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A Preclinical Model Of Ionizing Radiation And Tnf-Alpha Gene Therapy For Cancer, Jun Li

Loma Linda University Electronic Theses, Dissertations & Projects

Long term control of high-grade brain tumors is rarely achieved with current therapeutic regimens. This study sought to determine if pretreatment with plasmid DNA expressing Tumor Necrosis Factor-α (TNF-α) could enhance the effect of ionizing radiation in an aggressive, rapidly growing glioma tumor (C6) model. Plasmid DNA is an attractive vector system for delivery of foreign genes into eukaryotic cells due to its advantages including low immunogenicity in vivo, lesser toxicity and relatively low cost. We have constructed a plasmid-based mammalian expression vector (pGL1-TNF) to secrete human TNF-α from cancer cells. Plasmid DNA was successfully transfected into C6 cells …

Family And Child Psychosocial Functioning Of Infant Heart Transplant Recipients, Kimberly R. Freeman

Loma Linda University Electronic Theses, Dissertations & Projects

With the advancement of medical procedures, heart transplantation has become a viable alternative for infants born with congenital or acquired heart disease. Although these children are thought to experience much improvement in their overall physical functioning post-transplantation, the long-term psychological functioning of these children and their families is currently unknown. This study examines the long-term family functioning and psychosocial development of infant heart transplant recipients in comparison to children with congenital heart disease (CHD) and non-clinical control children. Results indicate that infant heart transplant recipients and their families experience fewer overall problems as compared to the CHD group, and more …

Structural Studies Of Recombinant Human Β-Casein Proteins, Yilin Hu

Loma Linda University Electronic Theses, Dissertations & Projects

β-Casein is the major component (~80%) of the human casein system. Interacting with calcium and phosphates through its phosphorylated N-terminus, β-casein participates in the formation of micelles which carry these otherwise insoluble nutrients indispensable for the growth and development of newborns. Human β-casein, or fragments thereof, are also found to have biological effects such as enhancement of calcium absorption. So far, knowledge of micelle formation is limited and structural studies of β-casein, especially its N-terminal portion will provide a better understanding of the structure-function relationship of milk micelles.

To elucidate the role that the N-terminus of the protein plays in …

Effect Of Pollution On Genetic Diversity In The Southern California Bight, Xiao Li Ma

Loma Linda University Electronic Theses, Dissertations & Projects

Two intertidal invertebrate species, M galloprovincialis and Balanus glandula, were collected from seven different bay sites along the Southern California coast to test if environmental contamination is associated with the decrease of genetic diversity at the population level. Collections were made at three relatively pristine "clean" sites and four "impacted" sites which were exposed to heavy industrial or boating activity and which had previously, been identified as having measurable levels of pollution. The "Comet" assay (Single Cell Gel electrophoresis) was performed to measure single-strand DNA breaks in mussels at several of the sites in order to confirm differing impacts …

Phylogeography Of The Night Lizard, Xantusia Henshawi, From Southern California, Robert Edward Lovich

Loma Linda University Electronic Theses, Dissertations & Projects

The granite night lizard, Xantusia henshawi, is a highly specialized crevice dwelling lizard found in the Peninsular Ranges of southern California, United States and northern Baja California, Mexico. Generally, little morphological variation is seen in this species over a variety of habitats throughout its range, from elevations near sea level to approximately 2000 meters, and from Mediterranean habitats near the Pacific coast to arid desert habitat in the Colorado Desert of California. One exception is the variation seen in the subspecies X h. gracilis, which differs from X h. henshawi in morphology, allozymes, ecology, and natural history.

In …

Front Matter, Journal Of Law Reform

University of Michigan Journal of Law Reform

Front matter for Volume 33, Issues 1 and 2 of the University of Michigan Journal of Law Reform.

Financing Plaintiffs' Lawsuits: An Increasingly Popular (And Legal) Business, Susan Lorde Martin

University of Michigan Journal of Law Reform

In the late eighties and early nineties there were a few publicized cases in which the plaintiffs invited investors to finance their litigation in exchange for a share of the awards if the plaintiffs won. This kind of arrangement provides access to the justice system which might otherwise be denied impecunious plaintiffs with meritorious claims. The problem with this kind of arrangement is that it is champerty, which is prohibited in most states. This Article discusses Massachusetts' recent rejection of the champerty prohibition, the expansion of exceptions to the prohibition in this country and others, and the emergence of firms …

Creating A Seamless Transition From Jury Box To Jury Room For More Effective Decision Making, Annie King Phillips

University of Michigan Journal of Law Reform

Why am I writing here? I am not a judge or lawyer, and I may never be. I don't even play one on TV. In searching for an answer to this question, it came to mind that at sometime in everyone's life, there is a need to enter the court system-as a victim, offender, witness, court staff or juror. The interactions among these persons impact the effective administration of justice in our court system. Every two years for the past eighteen years (like the tick of a clock), I am summoned to jury duty at either the District of Columbia …

The Rise And Fall Of Affirmative Action Injury Selection, Avern Cohn, David R. Sherwood

University of Michigan Journal of Law Reform

The U.S. District Court for the Eastern District of Michigan has historically experienced difficulty in achieving jury compositions that truly represented the surrounding community. In response, the Authors share their insight as to how the court instituted a "balancing" program. By reducing the number of white names in the jury wheel, the balancing program successfully incorporated more minorities into the jury system. The Authors further discuss the Sixth Circuit decision, United States v. Ovalle, which marked the end of the balancing program.

The Interplay Of Race And False Claims Of Jury Nullification, Nancy S. Marder

University of Michigan Journal of Law Reform

After the verdicts in the OJ Simpson and Stacey Koon/Laurence Powell cases, many in the press explained the juries' acquittals as instances of jury nullification. However these were unlikely to have been instances of nullification, particularly because the jurors explained that their verdicts were based on reasonable doubt. One motivation for these false claims of jury nullification was the homogeneity of the juries-a largely African-American jury in the case of Simpson and a largely white jury in the case of Koon/Powell. Nullification became the term by which press and public attempted to discredit verdicts rendered by juries they distrusted. A …

The Arizona Jury Reform Permitting Civil Jury Trial Discussions: The Views Of Trial Participants, Judges, And Jurors, Valerie P. Hans, Paula L. Hannaford, G. Thomas Munslerman

University of Michigan Journal of Law Reform

In 1995, the Arizona Supreme Court reformed the jury trial process by allowing civil jurors to discuss the evidence presented during trial prior to their formal deliberations. This Article examines and evaluates the theoretical, legal, and policy issues raised by this reform and presents the early results of afield experiment that tested the impact of trial discussions. Jurors, judges, attorneys, and litigants in civil jury trials in Arizona were questioned regarding their observations, experiences, and reactions during trial as well as what they perceived to be the benefits and drawback of juror discussions. The data revealed that the majority of …

Should The Tax Law Require Current Accrual Of Interest On Derivative Financial Instruments?, David A. Weisbach

Coase-Sandor Institute for Law & Economics Research Paper Series

No abstract provided.

A Numerical Simulation Of A Carbon Black Suspension Cell Via A Time-Reversed, Double Layer Compute Algorithm, Gregg T. Anderson

Theses and Dissertations

A numerical simulation of a carbon black suspension cell is explored which models a laser-induced plasma within a liquid ethanol medium of approximately 1 mm thickness. The simulation model assumes a laser pulse with a pulse width of approximately 9 nsecs propagating in the left-to-right direction striking the front surface of the medium and focusing to a spot within the liquid volume. When the energy density within a given irradiated volume is sufficiently high, it ignites the carbon particles and generates a large number of free electrons, i.e., a plasma. The plasma couples with the in-coming laser energy on a …

An Assessment Of Mentoring Functions And Barriers To Mentoring, Kristopher A. Singer

Theses and Dissertations

A study of 91 Coast Guard junior officers and their mentors established the construct validity for mentoring functions and barriers to mentoring. The Air Force relies on supervisors to provide mentoring to their subordinates. The key predictors of whether junior officers report their supervisors as mentors were similarity between mentor and mentee and the quality of the supervisory relationship in terms of LMX and psychosocial and career development mentoring functions. The results demonstrated evidence for a compensatory theory of mentoring. Multiple mentors do not have a synergistic effect on mentoring relationships. The key predictors of reporting an additional mentor (other …

Electrical And Optical Characterization Of Intrinsic And Ion-Implantation Induced Defects In 6h- And 4h-Sic, Michael B. Scott

Theses and Dissertations

Deep level transient spectroscopy (DLTS), Hall effect, and cathodolummescence (CL) measurements are used to characterize the intrinsic and ion-implantation induced defects in high-temperature (475 and 500 °C) ion-implanted epitaxial n-type 6H- and 4H-SiC, ion-implanted with Cr, Mg, Ar, N, and P atoms. Comparison of room-temperature and high-temperature ion-implanted 6H-SiC:Mg and :Cr indicate the significance of high-temperature ion implantation on the activation of the ion-implanted atoms and damage-recovery of the crystalline lattice. The effects of high-temperature annealing on both damage-recovery and implanted ion activation are detected and analyzed, from 1200 to 1800 °C. Trap parameters of both damage-related and species-related defects …

Reverse Engineering Of Foreign Missiles Via Genetic Algorithm, Jon D. Wollam

Theses and Dissertations

One mission of the National Air Intelligence Center (NAIC) is the reverse engineering of foreign missile weapon systems from incomplete observational data. In the past, intuition and repeated runs of a missile performance model were required to converge to a solution compatible with observed flight characteristics. This approach can be cumbersome and time consuming, as well as being subject to undesirable influences from the analyst's preconceptions and biases. An alternative approach has been created to apply genetic algorithm (GA) techniques to allow automation of the process, wider exploration of the design space, and more optimal solutions matching the observational data. …

Implementation Of Speech Recognition Software For Text Processing: An Exploratory Analysis, Sean P. Abell

Theses and Dissertations

The rationale behind implementing new information technologies is often to gain productivity improvements associated with the substitution of machinery for labor. However, the literature shows little direct evidence of a positive relationship between information technology investment and subsequent productivity benefits. This thesis reports on the examination into the productivity implications of implementing speech recognition software in a text processing environment. More specifically, research was conducted to compare text processing speeds and error rates using speech recognition software versus the keyboard and mouse. Of interest was the time required to input and proofread text processing tasks as well as the number …

Towards A Game Theory Model Of Information Warfare, David A. Burke

Theses and Dissertations

The repeated game of incomplete information model, a subclass of game theory models, was modified to include aspects of information warfare. The repeated game of incomplete information model was first developed to analyze nuclear weapons disarmament negotiations. The central role of information in this model suggested its applicability to IW, which focuses on the defense and acquisition of information. A randomized experimental design was utilized to determine how people behave in a laboratory IW setting and to test the IW game model's basic predictions. The impact of experience and learning on IW performance was also assessed during the experiment. IW …

Network Security Versus Network Connectivity: A Framework For Addressing The Issues Facing The Air Force Medical Community, Franklin E. Cunningham Jr.

Theses and Dissertations

The Air Force has instituted Barrier Reef to protect its networks. The Air Force medical community operates network connections that are incompatible with Barrier Reef. To overcome this problem, OASD(HA) directed the Tri-Service Management Program Office (TIMPO) to develop an architecture that protects all military health systems and allows them to link with all three services and outside partners. This research studied the underlying networking issues and formed a framework based on data from network experts from the Air Force's medical centers and their base network organizations. The findings were compared TIMPO and a composite framework was developed that more …

Effects Of Foreign Object Damage From Small Hard Particles On The High-Cycle Fatigue Life Of Ti-6a1-4v, Joseph L. Hamrick Ii

Theses and Dissertations

Thin rectangular samples of Ti-6Al-4V were damaged by four methods to represent foreign object damage found in turbine engine blades: 1) impact with 2 mm and 5 mm diameter glass spheres at 305 m/s, 2) impact with 2 mm and 4 mm diameter steel spheres at 305 m/s, 3) quasi-static displacement controlled indentation using steel chisels with 1 mm, 2 mm and 5 mm diameter tips and 4) shearing notches with a 2 mm diameter chisel point under a quasi-static loading condition. Finite element analysis was used to study the relationship between the stress state created by the plastic damage …

Impact Of Actual Facilitator Alignment, Co-Location, And Video Intervention On The Efficacy Of Distributed Group Support Systems, Brian J. Heberlie, Mary O. Tolbert

Theses and Dissertations

The growth of distributed group support systems (GSS) suggests that organizations will continue to bring dispersed groups of people together to make decisions over computer networks. In many instances those groups are temporarily assembled to address a task and then summarily disbanded never to work together again. In order for users to effectively use the GSS issues of trust and control need to be addressed within the GSS design. Users have perceptions about the fairness of structural and social determinants of the GSS design. These perceptions influence both the decision making process and process outcomes. This article shows the negative …

Why Didn’T You Tell Me?: Toward Building A Model Of Why Information Is Not Shared Well In Organizations, Robert C. Kitchen

Theses and Dissertations

The effective use of information in an organization is vital to its success. One of the biggest investments being made today by companies is in their information infrastructures. However, with all of the resources being dedicated to improving information flows, evidence shows that organizations still do not share information as widely as they could or should be. Many studies have been conducted to learn the reasons why people in organizations do not share information as well as would be good. However, no study was found that reported the relative frequency of reported reasons for not sharing information. This paper gathers …

Application Of The Interaction Picture To Reactive Scattering In One Dimension, Michael J. Maclachlan

Theses and Dissertations

The interaction picture is used together with the channel-packet method in a new time-dependent approach to compute reactive scattering matrix elements. The channelpacket method enables the use of the interaction picture for computing reactive S-matrix elements by splitting the computational effort into two parts. First, asymptotic reactant and product wavepackets are individually propagated into the interaction region of the potential to form Moller states. The interaction picture, in contrast to the usual Schrödinger picture of quantum mechanics, is so constructed that a wavefunction that experiences no change in potential (that is, a free-particle wavefunction) remains always fixed, with no translation …

An Analysis Of Training Adequacy And Additional Training Requirements As Perceived By Communications And Information Officers, Rex W. Little

Theses and Dissertations

This study explores requirements for additional training Communications and Information officers. This research also looks at the best time to provide training/education in the identified training deficient areas. Training areas and categories were established by two previous theses and were modified by a group of field experts for this research. The following questions were posed in an effort to obtain the perception of officers in the field: (1) What training areas do Communications and information officers feel are deficient? (2) At what point during a Communications and Information officer's career would it be most appropriate to receive training in necessary …

California Vehicle License Fees: Incidence And Equity, Jennifer Dill, Todd Mitchel Goldman, Martin Wachs

Urban Studies and Planning Faculty Publications and Presentations

Most states tax the value of residents' motor vehicles. In recent political debates over the future of these levies, the relative effects of these taxes on different socioeconomic groups have been a prominent question. By linking data from the Nationwide Personal Transportation Survey with estimates of vehicle values from consumer vehicle pricing guides, the socioeconomic and demographic incidence of California's Vehicle License Fee is examined. After the effects of state and federal income tax deductions are taken into account, the fee is found to be as regressive as the state's sales tax.

Service Reliability Impacts Of Computer-Aided Dispatching And Automatic Vehicle Location Technology: A Tri-Met Case Study, James G. Strathman, Kenneth Dueker, Thomas J. Kimpel, Rick Gerhart, Ken Turner, Pete Turner, Steve Callas, David Griffin

Center for Urban Studies Publications and Reports

This paper presents findings on initial changes in service reliability following Tri-Met’s deployment of a new bus dispatching system using automatic vehicle location and automatic passenger counter technology. Changes in on-time performance, headway variation, run time variation, and run times were determined with respect to pre-deployment levels. Changes in headway variation and run times were also used to estimate the initial benefits of the new system with respect to operating costs, passenger waiting, and passenger travel time.

Intermediate Questions Of Religious Exemptions - A Research Agenda With Test Suites, Eugene Volokh

Cardozo Law Review

No abstract provided.

Religious Liberty Protection Act: Impact On Religious Services In Prison, David Schwarz

Cardozo Law Review

No abstract provided.

A Summary Of Highway Revenues, Distributions, & Expenses For Indiana Counties, Cities & Towns 1999, John Habermann

Indiana Local Technical Assistance Program (LTAP) Publications

This report provides information on revenues, distributions, and expenses of state and local governments for highway, road, and street work. Since the Motor Vehicle Highway (MVH) and Local Road and Street (LRS) Accounts are the principal source of funds for local road or street construction and maintenance operations, this summary may be used to see the trends in income sources and in the expenses charged to the funds prior to their being distributed to the highway, road, and street agencies.

Brief Amicus Curiae Of The Society Of Catholic Social Scientists In Support Of Respondent, Stephen M. Krason, Richard W. Garnett

Court Briefs

No. 99-138
Jenifer Troxel v. Tommie Granville

On Writ Of Certiorari To The Supreme Court Of Washington

From the Summary of the Argument

The fundamental rights of parents to direct and control the upbringing of their children and the autonomy of the family have been recognized time and again by this Court. These rights and this autonomy are not creatures of positive law, but are grounded in the natural moral order. The family is the "building block" of civil society and has as its natural end, or telos, the nurturing and development of flourishing human persons and good citizens. …