Digital Commons Network^™

Srebp-1 Integrates The Actions Of Thyroid Hormone, Insulin, Camp, And Medium-Chain Fatty Acids On Accalpha Transcription In Hepatocytes, Yanqiao Zhang, Liya Yin, F Bradley Hillgartner

Faculty & Staff Scholarship

In chick embryo hepatocytes, activation of acetyl-CoA carboxylase-α (ACCα) transcription by 3,5,3′-triiodothyronine (T3) is mediated by a cis-acting regulatory unit (−101 to −71 bp) that binds the nuclear T3 receptor (TR) and sterol regulatory element-binding protein-1 (SREBP-1). SREBP-1 directly interacts with TR on the ACCα gene to enhance T3-induced transcription. Here, we show that treating hepatocytes with T3 or insulin stimulates a 4-fold increase in the concentration of the mature, active form of SREBP-1. When T3 and insulin are added together, a 7-fold increase in the mature SREBP-1 concentration is observed. Time course studies indicate that the T3-induced increase in …

Acute Myeloid Leukemia In Children In Pakistan: An Audit, S. Zaki, I. A. Burney, Mohammad Khurshid

Section of Haematology/Oncology

Objective: To see the clinical features and treatment of children with Acute Myeloid Leukemia (AML) in Pakistan. Setting: Tertiary referral at a specialist Hematology/Oncology center.
Methods: Retrospective, chart-based review of children (less than 14 years) admitted to the hospital with a diagnosis of AML between January 1987 and August 1997.
Results: A total of 23 patients were admitted. There were 18 males and 5 females. The mean age was 8 5 years. M3 was the commonest morphological subtype (43%). Twenty- two percent of the patients presented with hyperleucocytosis (TLC> 100 x i09 /L) and 95% with an elevated …

Toward A Women-Centred Approach To Infant Feeding Research, Lynne Callaghan

School of Psychology Theses

This thesis aimed to provide an integrated model of infant feeding, centred on women's experiences. Two studies were employed in order to meet this aim. Firstly, a questionnaire-based longitudinal study within a Social Cognitive framework was carried out in order to understand the internal and external processes involved in the infant feeding experience. Eighty-five first time mothers participated in this study. Participants were assessed at three stages; once during pregnancy, once at six to eight, and again at four to six moths postpartum. The results of the longitudinal study supported the use of the Social Cognitive framework, and more specifically …

Myeloperoxidase Produces Nitrating Oxidants In Vivo, Joseph P. Gaut, Jaeman Byun, Hung D. Tran, Wendy M. Lauber, James A. Carroll, Richard S. Hotchkiss, Abderrazzaq Belaaouaj, Jay W. Heinecke

Open Access Publications

No abstract provided.

Feminist Issues And Concerns In The Fictions Of Two Egyptian Women Writers: Alifa Rifaat And Nawal El-Saadawi, Shafiqa Anwar Fakir

Dissertations and Theses @ UNI

This thesis involves an examination of feminist issues and concerns in the fictions of two contemporary Egyptian women writers: Alifa Rifaat and Nawal el-Saadawi. The main focus will be on illuminating the social, sexual, economical problems that the literary female characters encounter and how they deal with these various forms of oppressions. Examination of these author's lives and works illustrates the complexity of women within the boundaries of the same nation in matters of gender justice and equality. This further, implicitly, illustrates the complexity of Arab women who tend to be viewed as a cohesive whole.

Community Knowledge, Attitude And Practices Regarding Sexually Transmitted Infections In A Rural District Of Pakistan, H A. Afsar, M A. Mahmood, N Barney, S Ali, M M. Kadir, M Bilgrami

Community Health Sciences

Objective: To determine knowledge, attitude and practices regarding sexually transmitted infections in district Khairpur, Sindh, Pakistan.DESIGN AND METHODOLOGY: A needs assessment study employing a community based survey, key informant interviews and focus group discussions was conducted in all seven sub-districts of the district. This paper is based on the results of the key informant interviews and the focus group discussions. Thirty interviews and six group discussions were held with members of the community and with the health care providers.Results: There was little awareness regarding causes and prevention of sexually transmitted infections in the community. The situation was slightly better among …

Factors Associated With Elevated Blood Lead Concentrations In Children In Karachi, Pakistan, Mohammad Hossein Rahbar, Franklin White, Mubina Agboatwalla, Siroos Hozhabri, Stephen Luby

Community Health Sciences

Objectives: To confirm whether blood lead concentrations in Karachi were as high as reported in 1989 and to identify which types of exposure to lead contribute most to elevated blood lead concentrations in children in Karachi.
Methods: A total of 430 children aged 36-60 months were selected through a geographically stratified design from the city centre, two suburbs, a rural community and an island situated within the harbour at Karachi. Blood samples were collected from children and a pretested questionnaire was administered to assess the effect of various types of exposure. Cooked food, drinking-water and house dust samples were collected …

The Social Welfare Of Advertising To Children, Dennis D. Crouch

Faculty Publications

The aim of this Comment is to approach the issue of advertising to children through an examination of economic incentives and efficiency. The Comment ultimately makes the claim that televised advertisement of products, such as junk food, directed toward children may be inefficient and tend to decrease social welfare. Although they may be compelling, this paper does not rely on the secondary negative externalities often associated with television, such as the cost of treating diabetes and heart disease. Rather, the inefficiency discussed in the Comment involves the informational qualities of advertising. Advertising directed towards young children can be thought of …

Sf 550 Healing And The Christian Faith, Donald E. Demaray

Syllabi

1. Donald E. Demaray, Experiencing Healing and Wholeness: A Journey in Faith. 2. Jennifer I. Woodruff, Experiencing Healing and Wholeness: A Journey in Faith study guide. 3. Bernie S. Siegel, Love, Medicine and Miracles. 4. Donald E. Demaray, Laughter, Joy and Healing. 5. Custom Course Packet which includes, Watch Out for Burnout, materials from John Wesley's writings on healing and pastoral care of the sick, and Scriptures on healing.

Evaluation Of Persistent Organic Pollutant Levels And Effects In Alaskan Natives, Marie Lenore Socha

All ETDs from UAB

Alaskan Native women may be at an increased risk of exposure to persistent organic pollutants (POPs) because they eat a subsistence diet that contains elevated levels of these chemicals. Research suggests that these chemicals may be capable of acting like estrogens, and thus could increase a woman's risk of developing breast cancer. The objectives of this research were to (1) determine overall body burdens of POPs in Alaskan Natives and compare these to results from the Second National Health and Nutrition Examination Survey (NHANES II); (2) determine if geographical location within Alaska correlates with a woman's body burden of POPS; …

The Influence Of Counseling And Education On Behavior And Pregnancy Outcome In African American Medicaid -Eligible Women, Crystal Bridget Brown Spivey

All ETDs from UAB

Objectives . The study sought to determine whether report of preventive health counseling and education influenced behavior and pregnancy outcome. Methods . This study involved the use of secondary data conducted prospectively on a group of high-risk, African American, Medicaid-eligible pregnant women served by public clinics in Birmingham, Alabama, between 1994 and 1996. One group of women participated in the Mother and Family Specialty Center program, which offered augmented prenatal care services, and the other group received the usual services offered by the health department clinics. The data were taken from interviews conducted with the women and from the women's …

Characteristics And Birth Outcomes: Women Receiving No Prenatal Care In The United States, 1995–1997, Cathy R. Taylor

All ETDs from UAB

Although prenatal care is an established mechanism for identifying and managing risk factors impacting pregnancy outcomes, about 70,000 women in the United States receive no prenatal care annually. It was hypothesized that women who receive no care comprise clusters (subgroups) with distinctive sociodemographic characteristics and that differences in birth outcomes exist among the clusters. A population-based, non-experimental, retrospective design, and secondary data were used to identify White, Black, and Hispanic ( n = 126,220) women delivering a live, singleton infant and reporting no prenatal care between 1995 and 1997. Cluster analysis was used to cluster (group) no care women with …

Heterogeneity Of Cytokine Mrna Expression In Activated T Cells., Laurel J. Karr

All ETDs from UAB

No abstract provided.

Investigation Of Lipid-Related Components In Sub-Retinal Pigment Epithelial Deposits Of Normal And Age-Related Maculopathy Eyes., Goldis Malek

All ETDs from UAB

No abstract provided.

Improving Chronic Disease Health Status And Utilization., Lloyd Adam Taylor

All ETDs from UAB

No abstract provided.

Biomechanics Of Periodontal Ligament Specific To Clinical Orthodontics., Stephanie Rose Toms

All ETDs from UAB

No abstract provided.

Community Dynamics And Diversity Of Ground Dwelling Arthropods Assemblages In A Maize Based Agroforestry System In Mtwapa, Coastal Kenya, Esther Kamunya

All Master’s Theses

The effect of diversification and intensification in agro ecosystems to arthropod diversity is not well understood, mainly because conservationists have greatly ignored agroecosystems, while most of the research work has been for a long time, directed towards the so called undisturbed systems like the natural forests. This study was intended to contribute towards evaluating relationships in agroecosystems and to assess the impacts of various cropping systems on the diversity and dynamics of soil dwelling arthropods. During the first phase of this study, Pitfall trapping was conducted every two weeks in all the plots from June 1999 to February 2000 and …

Accumulation Of Lead In The Gill, Liver, Kidney And Brain Tissues Of Tilapia Zilli, Sahi̇re Karataş, Mustafa Kalay

Turkish Journal of Veterinary & Animal Sciences

In this study, the accumulation of lead in various tissues of Tilapia zilli was tested at varying concentrations of lead in the medium for different exposure times. Experimental animals were exposed to 1.0, 2.5 and 5.0 ppm lead over periods of 1, 7, 15 and 30 days and accumulation of lead in gill, liver, kidney and brain tissues was determined by atomic absorbtion spectrophotometry (AAS). In general, the accumulation of lead in tissues increased with increasing concentrations of lead in the experimental medium and with increasing time of experiment. The ratios of total lead in the tissues were 15.47, 6.10, …

Comparison Of Muscle Fatty Acids Of Three Trout Species (Salvelinus Alpinus, Salmo Trutta Fario, Oncorhynchus Mykiss) Raised Under The Same Conditions, H. İbrahi̇m Hali̇loğlu, N. Mevlüt Aras, Hasan Yeti̇m

Turkish Journal of Veterinary & Animal Sciences

During recent decades, the study of fatty acids (FAs) belonging to the n-3 family in seafood has intensified due to their beneficial effect on cardiovascular disease. This study was undertaken to determine the FA composition of muscle lipids of three different farm raised trouts (Salvelinus alpinus, Salmo trutta fario and Oncorhynchus mykiss) fed the same diet and raised under the same conditions. Palmitic acid (16:0) in total saturated fatty acid (SFA) and oleic acid (18:1 n-9) in monounsaturated fatty acid (MUFA) were the most abundant FAs and significant differences (P < 0.05) were observed between fish species. The differences in total SFA among the trouts were significant (P < 0.01), and O. mykiss had the highest (31.92%) SFA content while S. trutta fario showed the lowest in their edible muscle tissue. However, there was a significantly (P < 0.01) opposite observation for MUFA among the trouts, in which S. trutta fario had the highest content (41.90%) of MUFA in their muscle tissue while O. mykiss had the lowest (30.81%). The differences for the polyunsaturated fatty acid (PUFA) content among the species were not significant (P > 0.05). O. mykiss had the highest n-3 PUFA (22.41%) while …

The Role Of Nf-Kb Activation In Hepatic Tumor Promotion By Polycholorinated Biphenyls (Pcbs), Zijing Lu

University of Kentucky Doctoral Dissertations

Polychlorinated biphenyls (PCBs) are nongenotoxic hepatic tumor promoters. PCBs have been shown to cause oxidative stress, but the exact mechanism by which PCBs exert their tumor promoting activity is not clear. In our study, PCB-153, a non-coplanar congener, caused a transient increase in hepatic NF-B DNA binding activity and cell proliferation, while PCB-77, a coplanar congener, showed no effect. Our second study using a mouse model that was deficient in the p50 subunit of NF-kB (p50-/-) showed that NF-kB contributes to the changes in hepatocyte proliferation and apoptosis in response to PCB-153 treatment: a single dose of PCB-153 increased hepatic …

The Global Digital Divide: Focusing On Children, Susanna Frederick Fischer

Scholarly Articles

This article addresses the global aspect of the digital divide in two ways. First, I will focus primarily on the issue of school-aged children's access to information and communications technologies (ICT) globally. My focus is on children for the simple reason that children embody the future. Second, I will limit my assessment of this issue to a comparison of children's access to ICT in six countries around the world. Located on five continents, these six countries range from highly developed OECD countries to lesser developed countries. They are the United States, the United Kingdom, France, Australia, Mongolia, and Tanzania.

In Situ Monitoring And Biogeochemical Cycling Of Nutrients In Estuarine Waters, Paulo Cesar Ferreira Da Costa Gardolinski

School of Geography, Earth and Environmental Sciences Theses

This thesis describes the use of in situ and laboratory techniques for monitoring nitrate, phosphate and master variables in the environment. Chapter One presents a general overview of nutrients, how they are essential for aquatic biota, their general characteristics and the importance of their behaviour in estuaries. Commonly used analytical methods for nutrient determinations in natural waters are also evaluated. Chapter Two reports the use of chemometrics to determine trends in historical time-series physicochemical datasets {e.g. nitrate+nitrite, phosphate, river flow, precipitation, suspended solids, water temperature and chlorophyll a) from the Tamar catchment, UK. The results provided useful information about correlations …

The Development And Study Of Chelating Substrates For The Separation Of Metal Ions In Complex Sample Matrices, James Cowan

School of Geography, Earth and Environmental Sciences Theses

The fabrication and study of high performance chelating substrates for the separation of trace metals using a single column under both isocratic and gradient elutions were investigated. Neutral polystyrene based resins from a variety of manufacturers including a hypercrosslinked resin (MN 200) were functionalised via impregnation with chelating dyestuffs or dynamically modified with small, low molecular weight organic molecules by physical adsorption and chemisorption processes respectively. Improvements in the impregnation of substrates were developed, based upon ultrasonic agitation, along with improvements in the detection of metal ions by the use of a noise reduction system, eluent clean-up procedures and large …

The Influence Of Extracts Of Ascophvllum Nodosum On Plant And Soil-Borne Pathogen Interactions, Felisberta Maria Jesus Cunha

Other Faculty of Science and Engineering Theses

This thesis presents an investigation into the responses to extracts of Ascophyllum nodosum (Maxicrop seaweed extracts - MSE) of two different plants species - wheat and strawberry, and their interactions with two soil-borne pathogens, Gaeumannomyces graminis and Phytophthora fragariae respectively, under various environmental conditions. The responses to MSE using hydroponic, glasshouse and field experiments showed that levels of Take-all infection in wheat were reduced by some of the treatments applied. Repeat experiments showed that consistency of results was poor but a positive trend for disease suppression followed MSE treatments. Studies of strawberry infection by Phytophthora fragariae revealed a significantly reduced …

Behavioral And Reproductive Aspects Of Captive Maxwell's Duiker (Cephalophus Mawellii) Husbandry, Janet Mcneill Mackinnon

College of Graduate Studies: Theses & Dissertations (1964–2006)

Female Maxwell's duikers (Cephalophus maxwellii) were studied at the Wildlife Survival Center on St. Catherine's Island, Georgia. The objectives were to quantify the effects of housing on activity budgets and progesterone cycling. Four animals were studied across two housing situations: housed individually versus housed in a grouped setting. Behavioral observations revealed no significant change in access to resources, rumination, or repetitive behaviors, once animals were housed together. Fecal samples were collected in order to determine levels of progesterone through radioimmunoassay (RIA). Fluctuations in progesterone levels revealed no clear estrous cycles. Animals showed less variability in progesterone levels and …

Affluence, Technology, And Well-Being, Indur M. Goklany

Case Western Reserve Law Review

No abstract provided.

Patterns Of Phamaceutical Advertising To Physicians: An Exploratory Content Analysis Of Printed Pharmaceutical Ads Targeted To Pediatricians, Paul Tebbey

Theses

A content analysis of pharmaceutical product ads targeted toward pediatricians in the professional media was conducted to determine the extent to which they were informative as well as the quantity and types of information presented. The content analysis model selected was based on previously published and widely implemented standards that have been documented to support research propositions. The study analyzed 67 separate products ads that were published in pediatrician-targeted journals during the first half of 2002. The results indicate that each pharmaceutical product ad contains an abundance of information (average = 5.1 cues) that may help in educating and Morming …

Gvsu Undergraduate And Graduate Catalog, 2002-2003, Grand Valley State University

Course Catalogs, 1963 - Current

Grand Valley State University 2002-2003 undergraduate and/or graduate course catalog published annually to provide students with information and guidance for enrollment.

Agency Rules With The Force Of Law: The Original Convention, Thomas W. Merrill, Kathryn Tongue Watts

Articles

The Supreme Court recently held in United States v. Mead Corp. that agency interpretations should receive Chevron deference only when Congress has delegated power to the agency to make rules with the force of law and the agency has rendered its interpretation in the exercise of that power.

The first step of this inquiry is difficult to apply to interpretations adopted through rulemaking, because often rulemaking grants authorize the agency to make "such rules and regulations as are necessary to carry out the provisions of this chapter" or words to that effect, without specifying whether "rules and regulations" encompasses …

Evaluation Of Native Isolates Of Basillus Thuringiensis And Metarhizium Anisopliae For The Control Of Plutella Xylostella (L.) (Lepidoptera: Plutellidae), Kahuro Thumbi

All Master’s Theses

Twelve isolates of b, thuringiensis and three of m anisopliae were isolated from the soil and cadavers obtained from diverse geographical regions of kenya. Pathogenicity of fifteen isolates of bithuringiensis and fourteen of m anisopliae to p. Xylostella was determined in the laboratory. Mortality caused by b. Thuringiensis to the first instar larvae varied between 6 and 100%. Five isolates caused mortality of 100 % in the first day after inoculation. Lethal time for the most virulent isolate was 0.5 days and 8.3 days for the less virulent. There were also differences in the pathogenicity of isolates of m anisopliae …