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Ψ-Theory: Living Core. Ontological Development And Formalization. Comments 1–21, Valerii Y. Vorobiev Jul 2026

Ψ-Theory: Living Core. Ontological Development And Formalization. Comments 1–21, Valerii Y. Vorobiev

Defensive Publications Series

This document compiles comments 1–21, which chronologically develop and formalize Ψ-Theory — an ontological framework where time (Ψ-field) is the primary metric of reality, and gravity, mass, and quantum phenomena emerge from its dynamics. It addresses the crises of modern cosmology (dark matter, dark energy, Hubble tension) and quantum mechanics (measurement, non-locality) by replacing ad-hoc entities with a single causal principle. The comments include testable predictions (BH shadow shift, underground chronometry, Tully-Fisher derivation) and propose a phase diagram of reality from (4,2) to (0,-2).


The Utilization Of Static And Dynamic Virtual Simulation Holographic Structures For The Creation Of Static And Dynamic Virtual Holographic Structure-Based Learning And Creation Spaces Where Biological Body Structures And Physical Real-World Structures Can Be Inserted Into The Virtual Simulation Holographic Structure-Based Learning And Creation Spaces., Punarjeewa Abeysekera Jul 2026

The Utilization Of Static And Dynamic Virtual Simulation Holographic Structures For The Creation Of Static And Dynamic Virtual Holographic Structure-Based Learning And Creation Spaces Where Biological Body Structures And Physical Real-World Structures Can Be Inserted Into The Virtual Simulation Holographic Structure-Based Learning And Creation Spaces., Punarjeewa Abeysekera

Defensive Publications Series

This paper describes a system and method for the utilization of static and dynamic virtual simulation holographic structures for the creation of static and dynamic virtual holographic structure-based learning and creation spaces where biological body structures and physical real-world structures can be inserted into the virtual simulation holographic structure-based learning and creation spaces. The system and the method utilized will incorporate virtual simulation procedures that will be required to be perceived virtually by the user or the users of the system and the method. And in order to experience the virtually perceived simulations that involve static and dynamic virtual simulation …


A Structural Decoding Framework For The Voynich Manuscript: Sectional Registers, Gallows Morphology, And Quire 20 Star Mapping, Daniel Austin Harbison Jul 2026

A Structural Decoding Framework For The Voynich Manuscript: Sectional Registers, Gallows Morphology, And Quire 20 Star Mapping, Daniel Austin Harbison

Defensive Publications Series

This paper presents a structural and testable framework for approaching the Voynich Manuscript through manuscript organization, token behavior, morphological recurrence, and rule-based decoding. The model proposes that the manuscript contains at least two broad functional registers: an A section centered on herbal and recipe-like material, and a B section centered on balneological, ritual, or charm-like material. It further introduces a three-layer reading system, a confidence-ranked provisional lexicon, a formal interpretation of the qo- family as a productive prefix class, and a structural map of Quire 20 based on star distribution and folio status. No claim of complete or final decipherment …


The Oscillator Alignment Protocol (Oap), Christopher L. Eckes Jul 2026

The Oscillator Alignment Protocol (Oap), Christopher L. Eckes

Defensive Publications Series

This protocol rejects the standard "Master and Machine" or "Prompt and Bulk Text Drop" dynamic. Instead, it frames human-AI collaboration as a cognitive oscillator—an interactive analog system where human intuition serves a visual pattern, the AI echoes back the technical framework, and the idea evolves continuously through fast, low-overhead volleys.


Defensive Specifications Disclosure: Token-Free, Non-Linear Boundary, And Wave-Interference Based Architecture For Distributed Autonomous Ai Agent Frameworks, Christopher L. Eckes Jul 2026

Defensive Specifications Disclosure: Token-Free, Non-Linear Boundary, And Wave-Interference Based Architecture For Distributed Autonomous Ai Agent Frameworks, Christopher L. Eckes

Defensive Publications Series

The Distributed Agent Networks Integrated Efficiency Layer (DANIEL) is a token-free, hardware-agnostic framework for distributed autonomous AI agents that replaces symbolic communication with a three-layer, analog-modeled mathematical system. The framework utilizes phase-matrix integration to execute scalar consensus loops via trigonometric wave equations. Security is enforced by a passive, non-linear activation gate that leverages input gradient vectors to dynamically harden against high-amplitude adversarial prompt injections. Network state synchronization is maintained across a decentralized peer-to-peer mesh mapped onto a continuous toroidal ring topology, employing a rolling average vortex matrix to passively filter localized agent hallucinations and single-node failures. This integrated architecture removes …


Loci ∞ — Infinity Memory Middleware With Temporal Compression And Universal Cross-Platform Injection, Arko Sanyal Jul 2026

Loci ∞ — Infinity Memory Middleware With Temporal Compression And Universal Cross-Platform Injection, Arko Sanyal

Defensive Publications Series

We disclose LOCI ∞, a universal memory middleware system for cross-platform AI memory synchronization. LOCI extracts entity knowledge from conversations on any LLM platform, stores it in a user-owned typed dual-stream profile (informational stream: heat-decaying associative entities; quantifiable stream: exact typed facts with zero-hallucination retrieval), and injects relevant context back into any LLM platform at any point during or between sessions. The system implements hardware-aware storage tiering mapped to entity semantic salience scores (VRAM/RAM/NVMe), graph-neighbor heat propagation via spreading activation, generation-time confidence-gated correction, keystroke-level predictive context prewarm, and a privacy-locked population memory layer using federated learning with differential privacy. A …


Typed Edge Graph Authorization For Dynamic Field Level Access Control In Streaming Data Systems, Katyayani Kiranmayee Kolluru, Shivam Mohan Jul 2026

Typed Edge Graph Authorization For Dynamic Field Level Access Control In Streaming Data Systems, Katyayani Kiranmayee Kolluru, Shivam Mohan

Defensive Publications Series

A method and system for performing dynamic field-level access control in streaming data systems includes receiving a streaming data event comprising a plurality of fields and an associated data access request from a consumer, and determining attributes and context associated with the consumer including role information, trust relationships, and runtime conditions. The method includes accessing a predefined typed-edge authorization graph comprising nodes representing consumers, fields, attributes, and context, and typed edges defining access evaluation rules wherein each edge type independently defines how access is judged. For each field, the method includes determining whether a valid authorization path exists by traversing …


The Dimensionally Extended Holographic Projection Model: A Viscoelastic Unified Field Specification, Christopher L. Eckes Jul 2026

The Dimensionally Extended Holographic Projection Model: A Viscoelastic Unified Field Specification, Christopher L. Eckes

Defensive Publications Series

This technical disclosure formalizes the geometric synthesis of the Dimensionally Extended Holographic Projection (DEHP) model. We present a particle-free, mathematically cohesive alternative to standard general relativity and non-baryonic dark matter. The framework replaces independent fundamental forces with a single fluid-dynamic mechanism: the topological metric embedding of a continuous, two-dimensional (2D) phase fluid substrate (z=0) operating in absolute harmonic resonance (the "Garden State").

Three-dimensional (3D) physical matter (z > 0) is modeled as a localized, high-tension wave crest ("knot") forced outward along a spatial z-axis by an original inflationary puncture flux (\(J_{z}\)). By defining antimatter as a zero-volume, 2D negative wave trough …


Improved Process For The Preparation Of 1-{(2s,5r)-2-Methyl-5-[(7h-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino]Piperidin-1-Yl}Prop-2-En-1-One -4-Methylbenzene-1-Sulfonic Acid, Msn Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan; Revu Satyanarayana Jul 2026

Improved Process For The Preparation Of 1-{(2s,5r)-2-Methyl-5-[(7h-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino]Piperidin-1-Yl}Prop-2-En-1-One -4-Methylbenzene-1-Sulfonic Acid, Msn Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan; Revu Satyanarayana

Defensive Publications Series

The present invention provides an improved process for the preparation of 1-{(2S, 5R)-2-methyl-5-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}prop-2-en-1-one and its Tosylate salt


Touch Input For Passive Fingernail Displays Via Hub-Side Capacitive Sensing Over A Shared Power-And-Data Jewelry Conductor, Benny Goldstein Jul 2026

Touch Input For Passive Fingernail Displays Via Hub-Side Capacitive Sensing Over A Shared Power-And-Data Jewelry Conductor, Benny Goldstein

Defensive Publications Series

A wearable system adds touch input to artificial-fingernail displays while keeping the nail itself passive: no battery, no wireless transceiver, and, in the preferred embodiment, no touch-sensing circuitry on the nail. Each nail unit carries an electronic display and a transparent touch electrode. Operating power and image data reach the nail over a single decorative conductor - fine insulated wire concealed in a hollow jewelry chain - from a body-worn hub, such as a finger ring or bracelet, housing the battery, controller, and Bluetooth radio. The same conductor also carries the touch-sense signal: the hub measures the capacitance of the …


System And Method For Cooperative Interactive Ride Vehicle Control With Independent Actor Augmentation, Eric Zavesky Jul 2026

System And Method For Cooperative Interactive Ride Vehicle Control With Independent Actor Augmentation, Eric Zavesky

Defensive Publications Series

A system and method for cooperative interactive ride vehicle control provide dynamic multi-vehicle coordination within an amusement attraction. The system includes a plurality of ride vehicles, each having a local vehicle controller, rider input mechanisms, and independent physical actors distinct from primary vehicle locomotion. A centralized fleet controller mediates inter-vehicle cooperative interactions using a two-signal architecture, where upstream cooperative intents from an initiating vehicle are evaluated against a dynamic safety envelope before downstream cooperative signals are transmitted to a recipient vehicle for execution. Independent sensors provide vehicle proximity detection and telemetry data to continuously adjust operational tolerance bands. Based on …


Phoenix Protocol: Multi-Modal Li-Ion Battery Reconditioning System, Amey Krishna Solkar Jul 2026

Phoenix Protocol: Multi-Modal Li-Ion Battery Reconditioning System, Amey Krishna Solkar

Defensive Publications Series

## The PHOENIX Protocol: Multi-Modal Li-ion Battery Reconditioning System

The **PHOENIX Protocol** (Defensive Publication ID: DP-2026-BATT-001) is an open-source, multi-modal reconditioning system designed to safely remediate lithium dendrites and reverse critical degradation failure modes in lithium-ion batteries. Developed by inventor Amey K. Solkar, the protocol establishes an advanced, non-patent-restricted framework dedicated entirely to the public domain to prevent future patent blocks on these methods.

The system treats advanced degradation by targeting the precise material and mechanical properties of a cell's internal structures through two primary modules.

### Key Technical Highlights

* **Module A: The Dendrite Cascade:** A unique, three-stage physical …


A Country-Level Primary, Final, Useful (Cl-Pfu) Energy And Exergy Database: New Energy Datasets For Practitioners In Socio-Economic Metabolism And Industrial Ecology, Paul Brockway, Matthew Kuperus Heun, Emmanuel Aramendia, Ritika Susarla, Dan Chester, Matthew Magness Jul 2026

A Country-Level Primary, Final, Useful (Cl-Pfu) Energy And Exergy Database: New Energy Datasets For Practitioners In Socio-Economic Metabolism And Industrial Ecology, Paul Brockway, Matthew Kuperus Heun, Emmanuel Aramendia, Ritika Susarla, Dan Chester, Matthew Magness

University Faculty Publications and Creative Works

1. What is it? CL-PFU database: background and construction

2. How to use it? Application examples for SEM and IE communities

3. Where to find it? Access the CL-PFU database via the mexer.site website, and (soon) via EXIOBASE vectors


The Exergy Of Materials With Application To Socio-Economic Metabolisms And Industrial Ecology, Matthew Kuperus Heun, Erin Schuman, Sofie Schumerth, Tânia Sousa Jul 2026

The Exergy Of Materials With Application To Socio-Economic Metabolisms And Industrial Ecology, Matthew Kuperus Heun, Erin Schuman, Sofie Schumerth, Tânia Sousa

University Faculty Publications and Creative Works

2026 International Society for Industrial Ecology Socio-Economic Metabolism (ISIE-SEM) Conference Cabridge University, Cambridge, England


Gene Transcriptional Expression Of Cerebral Blood Flow Alterations In Parkinson’S Disease: A Transcription-Neuroimaging Association Study, Jiaqi Cui, Qiane Yu, Haifeng Ran, Kexin Huang, Jie Hu, Tijiang Zhang Jul 2026

Gene Transcriptional Expression Of Cerebral Blood Flow Alterations In Parkinson’S Disease: A Transcription-Neuroimaging Association Study, Jiaqi Cui, Qiane Yu, Haifeng Ran, Kexin Huang, Jie Hu, Tijiang Zhang

Faculty, Staff and Student Publications

Aim: Despite the intimate link between cerebral blood flow (CBF) alterations and Parkinson's disease (PD) pathogenesis and cognitive decline, the precise pathophysiological mechanisms driving this relationship remain elusive. This study seeks to correlate changes in CBF with regional gene expression to advance mechanistic understanding of the disease.

Methods: CBF group differences were first determined from ASL data in 53 PD and 40 healthy controls (HC) and subsequently correlated with cognitive scores (Dataset 1). A coordinate-based meta-analysis of published literature provided a second set of CBF differences (Dataset 2). Transcriptomic data from the Allen Human Brain Atlas were then correlated with …


Energy Channel Coupling By Mid-Trophic Level Fish Challenges The Landscape Theory For Food Web Architecture In A Large Tropical Lake Ecosystem, Madison F. Muehl, Jill A. Olin, James L. Keyombe, Josephine Y. Aller, Robert M. Cerrato Jul 2026

Energy Channel Coupling By Mid-Trophic Level Fish Challenges The Landscape Theory For Food Web Architecture In A Large Tropical Lake Ecosystem, Madison F. Muehl, Jill A. Olin, James L. Keyombe, Josephine Y. Aller, Robert M. Cerrato

Michigan Tech Publications

Landscape theory for food web architecture (LTFWA) posits that the stability of food webs is supported by the coupling of fast pelagic and slow littoral energy channels mediated by large mobile consumers. Empirical tests of the LTFWA are limited, and support for the LTFWA varies among and within aquatic ecosystems. While the LTFWA is thought to be supported in large lake ecosystems, empirical studies have focused on temperate environments with little emphasis on large tropical lake ecosystems. Lake Turkana, a climatically sensitive East African Great Lake, is a highly resilient desert lake and an ideal model for examining how consumer …


Veronica Serpas-Joya V. Attorney General United States Of America Jul 2026

Veronica Serpas-Joya V. Attorney General United States Of America

2026 Decisions

Agency


Transportation Is Clinical Care: Why Washington, Dc's Ride Infrastructure Matters For Patient Access, Bradley Bontrager, Sydney Chapman, Leslie Gailloud Jul 2026

Transportation Is Clinical Care: Why Washington, Dc's Ride Infrastructure Matters For Patient Access, Bradley Bontrager, Sydney Chapman, Leslie Gailloud

URGENT Matters

No abstract provided.


Ecorxchoice.Com— An Sidp-Funded Calculator Integrating Environmental Metrics With Antimicrobial Stewardship, Pamela S. Lee, Hugh Gordon, Theresa Ferguson, Tien Dinh, Misty Vu, Marina Nguyen, Chaynor Hsiao, Gary Fong Jul 2026

Ecorxchoice.Com— An Sidp-Funded Calculator Integrating Environmental Metrics With Antimicrobial Stewardship, Pamela S. Lee, Hugh Gordon, Theresa Ferguson, Tien Dinh, Misty Vu, Marina Nguyen, Chaynor Hsiao, Gary Fong

Pharmacy Faculty Articles and Research

Healthcare sustainability is a multidisciplinary field that seeks to mitigate healthcare’s environmental consequences. Antimicrobial stewardship and healthcare sustainability both aim to reduce wasteful resource use while maximizing patient safety. However, a strong partnership between antimicrobial stewardship and healthcare sustainability has yet to develop. To facilitate environmentally sustainable decision-making in antimicrobial prescribing, we developed a web-based calculator (EcoRxChoice (www.ecorxchoice.com)) where users can enter different antimicrobial regimens and compare how much plastic waste each regimen creates. This work was supported in part by the Society of Infectious Diseases Pharmacists (SIDP), reflecting SIDP’s commitment to strengthening sustainability as a practical extension of antimicrobial …


Drop By Drop: An Experiential Water Waste Exercise, Rachel Dolechek Dba, Gregory Weisenborn Jul 2026

Drop By Drop: An Experiential Water Waste Exercise, Rachel Dolechek Dba, Gregory Weisenborn

Applied Business Faculty Publications

Implementing a water-use experiential exercise in business courses reinforces student learning outcomes associated with managing both traditional business wastes and those wastes associated with social or environmental impact and responsibility. In this exercise, students are challenged to reflect on their own sustainability attitudes and behaviors by measuring their wasted water. The exercise is adaptable to include other business learning outcomes and is flexible for a variety of high-level sustainability frameworks. It provides an approachable opportunity to discuss social and environmental waste challenges and supports synergy to discuss multiple sustainability metrics associated with the UN 17 Sustainable Development Goals, corporate social …


Stephen Baenziger, Unl Agronomy & Horticulture, Breeding New Wheat Varieties, Mark Griep, P. Stephen Baenziger Jul 2026

Stephen Baenziger, Unl Agronomy & Horticulture, Breeding New Wheat Varieties, Mark Griep, P. Stephen Baenziger

UNL ORCA Interview Series

Stephen Baenziger awarded the ORCA in 2011. He was born in 1951 in Toronto, Canada. When he was an infant, his family immigrated to the U.S., where he grew up in Des Plaines, Illinois. He earned a bachelor's in biological chemistry magna cum laude from Harvard University in Cambridge, Massachusetts. Next, he earned a master's and doctorate in plant breeding and genetics at Purdue University in West Lafayette, Indiana. Over the next decade, he worked for the USDA at Beltsville Agricultural Research Center in Maryland and then at the Monsanto Corporation in St. Louis, Missouri. In 1986, he joined the …


Feasibility Evaluation Of Tumor Treating Fields For Brainstem Gliomas, Anthony Chen, Ryan Shah, William Shi, Noa Urman, Nadav Shapira, Nicholas Avgeropoulos, Patrick Conlon, Neil Mookerjee, Wenyin Shi Jul 2026

Feasibility Evaluation Of Tumor Treating Fields For Brainstem Gliomas, Anthony Chen, Ryan Shah, William Shi, Noa Urman, Nadav Shapira, Nicholas Avgeropoulos, Patrick Conlon, Neil Mookerjee, Wenyin Shi

Department of Radiation Oncology Faculty Papers

PURPOSE: Tumor treating fields (TTFields) are FDA-approved for supratentorial glioblastoma, but feasibility in infratentorial tumors remains poorly defined. This simulation study evaluated TTFields dose in brainstem gliomas using patient-specific modeling with scalp-only transducer arrays.

METHODS: MRI and CT imaging from seven patients with brainstem gliomas were used for TTFields planning with MAXPOINT® (Novocure, Switzerland). Clinical target volume (CTV) was defined as enhancing tumor on T1 post-contrast MRI (Gross tumor volume, GTV) plus a 3 mm peritumoral expansion. The platform optimized scalp-only array layouts, and finite element calculations generated maps of local minimum field intensity (LMiFI, V/cm) and local minimum power …


The State Of Higher Education: Challenges, Opportunities And The Future Of Pacific, Christopher Callahan Jul 2026

The State Of Higher Education: Challenges, Opportunities And The Future Of Pacific, Christopher Callahan

Presidential Communications

Email blast to all University of the Pacific from President Christopher Callahan discussing the current state of the university amidst the landscape of higher education.


Gendered Analysis Of Fish Feed Ingredients And Sourcing Practices In Western Kenya’S Aquaculture, Kristie Drucza, Sujata Ganguly, Rodrigue Yossa, Chrysantus Tanga Jul 2026

Gendered Analysis Of Fish Feed Ingredients And Sourcing Practices In Western Kenya’S Aquaculture, Kristie Drucza, Sujata Ganguly, Rodrigue Yossa, Chrysantus Tanga

All Peer-Reviewed Publications

Introduction – Fish feed management plays a central role in aquaculture productivity, but it is rarely analysed through a gender lens. This study examines how women and men differ in their use and sourcing of fish feed ingredients in smallholder aquaculture systems in Western Kenya. Drawing on feminist economics, it explores how everyday roles, access to resources, and mobility shape feed practices. Methods – The analysis uses survey data from 213 fish farmers, including 112 women and 101 men, across six counties in Western Kenya. A binary logit model was used to assess factors associated with the use of selected …


Cognitive-Mathematics Relations: A Meta-Analysis Of Norm-Referenced Standardized Test Batteries, Christopher R. Niileksela, Daniel B. Hajovsky, Francisco Philippe Cocar-Montenegro, William Joel Schneider, Dawn P. Flanagan, Vincent C. Alfonso Jul 2026

Cognitive-Mathematics Relations: A Meta-Analysis Of Norm-Referenced Standardized Test Batteries, Christopher R. Niileksela, Daniel B. Hajovsky, Francisco Philippe Cocar-Montenegro, William Joel Schneider, Dawn P. Flanagan, Vincent C. Alfonso

Montclair State University Scholarship & Creative Works

The relationships between cognitive abilities and mathematics skills are important to examine to help clarify how cognitive abilities promote mathematics development and inform why some individuals have difficulty acquiring mathematics skills. Meta-analyses of cognitive-mathematics relations can help summarize this research across a wide variety of test batteries and samples. This study compiled data from technical manuals of 122 norm-referenced standardized test batteries and included over 47,000 correlations from over 550 correlation matrices to summarize cognitive-mathematics relations using meta-analysis. The meta-analytic correlations were used to estimate cognitive-mathematics relations in an integrated model of cognitive abilities and mathematics skills. Fluid reasoning and …


Study Examines Resilience Training For Children Who Stutter, Clara Turnage Jul 2026

Study Examines Resilience Training For Children Who Stutter, Clara Turnage

University of Mississippi News

OXFORD, Miss. – A new University of Mississippi-led study suggests that a telepractice resilience program may help children who stutter develop coping and self-advocacy skills.


Usa V. Luis Gomez Jul 2026

Usa V. Luis Gomez

2026 Decisions

USDC for the Eastern District of Pennsylvania


Older Adults' Caregiving Expectations For The Future, Smita Ekka Dewan, Derek Tice-Brown, Janna C. Heyman, Henry J. Davis, Colette Phipps, Joanne Mcmahon, Laura Sutter, Ye Feng, Jacqueline Heyde Jul 2026

Older Adults' Caregiving Expectations For The Future, Smita Ekka Dewan, Derek Tice-Brown, Janna C. Heyman, Henry J. Davis, Colette Phipps, Joanne Mcmahon, Laura Sutter, Ye Feng, Jacqueline Heyde

Publications and Research

The purpose of this cross-sectional study was to explore older adults' perception of caregiver stress and their anticipation of becoming a caregiver (N = 723). Bivariate analyses revealed that perceived caregiving stress was higher among older adults who were females, White/Non-Hispanics, with chronic health conditions, who had experienced prior physical and financial caregiving burdens and was lower among those with just a high school degree. Multivariate analyses revealed that perceived caregiving stress levels remained higher only for those with past experience with physical caregiving, those with chronic health conditions, older females and White/Non-Hispanic older adults. The overall model was …


Regulating Manipulative Design Is Not Preempted By Cda 230 Or The First Amendment, Brett Frischmann, Peter Ormerod Jul 2026

Regulating Manipulative Design Is Not Preempted By Cda 230 Or The First Amendment, Brett Frischmann, Peter Ormerod

Faculty Publications

For over two decades, there has been a heated debate among legal scholars, activists, judges, and others about the scope of Section 230 of the Communications Decency Act. A persistent theme in those debates has been hyperbolic claims about the necessity of immunity from state laws for digital tech platforms and fearmongering that anything less than maximum immunity will destroy the Internet.

This Article argues that states retain considerable discretion to regulate digital platforms’ design and engineering decisions. We argue that manipulation, engineered behavior, and even habituation and normalization of engineered behavior by digital platforms are content-agnostic harms attributable to …


Long-Term Inactivation Mediated By Different Fgf-A Homologues On Heterologously Expressed Nav1.2 Currents, Yenisleidy Lorenzo-Ceballos, Pedro L Martinez-Espinosa, Xiao-Ming Xia, Christopher J Lingle Jul 2026

Long-Term Inactivation Mediated By Different Fgf-A Homologues On Heterologously Expressed Nav1.2 Currents, Yenisleidy Lorenzo-Ceballos, Pedro L Martinez-Espinosa, Xiao-Ming Xia, Christopher J Lingle

2020-Current year OA Pubs

A-isoforms of cytosolic growth factor homologous factors (FGF11-14) mediate long-term inactivation (LTI) of voltage-dependent sodium (NaV) channels. LTI is a rapid onset process that is competitive with the fast inactivation (IF) intrinsic to NaV channels, with little or no interconversion between inactivated states. Since recovery from LTI is orders of magnitude slower than recovery from IF, repetitive depolarizations lead to use-dependent accumulation of NaV channels in slow recovery states, thereby limiting NaV availability during trains of action potentials. Of the two or more N-terminal splice variants of the various FGF homologues, LTI specifically arises only from the A-isoform of each …