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Articles 6421 - 6450 of 8909
Full-Text Articles in Entire DC Network
The Rockefeller University Hospital: Transforming Medicine, The Rockefeller University
The Rockefeller University Hospital: Transforming Medicine, The Rockefeller University
The Rockefeller University Hospital: Transforming Medicine
Translating basic discoveries into medical treatments and preventions is more important than ever. More and more, both basic scientists and physician-scientists are exploring medical applications of their discoveries.
Biogenesis And Traffic Of The Potassium Channel, Natalie De Souza
Biogenesis And Traffic Of The Potassium Channel, Natalie De Souza
Student Theses and Dissertations
Excitability of nerve and muscle cells depends on the number and the types of ion channels expressed at the plasma membrane. This work examines aspects of biogenesis and traffic of the Shaker voltage-gated potassium channel. Shaker is an oligomeric, polytopic membrane protein and, as such, its biogenesis begins at the endoplasmic reticulum (ER). I have studied (i) targeting of Shaker to the ER and stable integration into the lipid bilayer, (ii) N-linked glycosylation, assembly and folding Shaker in the ER, and (iii) export of Shaker from the ER and subsequent traffic to the surface. Targeting to the endoplasmic reticulum, integration …
Transcription, Editing, And Switching Of Antibody Genes, Rafael Casellas
Transcription, Editing, And Switching Of Antibody Genes, Rafael Casellas
Student Theses and Dissertations
B lymphocytes are the antibody producing cells of the immune system. During B cell lymphopoiesis in the bone marrow, immunoglobulin molecules are assembled from V, D, and J gene segments through a process known as V(D)J recombination. Because of its stochastic nature, V(D)J recombination is expected to create self-reactive specificities. In targeted animals carrying autoantibodies, these specificities were shown to be silenced by deletion, anergy, and receptor editing. While anergy and deletion physically eliminate the autoreactive clone, receptor editing salvages it by replacing its immunoglobulin receptor through ongoing V(D)J recombination. Once a functional non-self -reactive receptor is generated, B lymphocytes …
Stress And Hippocampal Plasticity, Kara Pham
Stress And Hippocampal Plasticity, Kara Pham
Student Theses and Dissertations
The addition of new neurons continues in the dentate gyrus of the adult rat, and this process has been previously shown to be regulated by adrenal steroid hormones, N-methyl-D-aspartate (NMDA) receptor activity, psychosocial stress and learning and memory. Repeated restraint stress is known to induce neuroanatomical changes in the hippocampus, such as dendritic remodeling in CA3 neurons and mossy fiber terminal rearrangement, and these alterations are reversible, suggesting that the hippocampal system experiences a certain degree of plasticity in response to stress. This dissertation examines the effects of chronic restraint stress on several parameters of hippocampal plasticity, including dentate gyrus …
Structural Studies Of Dna Replication Proteins By X-Ray Crystallography And Molecular Dynamics, Yanxiang Zhao
Structural Studies Of Dna Replication Proteins By X-Ray Crystallography And Molecular Dynamics, Yanxiang Zhao
Student Theses and Dissertations
Organisms that span evolutionary space utilize an assembly of proteins (the replicase) in a coordinated effort to faithfully replicate their genomes. This chromosomal replicase consists of three functionally distinct subassemblies. The first of these is the polymerase/exonuclease complex, which harbors DNA synthesis and proofreading activities. The second functional complex is the sliding clamp which adopts a ring-shaped structure, composed of either two or three protomers. It confers processivity onto the polymerase subunit by tethering it to the template. The third complex is the clamp loader complex, which loads the sliding clamp onto DNA using energy from ATP binding and hydrolysis. …
Targeting Receptor-Histidine Kinase Signaling In Staphylococcus Aureus, Gholson J. Lyon
Targeting Receptor-Histidine Kinase Signaling In Staphylococcus Aureus, Gholson J. Lyon
Student Theses and Dissertations
Two-component signaling systems involving receptor-histidine kinases (RHKs) are present in all branches of life outside of the animal kingdom. Remarkably, very little is known concerning the extracellular ligands that presumably bind to RHKs to initiate signaling. The two-component agr signaling circuit in the bacterial pathogen, Staphylococcus aureus, is one system where the ligands are known in chemical detail. These ligands (the AIPs) are short (7-9 aminoacyl residue) peptides containing a thiolactone structure, in which the α-carboxyl group of the C-terminal amino acid is linked to the sulfhydryl group of a cysteine, which is always the fifth amino acid from the …
Mapping Genes For Complex Traits: Obesity, Diabetes, Hypertension, And Dyslipidemia On The Pacific Island Of Kosrae, Dvora Shmulewitz
Mapping Genes For Complex Traits: Obesity, Diabetes, Hypertension, And Dyslipidemia On The Pacific Island Of Kosrae, Dvora Shmulewitz
Student Theses and Dissertations
One of the current challenges in human genetics is to map genes for common, complex diseases. For powerful mapping of such phenotypes, the suggestions are to analyze the underlying quantitative traits with covariate corrections in large extended pedigrees with multipoint analysis. This is virtually impossible to do with the current linkage programs, due to the computation difficulties of exactly calculating every possibility. Instead, sampling methods that sample the most likely data configuration from all the possibilities need to be used. This has been implemented in the reversible jump Markov chain Monte Carlo method Loki, which can carry out segregation and …
Leptin And The Control Of Body Weight And Metabolism: Role For Stearoyl Coa Desaturase-1 And Other Leptin-Regulated Genes In The Liver, Paul Cohen
Student Theses and Dissertations
Leptin is an adipocyte-derived hormone that regulates energy balance, metabolism, and the neuroendocrine response to altered nutrition. Mice lacking leptin (ob/ob) or its receptor (db/db) are massively obese and hyperphagic. They also have increased triglyceride deposits in multiple peripheral organs, including the liver, massively enlarged and steatotic. Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone. This response is characterized by weight loss, depletion of lipid from peripheral tissues, and enhanced insulin sensitivity. The mechanisms underlying these actions were largely unknown. This thesis addressed leptin's metabolic effects on the liver, an organ with a critical …
Nova Regulation Of Alternative Splicing In The Cns, B Kate Dredge
Nova Regulation Of Alternative Splicing In The Cns, B Kate Dredge
Student Theses and Dissertations
Nova-1, an autoantigen in paraneoplastic opsoclonus myoclonus ataxia (POMA), a disorder associated with gynecologic cancer and CNS motor dysfunction, is a neuronspecific nuclear RNA binding protein. The work presented here confirms that Nova-1 acts as a regulator of alternative splicing in vivo. In addition to the known target Nova-dependent splicing regulation, exon 3A of glycine receptor α2 subunit (GlyRα2), two new targets are identified, which are the alternative exon, E9 in the inhibitory neurotransmitter receptor subunit, GABAARγ2, and the alternatively spliced exon H in Nova-1's own message. Nova acts to enhance alternative exon inclusion in GlyRα2 and GABAARγ2 mRNAs and …
Site-Specific Incorporation Of Biochemical And Biophysical Probes Into Proteins Using Expressed Protein Ligation, Mande Holford
Site-Specific Incorporation Of Biochemical And Biophysical Probes Into Proteins Using Expressed Protein Ligation, Mande Holford
Student Theses and Dissertations
Protein engineering can be made far more powerful if a protein is not only expressed recombinantly but also altered covalently using synthetic chemistry. These two methods are brought together in the protein semi-synthesis technique Expressed Protein Ligation (EPL). In EPL, recombinant and synthetic polypeptides are joined together via a chemoselective ligation reaction. EPL was originally used to attach synthetic constructs to the C-terminus of recombinant proteins, but is now used to attach recombinant or synthetic polypeptides either at the N- or C-terminus of a protein or into the core of a protein. This thesis illustrates, with three distinct applications, the …
The Osteopetrotic Mutation Toothless (Tl) Is A Loss-Of-Function Frameshift Mutation In The Rat Csf1 Gene: Evidence Of A Crucial Role For Csf-1 In Osteoclastogenesis And Endochondral Ossification, Liesbeth Van Wesenbeeck, Paul R. Odgren, Carole A. Mackay, Marina D'Angelo, Fayez F. Safadi, Steven N. Popoff, Wim Van Hul, Sandy C. Marks Jr.
The Osteopetrotic Mutation Toothless (Tl) Is A Loss-Of-Function Frameshift Mutation In The Rat Csf1 Gene: Evidence Of A Crucial Role For Csf-1 In Osteoclastogenesis And Endochondral Ossification, Liesbeth Van Wesenbeeck, Paul R. Odgren, Carole A. Mackay, Marina D'Angelo, Fayez F. Safadi, Steven N. Popoff, Wim Van Hul, Sandy C. Marks Jr.
PCOM Scholarly Works
The toothless (tl) mutation in the rat is a naturally occurring, autosomal recessive mutation resulting in a profound deficiency of bone-resorbing osteoclasts and peritoneal macrophages. The failure to resorb bone produces severe, unrelenting osteopetrosis, with a highly sclerotic skeleton, lack of marrow spaces, failure of tooth eruption, and other pathologies. Injections of CSF-1 improve some, but not all, of these. In this report we have used polymorphism mapping, sequencing, and expression studies to identify the genetic lesion in the tl rat. We found a 10-base insertion near the beginning of the open reading of the Csf1 gene that yields a …
A Majority-Minority Nation: Racing The Population In The Twenty-First Century, John A. Powell
A Majority-Minority Nation: Racing The Population In The Twenty-First Century, John A. Powell
Fordham Urban Law Journal
This article explores the factors that affect the creation of racial classifications and how they are reflected in the Census categories, particularly in regard to the classification of Hispanics. The article argues that an increase in racial minorities will not solely stop white racial domination of political power structures because of entrenched racial policies and practices. To end this domination, racial minorities must organize and collaborate to take down these racially oppressive structures.
Therapeutic Jurisprudence And Cognitive Complexity: An Overview, Philip Gould, Patricia Murrell
Therapeutic Jurisprudence And Cognitive Complexity: An Overview, Philip Gould, Patricia Murrell
Fordham Urban Law Journal
No abstract provided.
Therapeutic Jurisprudence, Neo-Rehabilitationism, And Judicial Collectivism: The Least Dangerous Branch Becomes The Most Dangerous, Morris Hoffman
Therapeutic Jurisprudence, Neo-Rehabilitationism, And Judicial Collectivism: The Least Dangerous Branch Becomes The Most Dangerous, Morris Hoffman
Fordham Urban Law Journal
No abstract provided.
Toward Epistemic Justice: A Response To Professor Goldberg, Dominic J. Balestra
Toward Epistemic Justice: A Response To Professor Goldberg, Dominic J. Balestra
Fordham Urban Law Journal
This Article is a response to Steven Goldberg's article and lecture "Religious Contributions to the Bioethics Debate: Utilizing Legal Rights while Avoiding Scientific Temptations," 30 Fordham Urb. L.J., 35 (2002) (available at http://new.fordhamj.org/demonstration/dc/v30/13_30FordhamUrbLJ35(2002-2003).pdf). The author argues that the question is not the place of values in a world of fact, but the place of facts in a world of values.
Assisted Reproductive Technologies And The Constitution, Carl H. Coleman
Assisted Reproductive Technologies And The Constitution, Carl H. Coleman
Fordham Urban Law Journal
This Article discusses potential policies regarding assisted reproductive technologies (ARTs). The initial question is whether ARTs should be viewed as private matters or as issues that affect overall social good. The author explains that this question may be answered by the Supreme Court's interpretation of the principles of procreative liberty. He then examines Supreme Court decisions regarding reproductive rights, including the unstated right to bear children as well as abortion rights. He extrapolates from these cases the Court's possible views on ARTs and what constitutional protections should be afforded reproductive technologies.
Protestant Perspectives On The Uses Of The New Reproductive Technologies, Cynthia B. Cohen
Protestant Perspectives On The Uses Of The New Reproductive Technologies, Cynthia B. Cohen
Fordham Urban Law Journal
This Article explores the emerging positions that Protestants may have on new reproductive technologies (NRTs). Although there is no central teaching, there are main points of agreement among Protestants and other Christians regarding the morality of using reproductive technology. The author examines Protestant teachings on the meaning of procreation, the good of the resulting children and the integrity of family bonds to show that these technologies are generally morally acceptable, but with certain limitations.
Protestant Perspectives On Informed Consent (Particularly In Research Involving Human Participants), James F. Childress
Protestant Perspectives On Informed Consent (Particularly In Research Involving Human Participants), James F. Childress
Fordham Urban Law Journal
This Article examines Protestant positions on informed consent/refusal regarding the use of human subjects in research. Primarily focusing on the work of Paul Ramsey, a Protestant scholar in science and ethics, the article describes the relationship between the God-man covenant and man-to-man covenants and the consequences thereof. Exploring the line between what Ramsey calls "charity" and "justice," the article finds differences between therapeutic and nontherapeutic research and who may participate with or without consent.
Informed Consent Without Autonomy, Daniel P. Sulmasy
Informed Consent Without Autonomy, Daniel P. Sulmasy
Fordham Urban Law Journal
This Essay explains why and how the Roman Catholic basis for informed consent is different from the secular basis. It argues that the Catholic basis, which is rooted in "natural law," is the better model for society to adopt. The author explains that the secular view is rooted in the belief that patient autonomy must never be violated but the Catholic view is based on human dignity, which simply requires doctors to allow patients to exercise their free will within moral limits. This view allows doctors to override patients' decisions if those decisions are morally wrong or irrational.
Intrusion Detection Using Artificial Neural Network / Gan Sze Kai, Sze Kai Gan
Intrusion Detection Using Artificial Neural Network / Gan Sze Kai, Sze Kai Gan
Student Works (2000-2009)
According to this thesis title - Intrusion Detection Using Artificial Neural Network is whereby a neural network technology must be built inside the Intrusion Detection System (IDS). IDS is one of the security techniques, which is being used currently. It can be said that, Intrusion Detection System is a companion of the firewall, (of is beyond the firewall). The firewall is analog to the locker in (our houses to lock the windows and doors) to prevent intruders' break-in. Therefore, the IDS is a burglar alarm system to alert the user when an intruder successfully get through the firewall. In addition, …
Educationally Related Mental Health Services For Children With Serious Emotional Disturbance: Addressing Barriers To Access Through The Idea, Lucy W. Shum
Journal of Health Care Law and Policy
No abstract provided.
One Man's Trash Is Another Man's Treasure, Bioprospecting: Protecting The Rights And Interests Of Human Donors Of Genetic Material, Anne Nichols Hill
One Man's Trash Is Another Man's Treasure, Bioprospecting: Protecting The Rights And Interests Of Human Donors Of Genetic Material, Anne Nichols Hill
Journal of Health Care Law and Policy
No abstract provided.
Regulation Of Research With Children: The Evolution From Exclusion To Inclusion, Duane Alexander
Regulation Of Research With Children: The Evolution From Exclusion To Inclusion, Duane Alexander
Journal of Health Care Law and Policy
No abstract provided.
Pediatric Priorities: Legislative And Regulatory Initiatives To Expand Research On The Use Of Medicines In Pediatric Patients, Michael S. Labson
Pediatric Priorities: Legislative And Regulatory Initiatives To Expand Research On The Use Of Medicines In Pediatric Patients, Michael S. Labson
Journal of Health Care Law and Policy
No abstract provided.
Money From Heaven: Should Qualified Air Rights Donations Be Characterized As Interests In Land Or Buildings - Why Does It Matter , Daniel Markey
Money From Heaven: Should Qualified Air Rights Donations Be Characterized As Interests In Land Or Buildings - Why Does It Matter , Daniel Markey
Cleveland State Law Review
Currently, the Internal Revenue Service (hereinafter I.R.S.) and the federal courts do not offer specific positive authority as to whether large amounts of easement value from donated air rights can be allocated against the capital account of "land" as opposed to a "building" on a given tract of real estate. A lack of authority in this area creates uncertainty in the real estate market. This uncertainty is not only with the payment of federal income, estate, and gift taxes, but it also has a ripple effect with the assessment of local property taxes. Most importantly, if a deal is on …
2002 Commencement Program, Morehead State University. Registrar's Office.
2002 Commencement Program, Morehead State University. Registrar's Office.
Morehead State Commencement Programs
2002 commencement programs of Morehead State University.
Putting The Precautionary Principle In Its Place: Parameters For The Proper Application Of A Precautionary Approach And The Implications For Developing Countries In Light Of The Doha Wto Ministerial, Laurent A. Ruessmann
Putting The Precautionary Principle In Its Place: Parameters For The Proper Application Of A Precautionary Approach And The Implications For Developing Countries In Light Of The Doha Wto Ministerial, Laurent A. Ruessmann
American University International Law Review
No abstract provided.
The Effect Of Cytosine Methylation On The Structure And Geometry Of The Holliday Junction: The Structure Of D(Ccggtacm5 Cgg) At 1.5 Å Resolution, Jeff Vargason, P. Shing Ho
The Effect Of Cytosine Methylation On The Structure And Geometry Of The Holliday Junction: The Structure Of D(Ccggtacm5 Cgg) At 1.5 Å Resolution, Jeff Vargason, P. Shing Ho
Faculty Publications - Department of Biological & Molecular Science
No abstract provided.
Pka Phosphorylation Of Src Mediates Camp's Inhibition Of Cell Growth Via Rap1, John M. Schmitt, Philip J. S. Stork
Pka Phosphorylation Of Src Mediates Camp's Inhibition Of Cell Growth Via Rap1, John M. Schmitt, Philip J. S. Stork
Faculty Publications - Department of Biological & Molecular Science
In fibrolast cells, cAMP antagonizes growth factor activation of ERKs and cell growth via PKA and the small P protein Rap1. We demonstrate here that PKA's activation of Rap1 was mediated by the Rap1 guanine nucleotide exchange factor C3G, the adaptor Crk-L, the scaffold protein Cbl, and the tyrosine kinase Src. Src was required for cAMP activation of Rap1 and the inhibition of ERKs and cell growth. PKA activated Src both in vitro and in vivo by phosphorylation was required for cAMP's activation of Src and Rap1, as well as cAMP's inhibition of ERKs and cell proliferation. This study identifies …
Crosstalk Between Camp And Map Kinase Signaling In The Regulation Of Cell Proliferation, Philip J. S. Stork, John M. Schmitt
Crosstalk Between Camp And Map Kinase Signaling In The Regulation Of Cell Proliferation, Philip J. S. Stork, John M. Schmitt
Faculty Publications - Department of Biological & Molecular Science
Hormonal stimulation of cyclic adenosine monophosphate (cAMP) and the cAMP-dependent protein kinase PKA regulates cell growth by multiple mechanisms. A hallmark of cAMP is its ability to stimulate cell growth in many cell types while inhibiting cell growth in others. In this review, the cell type-specific effects of cAMP on the mitogen-activated protein (MAP) kinase (also called extracellular signal-regulated kinase, or ERK) cascade and cell proliferation are examined. Two basic themes are discussed. First, the capacity of cAMP for either positive or negative regulation of the ERK cascade accounts for many of the cell type-specific actions of cAMP on cell …