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Sf6 Gas Leakage Detection Method For Gis Equipment Based On Improved Yolo 11 Model, Cheng Zeng, Shaosheng Fan, Jiashun Xie, Kaiyu Guo Sep 2026

Sf6 Gas Leakage Detection Method For Gis Equipment Based On Improved Yolo 11 Model, Cheng Zeng, Shaosheng Fan, Jiashun Xie, Kaiyu Guo

Journal of Electric Power Science and Technology

An SF6 gas leakage detection method for GIS equipment based on an improved YOLO 11 model is proposed to address the problem of internal SF6 gas leakage in outdoor substation gas insulated switchgear (GIS) equipment caused by environmental factors and equipment aging.The Real-ESRGAN super-resolution generative adversarial network is adopted for denoising and enhancement,and then the YOLO 11 model is improved to solve the problems of missed detection of small gas plumes,false detection due to cloud interference,and inability to perform multi-task detection in the original YOLO 11 model.The improved model increases the number of detection heads to four and incorporates a …


Distribution Network Energy Storage Siting Planning Based On Predictive Load Generation Using Prophet And Gan, Jiayu Xu, Xiaodong Chen, Yafeng Wang, Zhaoyan Liu, Yiyu Gong, Fanglan Liu, Jiaoxin Jia Sep 2026

Distribution Network Energy Storage Siting Planning Based On Predictive Load Generation Using Prophet And Gan, Jiayu Xu, Xiaodong Chen, Yafeng Wang, Zhaoyan Liu, Yiyu Gong, Fanglan Liu, Jiaoxin Jia

Journal of Electric Power Science and Technology

An energy storage siting and sizing planning method based on load trend extraction and forecasting is proposed to address the challenges of photovoltaic (PV) curtailment and bidirectional power flow overloads posed by distribution networks with high PV penetration.Firstly,the Prophet algorithm is adopted to decompose the net load of each node into trends and seasonal components,and the residual load is obtained.Secondly,a generative adversarial network (GAN ) is employed to model the relatively random residual component and generate load forecast data for the following year.The generated residual data are then combined with the trend and seasonal components to obtain a new annual …


Optimal Regional Allocation Of Mobile Energy Storage In Urban Distribution Networks Considering Distribution-Transportation Coupling, Zifa Liu, Chang Wang, Mengni Ye Sep 2026

Optimal Regional Allocation Of Mobile Energy Storage In Urban Distribution Networks Considering Distribution-Transportation Coupling, Zifa Liu, Chang Wang, Mengni Ye

Journal of Electric Power Science and Technology

Given the increasing demand for flexible resources in distribution networks,investigating the trade-off between the economic efficiency of resource allocation during the pre-planning phase and the enhancement of resilience in the fault recovery stage is essential for avoiding asset underutilization and excessive investment.To address this issue,the paper proposes a regional allocation method for mobile energy storage systems (MESSs ) that considers power-transportation coupling.First,a coupled distribution-transportation model is constructed based on the interactions among vehicles,charging stations,and the distribution network to characterize traffic flow dynamics.Next,a comprehensive indicator integrating electrical modularity and geographic accessibility is developed and an improved genetic algorithm is employed to …


Relocation And Charging/Discharging Power Optimization Of Modular Energy Storage For Voltage Limit Violation Mitigation In Rural Photovoltaic Distribution Station Areas, Haifeng Yu, Yifei Wang, Yu Li, Hanhang Yin, Siyuan Peng, Puling Huang, Zheng Peng Sep 2026

Relocation And Charging/Discharging Power Optimization Of Modular Energy Storage For Voltage Limit Violation Mitigation In Rural Photovoltaic Distribution Station Areas, Haifeng Yu, Yifei Wang, Yu Li, Hanhang Yin, Siyuan Peng, Puling Huang, Zheng Peng

Journal of Electric Power Science and Technology

To address the seasonal overvoltage and undervoltage issues in China ’s rural photovoltaic (PV) distribution station areas,this study proposes a relocation and charging/discharging power optimization method for modular energy storage adapted to the mitigation of voltage limit violations in the rural PV distribution station areas.Voltage limit violations are mitigated by relocating modular energy storage units to PV distribution station areas and regulating the active charging/discharging power of the energy storage units and the reactive power of the inverters.Specifically,the source-load characteristics of China's rural PV distribution station areas are analyzed.The feeder voltage equation is applied to reveal that the voltage limit …


Inversion Model For Point Of Maximum Vibration In Oil-Immersed Transformer Based On Multiphysics Load-Transfer Characteristics, Xingxing Hao, Haiying Li, Jiancheng Song Sep 2026

Inversion Model For Point Of Maximum Vibration In Oil-Immersed Transformer Based On Multiphysics Load-Transfer Characteristics, Xingxing Hao, Haiying Li, Jiancheng Song

Journal of Electric Power Science and Technology

Accurately obtaining data at the point of maximum vibration in a transformer core is one of the challenges in power equipment health management.To address this problem,a new method based on multiphysics modeling and inversion techniques was proposed for detecting the point of maximum vibration acceleration in a transformer.First,a multiphysics load-transfer coupling model incorporating electromagnetic,structural,and fluid fields was used to analyze the vibration mechanism under an alternating and nonuniformly distributed magnetic field.The point of maximum i nternal vibration was then determined through harmonic response analysis.Second,considering data correlations,vibration measurement points on the outer wall of the oil tank that were strongly correlated …


Robust Bidding Strategy Analysis For Charging Stations Considering Response Uncertainty, Xiaofeng Jiang, Bo Zhou, Chun Tang, Yunyang Xu, Wei Wei, Xinwei Sun, Jianwei Yang Sep 2026

Robust Bidding Strategy Analysis For Charging Stations Considering Response Uncertainty, Xiaofeng Jiang, Bo Zhou, Chun Tang, Yunyang Xu, Wei Wei, Xinwei Sun, Jianwei Yang

Journal of Electric Power Science and Technology

The large-scale integration and interaction of electric vehicles with the power grid have become an inevitable trend.As key entities in the interaction between electric vehicles and the power grid,charging stations can aggregate the charging and discharging resources of electric vehicles to participate in electricity market bidding,thus balancing their own interests and the operational needs of the power grid.Based on this,a model capable of predicting the day-ahead responsive capacity was first proposed by considering the active charging response of electric vehicles.Second,a robust optimization bidding model was established for charging stations participating in the day-ahead electricity market,considering the effects of uncertainties in …


Mechanism-Guided Temporal Representation And Risk-Aware Identification Method For High-Impedance Ground Faults In Distribution Networks Under Multiple Types Of Confusing Disturbances, Huaizhou Liu, Junqin Liu, Feng Deng Sep 2026

Mechanism-Guided Temporal Representation And Risk-Aware Identification Method For High-Impedance Ground Faults In Distribution Networks Under Multiple Types Of Confusing Disturbances, Huaizhou Liu, Junqin Liu, Feng Deng

Journal of Electric Power Science and Technology

To address the difficulty of representing the weak features of high-impedance ground faults (HIFs ) under multiple types of confusing transient disturbances,as well as the insufficient consideration of missed-detection risk,a mechanism-guided identification method based on multi-scale residual attention temporal representation and a risk-aware light gradient boosting machine (LightGBM ) is proposed.First,using the original zero-sequence current as input,a multi-scale residual attention temporal convolutional network is constructed based on the HIF waveform mechanisms of random arcing,local spikes,half-cycle asymmetry,and nonstationary fluctuations to adaptively extract deep discriminative features at different time scales.Second,the deep temporal features are input into LightGBM,and protection-oriented class risk weights are …


Extradition In The Early Republic: International Law And Constitutional Authority, Curtis A. Bradley Sep 2026

Extradition In The Early Republic: International Law And Constitutional Authority, Curtis A. Bradley

University of Chicago Law Review

This Article is the first comprehensive account of the constitutional foundations of U.S. extradition practice and its relationship to international law. Through detailed analysis of early American extradition controversies—including the Longchamps Affair and the Robbins case—the Article shows how political actors and courts constructed the modern constitutional law of extradition, resolving key issues concerning presidential power, the role of the states, and the scope of congressional authority. This regime, the Article argues, emerged not from appeals to the constitutional text or original understandings, but rather from structural intuitions, consequentialist considerations, and, as time went on, historical traditions. As the Article …


Native Marburys: Judicial Review In Tribal Courts, Elizabeth Hidalgo Reese Sep 2026

Native Marburys: Judicial Review In Tribal Courts, Elizabeth Hidalgo Reese

University of Chicago Law Review

Not all of America’s courts have judicial review. This Article is the first to dis- cuss a body of judicial review case law in which this extraordinary judicial power has been rejected, is a recent development, or is not yet a settled question—judicial review cases from tribal courts. In a time when skepticism about the power that judicial review gives to the federal courts is at an all-time high, it is that much more important that we look to other examples of government systems wrestling with whether to give their courts the power of judicial review—to other courts that are …


Establishing A Right To Civil Transcription, Shruti Bax Sep 2026

Establishing A Right To Civil Transcription, Shruti Bax

University of Chicago Law Review

Court reporters have long been a fixture of American jurisprudence, but tightening state budgets and a nationwide shortage of certified reporters have left many state court civil proceedings without any form of verbatim transcription at public expense. While litigants with means can hire private court reporters to accompany them to their proceedings, indigent parties must go without—even though the absence of a transcript is often deadly to one’s chances of prevailing on appeal, no matter how meritorious the claim.

In the 1956 case Griffin v. Illinois, the Supreme Court held that the principle of equal justice demands that “[d]estitute defendants …


Mda At Your Service - Protecting Your Practice, Finding Talent And More, Mda Membership Department Staff Sep 2026

Mda At Your Service - Protecting Your Practice, Finding Talent And More, Mda Membership Department Staff

The Journal of the Michigan Dental Association

This Q&A compiled by MDA staff provides critical guidance to support practice owners. It outlines key warning signs of employee embezzlement, such as closely guarding job duties or refusing cross-training, and highlights complimentary risk assessment tools and endorsed investigative services available through Prosperident. Furthermore, the article introduces free recruitment resources on the MDA Job Board for searching job-seeker profiles and posting openings. It also provides practical advice for resolving communication and online portal login issues by verifying registered email addresses with the MDA membership department.


Um Dean's Report - Meeting The Challenge Of Educating Dentists In A Constantly Evolving Profession, Jacques E. Nör Sep 2026

Um Dean's Report - Meeting The Challenge Of Educating Dentists In A Constantly Evolving Profession, Jacques E. Nör

The Journal of the Michigan Dental Association

University of Michigan School of Dentistry Dean Jacques Nör highlights the school's historical legacy during its 150th anniversary and details recent academic, clinical, and research progress. Key developments include the establishment of the state-of-the-art Digital Dentistry Center for in-house digital workflows, a pediatric certificate program in Social Epidemiology funded by a $2.1 million federal grant, the transition to Epic electronic health records (integrated with MyChart), and the community-based collaborative care rotation program in Marquette. The report also highlights national faculty leadership roles and $24.1 million in research funding.


When Dentists Spoke Up, The Law Changed, Timothy Rath Sep 2026

When Dentists Spoke Up, The Law Changed, Timothy Rath

The Journal of the Michigan Dental Association

This article details how grassroots member advocacy led to the passage of Michigan Senate Bill 105. Championed by the Michigan Dental Association, the law requires insurers to offer at least one fee-free payment method for dental reimbursements, protecting practices from being forced to pay transaction fees of 3% to 5% to access virtual credit card payments. Once a dentist opts out under the new law, insurers must maintain the alternative payment method. This legislative victory highlights the power of organized dentistry in relieving the administrative and financial burdens faced by individual practitioners amid rising operational overhead costs.


Serum Proenkephalin A (Penk) As An Emerging Biomarker Of Renal Failure And Its Association With Mineral, Endocrine, And Hematological Parameters, Zahraa H. K. Aljelawy, Haider Abdul-Moneem Al-Mothafer Sep 2026

Serum Proenkephalin A (Penk) As An Emerging Biomarker Of Renal Failure And Its Association With Mineral, Endocrine, And Hematological Parameters, Zahraa H. K. Aljelawy, Haider Abdul-Moneem Al-Mothafer

Muthanna Medical Journal

Objective: Renal failure is related to metabolic and endocrine disorders, in particular chronic kidney disease-Mineral and Bone Disorder (CKD-MBD). In this study, the clinical utility of serum Proenkephalin A (PENK) as a novel renal biomarker was evaluated, and its changes and correlation matrix with established renal, mineral, bone and hematological parameters in patients with renal failure were studied. Materials and Methods: A case control study was performed including patients diagnosed clinically with renal failure and age and gender matched healthy controls. Venous blood samples were collected to analyze serum PENK, including urea, creatinine, parathyroid hormone (PTH), calcium, phosphate, Vitamin D, …


Connected But Disconnected: A Covid-19 Youth Participatory Action Research Study, Vianney Atugonza, Jodi Dworkin, Stacey S. Horn, Joanna A. Tzenis, Samantha Lebouef Sep 2026

Connected But Disconnected: A Covid-19 Youth Participatory Action Research Study, Vianney Atugonza, Jodi Dworkin, Stacey S. Horn, Joanna A. Tzenis, Samantha Lebouef

Journal of Youth Development

In 2020, the COVID-19 pandemic forced most schools across the U.S. to close and transition to remote learning. Families were forced to transform their homes into classrooms while facing challenges to their health, finances, and social connections. To better understand how young people experienced these changes, a Youth Participatory Action Research (YPAR) project was employed to engage young people in naming, exploring, and sharing their experiences during this time. Nine high school youth leaders were trained as researchers to conduct interviews with their peers. These youth scholars were also trained on how to code, sort, and disseminate data and results. …


Exploring 21st-Century Skills In A Summer Camp: A Qualitative Methodological Triangulation Approach, Alexander Bowman, Jing Song Sep 2026

Exploring 21st-Century Skills In A Summer Camp: A Qualitative Methodological Triangulation Approach, Alexander Bowman, Jing Song

Journal of Youth Development

Despite the recognized importance of 21st-century skills and the substantial body of research on these skills, little is known about how to identify growth in these skills. The lack of reliable methods to measure 21st-century skill growth presents a challenge for the design of relevant learning environments and for evaluating if such learning environments are effective. Using a qualitative methodological triangulation approach, this study explored camp counselors’ learning processes. Using a systematic data integration method, field observations were synthesized with participant reflections about how their skills develop. Data were collected from 13 high-school-aged junior camp counselors at a summer camp …


Becoming Who I Am: How Youth Leadership Experiences Shape Lifelong Leadership Journeys, Dustin Evatt, Deborah Acker, Parker R. Watson, Jennifer T. Peters Sep 2026

Becoming Who I Am: How Youth Leadership Experiences Shape Lifelong Leadership Journeys, Dustin Evatt, Deborah Acker, Parker R. Watson, Jennifer T. Peters

Journal of Youth Development

Youth leadership experiences have the power to shape individuals’ values, identities, and leadership behaviors well into adulthood, yet limited empirical research has examined how these formative experiences contribute to leadership development over time. This study examines the long-term impact of youth leadership experiences using the six-stage Leadership Identity Development (LID) model as a guiding and interpretive framework by exploring the journeys of alumni from the Shelton Challenge, a six-day immersive high school leadership program at NC State University rooted in values-based and positive youth development (PYD) principles. Using narrative inquiry, we conducted interviews and focus groups with 30 alumni ages …


4-H Program Staff Perceptions Of Including Youth With Disabilities, Brittney Muschetto, Amy Leman Sep 2026

4-H Program Staff Perceptions Of Including Youth With Disabilities, Brittney Muschetto, Amy Leman

Journal of Youth Development

This study’s focus is to examine 4-H youth development county program staff’s perceptions of the inclusion of youth with disabilities in the Illinois 4-H program. The majority of program staff identified positive perceptions about including youth with disabilities in 4-H. However, they also noted that there was a need for more staff training to adequately include youth with disabilities in 4-H programming. As more youth are being diagnosed with disabilities, 4-H must continue to improve its knowledge and skills to make 4-H inclusive to all youth.


A Hip-Hop-Based Workshop Cultivates Urban Underserved Youths’ Critical Consciousness Around Food Systems, Jacob Rowell, Hannah Scherer, Kim Niewolny, Anthony Kwame Harrison, Kendrick Spencer Sep 2026

A Hip-Hop-Based Workshop Cultivates Urban Underserved Youths’ Critical Consciousness Around Food Systems, Jacob Rowell, Hannah Scherer, Kim Niewolny, Anthony Kwame Harrison, Kendrick Spencer

Journal of Youth Development

Hip hop is social commentary and critique that highlights the complexity of issues within society, including systemic inequity in the food system, which disproportionately affects urban and African American populations. After-school and non-formal programs are innovative educational opportunities to engage youth in learning about and addressing local problems through culturally-relevant program design and enactment of critical pedagogy. To meaningfully connect middle-school-aged urban youth, their lived experiences, and inequities in the food system, we designed a hip-hop-based workshop and delivered it in an established afterschool program. In this qualitative case study, we explored participants’ critical consciousness related to the food system …


A Billion People In The Shadows: Understanding Disability, Kelly Dziak Sep 2026

A Billion People In The Shadows: Understanding Disability, Kelly Dziak

Journal of Youth Development

The disability community is the largest minority group and encompasses people of all ages and backgrounds. Despite its size, members of this community frequently encounter social, educational, and economic barriers that limit opportunities for full participation. Youth development programs have the potential to support skill-building and foster a sense of belonging. However, professionals often face challenges to effectively support individuals with disabilities including limited training and accessibility barriers. A Billion People in the Shadows: The Ultimate 1-Hour Guide to Understanding Disability by Doug McCullough provides practical guidance for improving understanding and support for this population. Drawing on personal experiences with …


A More Perfect Union: An Examination Of The Film, Salt Of The Earth, And The American Labor Movement, Amber Montgomery Sep 2026

A More Perfect Union: An Examination Of The Film, Salt Of The Earth, And The American Labor Movement, Amber Montgomery

Say Something Theological: The Student Journal of Theological Studies

This paper examines the film, Salt of the Earth, which is based on the actual events of the Mine-Mill strike that took place in Hanover, New Mexico, in 1949. The strike was organized by Mexican workers with the help of their wives. The fight was over workers’ rights, as well as their dignity. At the same time, another fight was taking place. The wives of these miners were also seeking equality within their marriages, serving as a parallel narrative to the strike. To understand the environment at this time, this paper will also analyze American politics during this period, …


Proxy End-Of-Life Decision-Making: Ethical, Religious And Existential Dimensions, Deborah Kaufman Giordano Sep 2026

Proxy End-Of-Life Decision-Making: Ethical, Religious And Existential Dimensions, Deborah Kaufman Giordano

Say Something Theological: The Student Journal of Theological Studies

End-of-life decision-making conducted by medical proxies on behalf of incapacitated loved ones presents profound theological, ethical, and existential challenges. In the qualitative study “Influence of Culture and Spiritual Tradition on Support for Families of Children Dying in Intensive Care Units” (Journal of Pediatric Nursing), Ju et al found that the most painful moment for parents and proxies was not the death itself, but the agonizing decision to withdraw life-sustaining treatment. As a hospital chaplain, I have witnessed these moments where faith, culture, and medical ethics collide. This paper argues that proxy decision-making cannot be understood solely through the lens of …


Evaluating The Case Against Fda Independence, Patricia J. Zettler, Rachel E. Sachs Sep 2026

Evaluating The Case Against Fda Independence, Patricia J. Zettler, Rachel E. Sachs

Utah Law Review

Many former FDA officials, both politically-appointed leaders and those from the career ranks, as well as numerous FDA scholars have advocated for increased FDA independence in varied forms, and for good reason. At the same time, there are advantages to FDA’s current structure, and there may be ways to insulate career scientific experts’ decisions from political influence and to address other problems by generating independence, without overhauling the agency’s design. Policymakers should consider all options, as particular independence features may, or may not, be the best way, to address concerns about FDA’s capacity to carry out its vital public health …


Fda In 2050: Best- And Worst-Case Scenarios, Michael S. Sinha Sep 2026

Fda In 2050: Best- And Worst-Case Scenarios, Michael S. Sinha

Utah Law Review

In 2025, the Trump administration disrupted many critical aspects of the biomedical research infrastructure in the United States. The Food and Drug Administration (FDA) was not spared. Robert F. Kennedy, Jr., a known vaccine denier with no health care experience, was confirmed as Secretary of the U.S. Department of Health and Human Services (HHS) in February 2025, followed by the confirmation of Dr. Martin Makary as Commissioner of the FDA in April. Departures of long-time FDA scientists, coupled with appointments of key personnel, seemingly because of their public stances on COVID-19 mRNA vaccines, have resulted in a tumultuous year for …


A Primer Of Medical Device Regulation: How To Go From Reactive To Proactive To Better Protect Patient Safety, Sneha Dave, Rita F. Redberg Sep 2026

A Primer Of Medical Device Regulation: How To Go From Reactive To Proactive To Better Protect Patient Safety, Sneha Dave, Rita F. Redberg

Utah Law Review

FDA oversight of medical devices has too often been reactive, following preventable disasters rather than based on a proactive commitment to patient safety. The history of the device framework, the expansion of expedited pathways, weak postmarket surveillance, broad preemption, and conflicted patient advocacy together create a perfect storm of a regulatory environment that tolerates uncertainty and externalizes costs onto patients. Reforms such as time‑limited breakthrough status, mandatory and enforceable postmarket studies, requirements for more robust safety and efficacy data, and strengthened reporting duty for clinicians would move device regulation closer to FDA’s statutory mandate to protect public health. It would …


Fireproofing The Fda: Power, Politics, And Public Health, Daniel G. Aaron Sep 2026

Fireproofing The Fda: Power, Politics, And Public Health, Daniel G. Aaron

Utah Law Review

On September 26, 2025, the S.J. Quinney College of Law hosted the Lee E. Teitelbaum Utah Law Review Symposium — Fireproofing the FDA: Power, Politics, and Public Health. The symposium is available on YouTube. Participants discussed problems longstanding and new in an attempt to chart a path for this vital agency. Topics included (1) What is the purpose of FDA?; (2) In what ways are the current Administration’s actions precedented or unprecedented?; (3) What is the current and ideal relationship between law and politics?; (4) How can law serve as an agent of public health?; and (5) How do we …


Fda Policymaking In The Trump Deregulation Era, Jordan Paradise J.D. Sep 2026

Fda Policymaking In The Trump Deregulation Era, Jordan Paradise J.D.

Utah Law Review

This Article endeavors to contribute to and continue the conversation about how the Trump deregulatory agenda is impacting a vital national public health agency, the FDA, and our national collective public health in ways that deviate from longstanding agency policy and practice. Various other FDA policy actions deserve concerted attention by legal scholars, including the agency’s recent moves in the direct-to-consumer marketing (DTC) drug space through targeted warning letters and publicity about reforming the “adequate provision” standards, food additives and generally recognized as safe (GRAS) listing processes and directives to industry, adjustments to the biosimilar interchangeability requirements through guidance document, …


Medical Device Regulation: We Can’T Just Go Back (Nor Should We), George Horvath Sep 2026

Medical Device Regulation: We Can’T Just Go Back (Nor Should We), George Horvath

Utah Law Review

For much of the twentieth century, the federal Food and Drug Administration maintained its reputation as the preeminent regulatory agency, renowned for providing vigilant and scientifically rigorous oversight that ensured the safety and effectiveness of drugs and medical devices. But a former FDA commissioner recently lamented that “[t]he FDA as we’ve known it is finished.” Many commentators have raised concerns that reductions in force will leave the Agency understaffed, that these shortages will prolong review times, and that the standards applied to premarket evaluations of medical products will allow unsafe and ineffective products to reach the market. But in the …


The Fda’S New Clinical Decision Support Software Guidance And Its Implications For Artificial Intelligence, Sara Gerke Sep 2026

The Fda’S New Clinical Decision Support Software Guidance And Its Implications For Artificial Intelligence, Sara Gerke

Utah Law Review

Artificial Intelligence (AI) is transforming healthcare. While the U.S. Food and Drug Administration (FDA) has authorized the marketing of more than 1,400 AI-based products classified as devices under Section 201(h)(1) of the Federal Food, Drug, and Cosmetic Act, many other AIbased products, including certain clinical decision support (CDS) software tools that provide recommendations to health care professionals about diagnosis, treatment, or prevention of a disease or condition, have been placed on the U.S. market without FDA premarket review. On January 6, 2026, the FDA issued a revised CDS Guidance, which superseded the September 28, 2022 CDS Guidance. Shortly after, the …


Post-Approval Problems, Anjali D. Deshmukh M.D., J.D. Sep 2026

Post-Approval Problems, Anjali D. Deshmukh M.D., J.D.

Utah Law Review

Sitting across from 4-year-old Jessica’s parents, I whispered the truth: the most promising drug to fight their daughter’s disease was a therapy approved for adults, not for children her age. We could estimate the dose, monitor her organs, and hope the toxicity would not outpace the benefits, but there was no high-quality clinical trial data proving it was safe for kids like her yet, despite congressional mandates. Unexpected safety issues are often identified after drugs are approved and used outside of a closely controlled clinical trial, especially in understudied populations like children, the elderly, and pregnant women. When I asked …