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Articles 4591 - 4620 of 2258851
Full-Text Articles in Entire DC Network
Greenhouse Gas Flux Response In Biochar- And Compost-Amended Lawn Soils Under Simulated Water Saturation Conditions, Angel Salinas, Chu-Lin Cheng, Engil Pereira, Rafael M. Almeida, James Jihoon Kang
Greenhouse Gas Flux Response In Biochar- And Compost-Amended Lawn Soils Under Simulated Water Saturation Conditions, Angel Salinas, Chu-Lin Cheng, Engil Pereira, Rafael M. Almeida, James Jihoon Kang
School of Earth, Environmental, & Marine Sciences Faculty Publications
Understanding greenhouse gas emission dynamics in lawn soils is important for improving climate change mitigation strategies in urban and suburban landscapes. In this greenhouse mesocosm study, carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) fluxes were measured from 12 turfgrass soil columns arranged in an unreplicated, completely randomized 4 × 3 factorial design. Four amendment treatments (biochar, compost, bio-com [1:1 volume ratio of biochar and compost], and unamended control) were combined with three water-table conditions (full saturation, half saturation, and unsaturated), with a single column representing each treatment combination. Columns were irrigated at 1 cm day−1 for 24 days, …
When Work Is Not Enough: Food Insecurity Among Employed Latinos Receiving Snap In Massachusetts And The Burden Carried By Latina Women, Phillip Granberry, Rafael M. Pérez Medina, Florita Coto Tristán
When Work Is Not Enough: Food Insecurity Among Employed Latinos Receiving Snap In Massachusetts And The Burden Carried By Latina Women, Phillip Granberry, Rafael M. Pérez Medina, Florita Coto Tristán
Gastón Institute Publications
Across Massachusetts, many SNAP recipients are workers, caregivers, parents, elders, people with disabilities, and families navigating low wages, unstable work schedules, high housing costs, and limited access to wealth building opportunities. Many of these workers held jobs that were labeled “essential” during the COVID-19 pandemic: food service, caregiving, cleaning, healthcare support, retail, transportation, construction, and other service sector jobs. Yet the public recognition of their essential labor has not been translated into adequate wages, benefits, or economic security.
Genwriter 2.0: A Hybrid Case-Based And Llm Rewriting Approach For Mitigating Implicit Gender Cues In Text, Shweta Soundararajan, Sarah Jane Delany
Genwriter 2.0: A Hybrid Case-Based And Llm Rewriting Approach For Mitigating Implicit Gender Cues In Text, Shweta Soundararajan, Sarah Jane Delany
Conference papers
Gendered language is the use of words or phrases that indicate an individual's gender. Although useful in some contexts, gendered language can reinforce gender stereotypes and introduce bias, particularly in machine learning models for tasks involving people such as recruitment or occupation classification. When textual content about individuals, such as biographies, contain gender cues, models can learn spurious associations between gender and other characteristics of individuals, such as profession, potentially resulting in unfair outcomes such as reduced hiring opportunities for women.
To address this challenge, we propose GenWriter 2.0, a hybrid approach that integrates Case-Based Reasoning (CBR) with Large …
Hvi-Cidnet+: Beyond Extreme Darkness For Low-Light Image Enhancement, Kangbiao Shi, Xiaowen Ma, Yixu Feng, Tao Hu, Peng Wu, Guansong Pang, Qingsen Yan
Hvi-Cidnet+: Beyond Extreme Darkness For Low-Light Image Enhancement, Kangbiao Shi, Xiaowen Ma, Yixu Feng, Tao Hu, Peng Wu, Guansong Pang, Qingsen Yan
Research Collection School Of Computing and Information Systems
Low-Light Image Enhancement (LLIE) aims to recover visually pleasing content and details from degraded low-light images. However, existing RGB-based methods often suffer from color bias and brightness artifacts due to inherent high color sensitivity. Although the HSV color space can decouple brightness and color, it introduces noticeable red and black noise artifacts. To address these challenges, we adopt the Horizontal/Vertical-Intensity (HVI) color space for LLIE, which is defined by the HV color map and learnable intensity. The former enforces small distances for red coordinates to alleviate red noise artifacts, while the latter adaptively compresses low-light regions to suppress black noise …
Kidney Transplant Access For Persons Who Are Incarcerated: A Call For Action, Yue-Harn Ng, Camilla L. Nonterah, Vineeta Kumar, Megan Urbanski, James L. Rogers, Martha Pavlakis, Carrie Thiessen
Kidney Transplant Access For Persons Who Are Incarcerated: A Call For Action, Yue-Harn Ng, Camilla L. Nonterah, Vineeta Kumar, Megan Urbanski, James L. Rogers, Martha Pavlakis, Carrie Thiessen
Psychology Faculty Publications
Mr H is a single father of multiple children who was referred for a kidney transplant evaluation. He was diagnosed with chronic kidney disease (CKD) stage 3, attributed to hypertension and ibuprofen use, when he presented with flu-like symptoms in the 1990s. He received care for approximately 3 years before being lost to follow-up. Nearly 30 years later, he re-established care after the initiation of dialysis and was referred for transplantation. At that time, the patient had spent more than 20 years in the prison system and had several years remaining on his current sentence. His Stanford Integrated Psychosocial Assessment …
Understanding What Works In Disseminating Clinical Practice Guidelines: A Qualitative Evidence Synthesis, Sumanth Kumbargere Nagraj, Tandekile Lubelwana Hafver, Valerie Reinthaler, Stijn Van De Velde, Carlos Zaror, Yan Jiao Shen, Susan Banda, Talitha Mpando, Gertrude Kunje, Suzgika Lakudzala, Ameer Hohlfeld, Emmanuel Effa, Denny Mabetha, Thomas Agoritsas, Per Olav Vandvik, Nicolas Delvaux
Understanding What Works In Disseminating Clinical Practice Guidelines: A Qualitative Evidence Synthesis, Sumanth Kumbargere Nagraj, Tandekile Lubelwana Hafver, Valerie Reinthaler, Stijn Van De Velde, Carlos Zaror, Yan Jiao Shen, Susan Banda, Talitha Mpando, Gertrude Kunje, Suzgika Lakudzala, Ameer Hohlfeld, Emmanuel Effa, Denny Mabetha, Thomas Agoritsas, Per Olav Vandvik, Nicolas Delvaux
Peninsula Dental School
Objective To identify the barriers and facilitators that influence the dissemination of clinical practice guidelines (CPGs) and to explore the perceived usefulness, practical utility, expectations, and unmet needs of end users in relation to current dissemination strategies. Methods This qualitative evidence synthesis (QES) is a part of mixed-methods evidence synthesis. We searched literature from MEDLINE, Embase, CINAHL, Web of Science, Scopus, Epistemonikos, and Agency for Healthcare Research and Quality and Medical Guidelines Clearing house on January 30, 2025. Screening, data extraction and quality appraisal of the included studies were done by at least two authors independently and in duplicate. We …
Towards Confucian Economic Democracy: A Relational Alternative To Possessive Individualism, Sor-Hoon Tan
Towards Confucian Economic Democracy: A Relational Alternative To Possessive Individualism, Sor-Hoon Tan
Research Collection School of Social Sciences
This article offers a Confucian conception of ownership and a different approach to equality based on a concept of relational person that could provide an alternative philosophical framework for economic democracy. The Confucian concept of nonexclusive and nonabsolute co-ownership, conditional on owners fulfilling their social responsibilities and sustained in networks of relationships mitigates the drive to appropriation and resistance to redistribution even without formalizing legal rights of equal ownership. Confucian texts’ condemnation of wide disparities between rich and poor corresponds with distributive ideas that balance equal satisfaction of needs with merit-based incentives for productivity constrained by social harmony. Without advocating …
When The Best-Fit Model Is Not Best: The Glass Slipper Fallacy And Latent Growth Mixture Modelling, Jonathan L. Chia, Markus Wettstein, Andree Hartanto
When The Best-Fit Model Is Not Best: The Glass Slipper Fallacy And Latent Growth Mixture Modelling, Jonathan L. Chia, Markus Wettstein, Andree Hartanto
Research Collection School of Social Sciences
Despite the use of latent growth mixture modelling (LGMM) to study longitudinal changes, existing practices may inadvertently impede this very investigation. Although subgroup trajectories may theoretically differ in their structure (e.g., some subgroups being linear, some curvilinear), the current convention advocates overreliance on the baseline model to derive subsequent profile trajectories, which may obscure these structural differences. In this article, we provide a brief description of extant LGMM practices, after which we explicate the pitfalls of the current approach. Finally, we provide a principled approach for LGMM research moving forward. Specifically, we recommend specifying a set of theoretically plausible models …
Artificial Intelligence (Ai) In Forensic Psychology: An Umbrella Review Of Potentials And Pitfalls, Ysabel Thereze Ang Guevarra, Nur Eva Alisha Binte Mohamed Hisham, Andree Hartanto
Artificial Intelligence (Ai) In Forensic Psychology: An Umbrella Review Of Potentials And Pitfalls, Ysabel Thereze Ang Guevarra, Nur Eva Alisha Binte Mohamed Hisham, Andree Hartanto
Research Collection School of Social Sciences
Artificial intelligence (AI) is becoming increasingly embedded within forensic psychological practice, shaping how criminal risk, legal responsibility and public safety are assessed. AI tools are now used in recidivism prediction, behavioural analysis, deception detection and investigative support, high-stakes domains where errors can have profound consequences. Despite this rapid adoption, the existing literature remains fragmented, with most reviews confined to narrow subdomains and offering limited integrated synthesis of AI′s broader role in forensic psychology. Thus, this umbrella review addresses this gap by synthesising findings from 43 reviews obtained from five major databases, namely EBSCOhost ERIC, EBSCOhost PsycInfo, PubMed, Scopus and Web …
Caring With Ai: The Efficacy Of A Customised Chatgpt-Delivered Self-Compassion Intervention On College Students' Well-Being And Academic Functioning, Tracy Xi Chen, Chi-Ying Cheng, Andree Hartanto
Caring With Ai: The Efficacy Of A Customised Chatgpt-Delivered Self-Compassion Intervention On College Students' Well-Being And Academic Functioning, Tracy Xi Chen, Chi-Ying Cheng, Andree Hartanto
Research Collection School of Social Sciences
College students face various challenges, including academic pressure, social stress, and the transition into adulthood, which can lead to increased anxiety and other mental health issues. By recognizing personal struggles as part of a shared human experience and responding with kindness, self-compassion serves as a powerful strategy for enhancing resilience, facilitating better well-being and performance outcomes. Although effective, Compassion-Focused Therapy often requires substantial resources and time, limiting its applicability to college students. To overcome these barriers, the current study designed and evaluated Your Self-Compassion Companion, a ChatGPT-powered AI chatbot intervention grounded in self-compassion theory and delivered over three weekly 20-min …
Transnational Social Protections And The Market: Seeking Support From The Global Cruise Industry, Yasmin Y. Ortiga
Transnational Social Protections And The Market: Seeking Support From The Global Cruise Industry, Yasmin Y. Ortiga
Research Collection School of Social Sciences
Migration studies have mostly portrayed employers as paternalistic or exploitative, creating the very conditions that make migrants’ lives insecure and unstable. This paper challenges this view by showing how the market can also be an unlikely source of protections, where extractive work conditions co-exist with a certain degree of social support. Drawing on interviews with 45 Filipino cruise workers during the COVID-19 pandemic, I discuss how migrants used a logic of employee rights to claim benefits such as food, housing and insurance. Cruise lines willingly provided such protections, but only while workers maintained active contracts onboard their ships. Rather than …
A Multistate Analysis Of Longitudinal Care Outcomes Among People Newly Linked To Human Immunodeficiency Virus Care In Missouri, Aditi Ramakrishnan, Daniel Vo, Ernie-Paul Barrette, Rachel M Presti, William G Powderly, Anne Trolard, Corey Grejtak-Heaps, Elvin H Geng, Aaloke Mody, Lindsey M Filiatreau
A Multistate Analysis Of Longitudinal Care Outcomes Among People Newly Linked To Human Immunodeficiency Virus Care In Missouri, Aditi Ramakrishnan, Daniel Vo, Ernie-Paul Barrette, Rachel M Presti, William G Powderly, Anne Trolard, Corey Grejtak-Heaps, Elvin H Geng, Aaloke Mody, Lindsey M Filiatreau
2020-Current year OA Pubs
BACKGROUND: Advancing the HIV response in Missouri, an Ending the HIV Epidemic priority state, requires stronger characterization of treatment gaps. Routine cross-sectional reporting may fail to capture important gaps in care that longitudinal methods can reveal.
METHODS: We characterized clinic engagement and viral suppression among people with Human Immunodeficiency Virus (HIV) aged ≥18 years who were newly linked to clinic in St Louis, Missouri, between 1 January 2015 and 15 March 2020. Using multistate analytic methods that capture change over time, we estimated the prevalence of individuals in 9 mutually exclusive and exhaustive states over 3 years following linkage to …
Language And Sound Exposure Across Neonatal Intensive Care Hospitalization And Relationships With Early Outcome, R Pineda, L J Woodward, Z A Vesoulis, C D Smyser, T E Inder, A M Mathur, B L Schlaggar
Language And Sound Exposure Across Neonatal Intensive Care Hospitalization And Relationships With Early Outcome, R Pineda, L J Woodward, Z A Vesoulis, C D Smyser, T E Inder, A M Mathur, B L Schlaggar
2020-Current year OA Pubs
OBJECTIVES: Examine relationships between quantitative measures of language and sound exposure in the NICU and infant neurobehavior.
STUDY DESIGN: Sixty-four preterm infants (≤28 weeks of gestation) had language and sound exposure measured across four time points: within two weeks of birth and at 30, 34, and 35-41 weeks postmenstrual age (PMA). Neurobehavior was assessed at 35-41 weeks PMA using the NICU Network Neurobehavioral Scales.
RESULTS: Higher average decibel levels in the NICU environment were associated with lower infant orientation scores (p = 0.04, β = -0.33). Higher peak decibel levels were associated with greater hypertonia (p = 0.01, β = …
Gender And Professional Identities In Businesswomen’S Negotiation, Chi-Ying Cheng, Amy J. Lim, Yi Wen Tan, Fiona Lee
Gender And Professional Identities In Businesswomen’S Negotiation, Chi-Ying Cheng, Amy J. Lim, Yi Wen Tan, Fiona Lee
Research Collection School of Social Sciences
Gender roles and expectations for women have been shown to account for why women tend to negotiate ineffectively in business settings. Drawing from the psychological literature on multiple identities, this paper examines how individual differences in perceived compatibility between gender and professional identities–captured by the construct Gender-Professional Identity Integration (G-PII)–shape businesswomen’s negotiation behaviors. Two studies examined how G-PII interacts with identity cues and cue valence to influence negotiation outcomes. We found that those who perceived their gender and professional identities as compatible (high G-PII) exhibited an “assimilation” effect–they negotiate more effectively when their professional identity was primed by professional identity …
The Ambivalent Wisdom Of Moral Disgust, Brandon Yip
The Ambivalent Wisdom Of Moral Disgust, Brandon Yip
Research Collection School of Social Sciences
This paper has two aims. First, to provide a positive account of moral disgust. I suggest that moral disgust is a response to acts that are socially corrosive, namely, acts that undermine the normative structure to which an agent is attuned. I support this analysis with two lines of evidence: (1) moral disgust serves the important function of guarding normative structures from socially corrosive actions and (2) the analysis provides an illuminating explanation of moral disgust in a wide variety of cases. The secondary aim of this paper is to probe the normative implications of my positive account. I suggest …
Cae-If: An Anomaly Detection Approach Based On Temporal Representation Of The Reconstruction Error, Haijun Geng, Zhi Zhang, Yuhua Qian, Bo Yang, Qi Ma, Haotian Chi, Jing Yang, Xia Yin
Cae-If: An Anomaly Detection Approach Based On Temporal Representation Of The Reconstruction Error, Haijun Geng, Zhi Zhang, Yuhua Qian, Bo Yang, Qi Ma, Haotian Chi, Jing Yang, Xia Yin
Faculty Research, Scholarly, and Creative Activity
In the field of network traffic anomaly detection, unsupervised learning plays a critical role yet encounters significant challenges, including accurately determining anomaly thresholds and modeling the intricate temporal dynamics of network traffic. To address these challenges, we present a novel approach, termed Convolutional Autoencoder-Isolation Forest (CAE-IF). By leveraging packet-level reconstruction errors with contextual information, our approach obviates the need for manual threshold setting and effectively captures temporal dynamics. The process commences with the application of the damped incremental statistics algorithm to extract statistical features from network traffic with temporal information. Subsequently, the Convolutional Autoencoder (CAE) is employed to compute the …
Lessons Learned From The Adrenalin Load Disaggregation Challenge, András Balázs Tolnai, Zheng Ma, Igor Sartori, Clayton Miller, Stephen White, Matt Amos, Gustaf Bengtsson, Akram Hameed, Nørregaard Bo Jørgensen
Lessons Learned From The Adrenalin Load Disaggregation Challenge, András Balázs Tolnai, Zheng Ma, Igor Sartori, Clayton Miller, Stephen White, Matt Amos, Gustaf Bengtsson, Akram Hameed, Nørregaard Bo Jørgensen
Research Collection College of Integrative Studies
Crowdsourced data science competitions have emerged as a powerful mechanism for advancing research in energy informatics, offering scalable pathways for developing machine learning solutions that enhance energy efficiency and smart building operations. The ADRENALIN Load Disaggregation Challenge addressed a central problem in energy analytics—non-intrusive load monitoring (NILM) of heating and cooling loads in commercial buildings—while emphasizing the importance of model generalization across different buildings. This paper presents a comprehensive reflection on the lessons learned from organizing and executing the ADRENALIN competition, including technical insights, organizational challenges, and recommendations for future energy data challenges. In addition to the ADRENALIN case, a …
Misplay Or Malice? Players’ Interpretations Of Poor Gameplay In Competitive Team-Based Multiplayer Online Games, Valerie Yu, Benjamin H. Detenber, Sonny Rosenthal
Misplay Or Malice? Players’ Interpretations Of Poor Gameplay In Competitive Team-Based Multiplayer Online Games, Valerie Yu, Benjamin H. Detenber, Sonny Rosenthal
Research Collection College of Integrative Studies
Research on perceptions of gaming toxicity has focused on its verbal forms, while gameplay-related forms remain relatively understudied. Furthermore, assessments of gameplay actions as toxic may depend on situational considerations. The present study used a controlled experiment to examine player interpretations of gameplay sabotage using pre-recorded gameplay scenarios from the game, League of Legends. We found that the presence of gameplay sabotage elicited stronger negative emotions and triggered greater player-reported intentions to retaliate and correct the offending player than in comparable instances of unintentional poor gameplay. Further exploratory analyses suggested that participants rated poor gameplay as less acceptable in more …
Surgeon Health And Well-Being Initiative: A Survey Of General And Orthopedic Surgery Residents' Reports Of Musculoskeletal Pain., Maryam Mohamed, Grace J Kim, Kristen Conrad-Schnetz, Zhan Yang, Mary Carneval
Surgeon Health And Well-Being Initiative: A Survey Of General And Orthopedic Surgery Residents' Reports Of Musculoskeletal Pain., Maryam Mohamed, Grace J Kim, Kristen Conrad-Schnetz, Zhan Yang, Mary Carneval
Ambulatory and Primary Care Articles
Background Musculoskeletal (MSK) pain is a well-known risk among surgeons, resulting from the multifactorial physical demands of the occupation. Because of the demands faced by resident surgeons, many individuals find themselves with sometimes debilitating MSK pain. Although these risks are well documented and there have been proposed solutions, there is little discussion on the role that osteopathic manipulative treatment (OMT) can play in relief of MSK pain over time in this population. Objective The purpose of this study is to determine the prevalence and distribution of MSK pain among general and orthopedic surgery residents at Cleveland Clinic Foundation (CCF). Based …
Carroll County Extension Update August 2026, Mikayla Cerney
Carroll County Extension Update August 2026, Mikayla Cerney
UNH Cooperative Extension
No abstract provided.
2026 Deerfield Fair 4-H Exhibit Building Premium Book, Extension
2026 Deerfield Fair 4-H Exhibit Building Premium Book, Extension
UNH Cooperative Extension
No abstract provided.
2026 Deerfield Fair 4-H Animal Premium Book, Extension
2026 Deerfield Fair 4-H Animal Premium Book, Extension
UNH Cooperative Extension
No abstract provided.
Air-Assist Or Mist Backpack Sprayer Calibration Worksheet, Amy Papineau
Air-Assist Or Mist Backpack Sprayer Calibration Worksheet, Amy Papineau
UNH Cooperative Extension
No abstract provided.
Nh Dfl - 25 Years Of Hwa - Peterborough_2026_Aug_11, Ryan Crandall
Nh Dfl - 25 Years Of Hwa - Peterborough_2026_Aug_11, Ryan Crandall
UNH Cooperative Extension
No abstract provided.
Electric Or Gas Powered Backpack Sprayer Calibration Worksheet - 128th Method, Amy Papineau
Electric Or Gas Powered Backpack Sprayer Calibration Worksheet - 128th Method, Amy Papineau
UNH Cooperative Extension
No abstract provided.
Nutrition Considerations In Youth With Type 2 Diabetes Using Glucagon-Like Peptide-1 Receptor Agonists: A Commentary, Maria E Diaz, Grace Kim, Mili Vakharia
Nutrition Considerations In Youth With Type 2 Diabetes Using Glucagon-Like Peptide-1 Receptor Agonists: A Commentary, Maria E Diaz, Grace Kim, Mili Vakharia
Faculty, Staff and Students Publications
No abstract provided.
Cost-Effectiveness Of Hes V2.0 And Galad For Hepatocellular Carcinoma Surveillance In Patients With Cirrhosis, Mert Sahinkoc, Gizem S Nemutlu, Hashem B El-Serag, Mary Linton B Peters, Ali Hajjar, Anthony E Samir, Leigh Anne Dageforde, Fasiha Kanwal, Jagpreet Chhatwal
Cost-Effectiveness Of Hes V2.0 And Galad For Hepatocellular Carcinoma Surveillance In Patients With Cirrhosis, Mert Sahinkoc, Gizem S Nemutlu, Hashem B El-Serag, Mary Linton B Peters, Ali Hajjar, Anthony E Samir, Leigh Anne Dageforde, Fasiha Kanwal, Jagpreet Chhatwal
Faculty, Staff and Students Publications
Background: Ultrasound-based surveillance for HCC is limited by suboptimal sensitivity and low adherence. Blood-based biomarkers are potential alternatives for routine HCC surveillance. We aimed to define optimal sensitivity, specificity, and cost parameters under which blood-based biomarkers could serve as cost-effective alternatives in patients with cirrhosis.
Methods: We developed a microsimulation model of the natural history of HCC in individuals with compensated cirrhosis. We compared the cost-effectiveness of biannual surveillance using 2 blood-based biomarkers-HES V2.0 and GALAD-versus ultrasound-based surveillance across a range of sensitivity, specificity, test costs, and adherence levels. Outcomes included quality-adjusted life years (QALYs), costs, and incremental cost-effectiveness ratios …
Colocalization Of Eqtls With Type 2 Diabetes And Glycemic Traits Using Whole-Genome Sequences In Diverse Populations From The Nhlbi Trans-Omics In Precision Medicine (Topmed) Program, Ningyuan Wang, Daniel A Dicorpo, Yixin Zhang, Erica Kleinbrink, Donna K Arnett, John Barnard, John Blangero, Donald W Bowden, April P Carson, Yii-Der Ida Chen, Mina K Chung, Joanne E Curran, Dawood Darbar, Ravindranath Duggirala, Patrick T Ellinor, Diane Fatkin, Myriam Fornage, Nancy Heard-Costa, Jiang He, Lifang Hou, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, David D Mcmanus, Braxton D Mitchell, Ryan L Minster, Kari E North, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Dan Roden, Jerome I Rotter, Moore B Shoemaker, Jonathan D Smith, David R Van Wagoner, Francois Aguet, Kristin Ardlie, Joshua C Bis, Jennifer A Brody, Brian E Cade, Clary B Clish, Paul S De Vries, James S Floyd, Barry I Freedman, Stacey Gabriel, Robert E Gerzsten, Mark O Goodarzi, Charles Gu, Xiuqing Guo, Namrata Gupta, Susan R Heckbert, Sarah Hsu, Yi-Jen Hung, Rita R Kalyani, Tanika N Kelly, Gregory L Kinney, Changwei Li, Simin Liu, Yongmei Liu, Donald M Lloyd-Jones, Joann E Manson, Rasika A Mathias, Josep M Mercader, Alanna C Morrison, Take Naseri, Suna Onengut, Nicholette D Palmer, Patricia A Peyser, Qibin Qi, Sridharan Raghavan, Alex P Reiner, Mary R Rooney, Magdalena Sevilla-Gonzalez, Chloe Sarnowski, Joshua D Smith, Jennifer A Smith, Nicole L Spartano, Usman Tahir, Kent D Taylor, Deirdre K Tobias, Russel P Tracy, Satupa'itea Viali, Heming Wang, Alexis C Wood, Lisa R Yanek, Wei Zhao, Yinan Zheng, Josée Dupuis, Ching-Ti Liu, Robert Sladek, Jennifer Wessel, James B Meigs, Alisa K Manning, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium
Colocalization Of Eqtls With Type 2 Diabetes And Glycemic Traits Using Whole-Genome Sequences In Diverse Populations From The Nhlbi Trans-Omics In Precision Medicine (Topmed) Program, Ningyuan Wang, Daniel A Dicorpo, Yixin Zhang, Erica Kleinbrink, Donna K Arnett, John Barnard, John Blangero, Donald W Bowden, April P Carson, Yii-Der Ida Chen, Mina K Chung, Joanne E Curran, Dawood Darbar, Ravindranath Duggirala, Patrick T Ellinor, Diane Fatkin, Myriam Fornage, Nancy Heard-Costa, Jiang He, Lifang Hou, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, David D Mcmanus, Braxton D Mitchell, Ryan L Minster, Kari E North, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Dan Roden, Jerome I Rotter, Moore B Shoemaker, Jonathan D Smith, David R Van Wagoner, Francois Aguet, Kristin Ardlie, Joshua C Bis, Jennifer A Brody, Brian E Cade, Clary B Clish, Paul S De Vries, James S Floyd, Barry I Freedman, Stacey Gabriel, Robert E Gerzsten, Mark O Goodarzi, Charles Gu, Xiuqing Guo, Namrata Gupta, Susan R Heckbert, Sarah Hsu, Yi-Jen Hung, Rita R Kalyani, Tanika N Kelly, Gregory L Kinney, Changwei Li, Simin Liu, Yongmei Liu, Donald M Lloyd-Jones, Joann E Manson, Rasika A Mathias, Josep M Mercader, Alanna C Morrison, Take Naseri, Suna Onengut, Nicholette D Palmer, Patricia A Peyser, Qibin Qi, Sridharan Raghavan, Alex P Reiner, Mary R Rooney, Magdalena Sevilla-Gonzalez, Chloe Sarnowski, Joshua D Smith, Jennifer A Smith, Nicole L Spartano, Usman Tahir, Kent D Taylor, Deirdre K Tobias, Russel P Tracy, Satupa'itea Viali, Heming Wang, Alexis C Wood, Lisa R Yanek, Wei Zhao, Yinan Zheng, Josée Dupuis, Ching-Ti Liu, Robert Sladek, Jennifer Wessel, James B Meigs, Alisa K Manning, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium
Faculty, Staff and Students Publications
Large-scale multiancestry genome-wide association studies have identified hundreds of loci associated with type 2 diabetes (T2D) and glycemic traits, yet imputed genotyping arrays limit the detection of low-frequency and rare variants. Whole-genome sequencing (WGS) offers a more complete view of genetic variation, especially across diverse populations. We analyzed high-coverage (38×) WGS data from 21,913 T2D case subjects, 61,036 control subjects, and up to 50,011 individuals with no diabetes with fasting glucose, fasting insulin, and HbA1c from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Program. We performed single-variant association testing, conditional analysis, fine-mapping, and Bayesian colocalization to …
Quantitative Imaging Of Pyruvate Metabolism In A Patient With Anaplastic Thyroid Cancer, James A Bankson, Joshua S Niedzielski, Collin J Harlan, Yunyun Chen, Christopher M Walker, Philip L Lorenzi, Lin Tan, Vikas Kundra, Matthew E Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B Peterson, Clifton D Fuller, Vlad C Sandulache, Stephen Y Lai
Quantitative Imaging Of Pyruvate Metabolism In A Patient With Anaplastic Thyroid Cancer, James A Bankson, Joshua S Niedzielski, Collin J Harlan, Yunyun Chen, Christopher M Walker, Philip L Lorenzi, Lin Tan, Vikas Kundra, Matthew E Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B Peterson, Clifton D Fuller, Vlad C Sandulache, Stephen Y Lai
Faculty, Staff and Students Publications
Purpose: Magnetic resonance imaging using hyperpolarized (HP) [1-13C]-pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi-quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular metabolism. A validated pharmacokinetic (PK) model for analysis of intracellular pyruvate metabolism is needed to enhance the accuracy of quantitative metrics and clinical translation of metabolic MRI using HP pyruvate.
Methods: A PK model with two physical compartments and two chemical pools was developed to analyze the conversion of labeled pyruvate into lactate in vitro. …
The Kdm-Family Inhibitor Jib-04 Sensitizes Aml Cells To Venetoclax By Inducing A Ferroptosis-Like Phenotype, Katharina Wohlan, Dandan Fan, Anna G Guzman, Alexis Quezada, Hyunji Park, Elmira Khabusheva, Farzane Sivandzade, Matthew Wither, Amber Alcorn, Tamara Thevarajah, Steven M Kornblau, Courtney D Dinardo, Jianzhong Su, Margaret A Goodell, Rachel E Rau
The Kdm-Family Inhibitor Jib-04 Sensitizes Aml Cells To Venetoclax By Inducing A Ferroptosis-Like Phenotype, Katharina Wohlan, Dandan Fan, Anna G Guzman, Alexis Quezada, Hyunji Park, Elmira Khabusheva, Farzane Sivandzade, Matthew Wither, Amber Alcorn, Tamara Thevarajah, Steven M Kornblau, Courtney D Dinardo, Jianzhong Su, Margaret A Goodell, Rachel E Rau
Faculty, Staff and Students Publications
Acute myeloid leukemia (AML) is an aggressive hematological malignancy with various molecular and cytogenetic subtypes. Treatment options for older adult patients are limited due to high toxicity of conventional chemotherapy. The B-cell leukemia/lymphoma 2 inhibitor venetoclax is effective in combination with hypomethylating agents or low-dose cytarabine, but ∼30% of patients do not respond to the initial combination treatment. Thus, alternative combinations are needed to sensitize AML cells to venetoclax and overcome resistance mechanisms. Here, we report that targeting histone lysine-specific demethylases induces a ferroptosis-like phenotype driven by oxidative stress in various AML subtypes. In both patient samples and cell lines, …