Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Series

Discipline
Institution
Keyword
Publication Year
Publication
File Type

Articles 4681 - 4710 of 2258963

Full-Text Articles in Entire DC Network

Hvi-Cidnet+: Beyond Extreme Darkness For Low-Light Image Enhancement, Kangbiao Shi, Xiaowen Ma, Yixu Feng, Tao Hu, Peng Wu, Guansong Pang, Qingsen Yan Aug 2026

Hvi-Cidnet+: Beyond Extreme Darkness For Low-Light Image Enhancement, Kangbiao Shi, Xiaowen Ma, Yixu Feng, Tao Hu, Peng Wu, Guansong Pang, Qingsen Yan

Research Collection School Of Computing and Information Systems

Low-Light Image Enhancement (LLIE) aims to recover visually pleasing content and details from degraded low-light images. However, existing RGB-based methods often suffer from color bias and brightness artifacts due to inherent high color sensitivity. Although the HSV color space can decouple brightness and color, it introduces noticeable red and black noise artifacts. To address these challenges, we adopt the Horizontal/Vertical-Intensity (HVI) color space for LLIE, which is defined by the HV color map and learnable intensity. The former enforces small distances for red coordinates to alleviate red noise artifacts, while the latter adaptively compresses low-light regions to suppress black noise …


Kidney Transplant Access For Persons Who Are Incarcerated: A Call For Action, Yue-Harn Ng, Camilla L. Nonterah, Vineeta Kumar, Megan Urbanski, James L. Rogers, Martha Pavlakis, Carrie Thiessen Aug 2026

Kidney Transplant Access For Persons Who Are Incarcerated: A Call For Action, Yue-Harn Ng, Camilla L. Nonterah, Vineeta Kumar, Megan Urbanski, James L. Rogers, Martha Pavlakis, Carrie Thiessen

Psychology Faculty Publications

Mr H is a single father of multiple children who was referred for a kidney transplant evaluation. He was diagnosed with chronic kidney disease (CKD) stage 3, attributed to hypertension and ibuprofen use, when he presented with flu-like symptoms in the 1990s. He received care for approximately 3 years before being lost to follow-up. Nearly 30 years later, he re-established care after the initiation of dialysis and was referred for transplantation. At that time, the patient had spent more than 20 years in the prison system and had several years remaining on his current sentence. His Stanford Integrated Psychosocial Assessment …


Understanding What Works In Disseminating Clinical Practice Guidelines: A Qualitative Evidence Synthesis, Sumanth Kumbargere Nagraj, Tandekile Lubelwana Hafver, Valerie Reinthaler, Stijn Van De Velde, Carlos Zaror, Yan Jiao Shen, Susan Banda, Talitha Mpando, Gertrude Kunje, Suzgika Lakudzala, Ameer Hohlfeld, Emmanuel Effa, Denny Mabetha, Thomas Agoritsas, Per Olav Vandvik, Nicolas Delvaux Aug 2026

Understanding What Works In Disseminating Clinical Practice Guidelines: A Qualitative Evidence Synthesis, Sumanth Kumbargere Nagraj, Tandekile Lubelwana Hafver, Valerie Reinthaler, Stijn Van De Velde, Carlos Zaror, Yan Jiao Shen, Susan Banda, Talitha Mpando, Gertrude Kunje, Suzgika Lakudzala, Ameer Hohlfeld, Emmanuel Effa, Denny Mabetha, Thomas Agoritsas, Per Olav Vandvik, Nicolas Delvaux

Peninsula Dental School

Objective To identify the barriers and facilitators that influence the dissemination of clinical practice guidelines (CPGs) and to explore the perceived usefulness, practical utility, expectations, and unmet needs of end users in relation to current dissemination strategies. Methods This qualitative evidence synthesis (QES) is a part of mixed-methods evidence synthesis. We searched literature from MEDLINE, Embase, CINAHL, Web of Science, Scopus, Epistemonikos, and Agency for Healthcare Research and Quality and Medical Guidelines Clearing house on January 30, 2025. Screening, data extraction and quality appraisal of the included studies were done by at least two authors independently and in duplicate. We …


Towards Confucian Economic Democracy: A Relational Alternative To Possessive Individualism, Sor-Hoon Tan Aug 2026

Towards Confucian Economic Democracy: A Relational Alternative To Possessive Individualism, Sor-Hoon Tan

Research Collection School of Social Sciences

This article offers a Confucian conception of ownership and a different approach to equality based on a concept of relational person that could provide an alternative philosophical framework for economic democracy. The Confucian concept of nonexclusive and nonabsolute co-ownership, conditional on owners fulfilling their social responsibilities and sustained in networks of relationships mitigates the drive to appropriation and resistance to redistribution even without formalizing legal rights of equal ownership. Confucian texts’ condemnation of wide disparities between rich and poor corresponds with distributive ideas that balance equal satisfaction of needs with merit-based incentives for productivity constrained by social harmony. Without advocating …


When The Best-Fit Model Is Not Best: The Glass Slipper Fallacy And Latent Growth Mixture Modelling, Jonathan L. Chia, Markus Wettstein, Andree Hartanto Aug 2026

When The Best-Fit Model Is Not Best: The Glass Slipper Fallacy And Latent Growth Mixture Modelling, Jonathan L. Chia, Markus Wettstein, Andree Hartanto

Research Collection School of Social Sciences

Despite the use of latent growth mixture modelling (LGMM) to study longitudinal changes, existing practices may inadvertently impede this very investigation. Although subgroup trajectories may theoretically differ in their structure (e.g., some subgroups being linear, some curvilinear), the current convention advocates overreliance on the baseline model to derive subsequent profile trajectories, which may obscure these structural differences. In this article, we provide a brief description of extant LGMM practices, after which we explicate the pitfalls of the current approach. Finally, we provide a principled approach for LGMM research moving forward. Specifically, we recommend specifying a set of theoretically plausible models …


Artificial Intelligence (Ai) In Forensic Psychology: An Umbrella Review Of Potentials And Pitfalls, Ysabel Thereze Ang Guevarra, Nur Eva Alisha Binte Mohamed Hisham, Andree Hartanto Aug 2026

Artificial Intelligence (Ai) In Forensic Psychology: An Umbrella Review Of Potentials And Pitfalls, Ysabel Thereze Ang Guevarra, Nur Eva Alisha Binte Mohamed Hisham, Andree Hartanto

Research Collection School of Social Sciences

Artificial intelligence (AI) is becoming increasingly embedded within forensic psychological practice, shaping how criminal risk, legal responsibility and public safety are assessed. AI tools are now used in recidivism prediction, behavioural analysis, deception detection and investigative support, high-stakes domains where errors can have profound consequences. Despite this rapid adoption, the existing literature remains fragmented, with most reviews confined to narrow subdomains and offering limited integrated synthesis of AI′s broader role in forensic psychology. Thus, this umbrella review addresses this gap by synthesising findings from 43 reviews obtained from five major databases, namely EBSCOhost ERIC, EBSCOhost PsycInfo, PubMed, Scopus and Web …


Caring With Ai: The Efficacy Of A Customised Chatgpt-Delivered Self-Compassion Intervention On College Students' Well-Being And Academic Functioning, Tracy Xi Chen, Chi-Ying Cheng, Andree Hartanto Aug 2026

Caring With Ai: The Efficacy Of A Customised Chatgpt-Delivered Self-Compassion Intervention On College Students' Well-Being And Academic Functioning, Tracy Xi Chen, Chi-Ying Cheng, Andree Hartanto

Research Collection School of Social Sciences

College students face various challenges, including academic pressure, social stress, and the transition into adulthood, which can lead to increased anxiety and other mental health issues. By recognizing personal struggles as part of a shared human experience and responding with kindness, self-compassion serves as a powerful strategy for enhancing resilience, facilitating better well-being and performance outcomes. Although effective, Compassion-Focused Therapy often requires substantial resources and time, limiting its applicability to college students. To overcome these barriers, the current study designed and evaluated Your Self-Compassion Companion, a ChatGPT-powered AI chatbot intervention grounded in self-compassion theory and delivered over three weekly 20-min …


Transnational Social Protections And The Market: Seeking Support From The Global Cruise Industry, Yasmin Y. Ortiga Aug 2026

Transnational Social Protections And The Market: Seeking Support From The Global Cruise Industry, Yasmin Y. Ortiga

Research Collection School of Social Sciences

Migration studies have mostly portrayed employers as paternalistic or exploitative, creating the very conditions that make migrants’ lives insecure and unstable. This paper challenges this view by showing how the market can also be an unlikely source of protections, where extractive work conditions co-exist with a certain degree of social support. Drawing on interviews with 45 Filipino cruise workers during the COVID-19 pandemic, I discuss how migrants used a logic of employee rights to claim benefits such as food, housing and insurance. Cruise lines willingly provided such protections, but only while workers maintained active contracts onboard their ships. Rather than …


Language And Sound Exposure Across Neonatal Intensive Care Hospitalization And Relationships With Early Outcome, R Pineda, L J Woodward, Z A Vesoulis, C D Smyser, T E Inder, A M Mathur, B L Schlaggar Aug 2026

Language And Sound Exposure Across Neonatal Intensive Care Hospitalization And Relationships With Early Outcome, R Pineda, L J Woodward, Z A Vesoulis, C D Smyser, T E Inder, A M Mathur, B L Schlaggar

2020-Current year OA Pubs

OBJECTIVES: Examine relationships between quantitative measures of language and sound exposure in the NICU and infant neurobehavior.

STUDY DESIGN: Sixty-four preterm infants (≤28 weeks of gestation) had language and sound exposure measured across four time points: within two weeks of birth and at 30, 34, and 35-41 weeks postmenstrual age (PMA). Neurobehavior was assessed at 35-41 weeks PMA using the NICU Network Neurobehavioral Scales.

RESULTS: Higher average decibel levels in the NICU environment were associated with lower infant orientation scores (p = 0.04, β = -0.33). Higher peak decibel levels were associated with greater hypertonia (p = 0.01, β = …


Gender And Professional Identities In Businesswomen’S Negotiation, Chi-Ying Cheng, Amy J. Lim, Yi Wen Tan, Fiona Lee Aug 2026

Gender And Professional Identities In Businesswomen’S Negotiation, Chi-Ying Cheng, Amy J. Lim, Yi Wen Tan, Fiona Lee

Research Collection School of Social Sciences

Gender roles and expectations for women have been shown to account for why women tend to negotiate ineffectively in business settings. Drawing from the psychological literature on multiple identities, this paper examines how individual differences in perceived compatibility between gender and professional identities–captured by the construct Gender-Professional Identity Integration (G-PII)–shape businesswomen’s negotiation behaviors. Two studies examined how G-PII interacts with identity cues and cue valence to influence negotiation outcomes. We found that those who perceived their gender and professional identities as compatible (high G-PII) exhibited an “assimilation” effect–they negotiate more effectively when their professional identity was primed by professional identity …


The Ambivalent Wisdom Of Moral Disgust, Brandon Yip Aug 2026

The Ambivalent Wisdom Of Moral Disgust, Brandon Yip

Research Collection School of Social Sciences

This paper has two aims. First, to provide a positive account of moral disgust. I suggest that moral disgust is a response to acts that are socially corrosive, namely, acts that undermine the normative structure to which an agent is attuned. I support this analysis with two lines of evidence: (1) moral disgust serves the important function of guarding normative structures from socially corrosive actions and (2) the analysis provides an illuminating explanation of moral disgust in a wide variety of cases. The secondary aim of this paper is to probe the normative implications of my positive account. I suggest …


Cae-If: An Anomaly Detection Approach Based On Temporal Representation Of The Reconstruction Error, Haijun Geng, Zhi Zhang, Yuhua Qian, Bo Yang, Qi Ma, Haotian Chi, Jing Yang, Xia Yin Aug 2026

Cae-If: An Anomaly Detection Approach Based On Temporal Representation Of The Reconstruction Error, Haijun Geng, Zhi Zhang, Yuhua Qian, Bo Yang, Qi Ma, Haotian Chi, Jing Yang, Xia Yin

Faculty Research, Scholarly, and Creative Activity

In the field of network traffic anomaly detection, unsupervised learning plays a critical role yet encounters significant challenges, including accurately determining anomaly thresholds and modeling the intricate temporal dynamics of network traffic. To address these challenges, we present a novel approach, termed Convolutional Autoencoder-Isolation Forest (CAE-IF). By leveraging packet-level reconstruction errors with contextual information, our approach obviates the need for manual threshold setting and effectively captures temporal dynamics. The process commences with the application of the damped incremental statistics algorithm to extract statistical features from network traffic with temporal information. Subsequently, the Convolutional Autoencoder (CAE) is employed to compute the …


Lessons Learned From The Adrenalin Load Disaggregation Challenge, András Balázs Tolnai, Zheng Ma, Igor Sartori, Clayton Miller, Stephen White, Matt Amos, Gustaf Bengtsson, Akram Hameed, Nørregaard Bo Jørgensen Aug 2026

Lessons Learned From The Adrenalin Load Disaggregation Challenge, András Balázs Tolnai, Zheng Ma, Igor Sartori, Clayton Miller, Stephen White, Matt Amos, Gustaf Bengtsson, Akram Hameed, Nørregaard Bo Jørgensen

Research Collection College of Integrative Studies

Crowdsourced data science competitions have emerged as a powerful mechanism for advancing research in energy informatics, offering scalable pathways for developing machine learning solutions that enhance energy efficiency and smart building operations. The ADRENALIN Load Disaggregation Challenge addressed a central problem in energy analytics—non-intrusive load monitoring (NILM) of heating and cooling loads in commercial buildings—while emphasizing the importance of model generalization across different buildings. This paper presents a comprehensive reflection on the lessons learned from organizing and executing the ADRENALIN competition, including technical insights, organizational challenges, and recommendations for future energy data challenges. In addition to the ADRENALIN case, a …


Misplay Or Malice? Players’ Interpretations Of Poor Gameplay In Competitive Team-Based Multiplayer Online Games, Valerie Yu, Benjamin H. Detenber, Sonny Rosenthal Aug 2026

Misplay Or Malice? Players’ Interpretations Of Poor Gameplay In Competitive Team-Based Multiplayer Online Games, Valerie Yu, Benjamin H. Detenber, Sonny Rosenthal

Research Collection College of Integrative Studies

Research on perceptions of gaming toxicity has focused on its verbal forms, while gameplay-related forms remain relatively understudied. Furthermore, assessments of gameplay actions as toxic may depend on situational considerations. The present study used a controlled experiment to examine player interpretations of gameplay sabotage using pre-recorded gameplay scenarios from the game, League of Legends. We found that the presence of gameplay sabotage elicited stronger negative emotions and triggered greater player-reported intentions to retaliate and correct the offending player than in comparable instances of unintentional poor gameplay. Further exploratory analyses suggested that participants rated poor gameplay as less acceptable in more …


Surgeon Health And Well-Being Initiative: A Survey Of General And Orthopedic Surgery Residents' Reports Of Musculoskeletal Pain., Maryam Mohamed, Grace J Kim, Kristen Conrad-Schnetz, Zhan Yang, Mary Carneval Aug 2026

Surgeon Health And Well-Being Initiative: A Survey Of General And Orthopedic Surgery Residents' Reports Of Musculoskeletal Pain., Maryam Mohamed, Grace J Kim, Kristen Conrad-Schnetz, Zhan Yang, Mary Carneval

Ambulatory and Primary Care Articles

Background Musculoskeletal (MSK) pain is a well-known risk among surgeons, resulting from the multifactorial physical demands of the occupation. Because of the demands faced by resident surgeons, many individuals find themselves with sometimes debilitating MSK pain. Although these risks are well documented and there have been proposed solutions, there is little discussion on the role that osteopathic manipulative treatment (OMT) can play in relief of MSK pain over time in this population. Objective The purpose of this study is to determine the prevalence and distribution of MSK pain among general and orthopedic surgery residents at Cleveland Clinic Foundation (CCF). Based …


Carroll County Extension Update August 2026, Mikayla Cerney Aug 2026

Carroll County Extension Update August 2026, Mikayla Cerney

UNH Cooperative Extension

No abstract provided.


2026 Deerfield Fair 4-H Exhibit Building Premium Book, Extension Aug 2026

2026 Deerfield Fair 4-H Exhibit Building Premium Book, Extension

UNH Cooperative Extension

No abstract provided.


2026 Deerfield Fair 4-H Animal Premium Book, Extension Aug 2026

2026 Deerfield Fair 4-H Animal Premium Book, Extension

UNH Cooperative Extension

No abstract provided.


Air-Assist Or Mist Backpack Sprayer Calibration Worksheet, Amy Papineau Aug 2026

Air-Assist Or Mist Backpack Sprayer Calibration Worksheet, Amy Papineau

UNH Cooperative Extension

No abstract provided.


Nh Dfl - 25 Years Of Hwa - Peterborough_2026_Aug_11, Ryan Crandall Aug 2026

Nh Dfl - 25 Years Of Hwa - Peterborough_2026_Aug_11, Ryan Crandall

UNH Cooperative Extension

No abstract provided.


Electric Or Gas Powered Backpack Sprayer Calibration Worksheet - 128th Method, Amy Papineau Aug 2026

Electric Or Gas Powered Backpack Sprayer Calibration Worksheet - 128th Method, Amy Papineau

UNH Cooperative Extension

No abstract provided.


Nutrition Considerations In Youth With Type 2 Diabetes Using Glucagon-Like Peptide-1 Receptor Agonists: A Commentary, Maria E Diaz, Grace Kim, Mili Vakharia Aug 2026

Nutrition Considerations In Youth With Type 2 Diabetes Using Glucagon-Like Peptide-1 Receptor Agonists: A Commentary, Maria E Diaz, Grace Kim, Mili Vakharia

Faculty, Staff and Students Publications

No abstract provided.


Colocalization Of Eqtls With Type 2 Diabetes And Glycemic Traits Using Whole-Genome Sequences In Diverse Populations From The Nhlbi Trans-Omics In Precision Medicine (Topmed) Program, Ningyuan Wang, Daniel A Dicorpo, Yixin Zhang, Erica Kleinbrink, Donna K Arnett, John Barnard, John Blangero, Donald W Bowden, April P Carson, Yii-Der Ida Chen, Mina K Chung, Joanne E Curran, Dawood Darbar, Ravindranath Duggirala, Patrick T Ellinor, Diane Fatkin, Myriam Fornage, Nancy Heard-Costa, Jiang He, Lifang Hou, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, David D Mcmanus, Braxton D Mitchell, Ryan L Minster, Kari E North, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Dan Roden, Jerome I Rotter, Moore B Shoemaker, Jonathan D Smith, David R Van Wagoner, Francois Aguet, Kristin Ardlie, Joshua C Bis, Jennifer A Brody, Brian E Cade, Clary B Clish, Paul S De Vries, James S Floyd, Barry I Freedman, Stacey Gabriel, Robert E Gerzsten, Mark O Goodarzi, Charles Gu, Xiuqing Guo, Namrata Gupta, Susan R Heckbert, Sarah Hsu, Yi-Jen Hung, Rita R Kalyani, Tanika N Kelly, Gregory L Kinney, Changwei Li, Simin Liu, Yongmei Liu, Donald M Lloyd-Jones, Joann E Manson, Rasika A Mathias, Josep M Mercader, Alanna C Morrison, Take Naseri, Suna Onengut, Nicholette D Palmer, Patricia A Peyser, Qibin Qi, Sridharan Raghavan, Alex P Reiner, Mary R Rooney, Magdalena Sevilla-Gonzalez, Chloe Sarnowski, Joshua D Smith, Jennifer A Smith, Nicole L Spartano, Usman Tahir, Kent D Taylor, Deirdre K Tobias, Russel P Tracy, Satupa'itea Viali, Heming Wang, Alexis C Wood, Lisa R Yanek, Wei Zhao, Yinan Zheng, Josée Dupuis, Ching-Ti Liu, Robert Sladek, Jennifer Wessel, James B Meigs, Alisa K Manning, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium Aug 2026

Colocalization Of Eqtls With Type 2 Diabetes And Glycemic Traits Using Whole-Genome Sequences In Diverse Populations From The Nhlbi Trans-Omics In Precision Medicine (Topmed) Program, Ningyuan Wang, Daniel A Dicorpo, Yixin Zhang, Erica Kleinbrink, Donna K Arnett, John Barnard, John Blangero, Donald W Bowden, April P Carson, Yii-Der Ida Chen, Mina K Chung, Joanne E Curran, Dawood Darbar, Ravindranath Duggirala, Patrick T Ellinor, Diane Fatkin, Myriam Fornage, Nancy Heard-Costa, Jiang He, Lifang Hou, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, David D Mcmanus, Braxton D Mitchell, Ryan L Minster, Kari E North, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Dan Roden, Jerome I Rotter, Moore B Shoemaker, Jonathan D Smith, David R Van Wagoner, Francois Aguet, Kristin Ardlie, Joshua C Bis, Jennifer A Brody, Brian E Cade, Clary B Clish, Paul S De Vries, James S Floyd, Barry I Freedman, Stacey Gabriel, Robert E Gerzsten, Mark O Goodarzi, Charles Gu, Xiuqing Guo, Namrata Gupta, Susan R Heckbert, Sarah Hsu, Yi-Jen Hung, Rita R Kalyani, Tanika N Kelly, Gregory L Kinney, Changwei Li, Simin Liu, Yongmei Liu, Donald M Lloyd-Jones, Joann E Manson, Rasika A Mathias, Josep M Mercader, Alanna C Morrison, Take Naseri, Suna Onengut, Nicholette D Palmer, Patricia A Peyser, Qibin Qi, Sridharan Raghavan, Alex P Reiner, Mary R Rooney, Magdalena Sevilla-Gonzalez, Chloe Sarnowski, Joshua D Smith, Jennifer A Smith, Nicole L Spartano, Usman Tahir, Kent D Taylor, Deirdre K Tobias, Russel P Tracy, Satupa'itea Viali, Heming Wang, Alexis C Wood, Lisa R Yanek, Wei Zhao, Yinan Zheng, Josée Dupuis, Ching-Ti Liu, Robert Sladek, Jennifer Wessel, James B Meigs, Alisa K Manning, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium

Faculty, Staff and Students Publications

Large-scale multiancestry genome-wide association studies have identified hundreds of loci associated with type 2 diabetes (T2D) and glycemic traits, yet imputed genotyping arrays limit the detection of low-frequency and rare variants. Whole-genome sequencing (WGS) offers a more complete view of genetic variation, especially across diverse populations. We analyzed high-coverage (38×) WGS data from 21,913 T2D case subjects, 61,036 control subjects, and up to 50,011 individuals with no diabetes with fasting glucose, fasting insulin, and HbA1c from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Program. We performed single-variant association testing, conditional analysis, fine-mapping, and Bayesian colocalization to …


Quantitative Imaging Of Pyruvate Metabolism In A Patient With Anaplastic Thyroid Cancer, James A Bankson, Joshua S Niedzielski, Collin J Harlan, Yunyun Chen, Christopher M Walker, Philip L Lorenzi, Lin Tan, Vikas Kundra, Matthew E Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B Peterson, Clifton D Fuller, Vlad C Sandulache, Stephen Y Lai Aug 2026

Quantitative Imaging Of Pyruvate Metabolism In A Patient With Anaplastic Thyroid Cancer, James A Bankson, Joshua S Niedzielski, Collin J Harlan, Yunyun Chen, Christopher M Walker, Philip L Lorenzi, Lin Tan, Vikas Kundra, Matthew E Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B Peterson, Clifton D Fuller, Vlad C Sandulache, Stephen Y Lai

Faculty, Staff and Students Publications

Purpose: Magnetic resonance imaging using hyperpolarized (HP) [1-13C]-pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi-quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular metabolism. A validated pharmacokinetic (PK) model for analysis of intracellular pyruvate metabolism is needed to enhance the accuracy of quantitative metrics and clinical translation of metabolic MRI using HP pyruvate.

Methods: A PK model with two physical compartments and two chemical pools was developed to analyze the conversion of labeled pyruvate into lactate in vitro. …


Tellurium Selenide Quantum Wires Synthesized By Pulsed Laser Ablation In Liquids, Rajendra Subedi, Francisco Ruiz-Zepeda, Iono Hill, Geraldine Hallais, Etienne Herth, Gregory Guisbiers Aug 2026

Tellurium Selenide Quantum Wires Synthesized By Pulsed Laser Ablation In Liquids, Rajendra Subedi, Francisco Ruiz-Zepeda, Iono Hill, Geraldine Hallais, Etienne Herth, Gregory Guisbiers

Faculty Scholarship

Tellurium–selenide (TexSe1-x) binary alloys are promising chalcogenide systems with tunable optoelectronic properties, yet their synthesis in quantumly confined one-dimensional forms remains limited. Here, we report the synthesis of TexSe1-x quantum wires (QWs) via a two-step pulsed laser ablation in liquids (PLAL) approach, enabling surfactant-free formation of alloyed nanostructures under non-equilibrium conditions. A tellurium colloid is first generated and subsequently exposed to selenium ablation, promoting in-situ alloying through repeated plasma-bubble interactions at high repetition rate. The resulting QWs exhibit an average diameter of ~17 ± 4 nm and a length of ~475 ± 46 nm. Structural and chemical analyses (XRD, Raman, …


Navigating Undone Science: The Search For Adequate Endometriosis Care, Heather Welty, Melanie Jeske Aug 2026

Navigating Undone Science: The Search For Adequate Endometriosis Care, Heather Welty, Melanie Jeske

Center for Medical Ethics and Health Policy Staff Publications

Endometriosis is an estrogen-dependent disease in which tissue similar to the lining of the uterus grows elsewhere in the body leading to a variety of symptoms including heavy and prolonged menstruation, chronic pain, cysts, infertility, and gastrointestinal issues. Despite being one of the most common gynecologic conditions, much remains unknown about potential risk factors for endometriosis, its etiology, and treatment options. First and second-line biomedical treatment options, complementary and alternative medicine, and lifestyle changes are all treatment options that people living with endometriosis (PLE) leverage to manage their symptoms. This article draws on in-depth interviews with 52 people living with …


Decision-Making Criteria In Polygenic Embryo Screening: A Survey Of Reproductive Medicine Physicians, Rémy A Furrer, Aayushi Gandhi, Dorit Barlevy, Shai Carmi, Todd Lencz, Stacey Pereira, Gabriel Lázaro-Muñoz Aug 2026

Decision-Making Criteria In Polygenic Embryo Screening: A Survey Of Reproductive Medicine Physicians, Rémy A Furrer, Aayushi Gandhi, Dorit Barlevy, Shai Carmi, Todd Lencz, Stacey Pereira, Gabriel Lázaro-Muñoz

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Polygenic embryo screening (PES) examines embryos for their genetic likelihood of developing complex conditions and traits. The commercialization of PES places reproductive endocrinologists and infertility specialists (REIs) as the primary decision-makers in its use, despite professional guidelines cautioning that PES is not ready for clinical use.

Methods: This survey examines how 152 US REIs perceive and approach potential clinical decision-making scenarios regarding the use of PES.

Results: REIs were more likely to offer PES for medical conditions (up to 62% for cancer) than for traits (eg, 0% for skin color, 10% for body mass index). When evaluating 11 potential …


A Blended Genome And Exome Sequencing Method Captures Genetic Variation In An Unbiased And Cost-Effective Manner, Toni A Boltz, Benjamin B Chu, Matthew Defelice, Calwing Liao, Julia M Sealock, Robert Ye, Jacqueline I Goldstein, Lerato Majara, Jack M Fu, Susan K Service, Lingyu Zhan, Sarah E Medland, Sinéad B Chapman, Simone Rubinacci, Jonna L Grimsby, Tamrat Abebe, Melkam Alemayehu, Fred K Ashaba, Elizabeth G Atkinson, Tim B Bigdeli, Amanda B Bradway, Harrison Brand, Lori B Chibnik, Samuel Deluca, Ana M Diaz-Zuluaga, Abebaw Fekadu, Michael Gatzen, Bizu Gelaye, Stella Gichuru, Marissa L Gildea, Toni C Hill, Hailiang Huang, Kalyn M Hubbard, Wilfred E Injera, Roxanne James, Moses Joloba, Christopher Kachulis, Phillip R Kalmbach, Rogers Kamulegeya, Gabriel Kigen, Soyeon Kim, Nastassja Koen, Edith K Kwobah, Joseph Kyebuzibwa, Seungmo Lee, Niall J Lennon, Penelope A Lind, Esteban A Lopera-Maya, Johnstone Makale, Serghei Mangul, Justin Mcmahon, Pierre Mowlem, Henry Musinguzi, Rehema M Mwema, Noeline Nakasujja, Carter P Newman, Lethukuthula L Nkambule, Conor R O'Neil, Ana Maria Olivares, Catherine M Olsen, Linnet Ongeri, Sophie J Parsa, Adele Pretorius, Shengying Qin, Raj Ramesar, Faye L Reagan, Chiara Sabatti, Jacquelyn A Schneider, Welelta Shiferaw, Christine Stevens, Anne Stevenson, Erik Stricker, Rocky E Stroud, Jessie Tang, Megan Townsend, David Whiteman, Mary T Yohannes, Mingrui Yu, Kai Yuan, Dickens Akena, Lukoye Atwoli, Symon M Kariuki, Karestan C Koenen, Charles R J C Newton, Dan J Stein, Solomon Teferra, Zukiswa Zingela, Carlos N Pato, Michele T Pato, Carlos Lopez-Jaramillo, Nelson B Freimer, Roel A Ophoff, Loes M Olde Loohuis, Michael E Talkowski, Benjamin M Neale, Daniel P Howrigan, Alicia R Martin Aug 2026

A Blended Genome And Exome Sequencing Method Captures Genetic Variation In An Unbiased And Cost-Effective Manner, Toni A Boltz, Benjamin B Chu, Matthew Defelice, Calwing Liao, Julia M Sealock, Robert Ye, Jacqueline I Goldstein, Lerato Majara, Jack M Fu, Susan K Service, Lingyu Zhan, Sarah E Medland, Sinéad B Chapman, Simone Rubinacci, Jonna L Grimsby, Tamrat Abebe, Melkam Alemayehu, Fred K Ashaba, Elizabeth G Atkinson, Tim B Bigdeli, Amanda B Bradway, Harrison Brand, Lori B Chibnik, Samuel Deluca, Ana M Diaz-Zuluaga, Abebaw Fekadu, Michael Gatzen, Bizu Gelaye, Stella Gichuru, Marissa L Gildea, Toni C Hill, Hailiang Huang, Kalyn M Hubbard, Wilfred E Injera, Roxanne James, Moses Joloba, Christopher Kachulis, Phillip R Kalmbach, Rogers Kamulegeya, Gabriel Kigen, Soyeon Kim, Nastassja Koen, Edith K Kwobah, Joseph Kyebuzibwa, Seungmo Lee, Niall J Lennon, Penelope A Lind, Esteban A Lopera-Maya, Johnstone Makale, Serghei Mangul, Justin Mcmahon, Pierre Mowlem, Henry Musinguzi, Rehema M Mwema, Noeline Nakasujja, Carter P Newman, Lethukuthula L Nkambule, Conor R O'Neil, Ana Maria Olivares, Catherine M Olsen, Linnet Ongeri, Sophie J Parsa, Adele Pretorius, Shengying Qin, Raj Ramesar, Faye L Reagan, Chiara Sabatti, Jacquelyn A Schneider, Welelta Shiferaw, Christine Stevens, Anne Stevenson, Erik Stricker, Rocky E Stroud, Jessie Tang, Megan Townsend, David Whiteman, Mary T Yohannes, Mingrui Yu, Kai Yuan, Dickens Akena, Lukoye Atwoli, Symon M Kariuki, Karestan C Koenen, Charles R J C Newton, Dan J Stein, Solomon Teferra, Zukiswa Zingela, Carlos N Pato, Michele T Pato, Carlos Lopez-Jaramillo, Nelson B Freimer, Roel A Ophoff, Loes M Olde Loohuis, Michael E Talkowski, Benjamin M Neale, Daniel P Howrigan, Alicia R Martin

Duncan NRI Faculty and Staff Publications

Here we developed and deployed the blended genome exome (BGE) method, a DNA library approach that generates low-pass whole-genome (1–4× mean depth) and deep whole-exome (30–40× mean depth) data in a single sequencing run. BGE is cost-effective, empowers most genomic discoveries possible with deep whole-genome sequencing and captures global common single-nucleotide polymorphism diversity. We applied BGE to sequence >53,000 samples from the PUMAS Project (Populations Underrepresented in Mental Illness Associations Studies), including African, African American and Latin American populations. Imputed genotypes showed high concordance with Illumina Global Screening Array calls (R2 ≥ 95% for minor allele frequency ≥1%; …


Hippo Signaling Regulates Cuticle Pigmentation And Dopamine Metabolism In Drosophila, Shelley B Gibson, Samantha L Deal, Ye-Jin Park, Bo Sun, Yanyan Qi, Jung-Wan Mok, Hyung-Lok Chung, Hongjie Li, Shinya Yamamoto Aug 2026

Hippo Signaling Regulates Cuticle Pigmentation And Dopamine Metabolism In Drosophila, Shelley B Gibson, Samantha L Deal, Ye-Jin Park, Bo Sun, Yanyan Qi, Jung-Wan Mok, Hyung-Lok Chung, Hongjie Li, Shinya Yamamoto

Duncan NRI Faculty and Staff Publications

Pigmentation plays multiple important roles in development, physiology and evolution. Melanization of the insect cuticle requires dopamine as a precursor of melanin and involves key enzymes in dopamine biosynthesis including Tyrosine hydroxylase (TH) and Dopa decarboxylase (Ddc). Some studies have hinted that disruption of the evolutionarily conserved Hippo signaling pathway, which has been primarily studied in the context of tissue growth, may lead to changes in cuticle pigmentation in the fruit fly Drosophila melanogaster. However, to our knowledge, there have not been any systematic investigations into their potential mechanistic links. In this study, we identified that all genes that comprise …


A Scoping Review Of Participatory Tools And Practices In Collaborative Processes: Towards Multi-Actor Collaboration In Integrated Landscape Approaches, Irmeli Mustalahti, Ida Herdieckerhoff, Rebecca Mclain, Anna Mustonen, Rijal Ramdani, Agustiyara Agustiyara, Denis Dobrynin, Nicole Klenk, Gadfly Stratton, Miriam Castillo Orozco, Multiple Additional Authors Aug 2026

A Scoping Review Of Participatory Tools And Practices In Collaborative Processes: Towards Multi-Actor Collaboration In Integrated Landscape Approaches, Irmeli Mustalahti, Ida Herdieckerhoff, Rebecca Mclain, Anna Mustonen, Rijal Ramdani, Agustiyara Agustiyara, Denis Dobrynin, Nicole Klenk, Gadfly Stratton, Miriam Castillo Orozco, Multiple Additional Authors

National Policy Consensus Center Publications

In this article, we ask how the different tools and practices used in participatory and collaborative processes could support multi-actor collaboration in integrated landscape approaches (ILAs). First, we conducted a scoping review to identify and synthesize literature on participatory and collaborative approaches related to forest, water, land and landscapes. Secondly, we analysed 130 articles to understand how and by which means these approaches engaged different actors in multi-actor collaborations. Our findings identified a wealth of different tools and practices available to support participatory and collaborative approaches, such as participatory mapping and modelling, games and visualizations, scenario development, and knowledge co-creation. …