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2026 Summer Commencement Program, The University Of West Alabama
2026 Summer Commencement Program, The University Of West Alabama
Commencement Programs
No abstract provided.
Transforming The Lives Of Adolescent Girls In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Transforming The Lives Of Adolescent Girls In West And Central Africa, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescents and Young People
The Girls’ Futures in Focus: Evidence from West and Central Africa series examines the challenges facing adolescent girls in the region and highlights evidence-informed approaches to improving their lives. The series focuses on eight countries that span the Sahel, coastal West Africa, and Central Africa and that reflect a range of fragility, conflict, and development contexts, allowing the GIRL Center’s findings to speak to adolescent girls’ compounded and diverse experiences across the region: Burkina Faso, Cameroon, Central African Republic, Democratic Republic of Congo, Guinea, Côte d’Ivoire, Niger, and Senegal. This series overview brief investigates their education, economic empowerment, mental health, …
Promouvoir La Santé Mentale Et La Résilience Des Adolescentes En Afrique De L’Ouest Et Du Centre, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Promouvoir La Santé Mentale Et La Résilience Des Adolescentes En Afrique De L’Ouest Et Du Centre, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescents and Young People
La série « L’avenir des filles en point de mire : données probantes d’Afrique de l’Ouest et du Centre » examine les défis auxquels font face les adolescentes de la région et met en lumière des approches éclairées par les données probantes pour améliorer leurs conditions de vie. Cette note souligne l’importance de la santé mentale et de la résilience des adolescentes dans le contexte de l’Afrique de l’Ouest et du Centre. Elle résume les données disponibles sur le fardeau des troubles de santé mentale chez les adolescentes, en s’appuyant sur les données issues des pays prioritaires du GIRL Center. …
Investissement Ciblé En Faveur Des Adolescentes Dans L’Espace Numérique En Afrique De L’Ouest Et Du Centre, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Investissement Ciblé En Faveur Des Adolescentes Dans L’Espace Numérique En Afrique De L’Ouest Et Du Centre, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescents and Young People
La série « L’avenir des filles en point de mire : données probantes d’Afrique de l’Ouest et du Centre » examine les défis auxquels font face les adolescentes de la région et met en lumière des approches éclairées par les données probantes pour améliorer leurs conditions de vie. Cette note résume les données disponibles sur les adolescentes les plus exclues de l’espace numérique en Afrique de l’Ouest et du Centre (AOC), en s’appuyant sur les pays prioritaires du GIRL Center. Elle identifie les approches numériques susceptibles d’être pertinentes pour les adolescentes dans le contexte ouest- et centre-africain, tout en reconnaissant …
Technological Competence And Generative Artificial Intelligence: Canadian Law Students’ Understanding And Use In Legal Education And Legal Practice, Hannah Rosborough
Technological Competence And Generative Artificial Intelligence: Canadian Law Students’ Understanding And Use In Legal Education And Legal Practice, Hannah Rosborough
Reports & Public Policy Documents
This report presents results from a national survey examining Canadian JD students' and recent graduates' understanding of technological competence and their use of generative artificial intelligence in legal education and legal practice.
The survey collected responses from 631 students and recent graduates across Canadian law schools between November 2025 and January 2026, combining closed-ended questions with thematic analysis of open-ended responses. The survey addressed how students understand the duty of technological competence under the Model Code, how they use generative AI in coursework and legal workplaces, their confidence in the accuracy of these tools, the guidance and training they receive, …
Fisheries Research Report No. 365: Recreational Fishing For Marron In South-West Western Australia In 2026, Claire B. Smallwood, Karina L. Ryan, Eva Lai
Fisheries Research Report No. 365: Recreational Fishing For Marron In South-West Western Australia In 2026, Claire B. Smallwood, Karina L. Ryan, Eva Lai
Fisheries Research Reports
The smooth marron (Cherax cainii) (‘marron’) is endemic to freshwater dams and rivers of south-west Western Australia. Marron are managed as a single stock within the South-West Recreational Freshwater Resource and are highly vulnerable to overexploitation due to the biological characteristics of the species (e.g., low fecundity, localised populations) as well as environmental (e.g., habitat loss, reduction in rainfall) and human (e.g., fishing, land clearing) pressures on freshwater ecosystems.
Due to this vulnerability, this species has been the focus of research, monitoring and management since the 1970’s. Since 2000, annual phone-recall (2000 – 2021) and online-recall (2022 – 2026) surveys …
Project Care Poster, Jeff Gutierrez, Rayna Sage, Rtc: Rural
Project Care Poster, Jeff Gutierrez, Rayna Sage, Rtc: Rural
Independent Living and Community Participation
The CARE Project connects rural Centers for Independent Living (CILs) and rural libraries to improve disability services and respond to community needs together. RTC:Rural has designed a participatory curriculum development project to collaboratively create a resource to provide a roadmap to community partnerships between rural CILs and libraries.
From Centralized To Decentralized Care: Assessing The Role Of Design In Cardiovascular Unit Performance, Lindsey Fay
From Centralized To Decentralized Care: Assessing The Role Of Design In Cardiovascular Unit Performance, Lindsey Fay
Interiors Faculty Publications
This report presents a comprehensive pre- and post-occupancy evaluation of the University of Kentucky HealthCare Cardiovascular Unit, conducted through a collaborative effort between the College of Design, College of Communication and Information, UK HealthCare, and GBBN Architects. The study examines the transition from a centralized to a decentralized care delivery model within a newly constructed hospital environment, with the goal of understanding how spatial design influences healthcare delivery, staff performance, and patient experience.
Using a mixed-methods approach, the research integrates quantitative and qualitative data collection techniques, including behavioral mapping, communication tracking, pedometer data, acoustic measurements, and staff and user feedback. …
Greenfield Farm Gift Celebrates A Family Legacy Of Readers, Angela Atkins
Greenfield Farm Gift Celebrates A Family Legacy Of Readers, Angela Atkins
University of Mississippi News
OXFORD, Miss. – Oxford entrepreneur and University of Mississippi alumna Helen Graeber Overstreet has given $100,000 toward the development of the Greenfield Farm Writers Residency.
Storm Surge And Tides In Convergent Estuaries: The Case Of Extratropical Storm Merbok In Alaska, Steven Dykstra, Stefan Talke, David A. Jay, Matthew Lobo, Silvia Innocenti, Pascal Matte
Storm Surge And Tides In Convergent Estuaries: The Case Of Extratropical Storm Merbok In Alaska, Steven Dykstra, Stefan Talke, David A. Jay, Matthew Lobo, Silvia Innocenti, Pascal Matte
Civil and Environmental Engineering Faculty Publications and Presentations
Coastal floods are composed of multiple drivers that interact with coastline geometries and are difficult to differentiate. To investigate the effects of basin shapes on storm surge and tides, we study the landfall of ex-Typhoon Merbok in the east Bering Sea, Alaska. Water levels at 34 stations are detided with a new tide wavelet tool, CWT_Multi (Lobo et al., 2024), and the spatial and temporal shifts in tides and surge are interpreted via long-wave theory. Results show nonstationary semiannual trends in tidal constituents due to ice effects and large interannual variability in mean-sea level (20-40 cm). After removing non-stationary tidal …
Underground Mine Tunnel Fire Dynamics: Experimental Investigation And Ai-Driven Characterization Of Flame Behavior, Jingmin Xu, Rui Tian, Ashish Kakoria, Aamir Iqbal, Tao Yang, Lina Zheng, Guang Xu
Underground Mine Tunnel Fire Dynamics: Experimental Investigation And Ai-Driven Characterization Of Flame Behavior, Jingmin Xu, Rui Tian, Ashish Kakoria, Aamir Iqbal, Tao Yang, Lina Zheng, Guang Xu
Mining Engineering Faculty Research & Creative Works
Underground mine tunnel fires pose serious threats to personnel safety and infrastructure integrity, yet their detection and characterization remain challenging due to complex ventilation environments and limited visibility. This study combines full-scale fire experiments with advanced computer vision analysis to investigate the influence of fire size and ventilation on thermal, chemical, and visual signatures of mine fires. Six full-scall controlled experiments were conducted using two fire pan sizes under three ventilation conditions. Fuel mass loss, temperature distribution, and gas concentrations were systematically recorded using thermocouples, gas sensors, and visual/thermal imaging. Results show that mass loss rate is primarily governed by …
Synthesis Of Bea Zeolite From Coal Fly Ash Nano-Silica Extract: Application In Co2 Adsorption, Alechine E. Ameh, Shabnam Feyziyeva, Jean Luc Mukaba, Keagan Pokpas, Baylar Zarbaliyev, Ojo O. Fatoba, Benoit Louis, Leslie F. Petrik, Oluwaseun O. Oyekola
Synthesis Of Bea Zeolite From Coal Fly Ash Nano-Silica Extract: Application In Co2 Adsorption, Alechine E. Ameh, Shabnam Feyziyeva, Jean Luc Mukaba, Keagan Pokpas, Baylar Zarbaliyev, Ojo O. Fatoba, Benoit Louis, Leslie F. Petrik, Oluwaseun O. Oyekola
Mining Engineering Faculty Research & Creative Works
This study demonstrates a circular economy approach to carbon dioxide sorption by re-purposing coal fly ash (CFA) into BEA zeolite using CFA-derived nano-silica and aluminum precursors via hydrothermal synthesis. The XRD patterns, with characteristic peaks at 15° and 37° 2θ, and SEM images both confirmed the complete transformation of the spherical-shaped CFA particles into amorphous nano-silica materials with particle sizes less than 100 nm. The absence of amorphous phases and the formation of high-intensity peaks at 7.8° and 22.8° 2θ further indicated the production of a highly crystalline BEA zeolite, obtained after hydrothermal synthesis durations between 10 and 72 h. …
Rural/Urban Disparities In Utilization Of Diabetes Self-Management Training (Dsmt) To The Fee-For-Service Medicare Population, 2017–2024, Wanying Zhu, Aleksandr Taraskin, Jeffrerey Talbert
Rural/Urban Disparities In Utilization Of Diabetes Self-Management Training (Dsmt) To The Fee-For-Service Medicare Population, 2017–2024, Wanying Zhu, Aleksandr Taraskin, Jeffrerey Talbert
Rural & Underserved Health Research Center Publications
Key Report Highlights
• A significant rural DSMT access gap exists. Rural beneficiaries accounted for 20.1% of Medicare beneficiaries with diabetes but only 7.8% of DSMT participants.
• Geographic availability remains limited. Only 16.8% of counties with DSMT utilization were rural.
• Access, not demand, appears to be the primary challenge. Rural counties offering DSMT achieved utilization rates more than twice those observed in urban counties (6.0% vs. 2.5%).
• Expanding rural DSMT capacity may represent a high-impact opportunity to improve diabetes self-management support among underserved Medicare beneficiaries.
Non-Metropolitan Vs. Metropolitan Variations In Alcohol, Illicit Drug, And Prescription Therapeutic Drug Misuse, Tyrone F. Borders
Non-Metropolitan Vs. Metropolitan Variations In Alcohol, Illicit Drug, And Prescription Therapeutic Drug Misuse, Tyrone F. Borders
Rural & Underserved Health Research Center Publications
Key Findings
Alcohol Use. The prevalence of past year and past 30-day drinking was lower among non-metropolitan (non-metro) than metropolitan (metro) residents. However, non-metro drinkers engaged in more frequent binge drinking than metro drinkers. Drinking 3-5, 6-19, and 20-30 days over the past 30 days were higher among non-metro than metro residents.
Illicit Drug Use. Hallucinogens were the mostly commonly used illicit drugs among non-metro as well as metro residents. Methamphetamine use was significantly higher among non-metro than metro residents.
Prescription Pain Reliever Use. The misuse of prescription pain killers, primarily prescription opioids, was higher among non-metro than …
High-Deductible Health Plans In Rural And Urban Populations: Outpatient Utilization And Out-Of-Pocket Costs, Aaron P. Smith, Jefferey Talbert
High-Deductible Health Plans In Rural And Urban Populations: Outpatient Utilization And Out-Of-Pocket Costs, Aaron P. Smith, Jefferey Talbert
Rural & Underserved Health Research Center Publications
Overview of Key Findings This policy brief explores rural-urban differences in High-Deductible Health Plan (HDHP) enrollment, subsequent healthcare utilization, and out-of-pocket (OOP) costs. ▪ HDHP enrollment was uncommon. Rural residents were slightly less likely to enroll than urban residents across all demographic groups. ▪ Switching plans influenced utilization. Compared to those who did not change healthcare plans, switching from a Traditional plan to a HDHP was associated with a larger reduction in 2022 outpatient visits for both rural and urban residents. Moving from a HDHP to a Traditional plan was associated with a smaller reduction in 2022 outpatient visits for …
Sabin Center For Climate Change Law Annual Report 2025-2026, Tiffany Challe
Sabin Center For Climate Change Law Annual Report 2025-2026, Tiffany Challe
Sabin Center for Climate Change Law
Over the past year, the Sabin Center continued to translate complex legal and scientific questions into practical tools that advance climate action and climate justice across climate litigation, renewable energy, local climate action, model climate laws, carbon management and greenhouse gas removal, climate law and science, and climate and business law.
Explore our 2025–2026 Annual Report to see the research, engagement, and impact behind the numbers — and what’s ahead.
Data Centers Face Volatile Regulatory Landscape, Michael B. Gerrard
Data Centers Face Volatile Regulatory Landscape, Michael B. Gerrard
Sabin Center for Climate Change Law
The construction of new data centers for artificial intelligence has become a major engine of the U.S. economy. More than 700 data centers are now under construction across 40 states, with many more to come.
These are typically multi-billion-dollar projects. This boom is facing growing public opposition, which has led to an extremely volatile regulatory land-scape, especially at the state and local levels. That landscape is the subject of this article. This volatility has raised the cost of capital for data centers and led to the cancellation of many, and to heightened due diligence by lenders and others.
Nurse Manager Perceptions Of Strategies To Overcome The Underutilization Of Nonpharmacological Pain Control Methods In Adult Acute Care, Landen M. Bonnell
Nurse Manager Perceptions Of Strategies To Overcome The Underutilization Of Nonpharmacological Pain Control Methods In Adult Acute Care, Landen M. Bonnell
Undergraduate Honors Theses
A basic patient right is to have pain adequately managed. However, research consistently indicates that many adult patients in acute care experience inadequately managed pain, which may contribute to adverse patient outcomes. Studies have shown that nonpharmacological pain management can lead to increased patient satisfaction, shorter hospital stays, and better patient outcomes. However, many barriers exist to nurses providing effective nonpharmacological pain control therapy, primarily including heavy workload and a lack of education and support. Currently, there is insufficient research on how to overcome these barriers. Four nurse managers with experience in nursing leadership were interviewed using a qualitative descriptive …
Climate Change And Adolescent Girls In West And Central Africa: Building A Girl-Intentional Response, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Climate Change And Adolescent Girls In West And Central Africa: Building A Girl-Intentional Response, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescents and Young People
The Girls’ Futures in Focus: Evidence from West and Central Africa series examines the challenges facing adolescent girls in the region and highlights evidence-informed approaches to improving their lives. This brief summarizes the evidence on how climate shocks reshape the lives of adolescent girls in West and Central Africa, drawing in particular on evidence from the GIRL Center’s priority countries. It examines gendered climate vulnerabilities, gaps in climate policies that overlook girls, and emerging adaptation strategies that hold promise for girls in the region. The brief points to what a girl-intentional climate response could look like across the priority countries.
Adolescentes En Afrique De L’Ouest Et Du Centre : Trajectoires, Risques Et Leviers De Changement, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescentes En Afrique De L’Ouest Et Du Centre : Trajectoires, Risques Et Leviers De Changement, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescents and Young People
La série « L’avenir des filles en point de mire : données probantes d’Afrique de l’Ouest et du Centre » examine les défis auxquels sont confrontées les adolescentes de la région et met en lumière des approches fondées sur des données probantes pour améliorer leur quotidien. Cette note de synthèse examine leur éducation, leur autonomisation économique, leur santé mentale, leur santé sexuelle et reproductive, leur accès au numérique et leurs usages technologiques, ainsi que leurs besoins face au changement climatique et dans des contextes humanitaires. En s’appuyant sur des données issues des pays prioritaires du GIRL Center, elle identifie les …
Changement Climatique Et Adolescentes En Afrique De L’Ouest Et Du Centre : Vers Une Réponse Centrée Sur Les Filles, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Changement Climatique Et Adolescentes En Afrique De L’Ouest Et Du Centre : Vers Une Réponse Centrée Sur Les Filles, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescents and Young People
La série « L’avenir des filles en point de mire : données probantes d’Afrique de l’Ouest et du Centre » examine les défis auxquels font face les adolescentes de la région et met en lumière des approches éclairées par les données probantes pour améliorer leurs conditions de vie. Cette note de recherche synthétise les données probantes sur la manière dont les chocs climatiques bouleversent la vie des adolescentes en Afrique de l’Ouest et du Centre (AOC), en s’appuyant notamment sur les données issues des pays prioritaires du GIRL Center. Elle examine les vulnérabilités climatiques liées au genre, les lacunes des …
Development Of Reduced Conflict U-Turn (Rcut) Guidance In Kentucky, Travis Thompson, Duane Thomas, Jill Asher, Jeff Jasper
Development Of Reduced Conflict U-Turn (Rcut) Guidance In Kentucky, Travis Thompson, Duane Thomas, Jill Asher, Jeff Jasper
Kentucky Transportation Center Research Report
A reduced conflict U-turn (RCUT) intersection eliminates left-turn and through movements from the minor road. Instead, drivers must turn right onto the main road and complete a U-turn at a downstream median opening. Recognized by the Federal Highway Administration (FHWA) as a proven safety countermeasure, RCUT intersections have reduced fatal and injury crashes 22 – 63%. Despite more than 35 RCUT intersections in operation across Kentucky, the Kentucky Transportation Cabinet (KYTC) lacked specific guidance for their planning, design, construction, and operation.
This project, conducted by the Kentucky Transportation Center (KTC) in cooperation with KYTC, addressed this gap through a comprehensive …
Impact Of Schedule V Controlled Substance Classification Of Gabapentin On Adult Gabapentin-Involved Overdose Rates, West Virginia, 2016–2019, Katherine Gora Combs, Juan M. Hincapie-Castillo, Nabarun Dasgupta, Rachel Vickers-Smith, Alan Kinlaw, Gordon S. Smith, Stephen W. Marshall
Impact Of Schedule V Controlled Substance Classification Of Gabapentin On Adult Gabapentin-Involved Overdose Rates, West Virginia, 2016–2019, Katherine Gora Combs, Juan M. Hincapie-Castillo, Nabarun Dasgupta, Rachel Vickers-Smith, Alan Kinlaw, Gordon S. Smith, Stephen W. Marshall
Epidemiology and Environmental Health Faculty Publications
Objective: Assess the association between West Virginia’s classification of gabapentin as a schedule V controlled substance and fatal overdoses involving gabapentin, relative to a control state. Methods: Using a controlled interrupted time series design, we modeled a segmented linear regression using Newey-West standard errors to estimate the immediate and trend changes in gabapentin-involved fatal overdoses among adults in West Virginia associated with gabapentin’s scheduling in June 2018. Data from North Carolina (no gabapentin scheduling) was used as a control to account for potential secular changes. Quarterly rates were computed from 2016 to 2019. Results: The introduction of West Virginia’s policy …
Locus Coeruleus Tdp-43 Pathology In A Community-Based Cohort, Allison M. Neltner, Ryan K. Shahidehpour, Megan E. Hall, Xiaotong Ning, Shuling Fister, Hannah Kang, Sonya Anderson, Gregory A. Jicha, Tiffany L. Lee, Erin L. Abner, David W. Fardo, Peter T. Nelson
Locus Coeruleus Tdp-43 Pathology In A Community-Based Cohort, Allison M. Neltner, Ryan K. Shahidehpour, Megan E. Hall, Xiaotong Ning, Shuling Fister, Hannah Kang, Sonya Anderson, Gregory A. Jicha, Tiffany L. Lee, Erin L. Abner, David W. Fardo, Peter T. Nelson
Epidemiology and Environmental Health Faculty Publications
The locus coeruleus (LC) is the source of norepinephrinergic innervation in the human brain. Locus coeruleus pathology has been linked to clinical conditions such as cognitive impairment and behavioral and psychiatric symptoms of dementia (BPSD). However, phosphorylated TDP-43 (pTDP-43) pathology in the LC has been understudied, particularly in the contexts of aging and limbic predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC). Here, a convenience sample (n = 134) of autopsied participants from the University of Kentucky Alzheimer’s Disease Research Center community-based cohort was analyzed for LC pTDP-43 and phosphorylated tau (pTau) pathologies. Locus coeruleus pTDP-43 pathology was found in 28/134 …
Mir155, Triplicated In Down Syndrome, Regulates The Development Of Neural Stem Cells And Gabaergic Interneurons In Alzheimer's Disease Mouse And Human Ipsc Models., Xiaodong Zhu, Jean-Vianney Haure-Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al-Subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E Ehrlich
Mir155, Triplicated In Down Syndrome, Regulates The Development Of Neural Stem Cells And Gabaergic Interneurons In Alzheimer's Disease Mouse And Human Ipsc Models., Xiaodong Zhu, Jean-Vianney Haure-Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al-Subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E Ehrlich
Faculty Research 2026
INTRODUCTION: Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown.
METHODS: We utilized in silico analyses of published databases, MIR155-deleted and -overexpressing human induced pluripotent stem cell (hiPSC)-derived cells, cortical organoids, and amyloid beta precursor protein (APP)/PS1-miR155 knockout mouse.
RESULTS: MIR155HG (miR155 host gene) colocalizes with APP in a neuron-specific, topologically associated domain (TAD) in chromosome 21. In human neural stem cells (NSCs), neurons, and cortical organoids, MIR155 deletion enhanced NSC proliferation and GABAergic interneuron generation. MIR155 overexpression inhibited NSC marker expression …
The Past, The Present, And The Future Of Preclinical Mouse Models For Alzheimer's Disease And Related Dementias., Adrian L Oblak, Michael Sasner, Gregory W. Carter, Gareth R Howell, Stacey J Sukoff Rizzo, Karina Leal, Paul R Territo, Bruce T Lamb
The Past, The Present, And The Future Of Preclinical Mouse Models For Alzheimer's Disease And Related Dementias., Adrian L Oblak, Michael Sasner, Gregory W. Carter, Gareth R Howell, Stacey J Sukoff Rizzo, Karina Leal, Paul R Territo, Bruce T Lamb
Faculty Research 2026
Over the past decade, the Model Organism Development and Evaluation for Late-Onset Alzheimer's Disease (MODEL-AD) consortium has transformed preclinical Alzheimer's disease (AD) research by addressing critical limitations in traditional mouse models that failed to translate to human disease. By leveraging human genetic discoveries, MODEL-AD has developed > 70 genetically informed mouse models, standardized phenotyping pipelines, and an open-access data infrastructure aligned with late-onset AD biology. These models incorporate human risk variants, environmental factors, and aging to better capture disease complexity, including emerging recognition of mixed pathologies such as vascular contributions, Lewy body disease, and TDP-43 proteinopathy. Despite substantial progress, key challenges …
Stromal Cell Senescence Augments Haematopoietic Cell Fitness In Clonal Haematopoiesis., Jayna J Mistry, Kira Young, Anna Navarro Figueredo, Gibran Edun, Alicia G Aguilar-Navarro, Patricia A Colom Díaz, Maria Telpoukhovskaia, Inés Fernández Maestre, Sheng F Cai, Katharina S Götze, Anastasia N Tikhonova, Ross L Levine, Jennifer J. Trowbridge
Stromal Cell Senescence Augments Haematopoietic Cell Fitness In Clonal Haematopoiesis., Jayna J Mistry, Kira Young, Anna Navarro Figueredo, Gibran Edun, Alicia G Aguilar-Navarro, Patricia A Colom Díaz, Maria Telpoukhovskaia, Inés Fernández Maestre, Sheng F Cai, Katharina S Götze, Anastasia N Tikhonova, Ross L Levine, Jennifer J. Trowbridge
Faculty Research 2026
Microenvironment remodelling impacts tumour growth and metastasis, but whether remodelling promotes pre-malignant clonal fitness remains unknown. Here, using single-cell RNA-sequencing of the bone-marrow microenvironment in a mouse model of DNMT3A-mutant clonal haematopoiesis (CH), we identify mesenchymal stromal cells (MSCs) in a molecular state of cellular senescence. Elevated bone-marrow MSC senescence is also observed in humans with CH driven by several common somatic mutations. MSC senescence is induced by mutant haematopoietic cells in a contact-independent manner through production of soluble factors including TNF-α and IL-6. These cytokines activate a Stat3-driven pathway that is necessary and sufficient for MSC senescence induction. Genetic …
A Collaborative Framework For Uncovering Molecular And Cellular Drivers Of Vcid: Foundations For Future Interventions In Dementia., M Luisa Iruela-Arispe, Jason D Hinman, Andrew C Yang, Fabrice Dabertrand, Jin-Moo Lee, Gareth R Howell, The Vcid Centers Without Walls Network
A Collaborative Framework For Uncovering Molecular And Cellular Drivers Of Vcid: Foundations For Future Interventions In Dementia., M Luisa Iruela-Arispe, Jason D Hinman, Andrew C Yang, Fabrice Dabertrand, Jin-Moo Lee, Gareth R Howell, The Vcid Centers Without Walls Network
Faculty Research 2026
Vascular-related factors are now considered major contributors to most forms of dementia, including Alzheimer's disease. However, the degree to which vascular deficits contribute to risk, onset, and progression of cognitive impairment and dementia has only recently been appreciated. Our understanding of the mechanisms by which vascular deficits drive cognitive decline in dementia is still limited. Further, the testing of therapeutic approaches to prevent vascular deficits to treat dementia are few. These factors motivated the establishment of the Vascular Contributions to Cognitive Impairment and Dementia (VCID) Center Without Walls (CWOW) network, comprising institutes across the United States. We describe the current …
Worldwide Innovative Network Consortium: Building A Common Global Cancer Database., Farhood Farahnak, Wafik S El-Deiry, Yves A Lussier, Razelle Kurzrock, Shai Magidi, Catherine Bresson, Shirin A Enger, Jia Liu, Jair Bar, Jeremy L Warner, Tobias Meissner, Eitan Rubin, Jens Rueter, Himabindu Gaddipati, Mandar Kulkarni, Zhen Chen, Sewanti Limaye, Rachel Elsey, Brenda M Rubenstein, Anthony M Joshua, Humaid O Al-Shamsi, Khaled M Musallam, Fanny Wunder, Jacques Raynaud, Guy Berchem, Manon Gantenbein, Amal Al Omari, Said Dermime, Hikmat Abdel-Razeq, Pierre Saintigny, Andrés Cervantes, Roger R Reddel, Adel T Aref, Juan Martin-Liberal, Conxi Lázaro, David Cordero Romera, Marina Sekacheva, Raanan Berger, C S Pramesh, Ioana Berindan-Neagoe, Eugenia Girda, Alejandro Piris-Gimenez, Carol J Farhangfar, Mohammed E Salem, Rodrigo Dienstmann, Ramon Salazar, Naftali Z Frankel, Zachary Batist, Yuri Quintana, Gerald Batist
Worldwide Innovative Network Consortium: Building A Common Global Cancer Database., Farhood Farahnak, Wafik S El-Deiry, Yves A Lussier, Razelle Kurzrock, Shai Magidi, Catherine Bresson, Shirin A Enger, Jia Liu, Jair Bar, Jeremy L Warner, Tobias Meissner, Eitan Rubin, Jens Rueter, Himabindu Gaddipati, Mandar Kulkarni, Zhen Chen, Sewanti Limaye, Rachel Elsey, Brenda M Rubenstein, Anthony M Joshua, Humaid O Al-Shamsi, Khaled M Musallam, Fanny Wunder, Jacques Raynaud, Guy Berchem, Manon Gantenbein, Amal Al Omari, Said Dermime, Hikmat Abdel-Razeq, Pierre Saintigny, Andrés Cervantes, Roger R Reddel, Adel T Aref, Juan Martin-Liberal, Conxi Lázaro, David Cordero Romera, Marina Sekacheva, Raanan Berger, C S Pramesh, Ioana Berindan-Neagoe, Eugenia Girda, Alejandro Piris-Gimenez, Carol J Farhangfar, Mohammed E Salem, Rodrigo Dienstmann, Ramon Salazar, Naftali Z Frankel, Zachary Batist, Yuri Quintana, Gerald Batist
Faculty Research 2026
This review shares the ongoing work of the global Worldwide Innovative Network (WIN) Consortium for Precision Medicine to synthesize emerging cancer treatment data and to define the requirements for a common global cancer database that can truly support precision oncology. We performed a narrative review of emerging cancer treatment data, molecular profiling technologies, and existing clinicogenomic databases, focusing on how tumors are characterized, how subgroups are defined, and how demographic, lifestyle, and environmental factors are captured. The growth in molecular profiling technologies and the development of new targeted therapies are transforming cancer care. Tumors, regardless of tissue origin, are increasingly …
Inhibition Of Moesin And Cd44 In Stem Cell-Derived Neurons Affects The Pathological Genetic Signature Associated With Alzheimer's Disease., Eiden H Brewer, Charles A Williams, Gregory Cary, Ranjita Betarbet, Inez K A Pranoto, Elizabeth L Zoeller, Haian Fu, Allan I Levey, Jesse C Wiley, Gregory W. Carter, Jessica E Young, Treat-Ad Consortium
Inhibition Of Moesin And Cd44 In Stem Cell-Derived Neurons Affects The Pathological Genetic Signature Associated With Alzheimer's Disease., Eiden H Brewer, Charles A Williams, Gregory Cary, Ranjita Betarbet, Inez K A Pranoto, Elizabeth L Zoeller, Haian Fu, Allan I Levey, Jesse C Wiley, Gregory W. Carter, Jessica E Young, Treat-Ad Consortium
Faculty Research 2026
INTRODUCTION: Post mortem proteomic analysis of Alzheimer's disease (AD) brain tissue has identified novel target genes and proteins for potential therapeutic development. Moesin (MSN) and CD44 were identified as candidate targets. Using human induced pluripotent stem cells (hiPSCs)-derived neurons, we assayed how reducing gene expression of MSN and CD44 affected amyloid beta secretion, tau phosphorylation, and transcriptional state.
METHODS: Knockdown of MSN and CD44 in hiPSC-derived neurons was performed using short hairpin RNA (shRNA). Amyloid precursor protein processing and intracellular tau phosphorylation was measured using chemiluminescent ELISA assays. Global gene expression was analyzed by bulk RNA sequencing (RNA-seq).
RESULTS: Knockdown …