance: Lessons From The 'Asean Way', Nicholas A. Robinson Jan 2002

Strengthening Sustainable Development In Regional Inter-Governmental Governance: Lessons From The 'Asean Way', Nicholas A. Robinson

Elisabeth Haub School of Law Faculty Publications

ASEAN was founded with the 1967 Bangkok Declaration in order to encourage stable relations among its original member states, i.e. Indonesia, Malaysia, Singapore, Thailand and the Philippines, and to resist destabilizing influences from the war in Viet Nam. The means to stability was to promote economic, social and cultural cooperation in the spirit of equality and partnership. A formal treaty system was not required. As the Viet Nam war ended, ASEAN held its first Summit Meeting in Bali (1976), followed by the 1977 Summit in Kuala Lumpur, where cooperation on regional industrializations was launched. In this first phase of cooperation, …

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Befogged Vision: International Environmental Law A Decade After Rio, Nicholas A. Robinson Jan 2002

Befogged Vision: International Environmental Law A Decade After Rio, Nicholas A. Robinson

Elisabeth Haub School of Law Faculty Publications

Environmental management has emerged as an important element of governance in practically every nation. This was not the case before the United Nations convened the 1972 Conference on the Human Environment in Stockholm. After Stockholm, nations learned to build environmental ministries and work across sectors nationally, and discovered how difficult it is to reshape entrenched national practices in order to curb pollution and conserve natural resources. With growing experience and knowledge, nations came to realize that no one government alone could safeguard the environment, and that international cooperation would need to be enhanced.

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A Generational History Of Environmental Law And Its Grand Themes: A Near Decade Of Garrison Lectures, Jeffrey G. Miller Jan 2002

A Generational History Of Environmental Law And Its Grand Themes: A Near Decade Of Garrison Lectures, Jeffrey G. Miller

Elisabeth Haub School of Law Faculty Publications

I have been privileged to hear, enjoy and learn from the talks of each of our Garrison Lecturers during the last eight years, as well as our discussions with them here today. In preparation for my duties as a summarizer, I studied their talks, printed in our Pace Environmental Law Review. I was delighted to find that the body of their commentary is far more than the sum of its parts. Together our lecturers take us on a grand journey through the history of modern environmental law, its heroes and villains, its accomplishments and its weaknesses. Together they sound all …

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The Number One Childhood Cancer: Acute Lymphoblastic Leukemia-- Its Treatment Protocol, Vanessa Cosby-Wambaugh Jan 2002

The Number One Childhood Cancer: Acute Lymphoblastic Leukemia-- Its Treatment Protocol, Vanessa Cosby-Wambaugh

Whittier Scholars Program

Mary Jones, age 7, has been diagnosed with Acute Lymphoblastic Leukemia. Prior to this decade, the chances of her reachering her 17th birthday would have been nonexistent. But, with the advent of various modern treatments, doctors would have been able to increase the survival rates of children affected with cancer. Now the survival rate is around 80%. As hopeful as these treatments are, the medical world is still unable to determine why children are affected with cancer and what is going on. The most common pediatric cancer is Acute Lymphoblastic Leukemia. I am interested in two things about this psrticular …

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Catskill Mtns. Chapter Of Trout Unlimited V. City Of New York, 273 F.3d 481 (2nd Cir. 2001), Daniel C. Wennogle Jan 2002

Catskill Mtns. Chapter Of Trout Unlimited V. City Of New York, 273 F.3d 481 (2nd Cir. 2001), Daniel C. Wennogle

Water Law Review

No abstract provided.

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Natural Res. Def. Council, Inc. V. Muszynski, 268 F.3d 91 (2d Cir. 2001), Matthew J. Costinett Jan 2002

Natural Res. Def. Council, Inc. V. Muszynski, 268 F.3d 91 (2d Cir. 2001), Matthew J. Costinett

Water Law Review

No abstract provided.

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Oregon Trout, Ed., Oregon Salmon: Essays On The State Of Fish At The Turn Of The Millennium, Erika Delaney-Lew Jan 2002

Oregon Trout, Ed., Oregon Salmon: Essays On The State Of Fish At The Turn Of The Millennium, Erika Delaney-Lew

Water Law Review

No abstract provided.

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Greg Shapland, Rivers Of Discord, David M. Jacob Jan 2002

Greg Shapland, Rivers Of Discord, David M. Jacob

Water Law Review

No abstract provided.

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Vol. 5, No. 2: Full Issue, Water Law Review Jan 2002

Vol. 5, No. 2: Full Issue, Water Law Review

Water Law Review

No abstract provided.

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Toward A Bridge: The Role Of Legal Academics In The Culture Of Private Practice, Camille Nelson Jan 2002

Toward A Bridge: The Role Of Legal Academics In The Culture Of Private Practice, Camille Nelson

Scholarly Articles in Law Reviews & Journals

No abstract provided.

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Virtual, On-Line, Frog Dissection Vs. Conventional Laboratory Dissection: A Comparison Of Student Achievement And Teacher Perceptions Among Honors, General Ability, And Foundations Level High School Biology Classes, Ronald H. Kopec Jan 2002

Virtual, On-Line, Frog Dissection Vs. Conventional Laboratory Dissection: A Comparison Of Student Achievement And Teacher Perceptions Among Honors, General Ability, And Foundations Level High School Biology Classes, Ronald H. Kopec

Seton Hall University Dissertations and Theses (ETDs)

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Cover And Contents Jan 2002

Cover And Contents

Turkish Journal of Physics

No abstract provided.

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Cover And Contents Jan 2002

Cover And Contents

Turkish Journal of Physics

No abstract provided.

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Cover And Contents Jan 2002

Cover And Contents

Turkish Journal of Biology

No abstract provided.

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Cover And Contents Jan 2002

Cover And Contents

Turkish Journal of Biology

No abstract provided.

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