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2001

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Estates & Trusts: 2001 Survey Of Florida Law, Eloisa Rodriguez-Dod Jan 2001

Estates & Trusts: 2001 Survey Of Florida Law, Eloisa Rodriguez-Dod

Faculty Publications

This article discusses relevant changes in Florida probate and trust statutes and regulations through mid-2001, updating a prior survey published in 1998. The article highlights and summarizes, some aspects of the elective share provisions and other legislative changes to the Florida Probate Code and Trust Administration Statutes. Amendments to the Florida Probate Rules are also highlighted. Lastly, the article highlights some significant cases decided during mid-2001 that affected this area of the law.

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Good Science, Bad Law: A Multiple Balancing Approach To Adjudication, Allison Morse Jan 2001

Good Science, Bad Law: A Multiple Balancing Approach To Adjudication, Allison Morse

South Dakota Law Review

No abstract provided.

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Poetry And The Practice Of Law, Tim Nolan Jan 2001

Poetry And The Practice Of Law, Tim Nolan

South Dakota Law Review

No abstract provided.

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Difficulties Associated With The Study Of Action Potential After-Potentials In Rat Cultured Sensory Neurones, Ahmet Ayar, Roderick H. Scott Jan 2001

Difficulties Associated With The Study Of Action Potential After-Potentials In Rat Cultured Sensory Neurones, Ahmet Ayar, Roderick H. Scott

Turkish Journal of Medical Sciences

We investigated the properties of action potential after-potentials in cultured dorsal root ganglion neurones from neonatal rats using the whole cell patch clamp technique. The aims of this study were to characterize after-potentials and investigate the possible influences of Ca^{2+}-induced Ca^{2+}release (CICR) on neuronal excitability. The reversal potentials of action potential after-depolarizations and after-hyperpolarizations were estimated. Although evidence for both Ca^{2+}-activated chloride and potassium conductances was obtained, the data indicated that the after-potentials were contaminatied by a variety of distinct ionic events. Apamin was used to attenuate potassium conductances and appeared to enhance the after-depolarizations due to Ca^{2+}-activated chloride conductances. …

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Sandwich-Type Enzyme Immunoassay For Amyloid A4 Protein In Cerebrospinal Fluid From Patients With Head Trauma, İbrahi̇m Pi̇ri̇m Jan 2001

Sandwich-Type Enzyme Immunoassay For Amyloid A4 Protein In Cerebrospinal Fluid From Patients With Head Trauma, İbrahi̇m Pi̇ri̇m

Turkish Journal of Medical Sciences

The aim of this study was to design a simple method for detecting the amyloid A4 protein in the cerebrospinal fluid (CSF) of patients who had severe brain trauma caused by traffic or other accidents and to evaluate its diagnostic and prognostic value. For this purpose, a sandwich type ELISA assay was used. A4, a 4kDa protein of 39-43 amino acids, is a metabolic product of a membrane-spanning, 695-770 aa, precursor molecule, the b-amyloid precursor protein (b-APP). The polyclonal rabbit antibody against synthetic A4 protein (1-40 residues) was used as an immobilized antibody. A mouse monoclonal antibody against synthetic A4 …

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Effects Of The Use Of Hypochlorite As A Cleaning Substance On Pulmonary Functions, Rezan Demi̇ralay Jan 2001

Effects Of The Use Of Hypochlorite As A Cleaning Substance On Pulmonary Functions, Rezan Demi̇ralay

Turkish Journal of Medical Sciences

This study was carried out to investigate the effects of a low hypochlorite concentration as a cleaning substance on pulmonary functions. For this purpose, 23 cleaning workers from the Faculty of Medicine of Suleyman Demirel University were selected as the study group and 14 people from technical personnel as the control group. The study group consisted of 17 females and 6 males with a mean age of 26.4±5.6 years and the mean duration of exposure to the substance in question was 10.3±10.7 months without any atopy history. The control group consisted of 12 females and 2 males with a mean …

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A Cadaveric Study Of The Anatomic Variations Of The Brachial Plexus Nerves In The Axillar Region And Arm, Z. Asli Aktan, Lokman Öztürk, Okan Bi̇lge, Mehmet Asim Özer, Yelda Atamaz Pinar Jan 2001

A Cadaveric Study Of The Anatomic Variations Of The Brachial Plexus Nerves In The Axillar Region And Arm, Z. Asli Aktan, Lokman Öztürk, Okan Bi̇lge, Mehmet Asim Özer, Yelda Atamaz Pinar

Turkish Journal of Medical Sciences

Forty-eight upper limbs were dissected in order to study the courses and relations of the brachial plexus nerves in the axilla. Connections between the musculocutaneous and median nerves were found in five arms. There was a suprascapular nerve arising from the union of C4 and C5 directly in one cadaver. A branch from the median nerve extending to the brachial artery was determined. In one of the cadavers the radial nerve arose only from the union of posterior divisions of the inferior and middle trunks.

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Comparison By Magnetic Magnetic Resonance Imaging Of The Effects Of Two Different Non-Steroidal Anti-Inflammatory Drugs On Edema Following The Surgical Extraction Of Impacted Third Molars, Mehmet Yaltirik, C. Korhan Oral, Okhan Oral, Çeti̇n Kasapoğlu, Vedat Çebi̇ Jan 2001

Comparison By Magnetic Magnetic Resonance Imaging Of The Effects Of Two Different Non-Steroidal Anti-Inflammatory Drugs On Edema Following The Surgical Extraction Of Impacted Third Molars, Mehmet Yaltirik, C. Korhan Oral, Okhan Oral, Çeti̇n Kasapoğlu, Vedat Çebi̇

Turkish Journal of Medical Sciences

Non-steroidal anti-inflammatory drugs are continuously being developed for use as therapeutic agents for inflammatory diseases. The NSAI agents are commonly used in the control of pain by their effects on suppressing the inflammatory reaction. Pain and edema are universal complications following the surgical extraction of impacted third molars. Felden (piroxicam) and Tilcotil (felden) were used in this study for comparing the antiinflammatory effects of two different chemical agents on the control of pain and inflammation following the surgical extraction of bilaterally impacted mesio-angullary positioned lower third molars. A total of 10 patients aged from 20 to 24 attending our clinic …

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Distribution Of Some Extracellular Matrix Proteins And Ultrastructural Findings In Sural Nerve Biopsy In Demyelinating Disease, Egemen İdi̇man, Göksemi̇n Demi̇r, Ü. Ali̇ Kayişli, İ. Ş. Şengün, Necdet Demi̇r, Ramazan Demi̇r Jan 2001

Distribution Of Some Extracellular Matrix Proteins And Ultrastructural Findings In Sural Nerve Biopsy In Demyelinating Disease, Egemen İdi̇man, Göksemi̇n Demi̇r, Ü. Ali̇ Kayişli, İ. Ş. Şengün, Necdet Demi̇r, Ramazan Demi̇r

Turkish Journal of Medical Sciences

The involvement of both the peripheral nervous system (PNS) and central nervous system (CNS) in multiple sclerosis is a seldom encountered combination in neurology clinics. In this report, immunohistochemical and ultrastructural techniques were used to analyse the disease course of a patient exhibiting involvement of both systems. In 1980, a 44-year-old man was admitted to our clinic with progressive weakness and decreased sensation of the right lower extremity, and sensory abnormality exhibiting stocking distribution. In electromyolography (EMG), demyelinating sensory motor polyneuropathy was determined. Ten years later, he was admitted again due to progression of weakness in the four extremities. Pyramidal …

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The Effects Of Benzo(A) Pyrene Doxorubicin And Paclitaxel On P170 Glycoprotein, Di̇dem Turgut Coşan, Ayşe Başaran Jan 2001

The Effects Of Benzo(A) Pyrene Doxorubicin And Paclitaxel On P170 Glycoprotein, Di̇dem Turgut Coşan, Ayşe Başaran

Turkish Journal of Medical Sciences

B(a)P is a mutagenic, carcinogenic and teratogenic substance. Paclitaxel and doxorubicin are antineoplastic drugs widely used in cancer treatment. The purpose of this study is to observe the effects of doxorubicin and paclitaxel on p170 glycoprotein in rat liver and kidney tissue after administration of B(a)P. As is well known, p170 glycoprotein is an indicator of drug resistance. We hypothesized that a combination of these antineoplastic drugs would cause lower p170 levels and thus would have a stronger effect than single drug administration. For confirmation, a combination of drugs was used to prevent the development of drug resistance. In this …

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Protective Effects Of Vitamin E Selenium And Allopurinol Against Stress-Induced Ulcer Formation In Rats, Nai̇me Canoruç, Ramazan Çi̇çek, Aytaç Atamer, Mehmet Dursun, Cengi̇z Turgut, Ensari̇ Güneli̇, Fi̇kri̇ Canoruç Jan 2001

Protective Effects Of Vitamin E Selenium And Allopurinol Against Stress-Induced Ulcer Formation In Rats, Nai̇me Canoruç, Ramazan Çi̇çek, Aytaç Atamer, Mehmet Dursun, Cengi̇z Turgut, Ensari̇ Güneli̇, Fi̇kri̇ Canoruç

Turkish Journal of Medical Sciences

This study was carried out in the Health Research Center (DÜSAM) laboratory of Dicle University. Vitamin E, Selenium and Allopurinol were given to counteract gastric damage caused by stress in rats. In the study 64 male Sprague dawley rats were used. They were divided into 8 groups, and protective agents were applied at different doses for 8 weeks. Then, performing cold-restraint stress stomach tissues were taken out and investigated macroscopically to determine mucosal damage. Lipid peroxidation levels in the stomach specimens were determined by identifying Malondialdehyde (MDA) levels by the thiobarbituric acid method. These agents have shown protective effects against …

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Apolipoprotein-E Genotyping In Patients With Coronary Heart Disease, İbrahi̇m Pi̇ri̇m, Muhammet Fevzi̇ Polat, Ersi̇n Akarsu, Yaşar Nuri̇ Şahi̇n, Engi̇n Bozkurt Jan 2001

Apolipoprotein-E Genotyping In Patients With Coronary Heart Disease, İbrahi̇m Pi̇ri̇m, Muhammet Fevzi̇ Polat, Ersi̇n Akarsu, Yaşar Nuri̇ Şahi̇n, Engi̇n Bozkurt

Turkish Journal of Medical Sciences

The aim of the study was to establish apolipoprotein E genotype in the patients with coronary heart disease (CHD) who are inhabitants of the north-east of Turkey. The study involved 106 patients (70 male, 36 female; ages ranging from 37 to 69 years) who are local people and were angiocardiographically diagnosed for CHD. The risk factors such as smoking, alcohol and obesity were determined and serum triglyceride, total cholesterol, LDL and HDL were measured in the subjects. Each patient sample was apolipoprotein E genotyped, which was achieved by PCR amplification of the 227 bp region followed by Cfo I digestion …

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The Effects Of Tooth Extraction On Cortical Thickness And Bone Mineral Density Of The Mandible: Evaluation With Computerized Tomography, Pinar Polat, Gözlem Ceylan, Selami̇ Suma, Nuran Yanikoğlu Jan 2001

The Effects Of Tooth Extraction On Cortical Thickness And Bone Mineral Density Of The Mandible: Evaluation With Computerized Tomography, Pinar Polat, Gözlem Ceylan, Selami̇ Suma, Nuran Yanikoğlu

Turkish Journal of Medical Sciences

The cortical thickness of the mandible (CTM) and its bone mineral density may be affected by tooth extraction. There is little knowledge of how the number of teeth in the mandible affect the cortical thickness and bone mineral density of the mandible in 2 different parts. The purpose of this study was to demonstrate whether there is any relationship between the number of teeth extracted and the cortical thickness and bone mineral density of the mandible. A total of 64 cases were evaluated in this study. The patients were divided into four groups. Group 1 consisted of 24 patients who …

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Fine Structural Demonstration Of Anionic Sites On Streptococcal And Staphylococcal Envelopes By Cationic Dyes, Yosun Mater, Sabi̇re Karaçali Jan 2001

Fine Structural Demonstration Of Anionic Sites On Streptococcal And Staphylococcal Envelopes By Cationic Dyes, Yosun Mater, Sabi̇re Karaçali

Turkish Journal of Medical Sciences

Anionic sites on bacterial envelopes of Streptococcus \beta-haemolyticus and Staphylococcus aureus ATCC 6538 P were investigated on materials fixed with Karnovsky fixative containing the cationic dyes ruthenium red (RR) or alcian blue (AB). Electron dense granules and short fibrils were found to be irregularly distributed around the cells on the glycocalyces of both genera. An electron dense stained reaction with RR or AB on the cell membrane and glycocalyx indicates the presence of rich anionic sites on these structures. Electron microscopic observations demonstrate that anionic sites in the glycocalyx are responsible for the adherence phenomenon during the formation of microcolonies. …

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Investigation Of Some Immune System Parameters And Gfap Immunoreactivity In Convulsive And Non-Convulsive Seizures In Rats, Ni̇lüfer Esen, Yeşi̇m Gürbüz, Deni̇z Şahi̇n, Nurbay Ateş Jan 2001

Investigation Of Some Immune System Parameters And Gfap Immunoreactivity In Convulsive And Non-Convulsive Seizures In Rats, Ni̇lüfer Esen, Yeşi̇m Gürbüz, Deni̇z Şahi̇n, Nurbay Ateş

Turkish Journal of Medical Sciences

The aim of this study was to investigate the systemic humoral and cell-mediated immune system parameters, and glial fibrillary acidic protein (GFAP) immunoreactivity in non-convulsive absence epilepsy and pentylenetetrazole (PTZ)- induced generalized tonic-clonic seizures. Animals were divided into three groups: i. the control group, ii. the genetic absence epilepsy WAG/Rij group, and iii. the chronic generalized tonic-clonic convulsion group injected with PTZ. After the experimental procedure, blood samples were collected intracardially, and CD3+ (T cells), CD4+ (T helper), CD8+ (T cytotoxic), CD19+ (B cells) and CD25+ (IL-2 reseptor, active T cell) cell ratios were determined by indirect immunoflourescence in FACScan, …

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Optimization Of Fluorometric Measurement Of Free And Total Carnitine In Serum, Muhi̇tti̇n A. Serdar, İsmai̇l Kurt, İnci̇ Bayraktar, Levent Kenar, Fati̇h Özçeli̇k, İbrahi̇m Onur, Türker Kutluay Jan 2001

Optimization Of Fluorometric Measurement Of Free And Total Carnitine In Serum, Muhi̇tti̇n A. Serdar, İsmai̇l Kurt, İnci̇ Bayraktar, Levent Kenar, Fati̇h Özçeli̇k, İbrahi̇m Onur, Türker Kutluay

Turkish Journal of Medical Sciences

Carnitine is a major molecule which plays a great role in the transfer of long chain fatty acids into the mitochondrion. Measurement of its total and free forms is essential in the clinical evaluation of carnitine deficiency that can arise from disorders either primarily or secondarily. In this study, different deproteinization methods (precipitation with perchloric acid, heat denaturation of freeze thawing and filtration) were evaluated for the optimization of fluorometric measurement of total and free carnitine in serum. The most appropriate method for the carnitine measurement was established by additional studies of deacylation at different temperatures, pH optimization of the …

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Fractal Scaling Of Heart Rate Variability In Young Habitual Smokers, Ferhan Esen, Fatma Yalçin Özbebi̇t, Hamza Esen Jan 2001

Fractal Scaling Of Heart Rate Variability In Young Habitual Smokers, Ferhan Esen, Fatma Yalçin Özbebi̇t, Hamza Esen

Turkish Journal of Medical Sciences

The effect of cigarette smoking on the fractal organisation of the heartbeat regulating system was investigated by power spectral analysis. The heart rate variability (HRV) signal was obtained from the consecutive RR intervals of ECG. Power law behaviour of 1/f\beta type was studied to assess the fractal organisation of the heartbeat. Changes in the ratio of low frequency (PLF) to high frequency power (PHF) were used to assess the state of sympathovagal balance. The following statistical procedures were employed, as appropriate: Student's t-test for unpaired samples to compare mean values and paired t-test to compare changes within groups, and linear …

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Antioxidant Status, Lipid Peroxidation Products And Cystatin C As Potential Clinical Markers Of Alzheimer's Disease In Systemic Circulation, Ayşegül Akbay Yarpuzlu, Çi̇ğdem Aydemi̇r, Selda Demi̇rtaş, Engi̇n Turan Tuncer, Orhan Canpolat, Yasemi̇n Genç Jan 2001

Antioxidant Status, Lipid Peroxidation Products And Cystatin C As Potential Clinical Markers Of Alzheimer's Disease In Systemic Circulation, Ayşegül Akbay Yarpuzlu, Çi̇ğdem Aydemi̇r, Selda Demi̇rtaş, Engi̇n Turan Tuncer, Orhan Canpolat, Yasemi̇n Genç

Turkish Journal of Medical Sciences

Growing data suggest oxidative stress contributes to the pathogenesis of Alzheimer's disease (AD). The objective of this study was to assess the value of antioxidant potential (AOP), antioxidant status (AOS) and thiobarbituric acid reactive substances (TBARS) and the cysteine protease inhibitor Cystatin C that plays a role in the processing of amyloid _ as clinical markers of AD in peripheral circulation and to find out the agreement limits of AOP and AOS as clinical laboratory tests. To do this, 21 severely demented patients fitting the DSM-IV diagnostic criteria for Alzheimer's type dementia as well as through minimental state examination were …

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Evaluation Of Temporomandibular Joint Dysfunction By Magnetic Resonanance Imaging, Mehmet Dalkiz, Emre Pakdemi̇rli̇, Bedri̇ Beydemi̇r Jan 2001

Evaluation Of Temporomandibular Joint Dysfunction By Magnetic Resonanance Imaging, Mehmet Dalkiz, Emre Pakdemi̇rli̇, Bedri̇ Beydemi̇r

Turkish Journal of Medical Sciences

Many diagnostic imaging techniques are available to aid clinicians, including transcranial radiography, conventional tomography, computed tomography, arthrography, single photon emission computed tomography (SPECT) imaging and magnetic resonance imaging (MRI). The aim of this study was to evaluate clinical findings and MRI features of temporomandibunlar joint (TMJ) disorders. The clinical histories of 251 patients (502 joints) with MR images were evaluated. Eight clinical variables (articular pain, clicking, locking, limitation of mouth opening, dislocation (luxation), headache (temporal, facial or neck), occlusal disharmony) and imaging findings "Normal, Anterior Disk Displacement With Reduction (ADDR), Anterior Disk Displacement Without Reduction (ADDWR) Anterior Disk Displacement With …

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Evaluation Of Non-Fatal Injuries With Relation To Where Assaults Occur, Yasemi̇n Günay Balci, Songül Acar Vai̇zoğlu, Çağatay Güler Jan 2001

Evaluation Of Non-Fatal Injuries With Relation To Where Assaults Occur, Yasemi̇n Günay Balci, Songül Acar Vai̇zoğlu, Çağatay Güler

Turkish Journal of Medical Sciences

The aim of the present study was to determine where injuries due to violence mostly occur and to find differences (if present) among where the assaults places in 334 patients who sustained injuries due to reasons other than accidents, randomly selected from the medical records and files of those referred to the Department of Traumatology of the Council of Forensic Medicine between 1 January and 31 December 1998 in İstanbul. The majority of both the injured (82.9%) and the accused (96.3%) were males. The distribution of places where assaults occurred in the order of frequency was as follows; workplaces (37.4%), …

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Comparative Lid Flora In Anterior Blepharitis, Destan Ni̇l Kulaçoğlu, Ahmet Özbek, Hakan Uslu, Fi̇kretti̇n Şahi̇n, Gülay Güllülü, İbrahi̇m Koçer, Yunus Karabela Jan 2001

Comparative Lid Flora In Anterior Blepharitis, Destan Ni̇l Kulaçoğlu, Ahmet Özbek, Hakan Uslu, Fi̇kretti̇n Şahi̇n, Gülay Güllülü, İbrahi̇m Koçer, Yunus Karabela

Turkish Journal of Medical Sciences

The microbiologic lid flora evaluations of 117 patients with anterior blepharitis were compared with those of 52 age- and sex-matched healthy controls. The sampled bacterial cultures were identified according to standard conventional techniques and fatty acid profiles by the Microbial Identification System (MIS). Chi-square and difference between two percentage Z tests were used for the statistical analyses. The most commonly isolated organisms were Staphylococcus epidermidis, Staphylococcus aureus, Propionibacterium acnes and mixed skin flora (diphtheroid rods, Neisseria spp. and Streptococcus viridans). The variability of aerobic bacteria between the patients and the control group was found to be statistically significant (P

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Can Cystatin C Be Used As A Marker Of Microalbuminuria?, Hülya Pinarcik, Zekeri̇ya Aktürk, Fulya Akin, Mehmet Akin, Gülperi̇ Pinarcik Jan 2001

Can Cystatin C Be Used As A Marker Of Microalbuminuria?, Hülya Pinarcik, Zekeri̇ya Aktürk, Fulya Akin, Mehmet Akin, Gülperi̇ Pinarcik

Turkish Journal of Medical Sciences

No abstract provided.

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Methods Used In Evaluating Telomerase Activity, Mübeccel Durusoy, Kami̇le Öztürk Jan 2001

Methods Used In Evaluating Telomerase Activity, Mübeccel Durusoy, Kami̇le Öztürk

Turkish Journal of Medical Sciences

No abstract provided.

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Thalamic Hemorrhage (Presentation And Prognosis Of Hemorrhages), Şule Bi̇len, Selçuk Çomoğlu, Yaşar Şahi̇n, Şenay Özbakir Jan 2001

Thalamic Hemorrhage (Presentation And Prognosis Of Hemorrhages), Şule Bi̇len, Selçuk Çomoğlu, Yaşar Şahi̇n, Şenay Özbakir

Turkish Journal of Medical Sciences

The thalamus is one of the most vulnerable areas for intracerebral hemorrhages. In this study, we investigated the parameters of thalamic hemorrhage such as risk factors, initial complaints, neurologic findings and the prognostic effects of the presence or absence of ventricular penetration, as well as the volume and size of hematoma. A total of 57 patients with thalamic hemorrhage, whose diagnosis was confirmed by cranial computerized tomography, were evaluated. The most significant risk factor was hypertension, while the most common initial clinic symptom was incontinence. Those patients who had small hemorrhagic size of low volume and the presence of ventricular …

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The Large Aortopulmonary Window Without Pulmonary Vascular Disease, Yahya Ünlü, Naci̇ Cevi̇z, Bi̇lgehan Erkut, Yusuf Veli̇oğlu, Hi̇kmet Koçak Jan 2001

The Large Aortopulmonary Window Without Pulmonary Vascular Disease, Yahya Ünlü, Naci̇ Cevi̇z, Bi̇lgehan Erkut, Yusuf Veli̇oğlu, Hi̇kmet Koçak

Turkish Journal of Medical Sciences

LÜ^1 Naci CEVİZ^2 Bilgehan ERKUT^1 Yusuf VELİOĞLU^1 Hikmet KOÇAK^1 Departments of ^1Cardiovascular Surgery, ^2Pediatric Cardiology, Faculty of Medicine, Atatürk University, Erzurum - TURKEY

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Ocular Toxocariasis With Bilateral Virtually Symmetrical Optic Nerve Head Granulomas, Gülay Güllülü, İlknur Akyol Salman, Ahmet Özbek, Nesli̇han Astam, Akin Levent Jan 2001

Ocular Toxocariasis With Bilateral Virtually Symmetrical Optic Nerve Head Granulomas, Gülay Güllülü, İlknur Akyol Salman, Ahmet Özbek, Nesli̇han Astam, Akin Levent

Turkish Journal of Medical Sciences

LLÜLÜ^1 İlknur AKYOL^1 Ahmet ÖZBEK^2 Neslihan ASTAM^1 Akın LEVENT^3 Departments of ^1Ophthalmology, ^2Microbiology and Clinical Microbiology, ^3Radiology, Faculty of Medicine, Atatürk University, Erzurum - TURKEY

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Primary Malignant Schwannoma Of The Small Bowel: A Case Report, Fahri̇ Yilmaz, Ali̇ Kemal Uzunlar, Yaşar Bükte, Selver Özeki̇nci̇, Yilmaz Akgün Jan 2001

Primary Malignant Schwannoma Of The Small Bowel: A Case Report, Fahri̇ Yilmaz, Ali̇ Kemal Uzunlar, Yaşar Bükte, Selver Özeki̇nci̇, Yilmaz Akgün

Turkish Journal of Medical Sciences

Malignant Schwannoma of the Small Bowel Fahri YILMAZ^1 Ali Kemal UZUNLAR^1 Yaşar BÜKTE^2 Selver ÖZEKİNCİ^1 Yılmaz AKGÜN^3 Departments of ^1Pathology, ^2Radiology, ^3General Surgery Faculty of Medicine, Dicle University, Diyarbakır - TURKEY

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Nitric Oxide I: Advances In The Measurements For Clinical Applications, Ayşe Baysal Jan 2001

Nitric Oxide I: Advances In The Measurements For Clinical Applications, Ayşe Baysal

Turkish Journal of Medical Sciences

Nitric oxide (NO) is a colorless gas with high affinity to ferrous hemoproteins. This simple molecule is a powerful messenger in the body. This study reviews a literature search using keywords and abstracts in English through Medline. Recent advances in the therapeutic uses of inhaled nitric oxide in lung diseases and other pathologic states urges the efficient and convenient use of nitric oxide in hospital practice. In addition, methods of inhaled nitric oxide delivery, chemiluminescence and electrochemical analyzers were reviewed. The performance characteristics of different equipment were compared. The novel methods of nitric oxide measurements that utilize simple and cheaper …

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Purification And Characterization Of Carbonic Anhydrase From Human Erythrocyte Plasma Membrane, Nazan Demi̇r, Yaşar Demi̇r, Fatma Coşkun Jan 2001

Purification And Characterization Of Carbonic Anhydrase From Human Erythrocyte Plasma Membrane, Nazan Demi̇r, Yaşar Demi̇r, Fatma Coşkun

Turkish Journal of Medical Sciences

Carbonic anhydrase is the basic enzyme in inhalation function. Untill now no research had been done to determine whether CA is in the human erythrocyte plasma membrane or not. Carbonic anhydrase (CA) was purified from human erythrocyte plasma membrane and described in this study. For this purpose, the blood samples taken from young human test subjects were hemolyzed, then the membrane fraction was separated, and this fraction was repeatedly washed. The enzyme (CA) was removed from the membrane with buffered TritonX-100 (1%), which was purified with a factor of 119.19 by affinity chromatography. The CA obtained from the erythrocyte membrane …

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Qsars Of Some 5- Or 6-Methyl-2-Substituted Benzoxazoles/Benzimidazoles Against Candida Albicans, Özlem Temi̇z Arpaci Jan 2001

Qsars Of Some 5- Or 6-Methyl-2-Substituted Benzoxazoles/Benzimidazoles Against Candida Albicans, Özlem Temi̇z Arpaci

Turkish Journal of Medical Sciences

QSAR analysis of some 5- or 6-methyl-2-substituted benzoxazoles/ benzimidazoles was studied for the antifungal activity against C. albicans using Hansch analysis. Prediction for the lead optimization in this QSAR analysis was described by the description of various hydrophobic, electronic, steric and structural parameters related to positions R_1, R_2, R_5, R_6, X, Y. The cross-validation method was also applied to the data set in order to prove the predictive power by using the BILIN statistical software. The resulting QSAR revealed that substitution at position Y with the CH_2 group was significant for the improved antifungal activity. Moreover, hydrophobic properties of the …

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