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Identification Of Ca2 As A Potential Candidate Gene Involved In The Therapeutic Effect Of Huatan Huoxue Decoction On Polycystic Ovary Syndrome: An Integrated Study Of Network Pharmacology, Mendelian Randomization, And Experimental Validation, Chan Zhu, Yijin Zhang, Panwei Hu, Cong Qi, Qiu Chen, Hong Yang, Jing Li

Journal of Food and Drug Analysis

Purpose: Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Methods: Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for PCOS from the FinnGen R12 database. These targets were integrated with the active ingredients and protein targets of HTHXD retrieved from the TCMSP and BATMAN-TCM databases for network pharmacology analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted. Core targets were validated using molecular docking. Experimental validation was performed using a letrozole-induced …

Impact Of The Widespread Use Of Online Pharmacies On Overall Consumer Safety, Hasanain Am. Abbas, Eswar Kumar Kilari, Shereen M. Mekkey, Hussein Ahmed Jabbar, Mohammed Haider Majid, Haider Majeed Abd Abbas, Hassanein Khaled Hassan

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Online pharmacies improve access to medicines by offering convenient ordering and home delivery, but their growth also creates important risks for medication safety and public health. This review examines the benefits and hazards associated with online medicine supply, including access without a valid prescription, falsified and substandard products, inappropriate medicine use, privacy breaches, and weak cross-border regulatory oversight. The available evidence indicates that illicit online sellers can expose consumers to products of uncertain identity, quality, and dose, while vulnerable users may have limited ability to distinguish legitimate services from unlawful vendors. At the same time, licensed platforms can support continuity …

Preparation And In Vitro Evaluation Of Gastro-Retentive Tablets Of Frusemide Using Gas Generating Excipients As Floating Mechanism, Yousif K. Younis, Ahmed Yousif Fadhel, Nihad Hussein Ahmed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Frusemide is a loop diuretic used for hypertension, heart failure among many other indications. It has an absorption window in the stomach and it's a class IV drug according to BCS with low bioavailability.
Floating tablets are one of the dosage forms that is best suited for drugs with such absorption window and gas generating excipients can be used to reduce floating lag times even more than traditional floating tablets that relay on density difference alone.
The aim of the study was to investigate the feasibility of floating tablets as a convenient dosage form for oral administration of frusemide aiming …

Impact Of Erythropoietin Therapy On Inflammatory Biomarkers In Chronic Kidney Disease: A Comparative Study, Riyam Naji Al_Alwani, Jahanbakhsh Asadi, Zainab Mohammadi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Chronic kidney disease (CKD) is a progressive disorder frequently complicated by anemia and a persistent inflammatory state, both of which significantly contribute to morbidity and mortality. Reduced renal production of erythropoietin (EPO) is the primary cause of anemia in CKD. Emerging evidence suggests that EPO may exert anti-inflammatory and metabolic effects beyond its hematopoietic role. This study aimed to compare serum EPO levels and inflammatory biomarkers in CKD patients treated with EPO versus untreated CKD controls.
Material and Methods: This cross-sectional analytical study was conducted on 60 adult patients with CKD undergoing regular hemodialysis. Participants were divided into two …

Current Advances In Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, And Future Perspectives, Mohamed E. Abd El-Hack, Mahmoud Moustafa, Mahmoud Kamal, Vincenzo Tufarelli, Muhammad Arif, Laith Aldabbagh

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Cancer immunotherapy has emerged as a transformative therapeutic strategy that harnesses the host immune system to recognize and eliminate malignant cells. This review provides a comprehensive overview of current immunotherapeutic approaches, including immune checkpoint inhibitors (ICIs), monoclonal antibodies (mAbs), cancer vaccines, dendritic cell (DC)-based vaccines, chimeric antigen receptor (CAR)-T cell therapy, and oncolytic virus therapy. The mechanisms of action, therapeutic applications, and clinical benefits of each modality are discussed. Monoclonal antibodies selectively target tumor-associated antigens, whereas ICIs restore antitumor immunity by blocking inhibitory immune checkpoints. Cancer vaccines and DC-based vaccines enhance antigen-specific immune responses, while CAR-T cell therapy employs genetically …

Computational Design, Molecular Docking, Sar, And Admet Analysis Of Novel Jak1 Inhibitors As A Possible Treatment For Rheumatoid Arthritis, Sarah Ahmed Waheed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Rheumatoid arthritis is an inflammatory autoimmune disease affecting the joints which eventually leads to systemic comorbidities. Its pathogenesis was attributed to disturbances in the Janus Kinase/Signal Transducer and Activator of Transcription signaling pathway. In this research, an innovative lead compound C6 was created and docked toward Janus Kinase1 (JAK1). The docking process was confirmed by re-docking of the co-crystallized ligand MI1 (Tofacitinib). C6 showed a predicted docking score of -9.17 kcal/mol, with enhancement of 1.26 kcal/mol over Tofacitinib. Evaluation of the interactions showed a framework of five hydrogen bonds within the binding site involving an important contact with Glu966 as …

Diagnostic Accuracy Of Quantitative Coronary Analysis As Compared With Instantaneous Wave-Free Ratio In Intermediate Coronary Lesions: A Prospective Vessel-Level Study, Tamer Mosaad Ragab, Khaled Ahmed Alkhashab, Mohamed Zaki Hussain, Ibrahim Mohammed Nosseir, Marwa Salah Sayed, Waleed Khaled Ali Salem

Journal of the Saudi Heart Association

Background: Instantaneous wave-free ratio (IFR) represents a new vasodilator-free innovative approach which is considered as a gold standard for functional assessment of the hemodynamic significance of intermediate coronary stenoses. Although relatively safe, iFR is still an invasive procedure that has its potential hazards, complications and cost. Two-dimensional quantitative coronary analysis (2D-QCA) is a non-invasive technique that has emerged robustly as an excellent and attractive tool for delineating coronary anatomy.

Aims: To assess the ability of two-dimensional quantitative coronary analysis (2D-QCA) to guide decision-making for quantification of severity of intermediate coronary stenoses (40–80% diameter stenosis) in each of the three main …

Electrospun Pvp/Zno/Ha Coatings On Silane-Modified Zk60: Corrosion, Antibacterial Activity, And In Vitro Apatite Formation, Qasim Saad Abdulwahid, Akeel Dhahir Subhi, Iman Adnan Annon

Engineering and Technology Journal

This study investigated a two-stage surface modification strategy for ZK60 magnesium alloy based on 3-aminopropyltriethoxysilane (APTES) pretreatment followed by electrospun polyvinylpyrrolidone (PVP) nanofibers containing ZnO and hydroxyapatite (HA) nanoparticles. Three PVP/ZnO/HA formulations were prepared to examine the effect of nanoparticle loading, and corresponding coatings with and without APTES pretreatment were compared. The coatings were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM/EDX), and a cross-hatch adhesion test. Corrosion behavior was evaluated in simulated body fluid (SBF) using open-circuit potential (OCP) monitoring and potentiodynamic polarization. Antibacterial activity was screened against S. …

Corrosion Inhibition By Carboxymethyl Cellulose Doped With Graphite Nanosheet And Silica Nanoparticles In Seawater Environment, Mohamed R. Mohssen, Sinan S. Hamdi, Rana A. Anaee, Mathew T. Mathew

Engineering and Technology Journal

This work aims to inhibit carbon steel surface as pipelines by adding carboxymethyl cellulose (CMC) with three concentrations (1, 3 and 5 g/L) in seawater environment at four temperatures in the range of 298 – 328 K. The investigation was done by recording Tafel plots and EIS curves to show that the lowest concentration is the best to protect the steel surface with efficiencies ranged between 95.68 – 89.36 % that decrease with increasing temperature due to the decomposition of CMC that begin after ≈ 308 K. An attempt to enhance the protection by CMC at higher temperature has been …

Reconfiguring Distribution Networks Using The Aco+Tnc Algorithm, Specifying The Location, Size, And Number Of Added Renewable Energy Sources, Mohammed Falah Hasan, Rana Ali Abttan

Engineering and Technology Journal

Distribution networks face increasing pressure from rising loads and renewable energy integration, making the simultaneous optimization of reconfiguration and distributed generation placement a critical engineering challenge, and conventional single-objective methods are insufficient for simultaneously addressing power losses, voltage profile degradation, and the structural constraints of radial networks. This paper proposes a hybrid framework that combines Ant Colony Optimization with the Truncated Newton Constrained method to jointly solve network reconfiguration alongside the optimal placement, sizing, and type selection of renewable distributed generation—both solar PV and wind—within a single unified model. The approach relies on a four-part weighted objective function covering active …

Involvement Of Melatonin In The Regulation Of Reactive Oxygen Species Levels In Plants, Bariş Uzi̇lday, Oğuzhan Yilmaz, Tolga Yalçinkaya, Zehra Özgecan Tanyolaç, İsmai̇l Türkan, Rengi̇n Özgür Uzi̇lday

Turkish Journal of Botany

Abiotic stress conditions impair plant metabolism partly by inducing the excessive production of reactive oxygen species (ROS). Melatonin, a multifunctional indoleamine, has emerged as an important regulator of plant responses to oxidative stress. This review highlights recent findings on the interactions among phytomelatonin, ROS homeostasis, antioxidant metabolism, photosynthetic protection, stress priming, and abiotic stress tolerance. We discuss how melatonin modulates the antioxidative response under diverse stress conditions and evaluate its effects on photosynthetic performance, ROS signaling, and membrane stability. Special attention is given to priming studies showing that melatonin pretreatment can improve stress tolerance. Emerging evidence from plant tissue culture …

Complete Chloroplast Genome Analysis Of Critically Endangered Endemic Prangos Denticulata And Insights Into Its Evolutionary Dynamics, Ayşenur Bozkurt, Doğa Seli̇n Kayihan, Hali̇s Batuhan Ünal, Ceyhun Kayihan

Turkish Journal of Botany

Prangos denticulata (Apiaceae) is a critically endangered and narrowly endemic species restricted to Ankara, Türkiye. To provide genomic resources for its conservation and evolutionary study, we sequenced, assembled, and annotated its complete chloroplast genome using short-read next-generation sequencing. The circular plastome was 153,486 bp in length, exhibiting the typical quadripartite structure with a large single-copy (86,440 bp), small single-copy (17,894 bp), and two inverted repeats (49,152 bp), and an overall GC content of 37.8%. A total of 116 genes were identified, including 92 protein-coding, 31 tRNA, and 5 rRNA genes, of which 20 contained introns. Comparative analyses with P. trifida, …

Unmasking Myths And Facts About Actinomyces Species: Analysis From A Tertiary Care Hospital, Kanak Vats, Bhawna Sharma, Deepthi Nair

Muthanna Medical Journal

Actinomycetes are gram-positive, non-spore-forming, filamentous anaerobic bacteria that constitute part of the normal oral and intestinal flora and are widely distributed in the environment. Actinomycosis is a chronic, suppurative granulomatous infection frequently associated with deep-seated and recurrent infections. This five-year retrospective study (June 2018–June 2024) aimed to determine the prevalence and antimicrobial susceptibility pattern of Actinomyces species isolated from various clinical specimens. Samples received for Anaerobic culture and sensitivity were processed as per standard protocol and antibiogram was obtained for the respective pathogen isolated. Of the 508 specimens processed, 109 (21.4%) yielded pathogenic anaerobes, among which Actinomyces species accounted for …

Drought Priming Improves Waterlogging Tolerance In Alfalfa, But Less Effectively Than Waterlogging Priming, Gürkan Demi̇rkol, Ni̇lüfer Kara

Turkish Journal of Botany

Waterlogging severely restricts growth and productivity in alfalfa (Medicago sativa L.), necessitating effective strategies to improve stress tolerance. This study investigated whether drought priming or waterlogging priming could enhance tolerance to subsequent waterlogging stress in the alfalfa cultivar “Bilensoy-80”. Plants were subjected to drought priming, waterlogging priming, or no priming prior to progressive waterlogging stress for 0, 4, 8, 12, 16, and 20 days. Waterlogging priming consistently alleviated growth inhibition, maintained chlorophyll content, and reduced oxidative damage under prolonged stress. Drought priming was associated with partial cross-tolerance, particularly through improved root growth, plant water status, and oxidative stress responses, although …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Red Light Accelerates Adventitious Root Primordium Initiation And Differentiation In Phoebe Bournei Cuttings By Modulating Auxin Signaling And Hormonal Balance, Yuewang Niu, Yuanyang Bi, Chenyu Gong, Shipin Chen

Turkish Journal of Botany

Adventitious root formation in stem cuttings of Phoebe bournei, an economically and ecologically significant woody species, is a major bottleneck in clonal propagation. To elucidate the impact of spectral quality on early adventitious root development, we characterized the morphological, hormonal, and transcriptomic dynamics of primordium initiation and differentiation under white, red, and blue light. Under red light, cuttings exhibited the earliest and most pronounced formation of white filamentous structures at lenticels, indicative of root primordium initiation, as early as 20 days after cutting, whereas white and blue light treatments showed delayed responses. Paraffin section analysis confirmed the induced origin of …

When Winning Got More Than Gold: Hope's Glory Days; How Hope College Built Its Physics Program, Mackenzie Niswonger, Ryan Mccreedy

Archives and Special Collections Quarterly

When Winning Got More Than Gold: Hope's Glory Days

Column: From the Director of Archives and Special Collections

How Hope College Built Its Physics Program

History And Tradition Is Not Originalism — Nor A Good Idea, Kermit Roosevelt Iii, Sarah Choudhary

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Board Of Editors - Vol. 50, No. 3 2026

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

The First Amendment Does Too Much To Protect Child Predators: An Examination Of Child Erotica Under First Amendment Jurisprudence, Michael Fuccile

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Modernizing And Clarifying Family Laws: The New Jersey Law Revision Commission’S Examination Of Self-Representation, Domestic Violence, And Parental Rights, Barbara B. Rivera, Whitney G. Schlimbach, Candy Ley Velazquez, Kyle M. Ryan

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Recreational Cannabis In The Workplace: The Importance Of Implementing Clear Standards For Employers To Determine Whether Employees Are Impaired At Work, Jessica Shinski

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Table Of Contents - Vol. 50, No. 3 2026

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

A Dangerous Precedent: How State V. Blevins Fails To Account For Self-Defense In Intimate Partner Violence Scenarios, Arooj Agha

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Death: The Great Antagonist In Poe’S “The Cask Of Amontillado”, Majed S. Al-Lehaibi

Journal of Arts and Social Sciences

Poe’s story “The Cask of Amontillado” has been read as a story of a premeditated crime, of revenge and the protagonist’s ultimate pride in his well-executed crime. Readers are repulsed by the sheer evil of Montresor, the main character of the story. However, this paper argues that this reading barely scratches the surface of the depth and complexity of this story. It argues that the story is told in the form of a confession. The narrator, an elderly Montresor, is full of remorse, and in telling the story, he is seeking absolution. In its deeper meaning, “The Cask of Amontillado” …

Colour Doppler-Guided Superthin Inferior Gluteal Artery Perforator Flap Elevation For Ischial Pressure Ulcer Reconstruction, Muhammed Said Aydin, Gökay Özler, Şükrü Kasap, Mustafa Nişanci

Sultan Qaboos University Medical Journal

Ischial pressure ulcer reconstruction requires durable coverage while preserving local donor options for possible recurrence. The inferior gluteal artery perforator (IGAP) flap is a muscle-sparing option, but superthin elevation requires precise knowledge of the superficial fascial plane and the subcutaneous course of the selected perforator. This technical note describes colour Doppler ultrasonography-guided superficial fascial plane mapping before superthin IGAP flap elevation in a 27-year-old paraplegic patient with a chronic left ischial pressure ulcer who presented in 2025 to a tertiary care university hospital in Muğla, Turkey. Preoperative high-frequency colour Doppler ultrasonography identified the dominant perforator, measured the relevant fascial intervals …

A Two-Winged Murcia: Spanish Dance, Italian Corelli, One Guitar, Ellwood P. Colahan

Soundboard Scholar

Review of Santiago de Murcia (1673–1739): Entre dos almas, by Stefano Maiorana (Baroque guitar).

A Living Source Report: Cristian Gutiérrez Plays Cifras Selectas, Ellwood P. Colahan

Soundboard Scholar

Review of Cifras selectas de guitarra, by Cristiano Gutiérrez (Baroque guitar).

Creolized Baroque: Early Music In A Brazilian Key, Ellwood P. Colahan

Soundboard Scholar

Review of Iberian and Afro-Brazilian Music of the 17th Century, by Ensemble Banza, Rogério Budasz, (Baroque guitar).

So Much For Musicology: William Carter Plays Santiago De Murcia, Ellwood P. Colahan

Soundboard Scholar

Review of La Guitarra Española: Santiago de Murcia (1682–1732), by William Carter (Baroque guitar).