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2002

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Exploiting Dendritic Cells To Improve Vaccine Efficacy, Ralph M. Steinman, Melissa Pope Jan 2002

Exploiting Dendritic Cells To Improve Vaccine Efficacy, Ralph M. Steinman, Melissa Pope

Publications

[No abstract available]

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Avoiding Horror Autotoxicus: The Importance Of Dendritic Cells In Peripheral T Cell Tolerance, Ralph M. Steinman, Michel C. Nussenzweig Jan 2002

Avoiding Horror Autotoxicus: The Importance Of Dendritic Cells In Peripheral T Cell Tolerance, Ralph M. Steinman, Michel C. Nussenzweig

Publications

The immune system generally avoids horror autotoxicus or autoimmunity, an attack against the body's own constituents. This avoidance requires that self-reactive T cells be actively silenced or tolerized. We propose that dendritic cells (DCs) play a critical role in establishing tolerance, especially in the periphery, after functioning T cells have been produced in the thymus. In the steady state, meaning in the absence of acute infection and inflammation, DCs are in an immature state and not fully differentiated to carry out their known roles as inducers of immunity. Nevertheless, immature DCs continuously circulate through tissues and into lymphoid organs, capturing …

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Preparation Of Clinical-Grade Recombinant Canarypox-Human Immunodeficiency Virus Vaccine-Loaded Human Dendritic Cells, Mary A. Marovich, John R. Mascola, Michael A. Eller Jan 2002

Preparation Of Clinical-Grade Recombinant Canarypox-Human Immunodeficiency Virus Vaccine-Loaded Human Dendritic Cells, Mary A. Marovich, John R. Mascola, Michael A. Eller

Publications

Preclinical data are reported that support a human immunodeficiency virus (HIV) vaccine strategy using recombinant canarypox-HIV vectors (ALVAC-HIV) to load human dendritic cells (DCs) with HIV antigens. Clinical-grade DCs were infected with good manufacturing practice-grade ALVAC-HIV vaccine constructs. ALVAC infection, HIV gene expression, and DC viability and function were monitored by use of immunohistochemistry, flow cytometry, blastogenesis assays, antigen-specific interferon (IFN)-γ enzyme-linked immunospot assay, and enzyme-linked immunosorbent assay protein detection. The vaccines infected both immature and mature DCs, and intracellular HIV-1 Gag protein was detected within hours. ALVAC-HIV induced DC maturation that was mediated by tumor necrosis factor-α and induced …

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Endogenously Expressed Nef Uncouples Cytokine And Chemokine Production From Membrane Phenotypic Maturation In Dendritic Cells, Davorka Messmer, Jean M. Jacqué Jan 2002

Endogenously Expressed Nef Uncouples Cytokine And Chemokine Production From Membrane Phenotypic Maturation In Dendritic Cells, Davorka Messmer, Jean M. Jacqué

Publications

Immature dendritic cells (DCs), unlike mature DCs, require the viral determinant nef to drive immunodeficiency virus (SIV and HIV) replication in coculture with CD4+ T cells. Since immature DCs may capture and get infected by virus during mucosal transmission, we hypothesized that Nef associated with the virus or produced during early replication might modulate DCs to augment virus dissemination. Adenovirus vectors expressing nef were used to introduce nef into DCs in the absence of other immunodeficiency virus determinants to examine Nef-induced changes that might activate immature DCs to acquire properties of mature DCs and drive virus replication. Nef expression …

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4th Annual Student Academic Conference: Conference Program & Abstracts Volume Iv, Minnesota State University Moorhead Jan 2002

4th Annual Student Academic Conference: Conference Program & Abstracts Volume Iv, Minnesota State University Moorhead

Student Academic Conference Abstract Books

Minnesota State University Moorhead Student Academic Conference abstract book.

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Bryn Mawr College Undergraduate College Catalogue And Calendar, 2002-2003, Bryn Mawr College Jan 2002

Bryn Mawr College Undergraduate College Catalogue And Calendar, 2002-2003, Bryn Mawr College

Bryn Mawr College Calendar

No abstract provided.

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Profile 2: Genesis Of A Dance, Rohan Preston Jan 2002

Profile 2: Genesis Of A Dance, Rohan Preston

Democratic Vistas Profiles

Liz Lerman, founder of the Liz Lerman Dance Exchange, and her ethical commitment to dance as a means of building community and connecting people across disciplines

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Profile 5: 'Art The Works': T. Allan Comp And The Reclamation Of A Toxic Legacy, Erik Reece Jan 2002

Profile 5: 'Art The Works': T. Allan Comp And The Reclamation Of A Toxic Legacy, Erik Reece

Democratic Vistas Profiles

T. Allan Comp's work to drain and refurbish toxic coalmines for use as public spaces

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Review Of Remnants Of Auschwitz: The Witness And The Archive, Trans. Daniel Heller-Roazen, Richard J. Bernstein Jan 2002

Review Of Remnants Of Auschwitz: The Witness And The Archive, Trans. Daniel Heller-Roazen, Richard J. Bernstein

Bryn Mawr Review of Comparative Literature

Giorgio Agamben, Remnants of Auschwitz: The Witness and the Archive, trans. Daniel Heller-Roazen New York: Zone Books, 1999. 175 pp. ISBN 189051161265.

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Review Of Shakespeare's Brain: Reading With Cognitive Theory, Nancy Selleck Jan 2002

Review Of Shakespeare's Brain: Reading With Cognitive Theory, Nancy Selleck

Bryn Mawr Review of Comparative Literature

Mary Thomas Crane, Shakespeare's Brain: Reading with Cognitive Theory. Princeton and Oxford: Princeton University Press, 2001. 265 pp. ISBN 0691069921 (paper).

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Making Discoveries That Transform Science, The Rockefeller University Jan 2002

Making Discoveries That Transform Science, The Rockefeller University

Making Discoveries that Transform Science

Written and designed by the Office of Communications and Public Affairs for The Rockefeller University, this publication spotlights pathbreaking research of a few of the university's 75 major laboratories: Roderick MacKinnon, Maria Karayirgou, Elaine Fuchs, Jan Breslow Jeffrey Friedman, Markus Stoffel, Terry Gaasterland, Madhav Dhodapkar, Marry Hatten, Nathaniel Heintz, and Tom Muir.

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Aquilegia, Vol. 26 No. 1, January-February 2002: Newsletter Of The Colorado Native Plant Society, Leo P. Bruederle, Alice Guthrie, Patrick Murphy, Georgia Doyle, James Erdman, Carolyn Crawford, Barbara Bash Jan 2002

Aquilegia, Vol. 26 No. 1, January-February 2002: Newsletter Of The Colorado Native Plant Society, Leo P. Bruederle, Alice Guthrie, Patrick Murphy, Georgia Doyle, James Erdman, Carolyn Crawford, Barbara Bash

Aquilegia - Colorado Native Plant Society

No abstract provided.

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West Virginia Registered Dietitians' Knowledge And Attitudes Of Diabetes Care, Marie R. Gravely Jan 2002

West Virginia Registered Dietitians' Knowledge And Attitudes Of Diabetes Care, Marie R. Gravely

Theses, Dissertations and Capstones

This study addresses diabetes knowledge and attitudes of West Virginia dietitians as they relate to Medicare certified provider guidelines. A questionnaire was developed using the Diabetes Attitude Scale, questions from A CORE Curriculum for Diabetes Education, and demographic questions addressing length and type of practice, route to registration, and specialty credentials. Responses were analyzed to determine overall knowledge and attitude as well as how demographic information affects knowledge and attitude. Results indicated demographic information (except for specialty credentials and hours working with diabetes) did not have a significant effect on the dietitian’s diabetes knowledge and attitude. Specialty credentials did have …

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Phylogenetic Structure Of Two Central Mexican Centruroides Species Complexes, William Ian Towler Jan 2002

Phylogenetic Structure Of Two Central Mexican Centruroides Species Complexes, William Ian Towler

Theses, Dissertations and Capstones

Central Mexico is home to numerous species of highly toxic Centruroides scorpions. Two species complexes C. infamatus, (C.L. Koch, 1844), and C. limpidus (Karsch, 1879) typify the complex relationships that exist between and within the complexes. Their existing taxonomic status is based on morphological features such as coloration and morphosculpture. A complete and modern study of these scorpions does not exist, and is needed. In an attempt to clarify the status and relationship between these complexes we initiated a molecular based approach applying mitochondrial gene markers (16S and CO1). This study confirms two divergent clades within C. infamatus; divergence rate …

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Comparisons In Morphology, Reproductive Status, And Feeding Ecology Of Plethodon Cinereus At High And Low Elevations In West Virginia, Mizuki Takahashi Jan 2002

Comparisons In Morphology, Reproductive Status, And Feeding Ecology Of Plethodon Cinereus At High And Low Elevations In West Virginia, Mizuki Takahashi

Theses, Dissertations and Capstones

To develop effects of elevation on morphological features, reproductive status, and feeding ecology of Plethodon cinereus in West Virginia, overall comparisons between high (>4000 ft) and low (<1260 ft) elevation populations were made. Adult P. cinereus from high elevations were smaller in SVL (female: p=0.003, male: p<0.001), but stored larger amounts of fat (female: p=0.041, male: p=0.006) in their tails than fromlow elevations. Larger amounts of tail fat could be an adaptation to harsh environments at high elevations. It was determined that in West Virginia, where as females at low elevations oviposit annually, females at high elevations oviposit biennially. Stomach content analysis revealed that salamanders at high elevations were confronted by food shortage. Because of less prey availability and longer winters at high elevations, salamanders at high elevations attained the smaller body size than at low elevations and could not obtain sufficient energy in 1 year to yolk a clutch.

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The California Psychological Inventory As An Assessment Method Of Behavioral Change In First-Time Expectant Fathers, Michaela R. Jellen-Tennant Jan 2002

The California Psychological Inventory As An Assessment Method Of Behavioral Change In First-Time Expectant Fathers, Michaela R. Jellen-Tennant

Theses, Dissertations and Capstones

Thirty-four randomly recruited first-time expectant fathers, ages 24 years to 38 years were individually administered the California Psychological Inventory (CPI) during the first and third trimester of their wife’s pregnancy. The purpose of this study is to assess whether there are attitudinal, behavioral, and personality changes that occur in an expectant father over the course of his wife’s pregnancy. It was hypothesized that the California Psychological Inventory (CPI), which is designed to measure interpersonal behavioral attitudes, behavioral patterns, and personality traits, was able to detect that change. The results suggested that no significant change occurred in the expectant father’s attitude, …

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Attachment And Memory : Does Attachment Experience Influence Eyewitness Testimony?, Fani Lougklou Jan 2002

Attachment And Memory : Does Attachment Experience Influence Eyewitness Testimony?, Fani Lougklou

Theses, Dissertations and Capstones

In an effort to examine the relationship between internal working models of attachment (Bowlby, 1969) and eyewitness testimony for child abuse (Lindberg, Kieffer, & Thomas, 2000), college students first watched a video of a mother hitting her son on the head and knocking him to the floor. After this, they filled out the Attachment and Personality Dynamics Questionnaire (APDQ) (Lindberg & Thomas, 1998). Finally, they were tested about details in the video, their memories for inferences about the characters, and their memories for the gist. They were also given several questions about their personal experiences with the type of discipline …

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A Mechanistic Study Of Myoglobin Nephrotoxicity, Jennifer L. Minigh Jan 2002

A Mechanistic Study Of Myoglobin Nephrotoxicity, Jennifer L. Minigh

Theses, Dissertations and Capstones

Myoglobin is an endogenous protein that can become nephrotoxic under certain conditions such as crush injuries, drug overdose, and seizures where prolonged contraction of muscle leads to cell death and leakage of myoglobin. The mechanism of myoglobin-induced nephrotoxicity is not fully understood. The purpose of this study was to characterize the sequence and mechanistic events associated with the in vitro toxicity of myoglobin in renal cortical slices. Renal tissue was isolated from Fischer 344 rats. Slices of renal cortex were prepared by freehand. These slices were then incubated for 60-180 minutes with myoglobin (0-12 mg/mL) pretreated with 4 mM ascorbic …

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Pkcα Translocation And Actin Remodeling In Contracting A7r5 Smooth Muscle Cells, Chenwei Li Jan 2002

Pkcα Translocation And Actin Remodeling In Contracting A7r5 Smooth Muscle Cells, Chenwei Li

Theses, Dissertations and Capstones

Recent research indicates that protein kinase C (PKC) plays an important role in smooth muscle contraction. Because PKC activation and specificity of substrate phosphorylation is believed to be associated with the relocalization of the enzyme to specific cell sites, we first investigated the subcellular translocation of PKCα in A7r5 smooth muscle cells by confocal microscopy through use of standard immunohistologic staining and PKCα - enhanced green fluorescent protein (PKCα -EGFP) fusion protein expression. PKCα was diffusely distributed throughout the cytosol in the unstimulated A7r5 cell. Upon stimulation with phorbol 12, 13 dibutyrate (PDBu), PKCα was translocated primarily to either the …

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Characterization Of Host-Bacteria Interactions Contributing To Group B Streptococcus Colonization, Jennifer Marie Smith Jan 2002

Characterization Of Host-Bacteria Interactions Contributing To Group B Streptococcus Colonization, Jennifer Marie Smith

Theses, Dissertations and Capstones

Group B streptococcus (GBS) is the leading cause of life-threatening bacterial infections during the first three months of life. GBS is also a frequent cause of maternal postpartum infections. Both types of infections stem from maternal vaginal and/or rectal colonization with GBS in the perinatal period. Limited information is available concerning how the colonization process occurs and what role the host immune system may play in the establishment of persistent colonization by GBS. The complex interactions between the immune system and GBS normally should end in clearance of the bacteria. However, since colonization by GBS occurs in a large number …

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Non-Physical Abuse Behavioral Changes In First Time Expectant Fathers, Sheila Tarr-Stiglich Jan 2002

Non-Physical Abuse Behavioral Changes In First Time Expectant Fathers, Sheila Tarr-Stiglich

Theses, Dissertations and Capstones

The nine months of a pregnancy produce monumental physical and psychological changes in the pregnant woman. Past research has indicated that intimate partner abuse can occur during this time. The objective of the current study was to determine if a change in non-physical abusive behavior occurred in men as they experienced the first pregnancy of the wives, and if so, could it be measured by a particular instrument. Thirty-three men were given the Non-Physical Abuse of Partner Scale, along with a battery of other instruments throughout the course of the pregnancy, in attempt to measure change. Results indicated no significant …

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Diets Of Bats In West Virginia, Theresa Sydney Burke Jan 2002

Diets Of Bats In West Virginia, Theresa Sydney Burke

Theses, Dissertations and Capstones

Little work has been conducted concerning feeding ecology of bats, and only 2 studies have been done in West Virginia. West Virginia is a prime location for the study of bats because 12 species are reported in the state. To increase knowledge of food habits of bats inhabiting West Virginia, fecal samples of 7 species were examined: Virginia Big-eared Bat (Corynorhinus townsendii virginianus), Rafinesquii’s Big-eared Bat (Corynorhinus rafinesquii), Big Brown Bat (Eptesicus fuscus), Red Bat (Lasiurus borealis), Little Brown Myotis (Myotis lucifugus), Northern Myotis (Myotis septentrionalis), and Eastern Pipistrelle (Pipistrellus subflavus). Collections of samples were made in the eastern mountainous …

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Molecular Systematics Of Rhinichthys Bowersi And Its Taxonomic Status, Gilbert Wesley Gladwell Ii Jan 2002

Molecular Systematics Of Rhinichthys Bowersi And Its Taxonomic Status, Gilbert Wesley Gladwell Ii

Theses, Dissertations and Capstones

Rhinichthys bowersi is a cyprinid fish that is found mostly in tributaries of the Monongahela River. Several investigators have examined the morphology, protein polymorphism, and parasite/host relationships of R. bowersi and concluded that it is a valid species of introgressive hybrid origin while others have examined the same data and concluded that it is an F1 hybrid of R. cataractae and Nocomis micropogon. In this study, mitochondrial DNA was amplified from the 12s gene of R. bowersi and compared to that of R. cataracta, N. micropogon, and R. atratulus, an outgroup. Mitochondrial DNA differences were analyzed by Neighbor Joining (NJ), …

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Effects Of Excessive Nitrogen Deposition On Foliar Nutrient Dynamics, Nutrient Concentrations, And Nutrient Ratios In A Central Appalachian Hardwood Forest, Sarah Beth Burdette Jan 2002

Effects Of Excessive Nitrogen Deposition On Foliar Nutrient Dynamics, Nutrient Concentrations, And Nutrient Ratios In A Central Appalachian Hardwood Forest, Sarah Beth Burdette

Theses, Dissertations and Capstones

Many forested systems of the eastern US are becoming significantly nitrogen (N) saturated due to chronic N deposition from the atmosphere. Nitrogen saturation has the potential to alter important internal plant processes, such as nutrient cycling. While extensive research has been conducted on the responses of soil to N saturation, considerably less research has focused on the response of plant nutrient dynamics, nutrient concentrations, and nutrient ratios to excess N. Research was conducted on two watersheds at the Fernow Experimental Forest in West Virginia: WS3 (fertilized with ammonium sulfate annually since 1989) and WS7 (untreated control). Presenescent and senesced leaves …

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The Natural History And Possible Extirpation Of Blanchard's Cricket Frog, Acris Crepitans Blanchardi, In West Virginia, Nancy J. Dickson Jan 2002

The Natural History And Possible Extirpation Of Blanchard's Cricket Frog, Acris Crepitans Blanchardi, In West Virginia, Nancy J. Dickson

Theses, Dissertations and Capstones

Blanchard’s Cricket Frogs, Acris crepitans blanchardi, historically occurred in Clay, Mason, Putnam, and Wayne counties of West Virginia. It has been since 1948 that a specimen was collected from these counties or any other in this state. The first objective of this study was to gather natural history information on A. c. blanchardi based on a population in Lawrence County, Ohio. The second objective of this study was to determine if A. c. blanchardi has been extirpated from West Virginia. The third objective was to determine differences between historical, potential, and current population sites based on vegetation sampling, predators, water …

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Actin And Myosin Remodeling In The A7r5 Smooth Muscle Cell, Michael E. Fultz Jan 2002

Actin And Myosin Remodeling In The A7r5 Smooth Muscle Cell, Michael E. Fultz

Theses, Dissertations and Capstones

Active remodeling of the cytoskeleton has been proposed to contribute to the low energy cost and maintenance of the sustained contraction in smooth muscle. Using confocal microscopy and standard immunohistochemical techniques, direct observation of actin remodeling was studied in the contracting A7r5 cell in response to the diacylglycerol (DAG) analog phorbol 12, 13 dibutyrate (PDBu). -actin was shown to exist in the resting cell as parallel stress cables that extend across the cell. Stimulation by PDBu resulted in a sustained contraction that occurred in approximately eighty-five percent of the A7r5 cells. The initial contraction was not uniform, but primarily occurred …

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Effects Of Developmental Activities On Streamside Salamander Communities In Boone County, West Virginia, Mindy S. Hamilton Jan 2002

Effects Of Developmental Activities On Streamside Salamander Communities In Boone County, West Virginia, Mindy S. Hamilton

Theses, Dissertations and Capstones

A study was conducted from May 1998 through June 1999 in three streams associated with mountaintop mining and valley fills in Boone County, West Virginia. Streamside salamander communities were monitored in these streams, as well as in two relatively undisturbed reference streams in the region, using refugia bags, rock-on-rock methodology, and day surveys. The relative abundance of salamanders was compared between the streams in order to detect effects of the associated valley fills to downstream biota. Relative abundance was lower in two of three streams associated with valley fills as compared to the reference streams. However, there was no significant …

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Symbolism And Ritual As Used By The National Socialists, Stephanie M. Holcomb Jan 2002

Symbolism And Ritual As Used By The National Socialists, Stephanie M. Holcomb

Theses, Dissertations and Capstones

Utilizing symbolism and ritual, the most important factors leading to the rise of National Socialism in Germany are examined. The thesis delineates the general history of Germany up to the rise of Hitler and reviews several major historical works on the Nazi’s rise. It also examines the theoretical literature on symbolism and ritual before analyzing the Nazi’s use of symbolism and ritual in their ascension to and maintenance of power.

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Detecting A Male's Attitudinal Change During The Course Of A Partner's Pregnancy Using The Index Of Marital Satisfaction, Melanie Ann Hummel Jan 2002

Detecting A Male's Attitudinal Change During The Course Of A Partner's Pregnancy Using The Index Of Marital Satisfaction, Melanie Ann Hummel

Theses, Dissertations and Capstones

Thirty-one married men who were expecting their first child were tested in the first, second, and third trimesters of pregnancy with the Index of Marital Satisfaction to see if the subjects experienced a significant drop in marital satisfaction during the course of pregnancy. Previous research has shown that couples’ marital satisfaction significantly declines after the birth of a baby, but little research has explored the male’s attitudinal change during the pregnancy itself. The current study found that there was no significant change in the subjects’ marital satisfaction from early to late pregnancy. A larger study with a sample more representative …

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Gravistimulation Of Pisum Sativum And Expression Of The Cell Membrane Expansin Proteins, Sherrine A. Ibrahim Jan 2002

Gravistimulation Of Pisum Sativum And Expression Of The Cell Membrane Expansin Proteins, Sherrine A. Ibrahim

Theses, Dissertations and Capstones

This thesis research investigates the regulation of gene expression in pea stems (Pisum sativum) after changes in orientation to gravity (gravistimulation). Specifically, this project examines the changes in extracellular soluble proteins due to gravistimulation in pea seedlings. This change in gravity alters the cellular growth pattern, which can be directly linked to enzymatic activity resulting in the expression of cell wall loosening proteins called expansins. This loosening of the cell wall matrix subsequently increases elasticity in growing cells, thus leading to an upward curvature of the stems. These changes in enzymatic activity and gene expression are crucial for …

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