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2001

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The Effects Of Enzyme And Probiotic Supplementation To Diets On Broiler Performance, Mustafa Mi̇di̇lli̇, Şaki̇r Doğan Tuncer Jan 2001

The Effects Of Enzyme And Probiotic Supplementation To Diets On Broiler Performance, Mustafa Mi̇di̇lli̇, Şaki̇r Doğan Tuncer

Turkish Journal of Veterinary & Animal Sciences

This study was carried out to determine the effect of the supplementation of enzyme and probiotic to broiler feeds based on barley and wheat on broiler performance, dressing percentage, the small intestinal length and weight, liver and abdominal fat weights, intestinal viscosity and the percentage of sticky droppings. In this experiment, 600 one - day - old Hubbard broiler chicks were used. This study was performed on four treatment groups, each containing 150 chicks. One of the groups was the control group and the others were the experimental groups. Each treatment group was divided into 6 replicates of 25 chicks. …

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Use Of Sunflower Meal With Enzyme Mixture Substituted For Soybean Meal In Broiler Diets, Fi̇gen Kirkpinar, Hati̇ce Basmacioğlu Jan 2001

Use Of Sunflower Meal With Enzyme Mixture Substituted For Soybean Meal In Broiler Diets, Fi̇gen Kirkpinar, Hati̇ce Basmacioğlu

Turkish Journal of Veterinary & Animal Sciences

The study was carried out to investigate the effects of sunflower meal with an enzyme mixture containing \alpha-amylase, ß-glucanase, cellulase, lipase and protease substituted for soybean meal in broiler diets on performance, intestinal weight, viscosity and pH, as well as the frequency of sticky droppings and abdominal fat. In the trial, a total of 960 one-day-old Avian broiler chicks were used. The trial lasted 6 weeks. A total of 12 experimental diets were supplied ad libitum. Dietary treatments consisted of 15%, 25%, 35% soybean meal, or sunflower meal or sunflower meal with the enzyme mixture (0.05% and 0.10%). Enzyme supplementation …

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Effects Of Copper Sulphate Administration To Pregnant Sheep On Some Mineral Levels In Blood Sera Of Sheep And Lambs, And Birth Weight Of Lambs, İbrahi̇m Çi̇mtay, Teki̇n Şahi̇n, Ali̇ Ölçücü, Gürbüz Aksoy Jan 2001

Effects Of Copper Sulphate Administration To Pregnant Sheep On Some Mineral Levels In Blood Sera Of Sheep And Lambs, And Birth Weight Of Lambs, İbrahi̇m Çi̇mtay, Teki̇n Şahi̇n, Ali̇ Ölçücü, Gürbüz Aksoy

Turkish Journal of Veterinary & Animal Sciences

In this study, copper sulphate was administered during the last period of pregnancy to sheep in the Şanlıurfa region in which enzootic ataxia was encountered in the past. The objectives of this study were to search the effect of copper sulphate administration on some mineral levels (copper, zinc, iron, calcium and magnesium) in blood serum of pregnant sheep and their lambs, and birth weight of lambs. This study was performed on 35 pregnant sheep (control group: 15, experimental group: 20). In the experimental group, copper sulphate (2% solution) was administered orally at sixth and fourth weeks before birth at 2 …

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Survey Of European Foulbrood Disease In Bee Farms Located In Elazığ And The Surrounding Provinces, Hali̇l Şi̇mşek, Canan Özcan Jan 2001

Survey Of European Foulbrood Disease In Bee Farms Located In Elazığ And The Surrounding Provinces, Hali̇l Şi̇mşek, Canan Özcan

Turkish Journal of Veterinary & Animal Sciences

A total of 250 specimens from 110 bee farms located in Elazığ and the surrounding provinces were taken in 1999 and 2000. The specimens were examined for European Foulbrood Disease. Under macroscopic examination clinical symptoms were noted in 12 specimens, and Paenibacillus alvei was isolated and identified from 8 of these specimens. As a result of the antibiotic sensitivity test, the isolate was found sensitive to enrofloxacin, streptomycin and erythromycin 75%, 75%, and 62,5% of the time respectively. In this study, the presence of European Foulbrood Disease was determined in 3.2% of cases in Elazığ and the surrounding provinces.

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Effects Of Copper Sulphate Administration On Body Weight Gain And Some Blood Parameters In Lambs, Teki̇n Şahi̇n, İbrahi̇m Çi̇mtay, Gürbüz Aksoy, Ali̇ Ölçücü Jan 2001

Effects Of Copper Sulphate Administration On Body Weight Gain And Some Blood Parameters In Lambs, Teki̇n Şahi̇n, İbrahi̇m Çi̇mtay, Gürbüz Aksoy, Ali̇ Ölçücü

Turkish Journal of Veterinary & Animal Sciences

The objectives of this study were to determine the effects of copper sulphate administration on body weight gain and some biochemical, haematological parameters in lambs which had serum copper levels at subclinical values. This study was performed on 30 Ivesi male lambs (control group: 12, experimental group: 18), aged with 15-20 days. In the experimental group, 100 mg copper sulphate (1% solution) was administered orally four times (with periods of two weeks). Blood samples were collected on 0, 14, 28, 42, 56th days and body weight of lambs was determined. Copper administration caused significant increases in weight gain, haemoglobin and …

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Vitamin A, Vitamin E And Selenium Levels In Blood And Milk Sera Of Cattle With Foot And Mouth Disease, Serdar Kizil, Ari̇f Altintaş Jan 2001

Vitamin A, Vitamin E And Selenium Levels In Blood And Milk Sera Of Cattle With Foot And Mouth Disease, Serdar Kizil, Ari̇f Altintaş

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to determine \beta-carotene, retinol (Vit A), selenium (Se) and \alpha-tocopherol (Vit E) levels in the sera of blood and milk from cattle with foot and mouth disease (FMD). A total of 120 blood sera and 22 milk sera were used for the analysis. \beta-carotene and Vit A, Se and Vit E levels were determined by spectrophotometer, fluorophotometer and HPLC respectively. Serum samples were obtained from 0-1 and 1-3-year-old cattle bred in public and state farms. Animals were grouped according to their sex, vaccination status and health or infection with FMD. Results of the biochemical …

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The Effect Of Genotype On The Antioxidative Metabolism In Angora Goats, Ulvi̇ Reha Fi̇danci, Fügen Turgay, Seda Zengi̇n, Funda Kargin, Sefa Çeli̇k, Umut Taşdemi̇r Jan 2001

The Effect Of Genotype On The Antioxidative Metabolism In Angora Goats, Ulvi̇ Reha Fi̇danci, Fügen Turgay, Seda Zengi̇n, Funda Kargin, Sefa Çeli̇k, Umut Taşdemi̇r

Turkish Journal of Veterinary & Animal Sciences

In this study, lipid peroxidation, intracellular, membrane and extracellular antioxidant activities in Turkish Angora goats (Genotype I) and American x Turkish crossbred Angora goats (Genotype II) were investigated, in order to show the effects of genotype on the antioxidative metabolism. Plasma malonlydialdehyde (MDA) levels of Angora goats in different genotype were analyzed to show the effects of free radicals. Glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activities in hemolysates of erythrocytes were analyzed as intracellular antioxidants, \beta-carotene in serum as membrane antioxidants and ascorbic acid in plasma, albumin, total bilirubin, glucose, uric acid and ceruloplasmine in serum as …

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Detection Of Antibodies Against Salmonella Enteritidis In Chicken Serum And Egg Yolk With Elisa, Gülay Altay, Hakan Yardimci Jan 2001

Detection Of Antibodies Against Salmonella Enteritidis In Chicken Serum And Egg Yolk With Elisa, Gülay Altay, Hakan Yardimci

Turkish Journal of Veterinary & Animal Sciences

A total of 473 sera from hens of different age groups and different breeds and a total of 430 eggs were collected from 11 breeders and egg producers in the districts of Adapazarı, Afyon, Ankara and Konya. Lipopolysaccharide (LPS), heat-extract (HE) and flagella antigens were tested in the standardizing ELISA technique. Flagella antigen was found useful in the screening of field samples. Of the 48 (10.2%) rapid plate agglutination positive sera, 7 were negative in ELISA. One hundred and seventy-three (36.6%) of the 473 sera and 76 (17.7%) of the 430 egg yolks were found to be positive with ELISA. …

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Photoinactivation Of Buffalo Liver And Kidney Tissue Arginases And Its Kinetic Properties, Necmi̇ Özdemi̇r, Mehtap Özçeli̇k Jan 2001

Photoinactivation Of Buffalo Liver And Kidney Tissue Arginases And Its Kinetic Properties, Necmi̇ Özdemi̇r, Mehtap Özçeli̇k

Turkish Journal of Veterinary & Animal Sciences

Exposure of buffalo liver and kidney tissue arginases to a 150 w light source from a distance of 8-10 cm, in the presence of 0.05mM methylene blue, caused significant inhibition of arginase activity. It was determined that this inhibition occurred differently in liver and kidney tissues. Arginase activity was spectrophotometrically measured using the Thiosemicarbazide diacetyl-monoxime urea (TDMU) method. Following preincubation with MnCl_2, exposure to a 150 w light source and the addition of methylene blue, the activity of arginase was found to be lower than that after preincubation with a 150 w light source and methylene blue and the addition …

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Effects Of Administration Of Fertirelin Acetate And Gentamycin Sulphate After Artificial Insemination On Pregnancy Rate Of Cows, Ati̇lla Yildiz Jan 2001

Effects Of Administration Of Fertirelin Acetate And Gentamycin Sulphate After Artificial Insemination On Pregnancy Rate Of Cows, Ati̇lla Yildiz

Turkish Journal of Veterinary & Animal Sciences

Two studies were conducted to evaluate if Fertirelin acetate (an analogue of GnRH) and Gentamycin sulphate would improve pregnancy rate in healthy cows or in nonpregnant cows although they were inseminated three times or more. The first investigation was carried out in sixty-eight healthy cows. Cows were alloted randomly to one of two treatment groups or one of two control groups when found to be in oestrus. The first treatment group was treated with 100 micrograms of Fertirelin acetate, while the first control grup was given saline (2 ml) intramuscularly immediately after artificial insemination. The second treatment group was treated …

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A Study On Some Production Traits And Egg Quality Characteristics Of Japanese Quail, Ahmet Nazligül, Kenan Türkyilmaz, Hüsnü Erbay Bardakçioğlu Jan 2001

A Study On Some Production Traits And Egg Quality Characteristics Of Japanese Quail, Ahmet Nazligül, Kenan Türkyilmaz, Hüsnü Erbay Bardakçioğlu

Turkish Journal of Veterinary & Animal Sciences

This investigation was carried out to demonstrate some production traits and egg quality characteristics of Japanese quails (Coturnix coturnix japonica). One hundred female quails were used in the study. The experiment was carried out for six months. Egg production, egg weight, feed consumption and some egg quality characteristics were taken into consideration. Egg quality characteristics were measured at 8-24 weeks of age. Average egg production (% HD) at 8, 12, 16, 20 and 24 weeks of age was 20.5, 33.8, 63.7, 73.8 and 72.5 respectively. Average egg weight (g) and daily feed consumption (bird/feed/day) at 8, 16 and 24 weeks …

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The Possibilities Of Using Sugar Beet Pulp Silage Produced By Different Methods In Lamb And Dairy Cow Rations 1 - Obtaining High Quality Sugar Beet Pulp Silage, Suphi̇ Deni̇z, Murat Demi̇rel, Şaki̇r Doğan Tuncer, Oktay Kaplan, Taylan Aksu Jan 2001

The Possibilities Of Using Sugar Beet Pulp Silage Produced By Different Methods In Lamb And Dairy Cow Rations 1 - Obtaining High Quality Sugar Beet Pulp Silage, Suphi̇ Deni̇z, Murat Demi̇rel, Şaki̇r Doğan Tuncer, Oktay Kaplan, Taylan Aksu

Turkish Journal of Veterinary & Animal Sciences

In this study, how to obtain high quality sugar beet pulp silage was investigated. Sugar beet pulp was mixed with wheat straw or grass hay in order to increase the level of dry matter to 20, 25 and 30%, and 5% molasses and different levels of urea were added (0, 1, 1.5 and 2% for wheat straw containing groups; 0, 0.5 and 1% for grass hay containing groups). The mixed materials were stored in containers of one kg for two months. At the end of the incubation period, the containers were opened and the silages were evaluated by measuring the …

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A Critical Evaluation Of Research Techniques In Animal Ecology, Michelle A. Baker Jan 2001

A Critical Evaluation Of Research Techniques In Animal Ecology, Michelle A. Baker

Biology Faculty Publications

No abstract provided.

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High Frequency Of Extra-Pair Paternity In Eastern Kingbirds, D. L. Rowe, M. T. Murphy, R. C. Feischer, Paul G. Wolf Jan 2001

High Frequency Of Extra-Pair Paternity In Eastern Kingbirds, D. L. Rowe, M. T. Murphy, R. C. Feischer, Paul G. Wolf

Biology Faculty Publications

Genetic parentage in the socially monogamous and territorial Eastern Kingbird( Tyrannust tyrannus) was examined in a central New York population by multilocus DNA fingerprinting. Extra-pair young were identified in 60% (12 of 20) of nests. Of the 64 nestlings profiled, 42% were sired by extra-pair males, but no cases of conspecific brood parasitism were detected. These results are markedly different from a previous electrophoretic study of the same species in a Michigan population, which reported 39% of nestlings were unrelated to one (typically the mother, quasiparasitismo)r both (conspecificb roodp arasitism) of the putative parents. In the New York population, extra-pairp …

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Cavemen In Eden? Bernard Shaw And Mark Twain Offer Radical Revisions Of Genesis, Julie A. Sparks Jan 2001

Cavemen In Eden? Bernard Shaw And Mark Twain Offer Radical Revisions Of Genesis, Julie A. Sparks

Faculty Publications, English and Comparative Literature

No abstract provided.

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Patch-Clamp Analysis Of Voltage-Activated And Chemically Activated Currents In The Vomeronasal Organ Of Sternotherus Odoratus (Stinkpot/Musk Turtle), D. A. Fadool, M. Wachowiak, J. H. Brann Jan 2001

Patch-Clamp Analysis Of Voltage-Activated And Chemically Activated Currents In The Vomeronasal Organ Of Sternotherus Odoratus (Stinkpot/Musk Turtle), D. A. Fadool, M. Wachowiak, J. H. Brann

Biology: Faculty Publications and Other Works

The electrophysiological basis of chemical communication in the specialized olfactory division of the vomeronasal (VN) organ is poorly understood. In total, 198 patch-clamp recordings were made from 42 animals (Sternotherus odoratus, the stinkpot/musk turtle) to study the electrically and chemically activated properties of VN neurons. The introduction of tetramethylrhodamine-conjugated dextran into the VN orifice permitted good visualization of the vomeronasal neural epithelium prior to dissociating it into single neurons. Basic electrical properties of the neurons were measured (resting potential, -54.5 +/- 2.7 mV, N=11; input resistance, 6.7 +/- 1.4 G Omega, N=25; capacitance, 4.2 +/- 0.3 pF, N=22; means +/- …

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Y2k, The Apocalypse, And Evangelical Christianity: The Role Of Eschatological Belief In Church Responses, Lisa Graham Mcminn Jan 2001

Y2k, The Apocalypse, And Evangelical Christianity: The Role Of Eschatological Belief In Church Responses, Lisa Graham Mcminn

Faculty Publications - Department of Sociology

Apocalyptic beliefs in Christianity have endured for two thousand years and on occasion have motivated and justified radical and even revolutionary collective action (Boyer 1992). Why apocalyptic visions are part of some Christians' belief system is grounded in their beliefs about the end times, or eschatologies, that shape church cultures and subsequent behaviors. This paper considers cultural aspects of collective action, applying the concept of frames that give events meaning and inspire and legitimize collective behavior to Christian church responses to Y2K as a recent example of an anticipated apocalyptic event. Five interpretive frames linking eschatological ideation with specific collective …

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Ethical Aspects Of Prenatal Genetic Diagnostics, Hille Haker Jan 2001

Ethical Aspects Of Prenatal Genetic Diagnostics, Hille Haker

Theology: Faculty Publications and Other Works

Starting with some basic distinctions, i.e. the distinction between an ethics of human self-fulfilment ,of individual and social values and of virtues on one hand, and an ethics of individual rights, of obligation and of social justice on the other, this paper explores the manifold scenario of the problems of prenatal diagnosis with respect to these different aspects of ethical analysis. This is followed by a normative evaluation of the status of the human embryo, and by an elaboration of different adressees of responsibility in the field of biomedicine and, especially, of prenatal genetic diagnosis. The author comes to the …

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Compassion As A Global Programme For Christianity, Hille Haker Jan 2001

Compassion As A Global Programme For Christianity, Hille Haker

Theology: Faculty Publications and Other Works

No abstract provided.

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Playing “Sherlock Holmes”: Enhancing Students’ Understanding Of Prejudice And Stereotyping, Ellen N. Junn, L. Grier, D. Behrens Jan 2001

Playing “Sherlock Holmes”: Enhancing Students’ Understanding Of Prejudice And Stereotyping, Ellen N. Junn, L. Grier, D. Behrens

Office of the Provost Scholarship

A very simple, innovative classroom exercise designed to heighten students' understanding of stereotyping and prejudice is described. Students' evaluation of the exercise was very positive. Students reported greater awareness and understanding of their own and others’ stereotypes and prejudice and of the negative effects of prejudice, with females more than males reporting enhanced awareness of others’ stereotyping. Students also rated the exercise as very enjoyable. There was a trend among Non-White more than White students to report that the exercise helped show them how to reduce stereotypes and more Non-White than White students offered solutions for reducing prejudice that involved …

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A Universidade Da Companhia De Jesus À Luz Do Carisma Inaciano, Peter-Hans Kolvenbach Jan 2001

A Universidade Da Companhia De Jesus À Luz Do Carisma Inaciano, Peter-Hans Kolvenbach

Ignatian Pedagogy Bibliography

No abstract provided.

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Sustaining Agropastoralism On The Bolivian Altiplano: The Case Of San José Llanga, David Layne Coppock, Corinne Valdivia Jan 2001

Sustaining Agropastoralism On The Bolivian Altiplano: The Case Of San José Llanga, David Layne Coppock, Corinne Valdivia

Utah State University Faculty Monographs

No abstract provided.

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Appraisal And Validation Of Rapid, Integrated Chemical And Biological Assays Of Environmental Quality, Gilberto Fillmann Jan 2001

Appraisal And Validation Of Rapid, Integrated Chemical And Biological Assays Of Environmental Quality, Gilberto Fillmann

School of Geography, Earth and Environmental Sciences Theses

To assess the significance of pollutants released into the environment it is necessary to determine both the extent of contamination and the biological effects they give rise to. This research is based on a tiered system, which commences with conventional analytical chemistry (gas chromatography), followed by the development, evaluation and application of rapid and simple immunochemical techniques and, finally, the integration of chemical and biological markers to assess pollution. GC-ECD/FID/MS have been used to investigate the status of chemical contamination of the Black Sea by organochlorine residues, hydrocarbons and faecal sterols. Useful information is provided and problems with e.g. HCHs …

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Determination Of Co And Mn In Marine Waters Using Flow Injection With Chemiluminescence Detection, Vincenzo Cannizzaro Jan 2001

Determination Of Co And Mn In Marine Waters Using Flow Injection With Chemiluminescence Detection, Vincenzo Cannizzaro

School of Geography, Earth and Environmental Sciences Theses

This thesis describes the design, optimisation and shipboard deployment of a flow injection - chemiluminescence (FI-CL) technique for the determination of cobalt (Co) and manganese (Mn) in seawater. Chapter One presents an overview of the marine environment and the biogeochemistry of Co and Mn. Current analytical methods for the determination of Co and Mn in natural waters are also reviewed. Chapter Two reports reagent clean-up techniques and the synthesis of an 8- hydroxyquinoline resin used for in-line matrix elimination and preconcentration. The resin is also characterised in terms of its chelating ability for the transition metals and the earth alkaline …

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Catchment Scale Monitoring And Modelling Of Phosphorus Using Flow Injection Analysis And An Export Coefficient Model, Grady Scott Hanrahan Jan 2001

Catchment Scale Monitoring And Modelling Of Phosphorus Using Flow Injection Analysis And An Export Coefficient Model, Grady Scott Hanrahan

School of Geography, Earth and Environmental Sciences Theses

Acquiring high quality in situ analytical data with good temporal resolution is required for developing models of phosphorus transport and biogeochemical behaviour. Chapter One describes the behaviour of phosphorus in the aquatic environment, its sources, its role in the eutrophication process and legislation to control its release into aquatic systems. It also summarises analytical techniques for the determination of phosphorus in natural waters. An examination of the hypothesis that the export coefficient modelling approach can be used to predict phosphorus loading in the River Frome catchment, Dorset on an armual and seasonal (monthly) basis is presented in Chapter Two. The …

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Pfiesteria: Review Of The Science And Identification Of Research Gaps. Report For The National Center For Environmental Health, Centers For Disease Control And Prevention, Jonathan Samett, Gary S. Bignami, Robert Feldman, William Hawkins, Jerry Neff, Theodore Smayda Jan 2001

Pfiesteria: Review Of The Science And Identification Of Research Gaps. Report For The National Center For Environmental Health, Centers For Disease Control And Prevention, Jonathan Samett, Gary S. Bignami, Robert Feldman, William Hawkins, Jerry Neff, Theodore Smayda

Graduate School of Oceanography Faculty Publications

In connection with the CDC National Conference on Pfiesteria, a multidisciplinary panel evaluated Pfiesteria-related research. The panel set out what was known and what was not known about adverse effects of the organism on estuarine ecology, fish, and human health; assessed the methods used in Pfiesteria research; and offered suggestions to address data gaps. The panel's expertise covered dinoflagellate ecology; fish pathology and toxicology; laboratory measurement of toxins, epidemiology, and neurology. The panel evaluated peer-reviewed and non-peer-reviewed literature available through June 2000 in a systematic conceptual framework that moved from the source of exposure, through exposure research and dose, …

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Zooplankton Feeding Behavior And Particle Selection In Natural Plankton Assemblages Containing Toxic Alexandrium Spp., Gregory J. Teegarden, Robert G. Campbell, Edward G. Durbin Jan 2001

Zooplankton Feeding Behavior And Particle Selection In Natural Plankton Assemblages Containing Toxic Alexandrium Spp., Gregory J. Teegarden, Robert G. Campbell, Edward G. Durbin

Graduate School of Oceanography Faculty Publications

Laboratory experiments suggest that toxic Alexandrium spp. cells are unpalatable to zooplankton grazers, and that toxic cells should be selectively avoided by zooplankton when feeding in mixtures of different prey species. Such avoidance, if practised in the wild, might contribute to harmful bloom formation by reducing losses of Alexandrium spp. due to grazing. In the spring of 1998 and 1999, during Œred tide¹ outbreaks in the southwestern Gulf of Maine, weekly experiments were performed using field collected natural water samples with ambient phytoplankton and dominant mesozooplankton grazers. The feeding response of Acartia hudsonica, Semibalanus balanoides nauplii, and Calanus finmarchicus …

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Nucleic Acids And Growth Of Calanus Finmarchicus In The Laboratory Under Different Food And Temperature Conditions, Melissa M. Wagner, Robert G. Campbell, Carla A. Boudreau, Edward G. Durbin Jan 2001

Nucleic Acids And Growth Of Calanus Finmarchicus In The Laboratory Under Different Food And Temperature Conditions, Melissa M. Wagner, Robert G. Campbell, Carla A. Boudreau, Edward G. Durbin

Graduate School of Oceanography Faculty Publications

We examined the effects of food concentration and temperature on nucleic acids and protein content of Calanus finmarchicus in order to evaluate the use of RNA as a growth rate index for this species. We measured RNA, DNA, and protein content of copepods reared from egg to adult stage in 5 combinations of food and temperature conditions (25 to 500 µg C l-1, 4 to 12°C). At 8°C, DNA, RNA and protein content and RNA:DNA differed among food treatments during Stages N6 through to adult female. Protein:DNA ratios and RNA:protein ratios were significantly different among food levels for …

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P-Glycoprotein-Associated Anthracycline Resistance In B-Cll: Potential For Cytokine Modulation, Varinia Graciela Munoz-Ritchie Jan 2001

P-Glycoprotein-Associated Anthracycline Resistance In B-Cll: Potential For Cytokine Modulation, Varinia Graciela Munoz-Ritchie

Other Faculty of Health Theses

The phenomenon of multidrug resistance (MDR) in cancer cells is generally associated with P-glycoprotein (P-gp) expression and presents an obstacle to successful chemotherapy. Attempts to overcome P-gp-associated MDR using P-gp modulators, such as verapamil, have been hindered by their intrinsic in vivo toxicity. In 1991, however, Scala et al. demonstrated the alteration of P-gp function by interferon-alpha (IFN-α) in vitro at non-toxic in vivo concentrations, suggesting a basis for the use of IFN-α clinically in patients exhibiting P-gp-associated MDR. Drug resistance in B-CLL has been linked to the phenomenon of MDR, however, publications regarding this have been conflicting. The contrasting …

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Prophylaxis Of Disease Caused By Bacterial Pathogens Of Man, Richard William Titball Jan 2001

Prophylaxis Of Disease Caused By Bacterial Pathogens Of Man, Richard William Titball

Other Faculty of Health Theses

This thesis reports research undertaken which will lead to improved pretreatments and therapies for disease caused by Clostridium perfringens, Francisella tularensis, Yersinia pestis and Burkholderia pseudomallei. C. perfringens is thought to be the most widely distributed bacterial pathogen and is the most important Clostridial species associated with enteric disease in domesticated animals. During warfare C. perfringens has been a significant causes of mortality. Between 1 and 10% of wounded personnel developed gas gangrene during the 1st and 2nd world wars. The ability of the bacterium to cause a range of diseases is due largely to the differential production of toxins. …

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