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Bambara Groundnut (Vigna Subterranea L.) Supplementation Ameliorates The Histological Structure Of Skeletal Muscle In Protein-Deficient Mice, Raquellynda Fadilla Syafanisa, Rimonta Febby Gunanegara, Sunarti Sunarti, Siti Aeniah, Ardaning Nuriliani

Makara Journal of Science

Protein deficiency may cause histological alterations and pathological effects in skeletal muscle, leading to reduced mus-cle size and functional degeneration. Bambara groundnuts contain essential amino acids that have the potential to meet the body’s protein requirements. Therefore, this study aimed to investigate the effect of bambara groundnut supplemen-tation on skeletal muscle in protein-deficient mice. Twenty-five female mice were divided into five groups (control, pro-tein deficiency, and protein deficiency with 100, 200, and 300 g of bambara groundnut supplementation/kg of feed). The treatment was administered for 2 months. At the end of the experiment, the left gastrocnemius muscles of the mice …

In Silico Exploration Of Alstonia Scholaris Secondary Metabolites As Antioxidant: Molecular Docking With Key Enzymes And Toxicity Prediction, Arifa Rizqi Nafisa, Anggiresti Kinasih, Muhammad Luqman Hakim, Arif Nur Muhammad Ansori

Makara Journal of Science

Degenerative diseases associated with oxidative stress necessitate the development of effective antioxidant therapies. Alstonia scholaris, a medicinal plant known for its diverse pharmacological properties, was investigated for its antioxidant potential using computational approaches. This study employed molecular docking to evaluate the interactions between bioactive compounds from Alstonia scholaris and key antioxidant target proteins, including lipoxygenase, CYP2C9, NADPH oxidase, and bovine serum albumin. Pharmacokinetic analyses based on Lipinski’s Rule of Five, along with toxicity assessments, were conducted to evaluate the compounds’ drug-likeness and safety profiles. The results demonstrated that (+)-Dicentrine exhibited the strongest and most stable binding affinity toward lipoxygenase …

Differential Gene Expression Of Ethylene Biosynthesis And Signaling Associated With Climacteric Behaviors In Indonesian Melon, Vida Rahma Latifah, Adib Fakhruddin Yusuf, Karso Suryo Putro, Dian Sartika, Anjar Tri Wibowo, Awik Puji Dyah Nurhayati, Karlia Meitha, Miftahudin Miftahudin, Budi Setiadi Daryono

Makara Journal of Science

Fruit ripening in melon (Cucumis melo L.) is a complex developmental process that is characterized by the coexistence of climacteric and non-climacteric varieties within the same species. This study characterized the ripening behavior of four local Indonesian melon cultivars (“Melona”, “GMP”, “Tacapa Gold”, and “Kinaya”) by integrating morphophysio-logical traits with transcriptional expression analysis of ethylene biosynthesis (CmACS, CmACO) and signaling (CmATH, CmEREBP) genes. The results revealed a strong agreement between the phenotypic traits and molecular regulation. “Melona” and “GMP” exhibited a strong climacteric profile, which was characterized by natural fruit abscission, sweet aroma …

Impact Of Disturbances On Butterfly Communities At The Forest Edge Of Bukit Mas Village, North Sumatra, Indonesia, Nurhayati Nurhayati, Mufti Petala Patria, Nurul Winarni, Fairuz Husna

Makara Journal of Science

Biotic homogenization can negatively impact ecosystem function and stability, reducing species diversity and interac-tions. Although deforestation has declined in Gunung Leuser National Park since 2011, associated pressures still operate at various places within the park, possibly leading to biotic homogenization. This study looked into the differences in butterfly diversity under three habitat types to understand their responses to various levels of disturbance, including en-vironmental factors. This research was carried out in September 2023 at the forest edge of the Bukit Mas Village, North Sumatra. We used the Point Count method; observations were made twice in the morning (08.00–12.00 h) and …

Network Pharmacology Of A Decaffeinated Green Coffee–Turmeric Combination: Potential Therapeutic Activity Against Hypertension And Diabetes Mellitus, Feri Eko Hermanto, Mohammad Saifur Rohman, Victor Alvianoes Guterez Hose, Mifetika Lukitasari, Dwi Adi Nugroho, Nashi Widodo, Inggita Kusumastuty

Makara Journal of Science

Decaffeinated green coffee and turmeric are recognized for their protective effects against hypertension (HTN) and diabetes mellitus (DM). Combining them into a functional drink, green coffee and turmeric (GCT), offers potential health benefits for managing these conditions. This study explored the bioactivity of GCT in HTN and DM through network biology, identifying intersecting protein targets and their roles in inflammation and glucose metabolism. Key proteins identified were AKT1, CCL2, CXCL8, IL-1β, and IL18. Molecular docking revealed that GCT compounds, particularly Cafestol, Chlorogenic Acid, Kahweol, Curcumin, and Desmethoxycurcumin, interacted strongly with AKT1 at its allosteric site, potentially inhibiting its activity. However, …

Lignin Valorization To Phenolic Compounds Over Metal Oxide-Modified Hierarchical Zsm-5 Zeolites Derived From Indonesian Minerals, Arnia Putri Pratama, Iman Abdullah, Yuni Krisyuningsih Krisnandi

Makara Journal of Science

Lignin, a key component of lignocellulosic biomass, offers significant potential as a renewable raw material for the sustainable production of aromatic chemicals. To investigate its heterogeneous catalytic depolymerization, benzyl phenyl ether (BPE) was used as a model compound. Hierarchical ZSM-5 catalysts were synthesized and modified with metal oxides (NiO and CuO). Belitung kaolin and Bayat natural zeolite, natural minerals from Indonesia, were used as silica and alumina sources to synthesize hierarchical ZSM-5 zeolite (labeled as ZSM-5N), which was compared with hierarchical ZSM-5 synthesized using pro-analysis precursors (labeled as ZSM-5S). Comprehensive physicochemical characterization using FTIR, XRD, BET, XRF, SEM-EDX, and NH₃-TPD …

Green Finance’S Role In Bank Risk: Empirical Evidence From The Emerging Economy, Viverita Viverita, Dwi Nastiti Danarsari, Ratih Dyah Kusumastuti, Ruhaini Muda

Journal of Environmental Science and Sustainable Development

Indonesia’s Financial Services Authority (OJK)’s sustainable finance roadmap, phases I and II, primarily aims to facilitate sustainable development by integrating economic, social, and environmental considerations into financial policies. A special objective is to promote the development of green financial products and services. This policy allows banks to mitigate reputational and regulatory challenges. Nevertheless, the prompt implementation of green credit may entail transition risks, such as policy adjustment costs. A limited body of research examines the direct relationship between green finance and bank risk, particularly in the context of sustainability mandates. This study analyzes the influence of green finance on banking …

A Fate-And-Transport Model For Diclofenac From Wastewater Treatment Plants To The Diyala–Tigris Rivers, Baghdad, Iraq, Mohammed A. Al-Ameri, Ghyda Y. Al Kindi, Noor S. Mahdi

Engineering and Technology Journal

Diclofenac is a widely used non-steroidal anti-inflammatory drug that is incompletely removed by conventional wastewater treatment. This study evaluates its fate and transport from consumption and excretion, through the three Al-Rustamiyah wastewater treatment plant (WWTP) units in Baghdad, to the Diyala River, the Tigris River, and the Al-Tuwaitha drinking-water intake. Discrete ``grab'' samples were collected during 12–14 November 2020 from WWTP influent and effluent streams and from river and intake sites. Diyala River concentrations ranged from 0.094 to 2.184 μg/L. At the Tigris confluence, diclofenac was 0.052 μg/L; the two immediate downstream measurements were below 0.01 μg/L …

Lessons Learned: William White, Mercedes Cardona

Journal of Financial Crises

William White spent 22 years at the Bank of Canada, where he served as deputy governor from September 1988 until 1994 before joining the Bank for International Settlements (BIS). He held a number of positions at the BIS until 2008, including head of the Monetary and Economic Department; he was also a member of the executive committee. He served as chairman of the Economic and Development Review Committee at the Organisation of Economic Co-operation and Development (OECD) from 2009 until 2019 and is currently a senior fellow at the C.D. Howe Institute in Toronto. This Lessons Learned summary is based …

Lessons Learned: Daniel K. Tarullo, Sophia Alden

Journal of Financial Crises

Daniel K. Tarullo was a member of the Board of Governors of the Federal Reserve System (the Board) and the Federal Open Market Committee from January 2009 to April 2017. Before his appointment to the Board, Tarullo held several government positions, including assistant secretary of state for economic and business affairs, deputy assistant to the president for economic policy, and assistant to the president for international economic policy. In addition to his work with the Federal Reserve, Tarullo has extensive experience in law and academia and has spent more than 15 years teaching at Georgetown and Harvard Law Schools. Tarullo …

The Lingering Effects On Junk Bond Spreads Of The Fed’S 2020 Corporate Bond Backstop Facilities, John V. Duca, An Nguyen

Journal of Financial Crises

The US corporate bond market is typically disrupted during financial crises, when uncertainty and risk premiums are high and bond issuance is depressed. During the COVID-19 recession, the Federal Reserve introduced two unprecedented interventions: the Primary Market Corporate Credit Facility and Secondary Market Corporate Credit Facility. These backstop facilities stood ready to purchase corporate bonds when corporate bond spreads were wide. While existing literature highlights their effects on investment-grade bonds, the implications for high-yield (junk) bonds remain less well understood. We track uncertainty using the Cboe Volatility Index, or VIX; Jurado, Ludvigson, and Ng’s measures of macroeconomic uncertainty; and other …

Lessons Learned: Agustín Carstens, Mercedes Cardona

Journal of Financial Crises

Agustín Carstens had a long career at Bank of Mexico, the country’s central bank, starting in 1980, before he was named the country’s minister of finance, a post he held from 2006 to 2009. In January 2010, he was named governor of Bank of Mexico and served in that role through 2017, when he became general manager of the Bank for International Settlements (BIS). Carstens managed multiple financial crises during his career. Mexico weathered a significant upheaval during the Mexican Peso Crisis of 1994–95, and again during the 2007–09 Global Financial Crisis (GFC). The Mexican economy did not have the …

A Framework For Understanding The Vulnerabilities Of New Money-Like Products, Kenechukwu Anadu, Patrick Mccabe, J.P. Perez-Sangimino, Nathan Swem

Journal of Financial Crises

New money-like products, such as tokenized money market funds (MMFs), money market exchange-traded funds, and stablecoins, could be transformative for finance. These products may offer significant benefits, but like other money-like assets, they also have certain vulnerabilities. We introduce a framework to analyze the vulnerabilities of new products by comparing their features to those that contribute to vulnerabilities in MMFs. Specifically, we examine the extent to which each product engages in liquidity transformation, is subject to threshold effects, serves as a money-like asset, poses contagion risks, and has reactive investors. Our framework is useful for assessing the potential effects of …

Presumptive Feline Infectious Peritonitis-Associated Uveitis With Posterior Segment Mass-Like Lesions On Ultrasonography, Hyun-Wook Kim, Danbee Kwon, Joon Young Kim

The Thai Journal of Veterinary Medicine

5-year-old neutered male domestic shorthair cat was presented with unilateral anterior uveitis and ocular pain in the left eye without systemic signs. Ophthalmic examination revealed a superficial corneal ulcer, keratic precipitates, and aqueous flare. Ocular ultrasonography identified ciliary body thickening and a nodular mass-like lesion posterior to the ciliary body. Despite systemic corticosteroid treatment after corneal ulcer healing, no clinical improvement was observed. Computed tomography revealed contrast-enhancing thickening of the ciliary body and uveoscleral region. Enucleation and histopathology demonstrated pyogranulomatous inflammation without evidence of neoplasia or detectable infectious organisms. Immunohistochemistry for feline coronavirus antigen was not performed at that time. …

Geotechnical Enhancement Of Noncohesive Coal Mine Overburden Using Microbially Induced Calcite Precipitation And Fly Ash Stabilization For Sustainable Pavement Applications, Atul Gautam, Laxmikant Yadu

Journal of Sustainable Mining

The majority of the waste generated from opencast mining, termed as overburden (OB), is dumped adjacent to the mine boundary and poses long-term stability issues. Various studies have been carried out to assess the risk of dump slope failure, and treatment strategies have been accordingly recommended to strengthen this OB dump. However, scant works are reported to sustainably utilize this OB for construction works. This study aims to quantify the performance of stabilized noncohesive coal mine OB collected from Gondegaon opencast mine (OCM) in India. Stabilization was achieved using two techniques, namely microbially induced calcite precipitation (MICP) through Sporosarcina pasteurii …

Owning The Mission: Reconciling The Past, While Implementing The Science Of Reading In An Education Preparation Program, Paula J. Adams

Journal of Inquiry and Action in Education

This reflective inquiry examines the first year of a two-year initiative to more explicitly align an established educator preparation program with the Science of Reading (SoR). Situated within a small private university in New York State, the article considers implementation as both curricular revision and institutional change. The process included faculty professional learning, curriculum mapping, alignment of student learning outcomes, revision of common course assessments, development of SoR-aligned models of candidate work, and consideration of clinical experiences. Particular attention is given to tensions that emerged around policy fatigue, academic freedom and responsibility, differing professional cultures, candidates’ prior experiences with literacy …

When Three Points Aren't Enough: Parameter Estimation In Newton's Law Of Cooling, Alberto A. Condori, Cara D. Brooks, Madeline R. Goldberg

CODEE Journal

We begin with a paradoxical three-point problem where the standard parameter estimation formula fails because temperature data must satisfy a concavity condition reflecting Newton's Law of Cooling's exponential structure. Although a closed-form solution for A exists for equally-spaced measurements, high sensitivity to error motivates the use of overdetermined systems with many measurements. The "profiling over A" technique transforms this three-parameter nonlinear problem into a sequence of simple linear regressions, providing computational efficiency and conceptual transparency. This approach can be generalized to many parameter estimation problems in science and engineering, making it a valuable tool for undergraduates interested in applied mathematics. …

My Negotiation Chatbot Toby And Pedagogical Governance, Renee Henson

Journal of Science & Technology Law

No abstract provided.

Automated Childrearing Through Ai Companions, Katharine B. Silbaugh

Journal of Science & Technology Law

Can we develop a method of regulating AI to protect families, households, children, and relationships? We want AI to do the dishes, not to raise our children. Scholars in family law and family dynamics in sociology and economics have worked to refine and explain characterizations of family life in ways that might help to formulate the challenges ahead. Where a characterization of family life is too thin, these scholarly efforts let us see the costs of conventional or incomplete understandings. For example, just because we are at home, doesn’t mean we aren’t working. Just because it is with and for …

Building On Sand: Ai Law And The Failures Of Alignment, Claire Boine

Journal of Science & Technology Law

AI alignment is increasingly in the spotlight. However, from a technical concept, the term has been broadened to cover all sorts of potential harms by advanced AI systems. This Article disambiguates three different problems: ensuring that systems pursue intended objectives through acceptable means, deciding which values should guide their behavior, and governing private companies whose incentives diverge from those of society. Drawing on technical research and documented incidents, the Article explains why goal alignment deserves serious attention without requiring claims about human-like intelligence. It then shows how value alignment can reframe normative conflict as an engineering problem and divert attention …

Misplaced Trust In Artificial Professional Advice, Claudia Haupt

Journal of Science & Technology Law

The professional relationship constitutes a distinctive social interaction in which the professional has knowledge that the client or patient lacks but needs to make important decisions. A specific legal and ethical framework governs this relationship. Traditionally, this framework assumes interactions between human actors and is designed to safeguard normative values inherent to human-centered professional advice-giving. Prominent among the foundational assumptions are expectations of competence, loyalty, and trust. Individuals seeking professional advice expect to receive accurate and comprehensive advice reflecting the insights of the profession.

This Essay examines the social relationship based on knowledge asymmetries and trust underlying the human professional …

Cartelized Parliament And The Decline Of Legislative Oversight In Indonesia’S Multiparty Presidentialism, Shanty Kartika Dewi, Anis Fuad

Jurnal Wacana Politik

This article examines the tendency of Indonesia’s House of Representatives (DPR RI) in the 2024–2029 term to move toward a cartelized parliament within Indonesia’s multiparty presidential system. It addresses how the dominance of an oversized governing coalition after the 2024 election weakens parliamentary opposition and reduces the effectiveness of checks and balances over the executive. The study employs a qualitative explanatory approach using a single-case study design, process tracing, and documentary analysis. The data are drawn from official state and parliamentary documents, KPU decisions, legislative agendas, democracy monitoring reports, credible media coverage, and public statements by political elites. The findings …

When Every Policy Is Called Innovation: Innovation Inflation And The Politics Of Policy Labelling In Indonesian Local Government, Anggia Ermarini, Anry Firmansyah, Rio Yusri Maulana, Ahmad Zaini Miftah

Jurnal Wacana Politik

This study examines how local governments construct policy innovation claims and the extent to which such claims are supported by substantive novelty, regulatory conformity, institutional capacity, and evidence of public benefit. The study employed a qualitative document analysis with a comparative multiple-case design. The analysis covered 29 documents, consisting of 21 documents related to six policy cases and eight national regulations used as comparative standards. The cases included Sekolah MAUNG, Panca Waluya Character Education, the 5 a.m. school policy, Qlue, Electronic Parking Terminals, and i-Jus Melon. The data were analysed using directed qualitative content analysis across three dimensions: substance, regulation …

Shakespeare Adapts, Grace C. Tiffany

Selected Papers of the Ohio Valley Shakespeare Conference

No abstract provided.

Shakespeare’S Troilus And Cressida And The Genre Of Comical Satire, Robert B. Pierce

Selected Papers of the Ohio Valley Shakespeare Conference

No abstract provided.

“Shall I Always Keep Below Stairs?”: The Waiting-Gentlewoman On The Margin Of Much Ado About Nothing, Daniel F. Gates

Selected Papers of the Ohio Valley Shakespeare Conference

No abstract provided.

A Mouth Too Full: Domination, Consumption, Kitchens And Witches In Macbeth, Bethany Decker

Selected Papers of the Ohio Valley Shakespeare Conference

No abstract provided.

Introduction, Emily Isaacson

Selected Papers of the Ohio Valley Shakespeare Conference

No abstract provided.

Creating Space For Student Voices, Glenda Da Rosa Mayeregger

Teaching and Learning Together in Higher Education

No abstract provided.

Exploring Theories Of Co-Creation, Mst Amina Antora

Teaching and Learning Together in Higher Education

No abstract provided.