Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (341678)
- Arts and Humanities (208437)
- Law (197272)
- Education (180707)
- Medicine and Health Sciences (161211)
-
- Physical Sciences and Mathematics (150043)
- Life Sciences (118142)
- Anthropology (98858)
- Archaeological Anthropology (91632)
- Higher Education (82959)
- History (75985)
- Engineering (75325)
- Business (65603)
- Medical Specialties (53681)
- Library and Information Science (49636)
- Religion (46243)
- United States History (37369)
- Sociology (35210)
- Communication (33469)
- Environmental Sciences (32766)
- Computer Sciences (32670)
- Medical Sciences (30680)
- Public Affairs, Public Policy and Public Administration (30064)
- Public Health (28965)
- Economics (28678)
- Earth Sciences (27401)
- Educational Administration and Supervision (26587)
- Music (25164)
- Higher Education Administration (22355)
- Physics (21923)
- Institution
-
- University of Nebraska - Lincoln (110773)
- Kenyon College (94715)
- University of New Hampshire (71768)
- University of Montana (64014)
- University of New Mexico (52624)
-
- Murray State University (47196)
- Brigham Young University Law School (40048)
- Villanova University Charles Widger School of Law (39067)
- Georgia Southern University (36243)
- University of South Florida (35409)
- Eastern Illinois University (33886)
- Western Kentucky University (31331)
- University of Dayton (26852)
- University of Mississippi (26254)
- Yale University (25749)
- Gallaudet University (25437)
- The Texas Medical Center Library (25427)
- Utah State University (24511)
- Western Michigan University (23610)
- University of Kentucky (22713)
- Singapore Management University (22359)
- Washington University School of Medicine (22201)
- University of Alabama at Birmingham (21973)
- City University of New York (CUNY) (21616)
- Purdue University (20638)
- Louisiana State University (18554)
- College of the Holy Cross (18261)
- California Polytechnic State University, San Luis Obispo (18224)
- University of Rhode Island (17630)
- Marquette University (17621)
- Keyword
-
- Press release; media release; press statement; news media information (30839)
- Latin America (30642)
- Spanish (30239)
- Humans (29860)
- University of New Mexico (29682)
-
- UNM (29628)
- LADB (29608)
- LAII (29608)
- Latin American and Iberian Institute (29608)
- Georgia Southern University (18240)
- Hearing impaired (17062)
- Deaf culture (17054)
- Pastoral care of people with disabilities (17051)
- Church work with the deaf -- Catholic Church (17050)
- Deaf -- Periodicals (17043)
- History (15869)
- United States (15858)
- Marriage (14734)
- Female (13849)
- Western Kentucky University (13014)
- Athletics (12387)
- Male (12304)
- Correspondence (11487)
- English (11317)
- Global Financial Crisis (2007-2009) (10522)
- Animals (9988)
- News Releases (9906)
- Education (9476)
- COVID-19 (9323)
- EIU (9304)
- Publication Year
-
- 2026 (38852)
- 2025 (58744)
- 2024 (64553)
- 2023 (67240)
- 2022 (67896)
-
- 2021 (82177)
- 2020 (74280)
- 2019 (70454)
- 2018 (71586)
- 2017 (68116)
- 2016 (69775)
- 2015 (66446)
- 2014 (63577)
- 2013 (60481)
- 2012 (56102)
- 2011 (52774)
- 2010 (52744)
- 2009 (51492)
- 2008 (51566)
- 2007 (41748)
- 2006 (38134)
- 2005 (36041)
- 2004 (38876)
- 2003 (28641)
- 2002 (35563)
- 2001 (27268)
- 2000 (31312)
- 1996 (37917)
- 1992 (31157)
- 1990 (32398)
- Publication
-
- Four Valleys Archive (90475)
- Faculty Publications (45946)
- University of Montana News Releases, 1928, 1956-present (30912)
- Faculty Scholarship (25540)
- Browse All News (21496)
-
- Documents (20016)
- Articles (19851)
- NotiSur (13785)
- Faculty, Staff and Student Publications (13701)
- Hillsborough County Marriage Records (13681)
- University of Mississippi News (13497)
- Obituaries (13305)
- The Murray Ledger & Times (13003)
- Defensive Publications Series (12653)
- University of Montana Course Syllabi (12469)
- Open Access Publications (11657)
- News Releases (11409)
- Legacy Scout Tickets from Pure Oil Company (11044)
- Publications and Research (10757)
- WKU Administration Documents (9922)
- NotiCen (9709)
- Publications (9709)
- Doctoral Dissertations and Projects (8778)
- American Indian and Alaskan Native Documents in the Congressional Serial Set: 1817-1899 (8744)
- Research Collection School Of Computing and Information Systems (8730)
- All Forum Articles (8604)
- Faculty, Staff and Students Publications (8365)
- Utah Supreme Court Briefs (1965 –) (8144)
- Press Releases (7900)
- News and Events (Discontinued Series) (7794)
Articles 8431 - 8460 of 2276720
Full-Text Articles in Entire DC Network
Advancing Data-Driven Health Research From The All Of Us Data Training And Engagement Program, Kristi Sadowski, Debran Tarver, Jennifer Burnette, Allissa Dillman, Regina Renfro, Lafrancis Gibson, Kelli Bursey, Laura Bartlett, Nadine Bonds-Bishop, Lisa Connor, Efraín Flores-Rivera, Sarah Joseph, Yuqi He, Margaret Henderson, Savannah L. Kelley, Maletta Payne, Brett Porter, Kimberly Prosper, Melissa Rethlefsen, For Full Author List, See Comments Below
Advancing Data-Driven Health Research From The All Of Us Data Training And Engagement Program, Kristi Sadowski, Debran Tarver, Jennifer Burnette, Allissa Dillman, Regina Renfro, Lafrancis Gibson, Kelli Bursey, Laura Bartlett, Nadine Bonds-Bishop, Lisa Connor, Efraín Flores-Rivera, Sarah Joseph, Yuqi He, Margaret Henderson, Savannah L. Kelley, Maletta Payne, Brett Porter, Kimberly Prosper, Melissa Rethlefsen, For Full Author List, See Comments Below
Faculty Research, Scholarly, and Creative Activity
Background: Fulfilling a recognized need in data skills training for academic librarians, the National Library of Medicine and the National Institutes of Health All of Us Research Program collaborated to enhance academic library workers’ skills in biomedical and public health data, as well as their library's research capacity, through the awareness and use of the All of Us Researcher Workbench. Case Presentation: The All of Us Data Training and Engagement Program for Academic Libraries (ALP) blended professional development training, hands-on learning, and peer-to-peer networking that focused on increasing knowledge of the All of Us Researcher Workbench. Activities were designed to …
State Engagement In Trump Accounts: A Policy-Design And Implementation Framework, Center For Social Development, Washington University In St. Louis, Pennsylvania Treasury Department
State Engagement In Trump Accounts: A Policy-Design And Implementation Framework, Center For Social Development, Washington University In St. Louis, Pennsylvania Treasury Department
Center for Social Development Research
Trump Accounts are IRAs for American children, with a $1,000 federal seed contribution available for those born from 2025 through 2028. Under the current design, families must take two separate steps to request an account. Children whose families do not complete both steps will receive neither the account nor the federal deposit. They also will be excluded from employer matches, philanthropic contributions, and other general contributions to Trump Accounts. The current opt-in design will leave behind the children who need the program most. States are well positioned to address this gap. This Policy Brief proposes a framework for state engagement …
Mcguire Memorial V. Teamsters Local 261, International Brotherhood Of
Mcguire Memorial V. Teamsters Local 261, International Brotherhood Of
2026 Decisions
USDC for the Western District of Pennsylvania
Bridging Pediatric To Adult Care In Cystinosis: A Scoping Review Of Healthcare Transition Of Care Protocols And A Roadmap For Future Practice., Sanat Subhash, Nicholas Pantelakis, Kyle Backston, Ruhaan Bajpai, Amir Safadi, Brandon Petrovich, Bradley A. Warady, Maria Diaz-Gonzalez De Ferris, Rupesh Raina
Bridging Pediatric To Adult Care In Cystinosis: A Scoping Review Of Healthcare Transition Of Care Protocols And A Roadmap For Future Practice., Sanat Subhash, Nicholas Pantelakis, Kyle Backston, Ruhaan Bajpai, Amir Safadi, Brandon Petrovich, Bradley A. Warady, Maria Diaz-Gonzalez De Ferris, Rupesh Raina
Manuscripts, Articles, Book Chapters and Other Papers
Cystinosis is a rare lysosomal storage disorder that affects approximately 1 in 100,000 to 200,000 live births worldwide. Long-term graft success in cystinosis depends on cysteamine adherence and structured multidisciplinary transition, supported by protocols developed by both pediatric nephrologists and hospital organizations. This review explores institutional and regional care models, structured programs such as the RISE protocol and Got Transition's Six Core Elements, and major barriers including adult nephrology expertise, psychosocial stressors, and insurance coverage gaps. Additionally, we explore the impact of digital health tools for their role in supporting cysteamine adherence and maintaining continuity of care. Emerging technologies such …
Striking A Chord For Southern Music Scholarship, Michael Newsom
Striking A Chord For Southern Music Scholarship, Michael Newsom
University of Mississippi News
OXFORD, Miss. – From the Delta blues to the birth of rock 'n' roll, many of the harmonies that shaped American music were first struck in the South, and a new gift aims to help the University of Mississippi study this rich history in depth.
How To Authenticate An Orcid On Your Experts Profile, Kimberly Holling
How To Authenticate An Orcid On Your Experts Profile, Kimberly Holling
ScholarWorks Publications
This document provides step-by-step instructions for researchers to authenticate their unique ORCID number on the Experts Portal profile. This allows for the two systems to update researcher profiles for either one or both systems, as preferred.
Scientific Advances In Ecology Through The Lens Of Ecological Processes, Jiquan Chen, De Hui Zeng, Guillermo Martínez Pastur, João C. Azevedo, James A. Lutz, Raffaele Lafortezza, Andrew Burton, Et Al.
Scientific Advances In Ecology Through The Lens Of Ecological Processes, Jiquan Chen, De Hui Zeng, Guillermo Martínez Pastur, João C. Azevedo, James A. Lutz, Raffaele Lafortezza, Andrew Burton, Et Al.
Michigan Tech Publications
In this perspective editorial, we analyzed publication trends and author-provided keywords across ten leading ecology journals from 2012 to 2025 to synthesize recent developments in ecological research. We identified six major trends that have shaped the field: (1) the shift from descriptive to mechanistic investigations, (2) the relevance of climate change and ecosystem feedbacks, (3) the growing integration of the human dimension into ecological research, (4) the application of advanced technologies and analytical methods, (5) the increasingly diverse contributions from the global scientific community, and (6) the rise of issue-focused research. Building on this synoptic overview, we discuss emerging frontiers …
Enhancing Resonance Wave–Matter Interaction In Finite-Size Dielectric Metasurfaces, Varsha Vijay Kumar, Elena Semouchkina
Enhancing Resonance Wave–Matter Interaction In Finite-Size Dielectric Metasurfaces, Varsha Vijay Kumar, Elena Semouchkina
Michigan Tech Publications
We investigate the dramatic effects produced by the presence of physical boundaries of finite-size metasurfaces (MSs), composed of identical cylindrical dielectric resonators without broken symmetry, on the complexity of their responses, observed at normal plane wave incidence, when constituent particles can support only dipolar Mie resonances. We demonstrate the possibility to excite extra high-quality resonance modes in these finite structures, which are quite distinct from the modes in infinite structures. We explore the formation of different types of high-quality modes in MS fragments of different configurations and sizes, which makes it possible to provide guidance for configuring their optimal designs. …
A Scoping Review Of The Role, Challenges, And Opportunities Of Academic Librarians In Research Data Management And Open Science In Africa, Aminu Umar Musa, Usman Hassan, Abubakar Mohammed Musa
A Scoping Review Of The Role, Challenges, And Opportunities Of Academic Librarians In Research Data Management And Open Science In Africa, Aminu Umar Musa, Usman Hassan, Abubakar Mohammed Musa
Library Philosophy and Practice (e-journal)
Objective: The increased data density of research has made research data management a critical service within university libraries. This paper provides a scoping analysis of the literature on academic librarians' roles, difficulties, and possibilities in research data management (RDM) and open science (OS) in Africa.
Methods: The review, which followed the Arksey and O'Malley scoping review framework and was presented in accordance with PRISMA-ScR principles, methodically mapped existing evidence from peer-reviewed literature published between 2010 and 2024. Scopus, Web of Science, Library and Information Science Source, and Google Scholar were all used for searches. Following screening and eligibility assessment, 43 …
Oregon State Rank Assessment For Steens Mountain Cushion Buckwheat (Eriogonum Ovalifolium Var. Rubidum), Lindsey K. Wise
Oregon State Rank Assessment For Steens Mountain Cushion Buckwheat (Eriogonum Ovalifolium Var. Rubidum), Lindsey K. Wise
Institute for Natural Resources Publications
Oregon state conservation status assessment for Steens Mountain Cushion Buckwheat (Eriogonum ovalifolium var. rubidum) using NatureServe methodology, 2026.
Investigating The Links Between Parent Math Anxiety, Parenting Behaviors, And Child Math Achievement And Math Anxiety In Middle Childhood, Kimia Akhavein
Investigating The Links Between Parent Math Anxiety, Parenting Behaviors, And Child Math Achievement And Math Anxiety In Middle Childhood, Kimia Akhavein
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Existing research indicates that parents’ math anxiety is a robust predictor of children’s math achievement and math anxiety. The current dissertation study moved the literature forward by examining the transmission of parents’ math anxiety to children’s math achievement and math anxiety via autonomy-supportive and controlling parenting behaviors using an observational coding scheme during a homework help task when children were in second grade. The first research aim examined if parents’ autonomy supportive and controlling behaviors mediated the link between parents’ math anxiety and children’s math achievement and math anxiety one year later. The second research aim examined whether parents’ emotion …
Analysis Of The Fracture Toughness Of Ercual A2 Cladding On Api X70 Using The Instrumented Charpy Impact Test, Martín Aguirre-Pulido, Francisco Fernando Curiel-López, Jose Jaime Taha-Tijerina, Jorge Alejandro Verduzco-Martínez, Víctor Hugo López-Morelos, Heriberto Granados-Becerra, Ariosto Medina-Flores
Analysis Of The Fracture Toughness Of Ercual A2 Cladding On Api X70 Using The Instrumented Charpy Impact Test, Martín Aguirre-Pulido, Francisco Fernando Curiel-López, Jose Jaime Taha-Tijerina, Jorge Alejandro Verduzco-Martínez, Víctor Hugo López-Morelos, Heriberto Granados-Becerra, Ariosto Medina-Flores
Mechanical Engineering Faculty Publications
The degradation of steel used in the oil industry has become a serious problem due to the high costs associated with material loss from corrosion. Applying thin layers of corrosion-resistant material promises to be a viable alternative for extending the service life of pipelines. ERCuAl-A2 electrode claddings were applied to API X70 carbon steel using the MIG brazing process with direct current (DC) and pulsed current (P). The cladding was applied under three conditions: base material (BM) at room temperature, BM preheated to 120 °C, and Ni-buttered BM. Microhardness profiles and Charpy impact tests were performed on the MB and …
Beyond Sticky Floors: Executive Gender Diversity And Firm-Level Gender Pay Inequality In Uk Firms, Yasser Eliwa, Sally Ahmed, Ahmed Saleh
Beyond Sticky Floors: Executive Gender Diversity And Firm-Level Gender Pay Inequality In Uk Firms, Yasser Eliwa, Sally Ahmed, Ahmed Saleh
All Works
This study examines whether executive gender diversity is associated with gender pay inequality in UK firms. Although prior research has extensively examined board diversity, less is known about whether gender diversity within executive leadership teams is linked to differences in pay inequality across firms. Using a panel of FTSE 350 non-financial firms from 2017 to 2023 and mandatory UK gender pay gap disclosures, we estimate regression models to examine the relationship between the proportion of female executives and the gender pay gap. The findings show that greater executive gender diversity is significantly associated with lower gender pay inequality. In contrast, …
Application Of Virtual Reality To Alter Sweetness Perception, Serena Wellbelove, John Gieng, Valerie A. Carr, Kate Mcleod, Xi Feng
Application Of Virtual Reality To Alter Sweetness Perception, Serena Wellbelove, John Gieng, Valerie A. Carr, Kate Mcleod, Xi Feng
Faculty Research, Scholarly, and Creative Activity
Regular consumption of excess sugar is linked to nutrition-based diseases, including gut problems, Non-Alcoholic Fatty Liver Disease, and Type 2 Diabetes Mellitus. Increasing sweetness perception is a novel technique to decrease sugar consumption. This experiment compared the sweetness perception of sweetened and unsweetened almond milk in response to different virtual environments with music and visuals. Two music types, the classical song Goldberg Variations, BMV. 998-Variation 13 and a jazz song generated by AI were used. Additionally, fall and spring forest backgrounds were generated by the Blockade Labs 3D image generator. Each participant tasted sweetened and unsweetened almond milk in music-only, …
Fostering Collaboration Through Learning Communities: A Case Report On Engaging With All Of Us Data Among Library Professionals, Faculty, And Students, Zachary Mcniece, Dawn Hackman, Nick Szydlowski, Yuqi He
Fostering Collaboration Through Learning Communities: A Case Report On Engaging With All Of Us Data Among Library Professionals, Faculty, And Students, Zachary Mcniece, Dawn Hackman, Nick Szydlowski, Yuqi He
Faculty Research, Scholarly, and Creative Activity
Background: Research data services (RDS) have expanded in academic libraries but can be challenging to develop, particularly in teaching-intensive and less-resourced institutions. Learning communities offer a promising model for building skills, fostering collaboration, and aligning services with local needs. Case Presentation: This case report describes the development and implementation of three learning communities—a library group, a faculty group, and a student group—at a teaching-focused institution. These communities brought together library professionals, faculty, and students from diverse disciplines—including health sciences, education, data science, and engineering—to collaboratively explore the All of Us dataset. By working with the same dataset, participants were able …
577 Vanderbilt Llc V. Hassell
All Decisions
Landlord commenced a nonpayment proceeding demanding the legal regulated rent. In 2018, landlord's predecessor-in-interest settled a prior nonpayment proceeding by two-attorney stipulation, granting tenant a preferential rent of $1,750 set to expire August 14, 2024. After HSTPA's enactment on June 14, 2019, RSL §26-511(c)(14) and RSC §2521.2(d) were amended to require that any tenant paying a preferential rent as of HSTPA's effective date be charged no more than that preferential rent for the lifetime of the tenancy. Tenant moved for summary judgment. The court granted the motion, holding that the 2018 stipulation's expiration date became unenforceable after HSTPA, that applying …
Hill Plaza Enters. Ny Llc V. Terris
Hill Plaza Enters. Ny Llc V. Terris
All Decisions
Court granted tenant's motion for a discretionary stay of the proceeding pending appeal under CPLR 5519(c), allowing tenant to challenge a prior decision denying summary judgment on her rent overcharge and fraudulent deregulation counterclaims. Court found minimal prejudice to landlord because the underlying nonpayment petition had already been dismissed, while potential prejudice to tenant from proceeding without resolution of the appeal was manifest.
Expert Opinion: Management Of Intraocular Inflammation And Vasculitis After Intravitreal Pegcetacoplan For Geographic Atrophy, Thomas Albini, Steven Yeh, Carl Regillo, Roy Schwartz, Philip Ferrone, Caroline Baumal, Charles Wykoff
Expert Opinion: Management Of Intraocular Inflammation And Vasculitis After Intravitreal Pegcetacoplan For Geographic Atrophy, Thomas Albini, Steven Yeh, Carl Regillo, Roy Schwartz, Philip Ferrone, Caroline Baumal, Charles Wykoff
Wills Eye Hospital Papers
BACKGROUND AND OBJECTIVE: This expert opinion review is intended to provide guidelines for diagnosis and management of intraocular inflammation (IOI) and vasculitis following pegcetacoplan.
PATIENTS AND METHODS: A case series of all post-marketing reports classified by experts as definite or suspected vasculitis over an 18-month period was assessed.
RESULTS: A total of 306,000 pegcetacoplan intravit real injections were given in the real world between March 1, 2023, and August 31, 2024. Twenty-four eyes from 22 patients (mean age 76 years, 59% female) with definite or suspected vasculitis were evaluated. Comorbidities included hypertension (55%), hypo thyroidism (27%), and recent COVID-19 infection …
Longitudinal Patterns In Stygobiont Distribution In The Hyporheic Zone Of The Karst Spring-Fed San Marcos River, Texas, Usa, Kenneth Sparks, Benjamin F. Schwartz, Safra Altman, Kathryn E. Perez, Zoey B. Chanin, Caroline Mierzejewski, Benjamin T. Hutchins
Longitudinal Patterns In Stygobiont Distribution In The Hyporheic Zone Of The Karst Spring-Fed San Marcos River, Texas, Usa, Kenneth Sparks, Benjamin F. Schwartz, Safra Altman, Kathryn E. Perez, Zoey B. Chanin, Caroline Mierzejewski, Benjamin T. Hutchins
School of Integrative Biological & Chemical Sciences Faculty Publications
Groundwater-obligate taxa (stygobionts) exhibit variable degrees of habitat specialization, ranging from those restricted to single micro-habitats to generalists occurring in a broad range of habitat types. The karstic Edwards Aquifer is the most biodiverse and well-studied groundwater habitat in the continental United States, but some Edwards Aquifer-associated species also occupy the hyporheic zone of rivers downstream from karst. The goals of this research were to 1) assess the potential of the off-karst hyporheic zone as habitat for ‘karst’ species and 2) to determine how stygobiont richness, diversity, and abundance related to distance from karst in the hyporheic zone of a …
Advancing Data-Driven Health Research From The All Of Us Data Training And Engagement Program, Maletta Payne, Kristi Sadowski, Debran Tarver, Jennifer Burnette, Allissa Dillman, Regina Renfro, Lafrancis Gibson, Kelli Bursey, Laura Bartlett, Nadine Bonds-Bishop, Lisa Connor, Efrain Flores-Rivera, Sarah Joseph, Yugi He, Margaret Henderson, Savannah Kelley, Brett Porter, Kimberly Prosper, Melissa Rethlefsen, Deborah Rhue, Dede Rios, Anna Simonson, Jocelyn Swick-Jemison, Linda Todd, Shelby Watson, Semhar Yohannes
Advancing Data-Driven Health Research From The All Of Us Data Training And Engagement Program, Maletta Payne, Kristi Sadowski, Debran Tarver, Jennifer Burnette, Allissa Dillman, Regina Renfro, Lafrancis Gibson, Kelli Bursey, Laura Bartlett, Nadine Bonds-Bishop, Lisa Connor, Efrain Flores-Rivera, Sarah Joseph, Yugi He, Margaret Henderson, Savannah Kelley, Brett Porter, Kimberly Prosper, Melissa Rethlefsen, Deborah Rhue, Dede Rios, Anna Simonson, Jocelyn Swick-Jemison, Linda Todd, Shelby Watson, Semhar Yohannes
Southern University and A&M College: John B. Cade Library Publications
Fulfilling a recognized need in data skills training for academic librarians, the National Library of Medicine and the National Institutes of Health All of Us Research Program collaborated to enhance academic library workers& skills in biomedical and public health data, as well as their library's research capacity, through the awareness and use of the All of Us Researcher Workbench.
Lightning Safety Tips Everyone Should Know, From A Unh Expert, Scott Ripley
Lightning Safety Tips Everyone Should Know, From A Unh Expert, Scott Ripley
UNH Today Archive
No abstract provided.
The Nsf Seafood Engine In New England Wins $15m Award To Strengthen Fisheries And Aquaculture, Tania Deluzuriaga
The Nsf Seafood Engine In New England Wins $15m Award To Strengthen Fisheries And Aquaculture, Tania Deluzuriaga
UNH Today Archive
No abstract provided.
Vamorolone For Duchenne Muscular Dystrophy A Cross-Trial Efficacy Comparison With Classic Corticosteroids From The For-Dmd Trial, Paula R. Clemens, Anders Berglund, Marianela Schiava, Meredith K. James, Michael P. Mcdermott, Katherine Bushby, Erik Lampa, Edward Thomas James Rochford, Leanne M. Ward, Robert C. Griggs, Eric P. Hoffman, Michela Guglieri
Vamorolone For Duchenne Muscular Dystrophy A Cross-Trial Efficacy Comparison With Classic Corticosteroids From The For-Dmd Trial, Paula R. Clemens, Anders Berglund, Marianela Schiava, Meredith K. James, Michael P. Mcdermott, Katherine Bushby, Erik Lampa, Edward Thomas James Rochford, Leanne M. Ward, Robert C. Griggs, Eric P. Hoffman, Michela Guglieri
Pharmacy Faculty Scholarship
Background and Objectives: Vamorolone demonstrated similar efficacy for Duchenne muscular dystrophy (DMD) compared with prednisone in a 24-week exploratory analysis and may reduce key side effects compared with classic corticosteroids. In this study, we compare the efficacy and anthropometric effect of vamorolone 6 mg/kg/d with prednisone 0.75 mg/kg/d and deflazacort 0.9 mg/kg/d in steroid-naïve boys aged 4 to < 7 years using data from 2 trials. Methods: VISION-DMD was a phase 2b, 48-week randomized, double-blind trial assessing vamorolone 2 and 6 mg/kg/d vs placebo and prednisone 0.75 mg/kg/d to 24 weeks. Finding the Optimum Steroid Regimen for DMD (FOR-DMD) was a double-blind, parallel-group randomized trial comparing daily prednisone 0.75 mg/kg/d, daily deflazacort 0.9 mg/kg/d, and intermittent prednisone 0.75 mg/kg (10/10 days on/off). Entropy balancing generated weighted data for mixed model for repeated measures analyses that compared VISION-DMD vamorolone 6 mg/kg/d efficacy and anthropometric outcomes with FOR-DMD prednisone and deflazacort outcomes at 6 and 12 months. Inclusion criteria were boys with genetically confirmed DMD, age 4 to < 7 years, ambulatory, and able to complete a time-to-stand (TTSTAND) assessment in < 10 seconds at baseline. Results: All interventions showed motor improvements relative to baseline at 6 and 12 months. Using the weighted cohorts and at 12 months, vamorolone 6 mg/kg/d (n = 28) had similar changes in TTSTAND velocity, the primary motor endpoint component in both trials, vs daily prednisone (n = 50) or deflazacort (n = 55; mean baseline age 5.42 years all groups), but with CIs overlapping minimal clinically important thresholds of 0.023 rises per second (TTSTAND velocity least squares mean [LSM] difference [95% CI]: vamorolone 6 mg/kg/d vs prednisone 0.75 mg/kg/d, 0.004 rises per second [−0.025 to 0.032] and vs deflazacort 0.9 mg/kg/d, 0.001 rises per second [−0.027 to 0.028]). Body mass index (BMI) Z-scores increased in all groups, greatest with vamorolone (12-month LSM difference [95% CI]: vamorolone vs prednisone 0.57 [0.24–0.90]; vamorolone vs deflazacort 0.29 [0.03–0.56]), whereas growth slowdown occurred in prednisone- and deflazacort-treated boys but not vamorolone (12-month LSM difference in height Z-scores [95% CI]: vamorolone vs prednisone 0.57 [0.24–0.90]; vamorolone vs deflazacort 0.72 [0.53–0.91]). Discussion: Vamorolone demonstrated numerically similar TTSTAND velocity changes to prednisone and deflazacort at 1 year; however, interpretations of differences are limited by 95% CIs crossing minimally important difference thresholds. Further evidence of the growth-protective effect of vamorolone was observed; however, all treatments increased BMI. Vamorolone provides a linear growth-protective classic corticosteroid alternative.
Optimizing Orthopedic Outcomes: Correlation Between Postoperative Disposition Planning And Quality Outcomes In Joint Reconstruction Patients, Mahdi Ali, Teresa Latvis Ma, Bsn, Rn, Carissa Hrichak Mba, Bsn, Rn, Ashleigh Solomon, Hannah Fortune Mha
Optimizing Orthopedic Outcomes: Correlation Between Postoperative Disposition Planning And Quality Outcomes In Joint Reconstruction Patients, Mahdi Ali, Teresa Latvis Ma, Bsn, Rn, Carissa Hrichak Mba, Bsn, Rn, Ashleigh Solomon, Hannah Fortune Mha
Research Scholars
No abstract provided.
Rethinking Vaginal Microbiome Resilience: A Conceptual Multi-Omic Framework, Brittnee Cagle-White, Rob E. Carpenter, Alaina Vincent, Ellen Kominek, Andrew Krouse
Rethinking Vaginal Microbiome Resilience: A Conceptual Multi-Omic Framework, Brittnee Cagle-White, Rob E. Carpenter, Alaina Vincent, Ellen Kominek, Andrew Krouse
Human Resource Development Faculty Publications and Presentations
The vaginal microbiome is often interpreted through static taxonomic patterns. Yet microbial composition alone does not explain why some communities resist perturbation, recover after disruption, or transition toward dysbiosis. This narrative review synthesizes evidence that vaginal microbiome stability is shaped by endocrine phase, epithelial substrate availability, microbial functional capacity, mucosal tone and candidate host modifiers. High-estrogen states, particularly pregnancy, are associated with epithelial maturation, glycogen accumulation, low vaginal pH, and Lactobacillus-dominant communities, whereas postpartum, lactational, menopausal, and other hypoestrogenic states are associated with reduced epithelial support and increased vulnerability to diverse anaerobe-rich configurations. We review the linking of the estrogen–glycogen–Lactobacillus …
Assessing The Role Of Model Complexity In Virtual Clinical Trial Outcomes, Jana L. Gevertz, Joanna R. Wares
Assessing The Role Of Model Complexity In Virtual Clinical Trial Outcomes, Jana L. Gevertz, Joanna R. Wares
Department of Math & Statistics Faculty Publications
Virtual clinical trials (VCTs) hold significant promise for improving the drug development process, yet their predictive reliability depends critically on design decisions that remain poorly understood. This study examines how model complexity influences VCT outcomes, as well as how the choice of prior parameter distributions and virtual patient inclusion criteria affects those outcomes. Using oncolytic virotherapy treatment of murine tumors as a case study, we compared a relative hierarchy of three mathematical models of increasing complexity under different parameter priors (uniform and normal distributions) and two inclusion methods (accept-or-reject and accept-or-perturb). Our results demonstrate that the simplest model produces a …
Illinois Wesleyan Launches New Podcast To Share Campus Stories, Emily Bollinger
Illinois Wesleyan Launches New Podcast To Share Campus Stories, Emily Bollinger
Press Releases 2020-2029
No abstract provided.
Llm-As-A-Judge For Infection Prevention And Control And Antimicrobial Resistance Impact: Comparing Three Main Llms Vs. Human Experts' Assessment, Marcello Di Pumpo, Leonardo Villani, Maria Rosaria Gualano, Danilo Buonsenso, Francesca Raffaelli, Daniele Donà, Patrizia Laurenti, Vittorio Maio, Stefania Boccia, Walter Ricciardi
Llm-As-A-Judge For Infection Prevention And Control And Antimicrobial Resistance Impact: Comparing Three Main Llms Vs. Human Experts' Assessment, Marcello Di Pumpo, Leonardo Villani, Maria Rosaria Gualano, Danilo Buonsenso, Francesca Raffaelli, Daniele Donà, Patrizia Laurenti, Vittorio Maio, Stefania Boccia, Walter Ricciardi
College of Population Health Faculty Papers
BACKGROUND: Large language models (LLMs) are increasingly used to generate health information, yet their reliability as evaluators remains unclear. This study investigated the feasibility of an LLM-as-a-judge methodology in the context of infection prevention and antimicrobial resistance (AMR), comparing automated ratings with human expert benchmarks.
METHODS: We performed a secondary analysis of an expert-annotated dataset of health messages. Three leading LLMs (ChatGPT, Claude, Gemini) independently evaluated the same messages using an adapted DISCERN tool across five domains: information reliability, quality, AMR impact, persuasiveness, and overall score. We utilized descriptive statistics, intra-rater reliability tests, and mixed-effects ordinal regression to analyze divergence …
Combining Menin And Mek Inhibition To Target Poor Prognosis Kmt2a-Rearranged Ras Pathway-Mutant Acute Myeloid Leukemia., Nastassja Scheidegger, Constanze Schneider, Gabriela Alexe, Yi-Cheng Wang, Todd A. Alonzo, Allen Basanthakumar, Wallace A. Bourgeois, Julia Dudkiewicz-Garbicz, Delan Khalid, Lucy A. Merickel, Jennifer A. Perry, Rhonda E. Ries, Silvi Salhotra, Audrey Taillon, Alan S. Gamis, Richard Aplenc, Marian H. Harris, Mark Wunderlich, Scott A. Armstrong, Jessica A. Pollard, Soheil Meshinchi, Yana Pikman, Kimberly Stegmaier
Combining Menin And Mek Inhibition To Target Poor Prognosis Kmt2a-Rearranged Ras Pathway-Mutant Acute Myeloid Leukemia., Nastassja Scheidegger, Constanze Schneider, Gabriela Alexe, Yi-Cheng Wang, Todd A. Alonzo, Allen Basanthakumar, Wallace A. Bourgeois, Julia Dudkiewicz-Garbicz, Delan Khalid, Lucy A. Merickel, Jennifer A. Perry, Rhonda E. Ries, Silvi Salhotra, Audrey Taillon, Alan S. Gamis, Richard Aplenc, Marian H. Harris, Mark Wunderlich, Scott A. Armstrong, Jessica A. Pollard, Soheil Meshinchi, Yana Pikman, Kimberly Stegmaier
Manuscripts, Articles, Book Chapters and Other Papers
KMT2A-rearranged (KMT2A-r) acute leukemias are especially prevalent in the pediatric population. KMT2A-fusion proteins drive leukemogenic gene expression through an interaction with a chromatin complex that includes the scaffold protein menin, giving rise to aggressive acute leukemias. RAS pathway mutations are also common in pediatric leukemia. In a cohort of 1750 patients enrolled on Children's Oncology Group (COG) trials, we identified RAS pathway mutations in 43% of acute myeloid leukemia (AML) cases. The presence of RAS pathway mutations in KMT2A-r AML was associated with a lower complete remission rate, poor event-free survival and overall survival (OS), and early relapses. Given the …