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Language Style Matching (Lsm) And Group Cohesion: Exploring Mechanisms Behind Psychological Wellbeing In Interpersonal Psychotherapy For College Students (Ipt-Cs), Bradley Orzada, Kirby Knapp, Ellie Malone, Colleen Conley Apr 2026

Language Style Matching (Lsm) And Group Cohesion: Exploring Mechanisms Behind Psychological Wellbeing In Interpersonal Psychotherapy For College Students (Ipt-Cs), Bradley Orzada, Kirby Knapp, Ellie Malone, Colleen Conley

Undergraduate Research and Engagement Symposium

Interpersonal psychotherapy (IPT) has been found to be effective for improving the anxiety and depression symptoms of college students, but little is known about the therapeutic mechanisms behind IPT nor for whom IPT does not work. Language style matching (LSM), given its associations with interpersonal relationships and psychological wellbeing, may further inform IPT mechanisms and serve as a tool to predict intervention outcomes. Using data from an IPT group for college students, the present study explored how participant LSM relates to anxiety, depression, and group cohesion. Group psychotherapy transcripts of participants (N = 9) were analyzed using Linguistic Inquiry and …

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Microbial Responses To Pharmaceutical Pollution In Streams, Darian Bolden Apr 2026

Microbial Responses To Pharmaceutical Pollution In Streams, Darian Bolden

Undergraduate Research and Engagement Symposium

Pharmaceuticals, which include prescription and non-prescription drugs, have been detected in human-impacted streams throughout the world, raising concerns about the potential ecological effects of these drugs. The goal of my project was to assess the potential effects of pharmaceutical pollution on leaf litter decomposition by microorganisms as an indicator of stream health. We added a mixture of eight antibiotics to four artificial stream channels, with four control channels receiving no antibiotics, and used cotton strips as a surrogate for leaves. Addition of antibiotics stimulated leaf litter decomposition, increased bacterial community diversity and altered bacterial community composition after 14 days, but …

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Investigating The Quantity & Composition Of “Nurdles” At Micro & Macro Levels, Andrew Conover, Maya Worek, Olivia Schaul Apr 2026

Investigating The Quantity & Composition Of “Nurdles” At Micro & Macro Levels, Andrew Conover, Maya Worek, Olivia Schaul

Undergraduate Research and Engagement Symposium

Plastic pollution is a pressing global concern. Plastic pre-production pellets, or “nurdles” are widespread in the environment, but not yet well documented in rivers. In particular, nurdles are well documented along coastlines; additional efforts are needed to report the presence and concentration of these pollutants in freshwater habitats to fully understand the scope of the problem. This project had 2 objectives: 1) use community science (i.e., volunteer-generated) data to quantify nurdle abundance in rivers at a continental scale, and 2) measure the magnitude of the distribution of nurdles in a single tributary of the Chicago River.

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The Relation Of Museum Visitors' Idea Framing Approaches And Engineering Engagement During A Community Design Puppet-Making Activity​, Adeline Sauer Apr 2026

The Relation Of Museum Visitors' Idea Framing Approaches And Engineering Engagement During A Community Design Puppet-Making Activity​, Adeline Sauer

Undergraduate Research and Engagement Symposium

Engaging in early informal learning opportunities for children provides a unique setting for fostering their engineering learning. Specifically, collaboration (e.g., sharing ideas and helping one another) can support children's learning during tinkering activities. We explore how 39 4- to 10-year-old children (Mean age = 6.63; 19 girls) and their caregivers define and engage in the engineering design process (EDP) during a hands-on puppet making activity at a children’s museum. It is hypothesized that children and caregivers who frame, or communicate, their ideas as group-centered will have the highest engagement in the EDP process over framing ideas as individual-centered and other-centered.

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Why Would I Tell?: The Role Of Gender, Identity Centrality, And Responsiveness In African American Romantic Relationships, Angela Okechukwu Apr 2026

Why Would I Tell?: The Role Of Gender, Identity Centrality, And Responsiveness In African American Romantic Relationships, Angela Okechukwu

Undergraduate Research and Engagement Symposium

For African American couples, shared racial identity can help facilitate sharing of experiences of racial microaggressions (Nightingale et al., 2019). High partner responsiveness can help manage stressors (Reis, 2012), and should correlate with increased willingness to share. African American couples answered questions about experiences of microaggressions, ethnic identity centrality, and partner responsiveness. Women shared more regardless of their identity centrality. However, men lower in identity centrality were more willing to share if they perceived their partner as more responsive, while men high in identity centrality shared regardless of how responsive they thought their partner was.

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Marsh Bird Passive Acoustic Monitoring Detections Affected By Plant Communities, Mikaila Cadavona Apr 2026

Marsh Bird Passive Acoustic Monitoring Detections Affected By Plant Communities, Mikaila Cadavona

Undergraduate Research and Engagement Symposium

Marsh-dwelling birds breed and forage in Laurentian Great Lakes coastal wetlands (GLCWs). Typha × glauca (hereafter Typha) has altered the plant composition of GLCWs and impacted marsh bird populations. Emerging technologies, autonomous recording units (ARUs) and BirdNET, can be used to passively monitor birds. This study aimed to determine how plant communities (sedge meadow, Typha, bulrush, open water) and distance affect marsh bird detection rates. Detections declined beyond 75 meters in all plant communities. Detections were lower in Typha stands compared to bulrush stands. This study informs monitoring strategies for marsh bird surveys by identifying accurate sampling methods in GLCWs.

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Identification Of An Unknown Bacterial Species From A Sink Handle, Angelo Ricarte, Ahman Dye Apr 2026

Identification Of An Unknown Bacterial Species From A Sink Handle, Angelo Ricarte, Ahman Dye

Undergraduate Research and Engagement Symposium

This project aims to identify an unknown bacterial species isolated from a sink handle. Using a series of tests, the bacterium’s physical appearance, growth conditions, and metabolic characteristics will be examined. Its shape, colony appearance, and responses to different biochemical tests will help narrow down its identity. By comparing these results with the profiles of known bacteria, this project aims to determine which species is present and better understand the types of microbes commonly found on everyday objects.

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Do Women Legislators Legislate Differently Than Men On Gun-Related Policy? A Suggestive Yes, Brady Mudge Apr 2026

Do Women Legislators Legislate Differently Than Men On Gun-Related Policy? A Suggestive Yes, Brady Mudge

Undergraduate Research and Engagement Symposium

Polls show that men are less likely to support gun restrictions than women, but do voter preferences translate into elite behavior? To answer this question, we use a novel dataset of hand-coded state firearm legislation across six politically diverse states (California, Florida, Iowa, Illinois, Michigan, Texas) to construct an 11-year panel dataset. Our results demonstrate that descriptively, women generally cosponsor more restrictive and fewer permissive gun policy bills than men, even after accounting for partisanship. Using multiple staggered difference-in-differences specifications, we find women are no more likely than men to advance restrictive gun bills, yet they do cosponsor fewer efforts …

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Area Approximation Of Jordan Curves Via The Isoperimetric Inequality And Cauchy-Crofton Formula, Nikita Veselkin, Rashad Kaiyal Apr 2026

Area Approximation Of Jordan Curves Via The Isoperimetric Inequality And Cauchy-Crofton Formula, Nikita Veselkin, Rashad Kaiyal

Mathematics Colloquium Series

We combine the Isoperimetric Inequality (Dido's Problem) and the Cauchy-Crofton formula to approximate the area enclosed by Jordan curves in the 2D plane. The Cauchy-Crofton formula provides a consistent estimate of a curve's length, which the Isoperimetric Inequality then uses to approximate the enclosed area. We additionally present software that automates the Cauchy-Crofton length computation, making the method practical for real-world use. Empirical testing validates the accuracy of this combined approach, with potential applications in tumor segmentation from MRI scans.

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Leveraging Agentic And Generative Ai For Intelligent Global Market Analysis, Anichur Rahman, Airin Afroj Aishi, Md Shohel Rana Apr 2026

Leveraging Agentic And Generative Ai For Intelligent Global Market Analysis, Anichur Rahman, Airin Afroj Aishi, Md Shohel Rana

GS4 Student Scholars Symposium

Global financial markets produce enormous amounts of structured and unstructured data on a per-second basis. The data is comprised of economic data, news feeds, social media data, and geopolitical data. Traditional approaches to financial market analysis have difficulties integrating these data sources and adapting to the changing global environment. This project aims to create a novel framework for autonomous financial market intelligence using Agentic AI and Generative AI technologies. Agentic AI is an emerging technology that allows for the creation of autonomous decision-making agents. The agents can be programmed to continuously monitor and analyze data sources, detect emerging trends, and …

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Multi-Omics Systems-Guided Insights Of Withanolide And Other Bioactives Contributions To Anti-Stress And Endurance Outcomes In Withania Somnifera, Deepak Mundkinajeddu Apr 2026

Multi-Omics Systems-Guided Insights Of Withanolide And Other Bioactives Contributions To Anti-Stress And Endurance Outcomes In Withania Somnifera, Deepak Mundkinajeddu

Oxford ICSB

Conventional Ashwagandha standardization is largely focused on total withanolide quantification, without insights on the functional contribution of other phytochemical fractions. In this discovery-driven development program, orthogonal array–based model combined with predictive transcriptomics was used to delineate the relative biological roles of withanolide and other bioactive components within Withania somnifera extracts. Validated animal models showed that withanolide-enriched fractions significantly reduced serum cortisol (p< 0.05), while other bioactive-enriched fractions significantly increased run-time to exhaustion (p< 0.05), confirming anti-stress and endurance mechanisms. By linking the phytochemical profile with predicted biological pathway activity, the composition of the extract is rationally optimized for the development of a standardized extract (Ashwa.30), designed to deliver both anti-stress and endurance benefits at a dose of 30 mg. Clinical evaluation of the Ashwagandha extract demonstrated significant reductions in perceived stress scores and circulating cortisol levels, alongside measurable improvements in endurance parameters compared to placebo (p< 0.05), confirming translational alignment from preclinical discovery to human outcomes. Untargeted metabolomic profiling revealed enrichment of glycine and serine metabolism, methionine metabolism, phenylalanine and tyrosine metabolism, and homocysteine degradation pathways. These integrated metabolic changes worked together to improve energy production, support mitochondrial repair, maintain antioxidant balance, and help reset the body’s stress response system. This work presents a systems-biology–based approach to holistic Ashwagandha standardization, integrating withanolides and complementary bioactivities. It establishes a precision-driven framework for clinically validated adaptogenic efficacy.

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How Is The Use Of Ai Impacting Nursing Students Education?, Lorna H. Strain Apr 2026

How Is The Use Of Ai Impacting Nursing Students Education?, Lorna H. Strain

GS4 Student Scholars Symposium

The use of Artificial Intelligence (AI) in education is rapidly increasing and reshaping how nursing students learn and engage with content. This thesis proposal takes a look at the impact of AI on the education of nursing students and explores students' perceptions of its use in their learning and education. As AI becomes more prevalent, many students are using it for study aids and content personalization, while schools are using it in simulations and textbook platforms. Many recognize its benefits, such as enhanced critical thinking, improved accessibility of materials, and more immersive learning. Concerns persist around ethical use, academic integrity, …

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Does A Youth-Led Faith Revival Suggest Promise For Reversing Decades-Long Trends Of Religious Decline, James Black Apr 2026

Does A Youth-Led Faith Revival Suggest Promise For Reversing Decades-Long Trends Of Religious Decline, James Black

Liberty University Research Week

Literature focusing on religious trends among demographic groups in both America and nationally have been generally understood to be showing a decline in the share of the population consistently practicing and holding religious beliefs, including Christianity. However, in more recent years, particularly from 2020 onwards, new research has been introduced, hinting at the possibility that these trends indicating religious decline among selected populations may be reversing due to increased church attendance and religious participation among younger demographics such as Milennials and Gen Z. While these trends are in their infancy, new literature suggests they are accompanied by broader cultural shifts …

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The Role Of Mentorship In Reducing Burnout In New Nurses And Nursing Students, Omari Andry Apr 2026

The Role Of Mentorship In Reducing Burnout In New Nurses And Nursing Students, Omari Andry

GS4 Student Scholars Symposium

Burnout among new nurses and nursing students is a consistent issue affecting the healthcare system by adding to early career turnover, emotional exhaustion, and decreased quality of patient care. Structured mentorship programs have emerged as a promising intervention to alleviate burnout by giving emotional support, professional development, and coping strategies. This proposal explores the role of mentorship in reducing burnout symptoms, improving job satisfaction, and promoting emotional resilience among new nurses and nursing students alike. Based on existing scholarly articles, the project will investigate how structured versus informal mentorship affects burnout rates, the qualities of effective mentors, and the outcomes …

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Bringing Worlds Together: How Social Studies Teachers Make Content Meaningful, Harley A. Payne Apr 2026

Bringing Worlds Together: How Social Studies Teachers Make Content Meaningful, Harley A. Payne

GS4 Student Scholars Symposium

Secondary educators in social studies classes face the challenge of maintaining the attention of twenty to thirty students while they instruct them about content that often seems irrelevant or unimportant. These educators know, however, that the material these students are disinterested in is useful and crucial for developing adolescents who are learning to interact with the world. Research suggests that bridging the gap between the classroom and the real world has been linked to greater classroom engagement (Cooper 2014, Tagliaferro, 2012). Students who are engaged and exert more effort in class derive academic benefits, such as placement in advanced pathways …

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Alkaloid Profiling Of Narcissus Poeticus L. Bulbs And Their Inhibitory Activity Of Cholinesterases, Maël Gainche, Isabelle Ripoche, Elodie Jagu Apr 2026

Alkaloid Profiling Of Narcissus Poeticus L. Bulbs And Their Inhibitory Activity Of Cholinesterases, Maël Gainche, Isabelle Ripoche, Elodie Jagu

Oxford ICSB

The Amaryllidaceae family is well known for its rich diversity of alkaloids, including lycorine- and galantamine-type structures with potent cholinesterase inhibitory properties. In this study, we investigated the phytochemical composition and cholinesterase inhibitory activity of alkaloids isolated from Narcissus poeticus L., a species native to the botanically rich Auvergne region of France. Phytochemical analysis and bioguided fractionation of bulb extracts led to the identification of three known alkaloids, pseudolycorine, norgalantamine, and 2-O-(3’-hydroxybutanoyl)-lycorine, as well as a newly characterized tetrahydroquinoline derivative, poeticine A. The inhibitory activities of these compounds against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were assessed using both a standard …

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The Erosion Of The Imago Dei: A Qualitative Study Of Religious Identity Maintenance Among Affluent Professionals In Secularized Environments, Shawn Hall Apr 2026

The Erosion Of The Imago Dei: A Qualitative Study Of Religious Identity Maintenance Among Affluent Professionals In Secularized Environments, Shawn Hall

Liberty University Research Week

While sociological research has extensively documented the decline of religious affiliation (the "rise of the Nones"), fewer studies examine the erosion of theological anthropology, the fundamental beliefs about the nature of the self among religious adherents who remain active within faith communities. Drawing on twenty years of qualitative participant observation in the Washington, D.C., metropolitan area, this study investigates how affluent Christians maintain or fail to maintain a "Bipartite" (Soul-Body) worldview while embedded in highly secularized, technocratic professional environments. Utilizing a reflexive ethnographic design and NVivo-supported thematic analysis, the research identifies a phenomenon of "Ontological Dissonance," where adherents profess orthodox …

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A Created Longing: Sehnsucht And The Creative Arts, Hope Dornfeld Apr 2026

A Created Longing: Sehnsucht And The Creative Arts, Hope Dornfeld

Liberty University Research Week

The German concept of Sehnsucht is expressed explicitly in several musical selections from the Romantic era; however, the emotional state it represents is implicit in a much greater field of music, crossing a wide variety of styles, genres, and periods of history. The concept first gained popularity through the writings of Goethe and Schiller, and was employed in poetic, musical form through the works of the German Romantic composers. Significant research exists on the philosophical and theoretical implications of Sehnsucht. However, the extent of its intersection with the creative arts has not been explored in a great deal of depth. …

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Temporal Variation In Dna Methylation Over 115 Years Post Introduction Facilitate Success Of House Sparrows, M. Ellesse Lauer, J. Dylan Maddox, Kevin D. Kohl, Mark Ravinet, Lynn B. Martin, Aaron W. Schrey Apr 2026

Temporal Variation In Dna Methylation Over 115 Years Post Introduction Facilitate Success Of House Sparrows, M. Ellesse Lauer, J. Dylan Maddox, Kevin D. Kohl, Mark Ravinet, Lynn B. Martin, Aaron W. Schrey

GS4 Student Scholars Symposium

House sparrows (Passer domesticus) have colonized most continents within the last 200 years. As such, they represent a unique study system for understanding the role that epigenetic mechanisms play in an individual’s responses to rapid environmental changes. DNA methylation facilitates the introduction success of non-native sparrows by compensating for reduced genetic diversity and supporting changes to phenotypes. In non-native populations of house sparrows, more recently introduced populations have higher variance in DNA methylation and respond to simulated infections with a greater magnitude of change in DNA methylation. To determine how DNA methylation changes temporally across 115 years post …

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Evaluation Of Fasted And Fed Gastrointestinal Transformation Of Withania Somnifera Plant Extracts And Bioactive Compounds Via Uplc-Ms/Ms And Untargeted Metabolomics, Sarah Barr, Wendy Strangman, R. Thomas Williamson, Amala Soumyanath, Melissa Bollen Apr 2026

Evaluation Of Fasted And Fed Gastrointestinal Transformation Of Withania Somnifera Plant Extracts And Bioactive Compounds Via Uplc-Ms/Ms And Untargeted Metabolomics, Sarah Barr, Wendy Strangman, R. Thomas Williamson, Amala Soumyanath, Melissa Bollen

Oxford ICSB

Ashwagandha (Withania somnifera) is a widely consumed botanical supplement recognized for its anti-inflammatory, antioxidant, and anti-aging properties. Despite its extensive use, limited information exists on how its complex chemical composition changes during gastrointestinal digestion. An untargeted UPLC-MS/MS-based metabolomics approach enables analysis of discrete changes in complex mixtures. Previous in vitro studies of W. somnifera relied on simulated gastric and intestinal models composed primarily of buffers and digestive enzymes. This study advances those methods by incorporating bile salts and phospholipids under fasted and fed conditions to better simulate physiological digestion of aqueous and ethanolic extracts of W. somnifera root and leaf. …

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Whole-Brain Emotional Processing Through The Meld Framework: A Music-Based Trauma-Informed Intervention, Janita Daggy, Arij Abdul, Tammy Griffin Apr 2026

Whole-Brain Emotional Processing Through The Meld Framework: A Music-Based Trauma-Informed Intervention, Janita Daggy, Arij Abdul, Tammy Griffin

Liberty University Research Week

The MELD Framework integrates music, emotion, language, and dialogue as a trauma-informed intervention supporting emotional regulation and self-expression. Grounded in neurobiology and trauma theory, this approach recognizes that traumatic experiences are stored in nonverbal, right-hemisphere systems and require embodied processing before verbal integration occurs. Using music and lyric analysis, the framework facilitates safe access to emotional states while promoting bilateral brain integration and narrative coherence. This mixed-methods study examines the impact of a single 20–25 minute MELD session on participants' emotional regulation, self-expression, and integration through pre- and post-intervention self-report measures and qualitative reflective writing prompts. Analysis focuses on shifts …

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Unmasking Ashwagandha Controversy: Safety, Toxicity, And Adulteration, Tahir Maqbool Mir Apr 2026

Unmasking Ashwagandha Controversy: Safety, Toxicity, And Adulteration, Tahir Maqbool Mir

Oxford ICSB

Ashwagandha (Withania somnifera) is an adaptogenic shrub valued for its roots, which support systemic health. Increasing use has raised safety concerns about adulteration and hepatotoxicity. The roots of ashwagandha are primarily preferred for systemic health, while the leaves were traditionally reserved for topical applications to treat joint inflammation and promote wound healing.  Although generally considered safe, ashwagandha supplements have been linked to drug-induced liver injury, including cholestasis, jaundice, and pruritus. Reports from various organizations like LARB in the Netherlands indicate a rise in liver toxicity cases, possibly due to cytotoxic withafrin A and DNA-damaging withanone. A major concern is widespread …

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Advancements In Botanical Toxicology, Characterization, And Regulatory Frameworks, Paula Brown Apr 2026

Advancements In Botanical Toxicology, Characterization, And Regulatory Frameworks, Paula Brown

Oxford ICSB

No abstract provided.

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Determinants Of Opioid-Relevant Exposure From 7-Hydroxymitragynine Products In The Evolving U.S. Marketplace, Igor Koturbash, Scott Alsbrook, George Pro Apr 2026

Determinants Of Opioid-Relevant Exposure From 7-Hydroxymitragynine Products In The Evolving U.S. Marketplace, Igor Koturbash, Scott Alsbrook, George Pro

Oxford ICSB

Kratom’s U.S. market has rapidly evolved from largely botanical powders and capsules to products enriched in 7-hydroxymitragynine (7-OH), a potent mu-opioid receptor agonist that is typically present only at trace levels in leaf material. To quantify downstream behavioral health burden and contextualize it with real-world signals of product diffusion, we analyzed National Survey on Drug Use and Health (NSDUH) data (2021-2023) alongside public health alert trends and systematic online product surveillance. In NSDUH, 5.8% of adults met criteria for serious mental illness (SMI). SMI increased by 150% among adults with combined opioid use disorder (OUD) and kratom use between 2021 …

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Naturally Derived Kratom Extracts: Toxicological Evaluation In Humans And Rodents, Sibyl Swift Apr 2026

Naturally Derived Kratom Extracts: Toxicological Evaluation In Humans And Rodents, Sibyl Swift

Oxford ICSB

Peer-reviewed literature provides limited toxicological data on the consumption of naturally derived kratom extracts. Given the increasing use of kratom products, understanding their safety profile is critical for public health and regulatory decision-making. To address this gap, we conducted a rodent toxicology assessment and a controlled human clinical study. Human Clinical Study: Healthy male and female participants consumed specified kratom extracts daily for 14 consecutive days under controlled conditions. Clinical observations and biochemical markers were monitored throughout the study. Rodent Toxicology Study: Equivalent extract doses were administered to rodents for 90 days to evaluate subchronic exposure. Assessments included body weight, …

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Everything You Know About The Piano Is Wrong, Khuong Vo Apr 2026

Everything You Know About The Piano Is Wrong, Khuong Vo

Liberty University Research Week

No abstract provided.

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Dramatic Interpretation, Christine Johnson Apr 2026

Dramatic Interpretation, Christine Johnson

Liberty University Research Week

No abstract provided.

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Epigenetic Variation Of American Alligators (Alligator Mississippiensis) In The Okefenokee Swamp, Mark Hoog, Kimberly M. Andrews, Aaron W. Schrey Apr 2026

Epigenetic Variation Of American Alligators (Alligator Mississippiensis) In The Okefenokee Swamp, Mark Hoog, Kimberly M. Andrews, Aaron W. Schrey

GS4 Student Scholars Symposium

An animal's survival is heavily influenced by how well adapted it is to the environment in which it lives; however, phenotypes are only able to change so quickly. Epigenetics allows for greater phenotypic plasticity through molecular mechanisms without altering the DNA sequence. DNA methylation is the most widely studied epigenetic mechanism. It has shown the ability to alter gene expression and may even be able to compensate for a lack of genetic variation. Changes in DNA methylation are often caused by stressors that range from anthropogenic causes to natural occurrences. We sought to examine the effect of environmental factors on …

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Detection Of 17Α Ethynylestradiol And 17Β Estradiol In Wastewater, Kezia J. Lemke Apr 2026

Detection Of 17Α Ethynylestradiol And 17Β Estradiol In Wastewater, Kezia J. Lemke

Research & Creative Achievement Day

Environmental estrogens act as endocrine disrupting chemicals, thereby affecting the metabolism, synthesis, and receptors of hormones. For this reason, estrogens can have serious health consequences for aquatic wildlife by negatively affecting their reproductive abilities. Synthetic estrogens, such as 17α ethynylestradiol, the synthetic analog of 17β estradiol, are particularly potent, and are shown to have more harmful effects at lower concentrations. This illustrates the importance of developing sensitive and efficient methods for 17α ethynylestradiol and 17β estradiol detection, so that areas of high concentration can be recognized and methods to decrease the estrogen concentrations can be put in place. To this …

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Computational Investigation Of Ruthenium Complex Interactions With Dna For Anticancer Applications, Mikayla A. Ertz Apr 2026

Computational Investigation Of Ruthenium Complex Interactions With Dna For Anticancer Applications, Mikayla A. Ertz

Research & Creative Achievement Day

Ruthenium complexes are being studied as potential alternatives to platinum-based cancer drugs because they are often less toxic and more selective for cancer cells. This project uses computational modeling to investigate how a ruthenium complex interacts with DNA, which is an important target for anticancer activity. All simulations were performed using the MSI Agate supercomputing system through Termius. The complex was first tested in the major groove of DNA with and without a leaving group, followed by the same set of simulations in the minor groove. Binding energies were analyzed to compare interaction strength and determine how groove position and …

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