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Articles 6091 - 6120 of 2260510
Full-Text Articles in Entire DC Network
Enhanced Mobilenet With Multi-Scale Feature Fusion For Automated Breast Cancer Histopathology Classification, Amany M. Abdo Prof.
Enhanced Mobilenet With Multi-Scale Feature Fusion For Automated Breast Cancer Histopathology Classification, Amany M. Abdo Prof.
Information Systems
Accurate and efficient diagnosis of breast cancer from histopathological images remains a major challenge in clinical practice due to subjective interpretation, inter-observer variability, and labor-intensive manual examination. To address these limitations, this work introduces a transfer learning–based framework for automated breast cancer classification using the Breast Cancer Histology Images (BACH) dataset. Several pre-trained deep architectures—including MobileNet, ResNet variants, EfficientNet, and Vision Transformers—were evaluated and extended with a Multi-Scale Feature Fusion (MSFF) module to capture morphological heterogeneity across spatial resolutions. Among these, the Enhanced MobileNet (E‑MobileNet) with MSFF outperforming recent state‑of‑the‑art models and achieving a classification accuracy of 95%, precision of …
Targeted Temperature Management: Controversy Surrounding Post-Cardiac Arrest Care, Ishan Abdullah, Shawn Reginauld, Ramesh Mazhari
Targeted Temperature Management: Controversy Surrounding Post-Cardiac Arrest Care, Ishan Abdullah, Shawn Reginauld, Ramesh Mazhari
URGENT Matters
No abstract provided.
Exercise Training Prior To And During Cancer In Mice Preserves Muscle Mass, Reduces Tumour Weight And Suppresses Molecular Mediators Of Cachexia, Stavroula Tsitkanou, Pieter J. Koopmans, Ana Regina Cabrera, Nathan Serrano, Calvin S. Peterson, Ruqaiza Muhyudin, Zain B. Malik, Micah Goeke, Eleanor R. Schrems, Francielly Morena, Yuan Wen, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene
Exercise Training Prior To And During Cancer In Mice Preserves Muscle Mass, Reduces Tumour Weight And Suppresses Molecular Mediators Of Cachexia, Stavroula Tsitkanou, Pieter J. Koopmans, Ana Regina Cabrera, Nathan Serrano, Calvin S. Peterson, Ruqaiza Muhyudin, Zain B. Malik, Micah Goeke, Eleanor R. Schrems, Francielly Morena, Yuan Wen, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene
Physiology Faculty Publications
Abstract: We investigated the prophylactic effects of exercise before and during cancer cachexia (CC) using a model designed to mimic endurance and resistance (i.e., concurrent) adaptations. Male and female Balb/c mice were randomly assigned to exercise or control groups whereby exercise groups were subjected to an 8-week voluntary progressive weighted wheel running (PoWeR) programme of habitual loading-mediated physical activity beginning at 8 weeks of age. At 16 weeks of age, mice were injected bilaterally with colon-26 adenocarcinoma (C26) cells or phosphate-buffered saline, and exercise training was maintained throughout disease progression. Twenty-five days post-tumour induction, we assessed whole-body and muscle phenotype, …
High School Students Have Stellar Experience At Umn Morris' First Astrophysics Summer Camp, Communications And Marketing
High School Students Have Stellar Experience At Umn Morris' First Astrophysics Summer Camp, Communications And Marketing
Campus News Archive
No abstract provided.
Lindenwood Digest, July 15, 2026, Lindenwood University
Lindenwood Digest, July 15, 2026, Lindenwood University
Lindenwood Digest
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Event & Date: Lindenwood University Employee Digest published on July 15, 2026.
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Geographic Grounding: Lindenwood University, St. Charles, Missouri.
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Key Honorees/Awards: Assistant Coach Andrew Magera was recognized in Q2 Moments for developing a customized spreadsheet tool to assist the compliance office and NCAA teams evaluate athlete status.
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Institutional Context: Highlights campus operational updates, including Move-In Day scheduled for August 20, 2026, call for 2026 Alumni Awards nominations by August 28, 2026, and upcoming Learning Academy sessions on gratitude, performance calibration, and LinkedIn Learning AI courses.
Climate Change, Governance Failure, And Violent Insurgency In Cabo Delgado, Hala Thabet
Climate Change, Governance Failure, And Violent Insurgency In Cabo Delgado, Hala Thabet
All Works
Contemporary literature increasingly links rising levels of armed violence in several African countries to the repercussions of climate change, particularly long-term environmental stresses such as the deterioration of agricultural livelihoods, resource scarcity, and recurrent climate shocks. However, this study argues that the relationship between climate change and violence is not an inevitable causal one, but can be understood as the result of the intersection of the failure of the post-independence nation-building project and the impacts of climate change on livelihoods and economic security. In Cabo Delgado province, northern Mozambique, repeated climate shocks and the resulting deterioration of coastal agriculture and …
Aberrant Stat Signaling And T Cell Dysregulation Define A Targetable Pediatric Sepsis Endotype, Robert B. Lindell, Samir U. Sayed, Jose S. Campos Duran, Sydney A. Sheetz, Apoorva Babu, Montana S. Knight, Andrea A. Mauracher, Ceire A. Hay, Peyton E. Conrey, Julie C. Fitzgerald, Nadir Yehya, Stephen T. Famularo, Teresa Arroyo, Richard Tustin, Hossein Fazelinia, Edward M. Behrens, David T. Teachey, Lisa R. Forbes Satter, Alexandra F. Freeman, Jenna Re Bergerson, Steven M. Holland, Jennifer W. Leiding, Scott L. Weiss, Mark W. Hall, Deanne M. Taylor, Rui Feng, E. John Wherry, Nuala J. Meyer, Sarah E. Henrickson
Aberrant Stat Signaling And T Cell Dysregulation Define A Targetable Pediatric Sepsis Endotype, Robert B. Lindell, Samir U. Sayed, Jose S. Campos Duran, Sydney A. Sheetz, Apoorva Babu, Montana S. Knight, Andrea A. Mauracher, Ceire A. Hay, Peyton E. Conrey, Julie C. Fitzgerald, Nadir Yehya, Stephen T. Famularo, Teresa Arroyo, Richard Tustin, Hossein Fazelinia, Edward M. Behrens, David T. Teachey, Lisa R. Forbes Satter, Alexandra F. Freeman, Jenna Re Bergerson, Steven M. Holland, Jennifer W. Leiding, Scott L. Weiss, Mark W. Hall, Deanne M. Taylor, Rui Feng, E. John Wherry, Nuala J. Meyer, Sarah E. Henrickson
Department of Pediatrics Faculty Papers
BACKGROUNDSepsis is a leading cause of morbidity and mortality in critically ill children, yet heterogeneous immune responses complicate the development of targeted therapies and the host immune factors driving sepsis pathobiology remain unclear.METHODSWe integrated deep immune phenotyping, plasma proteomics, single-cell transcriptomics, and phosphoflow cytometry in a prospective cohort of 88 critically ill children to elucidate the mechanisms underlying immune heterogeneity.RESULTSUnsupervised clustering of plasma cytokines identified 3 immunologic subgroups, including a high-severity group ("Group C") characterized by hypercytokinemia driven by IL-6 and IFN-γ. Group C exhibited distinct alterations in immune cell frequency and activation, with a strong association between hyperinflammatory cytokine …
The Tagmatized Echinoderm, Richard L. Turner
The Tagmatized Echinoderm, Richard L. Turner
Ocean Engineering and Marine Sciences Faculty Publications
Synopsis Tagmosis is a derived condition of metamerism in annelids, arthropods, and chordates in which groups of adjacent segments are modified to perform specific functions. Examples are the clitellum of earthworms, the carapace of lobsters, and the sacrum of tetrapods, to mention a few. The argument is advanced here that examples of tagmosis are not hard to find among echinoderms, a fourth major group of metameric animals; but the degree of tagmosis is weak in most cases. The first few segments of the axial skeleton are often conjoined as a perioral tagma (e.g., the jaws and other parts of the …
William Webb, Jr. V. Kirk Neal
Bar-And-Hinge Model For Elasto-Plastic Origami Analysis, Yansong Tang, Yeqi Chu, Yue Mei, Yi Zhu, Ke Liu
Bar-And-Hinge Model For Elasto-Plastic Origami Analysis, Yansong Tang, Yeqi Chu, Yue Mei, Yi Zhu, Ke Liu
Michigan Tech Publications
Origami-inspired structures are attracting considerable attention in engineering owing to their ability to facilitate intricate deformations and deployable configurations. However, accurately simulating their mechanical behaviour under realistic conditions involving permanent deformations and energy dissipation remains a significant challenge. In this study, we present an elasto-plastic formulation based on the nonlinear bar-and-hinge model for non-rigid origami simulation. We integrate rate-independent elasto-plastic constitutive models for both the hinges and the bars, enabling tunable representation of both elastic and plastic deformations in origami structures. The formulation employs a return mapping algorithm to ensure consistency with yield conditions checked at each incremental time step, …
Achieving Low-Carbon Buildings Through Advancing Concrete Materials And Automated Construction: A Review, Thanh Ha Ngo, Hai Hoang Khieu, Yingyan Zhang, Quang Tran, Phuong Tran
Achieving Low-Carbon Buildings Through Advancing Concrete Materials And Automated Construction: A Review, Thanh Ha Ngo, Hai Hoang Khieu, Yingyan Zhang, Quang Tran, Phuong Tran
Michigan Tech Publications
The construction industry is a major contributor to global carbon emissions and faces urgent demands to align with net-zero targets through targeted material selection, manufacturing, and construction methods. Conventional concrete production contributes significant CO2 emissions, necessitating innovative approaches to reduce embodied and operational carbon. This scoping review examines advances in low-carbon concrete production, automated construction methods, their integration and practical applications. The review is based on literature published between 2015 and 2025, collected from Elsevier ScienceDirect and additional sources, focusing on low-carbon concrete materials, 3D concrete printing, and automated construction. The findings show that strategies such as carbonation curing, direct …
20260715: Registrar, Schedule Of Courses, 1964-1997, Registrar
20260715: Registrar, Schedule Of Courses, 1964-1997, Registrar
Guides to University Archives
These items include materials from the Office of the Registrar. Items were received in the 1990s but were not processed until 2026. Items include notable materials from or about the Registrar's Office and include schedule of courses and some student ID numbers from 1964-1997. Please download the finding aid for a full list of contents.
2026 Ids Network Conference Opening Statements, Mark Sullivan
2026 Ids Network Conference Opening Statements, Mark Sullivan
Conference Presentations
No abstract provided.
July 15, 2026 Minutes, Swosu Faculty Senate
July 15, 2026 Minutes, Swosu Faculty Senate
Faculty Senate Minutes
No abstract provided.
Tau Seeds Induce Neurofibrillary Tangle Formation Across Brain Regions Via Individual-Specific Connectivity, Audrey J Weber, Bernard Ng, Kelsey M Greathouse, David A Bennett, Shinya Tasaki, Chris Gaiteri, Jeremy H Herskowitz
Tau Seeds Induce Neurofibrillary Tangle Formation Across Brain Regions Via Individual-Specific Connectivity, Audrey J Weber, Bernard Ng, Kelsey M Greathouse, David A Bennett, Shinya Tasaki, Chris Gaiteri, Jeremy H Herskowitz
Faculty, Staff and Student Publications
The spread of tau pathology across the cerebral cortex is closely tied to cognitive decline in Alzheimer's disease (AD). To investigate mechanisms underlying tau spread, we measured bioactivity of tau seeds from inferior temporal gyrus (ITG) and superior frontal gyrus (SFG) synaptosomes in 128 individuals and demonstrated that tau seed bioactivity associates with tau phosphorylation, neurofibrillary tangles (NFTs), and cognitive impairment. Incorporating genotype data from the same individuals within a Mendelian randomization framework showed that tau seeds in ITG induce NFTs locally as well as drive tau seeds and NFTs in SFG. Integrating antemortem functional magnetic resonance imaging data from …
Ay 2026/2027 Sec Meeting Minutes, 2026-07-15, Faculty Senate
Ay 2026/2027 Sec Meeting Minutes, 2026-07-15, Faculty Senate
Faculty Senate Archives
No abstract provided.
Navigating Queer Identities In Rural Communities: The Role Of Social Support In Shaping Lgbq+ Adolescents’ Identity Development, Michaela Elaine Pierson
Navigating Queer Identities In Rural Communities: The Role Of Social Support In Shaping Lgbq+ Adolescents’ Identity Development, Michaela Elaine Pierson
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Adolescents who identify as lesbian, gay, bisexual, or queer (LGBQ+) develop their identities within complex social contexts. In rural settings, limited access to affirming resources and greater exposure to stigma may further shape identity development. Guided by social ecological and minority stress theories, this study examined whether perceived family and friend support predict identity affirmation and internalized homonegativity among rural LGBQ+ adolescents. Participants included 53 adolescents ages 13 to 18 drawn from a larger dataset. Group differences across demographic variables were examined, and regression analyses were used to evaluate the predictive role of family and friend support. No significant group …
The Data Drill: A Useful Crisis-Response Tool, Dan Ferris, Jenrose Fitzgerald, Hilary Sedovic, Ally Terhaar
The Data Drill: A Useful Crisis-Response Tool, Dan Ferris, Jenrose Fitzgerald, Hilary Sedovic, Ally Terhaar
Center for Social Development Research
Social sector organizations are often on the front lines of crisis response. Whether the crisis is a natural disaster or a result of human decisions, agencies must act quickly to minimize negative impact on the community. Doing this effectively requires significant planning and data coordination. A data drill is a planning tool developed by Amen Ra Mashariki. Much like a fire drill prepares an organization for the worst-case scenario, a data drill can prepare leaders to utilize data to make clear, informed decisions in a crisis. This case study highlights a data drill designed to address a funding crisis facing …
Techno-Economic And Environmental Analysis Of A Hybrid Renewable Energy System With V2h Support For Remote Australian Communities, Tushar Kanti Roy, K. Das, Md Apel Mahmud
Techno-Economic And Environmental Analysis Of A Hybrid Renewable Energy System With V2h Support For Remote Australian Communities, Tushar Kanti Roy, K. Das, Md Apel Mahmud
Research outputs 2022 to 2026
Remote Australian communities continue to experience persistent energy insecurity and increased greenhouse gas emissions due to their reliance on diesel-based microgrids. In response, this study presents a comprehensive techno-economic and environmental assessment of a hybrid renewable energy system integrating solar photovoltaics (PVs), wind turbines (WTs), battery energy storage systems (BESSs), and electric vehicles (Evs) with vehicle-to-home (V2H) functionality. Three system configurations are evaluated over a full-year simulation horizon using realistic solar irradiance, wind speed, household electricity demand, and driving profiles of electric vehicles: (i) off-grid (PV–WT–diesel generator (DG)), (ii) on-grid (PV–WT-BESS–Grid), and (iii) off-grid with V2H. System operation is coordinated …
When Leadership Is Denied: A Phenomenological Study Of Women's Lived Experiences Of Promotion Rejection In The Pakistani Fashion Industry, Atif Bilal, Faiza Majid, Shumaila Zeb, Saqlain Raza, Aliya Abdul Hayee, Wali Ur Rehman
When Leadership Is Denied: A Phenomenological Study Of Women's Lived Experiences Of Promotion Rejection In The Pakistani Fashion Industry, Atif Bilal, Faiza Majid, Shumaila Zeb, Saqlain Raza, Aliya Abdul Hayee, Wali Ur Rehman
Plymouth Business School
Despite the growing presence of women in creative and leadership roles within the fashion industry, many continue to face barriers to leadership progression. Leadership rejection remains a critical yet underexplored experience that can significantly affect women's professional identity and aspirations. The research aims to explore the lived experiences of women in the fashion industry who perceive being rejected from leadership positions due to discrimination. Using a qualitative, phenomenological approach, 13 semi-structured interviews were conducted with women in the fashion industry of Pakistan. Interpretative Phenomenological Analysis guided data collection and analysis, allowing for a rich exploration of meaning-making processes. The study …
Design And Development Of A Novel Lxrβ/Pparδ Dual Agonist For Memory Impairment And Pathology In 3xtg-Ad Animal Model Of Alzheimer's Disease, Meenakshi Singh, Ian Steinke, Vishnu Suppiramaniam
Design And Development Of A Novel Lxrβ/Pparδ Dual Agonist For Memory Impairment And Pathology In 3xtg-Ad Animal Model Of Alzheimer's Disease, Meenakshi Singh, Ian Steinke, Vishnu Suppiramaniam
Faculty Articles
The rising prevalence of Alzheimer’s disease (AD) underscores an urgent need for neuroprotective strategies that modulate cholesterol metabolism, neuroinflammation, improve pathology, and cognitive function. While Liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs) are validated targets for enhancing amyloid-β and tau clearance, clinical translation of first-generation LXR agonists has been hindered by LXRα-mediated hepatic steatosis and hypertriglyceridemia. Here, we report the structure-based design of AU403, a potent, isoform-selective LXRβ/PPARδ dual agonist designed to bypass LXRα-driven hepatotoxicity. Molecular modeling indicates that AU403 achieves LXRβ selectivity by engaging residues Phe329 and Leu330 while avoiding the corresponding LXRα residues Arg305 and Leu316. …
Comparative Analysis Of Traditional And Deep Learning Time Series Architectures For Influenza A Infectious Disease Forecasting, Edmund Fosu Agyemang, Hansapani Rodrigo, Vincent Agbenyeavu
Comparative Analysis Of Traditional And Deep Learning Time Series Architectures For Influenza A Infectious Disease Forecasting, Edmund Fosu Agyemang, Hansapani Rodrigo, Vincent Agbenyeavu
School of Mathematical & Statistical Sciences Faculty Publications
Influenza A remains a major cause of respiratory mortality worldwide, motivating accurate forecasting to support timely preparedness and resource allocation. This study presents a comparative evaluation of two traditional seasonal time series baselines, ARIMA and Holt–Winters exponential smoothing (ETS), and six deep learning (DL) architectures (Simple RNN, LSTM, GRU, BiLSTM, BiGRU, and a Transformer) for forecasting monthly Influenza A case counts in the United States. Data from January 2009 to December 2023 were analyzed, using January 2009 to December 2022 for training and January 2023 to December 2023 for out-of-sample testing. Models were tuned using a validation split and assessed …
Pediatric Oncology Progress And Challenges In Southeast Asia: Strengthening Cancer Care Systems, Allison Tang, Teeradon Treechairusame, Esther Saguil, Adrian E. Go, Frederic Ivan L. Ting, Kevin Knopf, Avram Denburg, Sanjeeva Gunasekera, Nirmala Bhoo-Pathy, Edward Christopher Dee, Rod Carlo Columbres
Pediatric Oncology Progress And Challenges In Southeast Asia: Strengthening Cancer Care Systems, Allison Tang, Teeradon Treechairusame, Esther Saguil, Adrian E. Go, Frederic Ivan L. Ting, Kevin Knopf, Avram Denburg, Sanjeeva Gunasekera, Nirmala Bhoo-Pathy, Edward Christopher Dee, Rod Carlo Columbres
Student Publications
No abstract provided.
Exploring Factors Associated With High Frequency Emergency Department Use By Children And Young People: A Retrospective Cohort Study, Akshay Kumar, Rebecca M Simpson, Kerryn Husk, Graham D Johnson, Chris Burton
Exploring Factors Associated With High Frequency Emergency Department Use By Children And Young People: A Retrospective Cohort Study, Akshay Kumar, Rebecca M Simpson, Kerryn Husk, Graham D Johnson, Chris Burton
Peninsula Medical School
Objective To explore drivers of high frequency emergency department (ED) use by children and young people, particularly among those attending EDs most often.Design A population-based retrospective cohort study using routinely collected linked healthcare data.Setting EDs in the Yorkshire and Humber region of the UK.Patients 288 545 children and young people aged 17 and under making at least one ED attendance in the year period 1 April 2016 to 31 March 2017.Main outcome measures ED attendances made by individuals in the year period.Results Of the 288 545 distinct children and young people making at least one attendance to an ED, 27 …
Cmk 169 Llc V. Mcgrath
All Decisions
Handwritten opinion. In a holdover proceeding where the apartment's rent regulatory status was in dispute, the court granted tenant's motion for discovery to determine regulatory status and denied landlord's application for use and occupancy, finding that outstanding potential rent overcharge and hazardous condition claims precluded such relief pending determination of the regulatory status.
Food Systems Transformation Would Reshape Global Agriculture, Matthew Gibson, Marina Sundiang, Daniel Mason-D’Croz, Thais Diniz Oliveira, Felicitas Beier, Lauren Benavidez-Brouk, Astrid Bos, Maksym Chepeliev, Jonathan Doelman, Shahnila Dunston, Shinichiro Fujimori, Tomoko Hasegawa, Petr Havlik, Jordan Hristov, Jonas Jägermeyr, Marta Kozicka, Marijke Kuiper, Page Kyle, Thijs De Lange, Benjamin Leon Bodirsky, Hermann Lotze-Campen, Hermen Luchtenbelt, David Meng-Chuen Chen, Abhijeet Mishra, Christoph Müller, Gerald Nelson, Amanda Palazzo, Ignacio Perez Dominguez, Alexander Popp, Ronald Sands, Marco Springman, Elke Stehfest, Timothy B. Sulser, Kiyoshi Takahashi, Gianmaria Tassinari, Ferike Thom, Philip Thornton, Kazuaki Tsuchiya, Willem-Jan Van Zeist, Hans Van Meijl, Dominique Van Der Mensbrugghe, Detlef Van Vuuren, Hannah H.E. Van Zanten, Isabelle Weindl, Keith Wiebe, Xin Zhao, Mario Herrero
Food Systems Transformation Would Reshape Global Agriculture, Matthew Gibson, Marina Sundiang, Daniel Mason-D’Croz, Thais Diniz Oliveira, Felicitas Beier, Lauren Benavidez-Brouk, Astrid Bos, Maksym Chepeliev, Jonathan Doelman, Shahnila Dunston, Shinichiro Fujimori, Tomoko Hasegawa, Petr Havlik, Jordan Hristov, Jonas Jägermeyr, Marta Kozicka, Marijke Kuiper, Page Kyle, Thijs De Lange, Benjamin Leon Bodirsky, Hermann Lotze-Campen, Hermen Luchtenbelt, David Meng-Chuen Chen, Abhijeet Mishra, Christoph Müller, Gerald Nelson, Amanda Palazzo, Ignacio Perez Dominguez, Alexander Popp, Ronald Sands, Marco Springman, Elke Stehfest, Timothy B. Sulser, Kiyoshi Takahashi, Gianmaria Tassinari, Ferike Thom, Philip Thornton, Kazuaki Tsuchiya, Willem-Jan Van Zeist, Hans Van Meijl, Dominique Van Der Mensbrugghe, Detlef Van Vuuren, Hannah H.E. Van Zanten, Isabelle Weindl, Keith Wiebe, Xin Zhao, Mario Herrero
Department of Agricultural Economics Faculty Publications
Food systems are a major contributor to exceeding planetary boundaries1,2,3 and poor quality diets are a key mortality risk globally4. Projected population and income growth could exacerbate these challenges5. In response, there are calls for transformation towards healthy and sustainable food systems6,7,8. However, the scale and distribution of the impacts of this transformation on agriculture are underexplored. Here we show that, by 2050, the transformation of food systems towards healthy diets (adoption of the EAT–Lancet reference diet), improved productivity and halving of food waste results in a fundamental restructuring of global agriculture, aspects of which break with historical trends. Scenario …
Premature Ventricular Contractions As A Result Of Subacute Myocarditis In A Professional Football Player, Charlotte Pirquet, Daniel Underberg, Brian Osler, Derek Schwabe-Warf, David Shipon
Premature Ventricular Contractions As A Result Of Subacute Myocarditis In A Professional Football Player, Charlotte Pirquet, Daniel Underberg, Brian Osler, Derek Schwabe-Warf, David Shipon
Department of Medicine Faculty Papers
BACKGROUND: Return-to-play (RTP) decisions for professional athletes with arrhythmias are challenging, particularly when the diagnosis is uncertain.
CASE SUMMARY: A 33-year-old professional football player presented for RTP evaluation of premature ventricular contractions (PVCs) and atypical chest pain. Work-up was significant for fragmented R waves and PVCs on electrocardiogram as well as late gadolinium enhancement on cardiac magnetic resonance imaging. Positron emission tomography scan was normal. These findings suggested possible subacute myocarditis. He elected to rest for 2 to 3 months and was treated with guideline-directed medical therapy. Risk stratification highlighted increased risks associated with late gadolinium enhancement and incomplete genetic …
Anoxia Tolerant Dna Replication Is Supported By Atr Kinase In The Annual Killifish Austrofundulus Limnaeus, Riley Roth-Carter, Erin Helms, Joshua C. Saldivar, Jason Podrabsky
Anoxia Tolerant Dna Replication Is Supported By Atr Kinase In The Annual Killifish Austrofundulus Limnaeus, Riley Roth-Carter, Erin Helms, Joshua C. Saldivar, Jason Podrabsky
Biology Faculty Publications and Presentations
Hypoxia and anoxia suppress cell proliferation due to an increase in replication stress and activation of DNA damage checkpoints. Embryos of the annual killifish Austrofundulus limnaeus tolerate prolonged anoxia, indicating improved genomic stability under oxygen starvation. We investigated the cell cycle regulation of the anoxia tolerant killifish embryonic cell line PSU-AL-WS40NE during anoxia. Live-cell imaging confirms continued proliferation of WS40NE cells for the first 24 h of anoxia with minimal cell death. Fluorescence imaging shows that cells accumulate in G1 after the first day in anoxia with a rapid entry into S phase upon reoxygenation. Pharmacological inhibition shows a reliance …